Development of prognostic factors and survival in cutaneous melanoma over 25 years: An analysis of the Central Malignant Melanoma Registry of the German Dermatological Society.

Abstract:

BACKGROUND:Recent studies revealed that incidence rates of cutaneous melanoma (CM) were leveling off predominantly among younger people and patterns suggested birth-cohort effects. The current study analyzed the development of prognostic factors and survival in incident CM over 25 years. METHODS:All 45,483 patients with incident CM diagnosed between 1976 and 2000 recorded by the German Central Malignant Melanoma Registry were considered. Linear and logistic regression analyses were used to judge time trends. Trends of survival rates were tested with the multivariate Cox model. RESULTS:Median tumor thickness decreased from 1.81 mm in 1976 to 0.53 mm in 2000 (P < 0.0001). The percentages of in situ and level II CM increased, respectively (P < 0.0001). The percentage of ulcerated CM decreased (P < 0.0001). The percentage of superficial spreading melanoma increased, whereas the percentage of nodular melanoma decreased (P < 0.0001). These time trends were all significant in the strata of gender, however, male patients presented in general with more advanced disease. Between 1976 and 2000, the average patient got older (P < 0.0001). The percentage of patients diagnosed with the primary tumor alone increased (P < 0.0001). Across the 25 years of observation, adjusted survival rates did not increase for females (P = 0.1561) but they increased for males (P < 0.0001). CONCLUSIONS:The data demonstrated a strong trend towards prognostically more favorable CM most likely due to earlier diagnosis. Men and older people should be the focus of health promotion activities as they presented with more advanced disease.

journal_name

Cancer

journal_title

Cancer

authors

Buettner PG,Leiter U,Eigentler TK,Garbe C

doi

10.1002/cncr.20816

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

616-24

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

103

pub_type

杂志文章

相关文献

CANCER文献大全
  • Evaluation of proposed staging systems for human papillomavirus-related oropharyngeal squamous cell carcinoma.

    abstract:BACKGROUND:Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV-negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC-7ed) staging system does not account for the prognostic advantage observed with HPV-po...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30512

    authors: Malm IJ,Fan CJ,Yin LX,Li DX,Koch WM,Gourin CG,Pitman KT,Richmon JD,Westra WH,Kang H,Quon H,Eisele DW,Fakhry C

    更新日期:2017-05-15 00:00:00

  • The usefulness of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) and a comparison of (18)F-FDG-pet with (67)gallium scintigraphy in the evaluation of lymphoma: relation to histologic subtypes based on the World Health Organization c

    abstract:BACKGROUND:Although studies comparing conventional imaging modalities with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) for the detection of lymphoma and although the relations between (18)F-FDG-PET and histologic types were reported previously, most studies were not systematic and involved rel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22807

    authors: Tsukamoto N,Kojima M,Hasegawa M,Oriuchi N,Matsushima T,Yokohama A,Saitoh T,Handa H,Endo K,Murakami H

    更新日期:2007-08-01 00:00:00

  • Comparative genomic hybridization analysis of genetic aberrations associated with development and progression of biliary tract carcinomas.

    abstract:BACKGROUND:Little is known about genetic aberrations associated with development and progression of biliary tract carcinomas. METHODS:To study chromosomal aberrations associated with development and progression of biliary tract carcinomas, the authors used comparative genomic hybridization to examine 50 such carcinoma...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010201)91:3<570::aid-cncr1036>

    authors: Shiraishi K,Okita K,Harada T,Kusano N,Furui T,Kondoh S,Oga A,Kawauchi S,Fukumoto Y,Sasaki K

    更新日期:2001-02-01 00:00:00

  • Validation of a tool for identifying women at high risk for hereditary breast cancer in population-based screening.

    abstract:BACKGROUND:Recent scientific advances provide the opportunity to identify women in the general population at increased breast cancer risk and to offer effective early detection and disease prevention interventions. METHODS:A pedigree assessment tool (PAT) was designed to identify women in primary care settings who are...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22202

    authors: Hoskins KF,Zwaagstra A,Ranz M

    更新日期:2006-10-15 00:00:00

  • Presentation and subsequent publication rates of phase I oncology clinical trials.

    abstract:BACKGROUND:Many trials submitted to scientific meetings are not reported in peer-reviewed journals. Results may vary substantially and the lack of final publication constitutes a form of reporting bias. The authors sought to determine the presentation and publication rates of Phase I trials submitted to a major oncolog...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21337

    authors: Camacho LH,Bacik J,Cheung A,Spriggs DR

    更新日期:2005-10-01 00:00:00

  • Endodermal sinus tumor of the mediastinum.

