Obesity, non-protein-bound estradiol levels, and distribution of estradiol in the sera of breast cancer patients.

Abstract:

:This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradiol on sex hormone-binding globulin (SHBG) and albumin in breast cancer patients and control patients. Normal-weight controls had significantly lower %NPBE compared with overweight controls and normal-weight and overweight breast cancer patients. There was a significant shift in the percent distribution of estradiol from SHBG to albumin in breast cancer patients, independent of body weight. Elevated %NPBE and abnormal percent estradiol distribution on albumin persisted after mastectomy and were unrelated to menopausal status, presence and stage of disease, and tumor estrogen receptor levels. These results show that breast cancer patients have increased exposure to unbound circulating estradiol and an increased percentage of estradiol bound to albumin, which may influence the availability of estradiol, considering its low binding affinity to albumin. Because these abnormalities persist after mastectomy, the current results may be important in developing dietary intervention protocols that correct %NPBE and abnormal estradiol distribution on binding proteins.

journal_name

Cancer

journal_title

Cancer

authors

Ota DM,Jones LA,Jackson GL,Jackson PM,Kemp K,Bauman D

doi

10.1002/1097-0142(19860201)57:3<558::aid-cncr28205

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

558-62

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

57

pub_type

杂志文章

相关文献

CANCER文献大全
  • Health care cost and utilization project analysis of comorbid illness and complications for patients undergoing hysterectomy for endometrial carcinoma.

    abstract:OBJECTIVE:The objective was to study the association of race, comorbid illness, and lymph node dissection (LND) with complications in patients undergoing hysterectomy for endometrial carcinoma. METHODS:The Health Care Cost Utilization Project analysis studied women undergoing hysterectomy for endometrial carcinoma in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010815)92:4<950::aid-cncr1405>

    authors: Brooks SE,Ahn J,Mullins CD,Baquet CR,D'Andrea A

    更新日期:2001-08-15 00:00:00

  • Measuring the significance of workload on performance of cytotechnologists in gynecologic cytology: a study using rapid prescreening.

    abstract:BACKGROUND:Workload is extensively regulated and often used as a measure of quality in gynecologic cytology. Whether workload correlates with the sensitivity of screening in gynecologic cytology is not known. METHODS:The sensitivity of gynecologic cytology screening was measured over an 8-month period using the result...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23497

    authors: Deschenes M,Renshaw AA,Auger M

    更新日期:2008-06-25 00:00:00

  • Receptor activator of NF-kappaB ligand, macrophage inflammatory protein-1alpha, and the proteasome: novel therapeutic targets in myeloma.

    abstract:BACKGROUND:The bone destruction in myeloma patients is largely responsible for the clinical features of the disease. However, only recently has attention focused on identifying and developing drugs targeted specifically at the osteolysis. Receptor activator of NF-kappaB ligand (RANKL), macrophage inflammatory protein (...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11133

    authors: Oyajobi BO,Mundy GR

    更新日期:2003-02-01 00:00:00

  • Involving providers and patients in cancer control and prevention efforts. Barriers to overcome.

    abstract::Although progress has been made in providing cancer prevention and control services to the population, there remain sizeable segments of the population that are either uninvolved or underinvolved with national and state efforts. One method of reaching most of the population, including those segments currently not invo...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930801)72:3+<1138::aid-cncr282

    authors: Iverson DC

    更新日期:1993-08-01 00:00:00

  • Binding of soybean agglutinin lectin to prostatic hyperplasia and adenocarcinoma.

    abstract::The binding of soybean agglutinin (SBA) lectin to routinely processed surgical pathology material from cases of prostatic hyperplasia, atypical hyperplasia, and adenocarcinoma was studied using an immunoperoxidase technique. Positive staining was obtained in eight of eight cases of nodular hyperplasia, eight of eight ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890415)63:8<1583::aid-cncr2820

    authors: Loy TS,Kyle J,Bickel JT

    更新日期:1989-04-15 00:00:00

  • Long-term outcome in localized extranodal mucosa-associated lymphoid tissue lymphomas treated with radiotherapy.