    abstract::Endodermal sinus tumor (EST) of the mediastinum is a rare germ-cell neoplasm affecting mainly young adult males. Ten patients with EST were treated with a multimodality approach that included surgery, chemotherapy, and radiotherapy. All patients had relapses after achieving a transient response except one who is still...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820815)50:4<766::aid-cncr28205

    authors: Kuzur ME,Cobleigh MA,Greco FA,Einhorn LH,Oldham RK

    更新日期:1982-08-15 00:00:00

  • Using data to effectively manage a national screening program.

    abstract::The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) of the Centers for Disease Control and Prevention (CDC) is implemented through cooperative agreements with state health departments, US territories, and tribal health organizations (grantees). Grantees typically contract with clinicians and othe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28821

    authors: Yancy B,Royalty JE,Marroulis S,Mattingly C,Benard VB,DeGroff A

    更新日期:2014-08-15 00:00:00

  • A phase I trial of intravenous melphalan, paclitaxel, and cisplatin plus granulocyte-colony stimulating factor in patients with suboptimal advanced epithelial ovarian carcinoma or peritoneal carcinoma.

    abstract:BACKGROUND:The primary purpose of this study was to establish the maximum tolerated dose (MTD) of intravenous melphalan in combination with paclitaxel and cisplatin plus granulocyte-colony stimulating factor (G-CSF) in patients with suboptimal advanced epithelial ovarian carcinoma or primary peritoneal carcinoma. METH...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Gershenson DM,Morris M,Burke TW,Levenback C,Wolf J,Lee JJ,Thall PF,Atkinson EN,Silva EG,Wharton JT

    更新日期:1999-12-01 00:00:00

  • Atypical squamous cells of undetermined significance on cervical smears: follow-up study of an Asian screening population.

    abstract:BACKGROUND:The current study reports on the significance of cervical smears identified as atypical squamous cells of undetermined significance (ASCUS) in the largest Asian screening population to date. METHODS:From January 1998 to December 1999, 190,000 cervical smears were evaluated by the cervical cytology laborator...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20045

    authors: Cheung AN,Szeto EF,Ng KM,Fong KW,Yeung AC,Tsun OK,Khoo US,Chan KY,Ng AW

    更新日期:2004-04-25 00:00:00

  • Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice.

    abstract:BACKGROUND:Glioblastoma, which is the most malignant brain tumor, remains incurable and almost always causes death. As a new treatment strategy, the combination of all-trans retinoic acid (ATRA) and paclitaxel was explored for controlling the growth of glioblastoma U87MG xenografts. METHODS:Human glioblastoma U87MG xe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23223

    authors: Karmakar S,Banik NL,Ray SK

    更新日期:2008-02-01 00:00:00

  • Physician interpretation of genomic test results and treatment selection.

    abstract:BACKGROUND:Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The Univ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31112

    authors: Brusco LL,Wathoo C,Mills Shaw KR,Holla VR,Bailey AM,Johnson AM,Khotskaya YB,Litzenburger BC,Sanchez NS,Zeng J,Bernstam EV,Eng C,Kee BK,Amaria RN,Routbort MJ,Mills GB,Mendelsohn J,Meric-Bernstam F

    更新日期:2018-03-01 00:00:00

  • Breast conservation therapy in the United States following the 1990 National Institutes of Health Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma.

    abstract:BACKGROUND:A National Institutes of Health (NIH) Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma, held in June 1990, recommended breast conservation therapy for the majority of women with Stage I or II breast carcinoma. The authors evaluated the national use of b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Lazovich D,Solomon CC,Thomas DB,Moe RE,White E

    更新日期:1999-08-15 00:00:00

  • Insular thyroid cancer: a population-level analysis of patient characteristics and predictors of survival.

    abstract:BACKGROUND:Insular thyroid cancer (ITC) is an uncommon, poorly differentiated thyroid malignancy. To date, there have been no population-level studies of the characteristics and outcomes of patients with ITC. METHODS:The authors used the Surveillance, Epidemiology, and End Results (SEER) database from 1999 to 2007 to ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26638

    authors: Kazaure HS,Roman SA,Sosa JA

    更新日期:2012-07-01 00:00:00

  • Cognitive impairment in men with testicular cancer prior to adjuvant therapy.

    abstract:BACKGROUND:Cognitive dysfunction experienced by individuals with cancer represents an important survivorship issue because of its potential to affect occupational, scholastic, and social activities. Whereas early efforts to characterize cognitive dysfunction primarily focused on the effects of chemotherapy, more recent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25298

    authors: Wefel JS,Vidrine DJ,Veramonti TL,Meyers CA,Marani SK,Hoekstra HJ,Hoekstra-Weebers JE,Shahani L,Gritz ER

    更新日期:2011-01-01 00:00:00

  • Lack of correlation of a histochemical method for estrogen receptors analysis with the biochemical assay results.

    abstract::Forty-nine specimens of carcinoma of the breast were analyzed for estrogen receptor content using the sucrose gradient method and a histochemical method using a conjugate of estradiol (6-BSA-Fluor-CMO-17 beta-estradiol). The specimens analyzed by the histochemical method were graded for fluorescent intensity, percenta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820515)49:10<2148::aid-cncr282

    authors: Panko WB,Mattioli CA,Wheeler TM

    更新日期:1982-05-15 00:00:00

  • Epithelial papilloma and squamous cell carcinoma of the nasal cavity and paranasal sinuses: a clinicopathological study.

    abstract::Seventeen cases of intranasal epithelial tumors are reviewed. Thirteen were epithelial papillomas and four were squamous cell carcinomas associated with epithelial papillomas. In two cases followed over a 10 year period, transformation from an initial papilloma into a carcinoma was demonstrated. The histopathologic ca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197612)38:6<2503::aid-cncr282038

    authors: Lasser A,Rothfeld PR,Shapiro RS

    更新日期:1976-12-01 00:00:00

  • Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium.

    abstract::Twenty-four patients with various solid tumors including metastatic liver cancer and cancer of the lung, gallbladder, and pancreas were treated with a lipophilic macromolecular drug, copoly(styrene-maleic acid) conjugated neocarzinostatin (SMANCS). The drug was dissolved in a lipid contrast medium Lipiodol and adminis...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841201)54:11<2367::aid-cncr282

    authors: Konno T,Maeda H,Iwai K,Maki S,Tashiro S,Uchida M,Miyauchi Y

    更新日期:1984-12-01 00:00:00

  • Outcome in 34 patients with juvenile-onset mycosis fungoides: a clinical, immunophenotypic, and molecular study.

    abstract:BACKGROUND:Mycosis fungoides (MF) is predominantly a disease of older patients, but occasionally occurs in children. The aims of the current study were to describe the clinical presentation, pathologic features, and disease progression (DP) in patients who developed MF before age 16 years. METHODS:A retrospective stud...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11780

    authors: Wain EM,Orchard GE,Whittaker SJ,Spittle M Sc MF,Russell-Jones R

    更新日期:2003-11-15 00:00:00

  • Acute myelomonocytic leukemia associated with paraproteinemia.

    abstract::A 49-year-old white woman with refractory anemia subsequently developed acute myelomonocytic leukemia with paraproteinemia 12 months later. The paraprotein was characterized as immunoglobulin G, type kappa, and the Bence Jones protein as free kappa chains. Further studies, including electron microscopy, cytochemistry,...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197603)37:3<1359::aid-cncr282037

    authors: Law IP,Koch FJ,Cannon GB,Herberman RB,Oldham RK

    更新日期:1976-03-01 00:00:00

  • Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases.

    abstract:BACKGROUND:Genes involved in the angiopoietin and pericyte pathways may become escape mechanisms under antivascular endothelial growth factor (anti-VEGF) therapy. The authors investigated whether variations within genes in these pathways are associated with clinical outcome in patients with colorectal liver metastases ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29259

    authors: Stremitzer S,Zhang W,Yang D,Ning Y,Stintzing S,Sebio A,Sunakawa Y,Yamauchi S,Matsusaka S,El-Khoueiry R,Stift J,Wrba F,Gruenberger T,Lenz HJ

    更新日期:2015-06-01 00:00:00

  • Ultrastructural observations on the histogenesis of alveolar rhabdomyosarcoma.

    abstract::Ultrastructural examination of an alveolar rhabdomyosarcoma revealed that the bulk of the tumor was composed of small polygonal cells containing polyribosomes, short strands of rough endoplasmic reticulum, and variable amounts of glycogen; the cells were joined by small desmosome-like structures. Similar cells, as wel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197804)41:4<1355::aid-cncr282041

    authors: Churg A,Ringus J

    更新日期:1978-04-01 00:00:00

  • Bacteria-associated hemophagocytic syndrome.

    abstract::Histiocytic medullary reticulosis (HMR) was originally defined as a neoplastic disorder. Some cases reported as HMR have been characterized by a systemic proliferation of mature histiocytes showing hemophagocytosis, bone marrow necrosis, pancytopenia, hepatitis, and coagulopathy. Clinically, these patients have fever ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841215)54:12<2968::aid-cncr282

    authors: Risdall RJ,Brunning RD,Hernandez JI,Gordon DH

    更新日期:1984-12-15 00:00:00

  • Late recurrence of surgically removed prolactinomas.

    abstract::The authors observed the clinical course of 24 women with surgically removed prolactinomas for a mean postoperative interval of 62 months. The frequency of late tumor recurrence and probable factors responsible for the recurrence were investigated. Hyperprolactinemia recurred in 4 of 13 patients with microadenomas (31...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860615)57:12<2422::aid-cncr282

    authors: Parl FF,Cruz VE,Cobb CA,Bradley CA,Aleshire SL

    更新日期:1986-06-15 00:00:00

  • Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia.

    abstract:BACKGROUND:CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation (pCXCR4) and is essential for the migration of hematopoietic precursors to bone marrow. CXCR4 overexpression predicts a poor prognosis in patients with acute myeloid leukemia. Data regarding the prognostic impact of CXCR4 in patients with B-acu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26113

    authors: Konoplev S,Jorgensen JL,Thomas DA,Lin E,Burger J,Kantarjian HM,Andreeff M,Medeiros LJ,Konopleva M

    更新日期:2011-10-15 00:00:00

  • Obesity, non-protein-bound estradiol levels, and distribution of estradiol in the sera of breast cancer patients.

    abstract::This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradiol on sex hormone-binding globulin (SHBG) and albumin in breast ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860201)57:3<558::aid-cncr28205

    authors: Ota DM,Jones LA,Jackson GL,Jackson PM,Kemp K,Bauman D

    更新日期:1986-02-01 00:00:00

  • Conservative treatment of distal rectal cancer by local excision.

    abstract::From 1954 through 1982, 57 patients with invasive, distal rectal cancer had a full-thickness local excision with curative intent. Prognostic criteria and need for further treatment were based on the histopathologic results of the operative specimen. The overall 5-year survival rate was 83.4%. The rectal cancer-specifi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890115)63:2<219::aid-cncr28206

    authors: DeCosse JJ,Wong RJ,Quan SH,Friedman NB,Sternberg SS

    更新日期:1989-01-15 00:00:00

  • Immunohistochemical studies of blood group-related antigens in human superficial esophageal carcinomas.

    abstract::A total of 63 surgically resected esophageal carcinomas (including 49 superficial esophageal carcinomas) and histologically normal tissue adjacent to the superficial carcinoma (nontumorous epithelium) were examined immunohistochemically for the blood group antigens (BGA) A, B, H, Lewisa, Lewisb, Lewisx, and Lewisy. De...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910615)67:12<3042::aid-cncr282

    authors: Tauchi K,Kakudo K,Machimura T,Makuuchi H,Mitomi T

    更新日期:1991-06-15 00:00:00

  • Nonlymphoblastic T-cell lymphoma in children.

    abstract::Three children with nonlymphoblastic, non-Hodgkin's lymphomas, showed morphologic features that suggested nonlymphoblastic T-cell origin. Tissue for immunologic study was available from two of the three patients; both showed immunophenotypes of T-cells. Although nearly all T-cell lymphomas in children are lymphoblasti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2099::aid-cncr282

    authors: Bitter MA,Nachman J,Jones N,Franklin WA,Le Beau MM,Vardiman JW

    更新日期:1987-06-15 00:00:00

  • Comparative tumor localization of whole immunoglobulin G anticarcinoembryonic antigen monoclonal antibodies IMMU-4 and IMMU-4 F(ab')2 in colorectal cancer patients.

    abstract:BACKGROUND:Previous studies in the literature have suggested that radiolabeled F(ab')2 fragments might be superior to whole immunoglobulin G (IgG) for imaging and therapy of cancer because of their greater penetration in tumors. To test this hypothesis, the authors compared tumor and normal tissue uptake along with pla...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940201)73:3+<850::aid-cncr2820

    authors: Murray JL,Rosenblum MG,Zhang HZ,Podoloff DA,Kasi LP,Curley SA,Chan JC,Roh M,Hohn DC,Brewer H

    更新日期:1994-02-01 00:00:00

  • Liver iron stores and hepatitis B antigen status.

    abstract::Higher serum iron and ferritin levels noted in hepatitis B antigen (HBAg) carriers than in noncarriers suggests that virus might actively replicate in hepatocytes, stimulate ferritin synthesis, and result in increased liver iron stores. A comparative semiquantitative study of immunohistochemical ferritin (0-12) and he...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851101)56:9<2201::aid-cncr2820

    authors: Cohen C,Berson SD,Shulman G,Budgeon LR

    更新日期:1985-11-01 00:00:00