    abstract:BACKGROUND:This study was conducted to evaluate the long-term outcomes in patients with stage IE and IIE mucosa-associated lymphoid tissue (MALT) lymphomas treated with involved field radiotherapy (RT). METHODS:Between 1989 and 2004, 192 patients with stage I and II MALT lymphomas were treated. The report focuses on 1...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25226

    authors: Goda JS,Gospodarowicz M,Pintilie M,Wells W,Hodgson DC,Sun A,Crump M,Tsang RW

    更新日期:2010-08-15 00:00:00

  • Breast adenomas.

    abstract::True adenomas of the breast are cellular epithelial lesions, which may be confused with carcinoma and are difficult to classify. We have reviewed 28 adenomas of the breast and have developed specific diagnostic criteria, as well as a classification of breast adenomas based on histologic features. Electron microscopic ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197606)37:6<2891::aid-cncr282037

    authors: Hertel BF,Zaloudek C,Kempson RL

    更新日期:1976-06-01 00:00:00

  • The size of breast masses at presentation. The impact of prior medical training.

    abstract::Five hundred and sixty-nine patients with breast cancer presenting for treatment at a community hospital were studied. The results showed no significant change in tumor size at presentation or reported patient delay over a 12-year span. This was in spite of considerable national discussion and increasing public concer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830501)51:9<1750::aid-cncr2820

    authors: Buttlar CA,Templeton AC

    更新日期:1983-05-01 00:00:00

  • Integration of human papillomavirus vaccination, cytology, and human papillomavirus testing.

    abstract::There is justifiable excitement about the recent introduction of prophylactic vaccines against human papillomavirus (HPV) types 16 (HPV-16) and HPV-18. Preventing these infections theoretically could avert approximately 70% of cervical cancer cases worldwide. In the U.S., numerous influential advocates are calling for...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22751

    authors: Schiffman M

    更新日期:2007-06-25 00:00:00

  • Reversal of multidrug resistance to cancer chemotherapy.

    abstract::In the past few years, the role of membrane-bound transport genes in human disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward transport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This ar...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19931201)72:11+<3484::aid-cncr28

    authors: Leyland-Jones B,Dalton W,Fisher GA,Sikic BI

    更新日期:1993-12-01 00:00:00

  • Are older breast carcinoma survivors willing to take hormone replacement therapy?

    abstract:BACKGROUND:Breast carcinoma survivors are the largest segment of the expanding cancer survivor community. As a result, there has been increasing discussion of the safety and efficacy of hormone replacement therapy for women with a past history of breast carcinoma. Little is known about the willingness of older breast c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Ganz PA,Greendale GA,Kahn B,O'Leary JF,Desmond KA

    更新日期:1999-09-01 00:00:00

  • Improving the prognostic value of DNA flow cytometry in breast cancer by combining DNA index and S-phase fraction. A proposed classification of DNA histograms in breast cancer.

    abstract::To optimize the prognostic value of DNA flow cytometry in breast cancer the authors calculated several parameters from the DNA histogram, including the DNA index, the size and number of aneuploid peaks as well as S-phase and G2/M-phase cell cycle fractions. Of these, DNA index and S-phase fraction (SPF) proved to be t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881115)62:10<2183::aid-cncr282

    authors: Kallioniemi OP,Blanco G,Alavaikko M,Hietanen T,Mattila J,Lauslahti K,Lehtinen M,Koivula T

    更新日期:1988-11-15 00:00:00

  • Multicenter Phase II study of estramustine phosphate plus weekly paclitaxel in patients with androgen-independent prostate carcinoma.

    abstract:BACKGROUND:The current study determined the efficacy and toxicity of weekly paclitaxel in combination with estramustine phosphate (EMP) in patients with androgen-independent prostate carcinoma (AIPC). METHODS:Patients with progressive AIPC received 90 mg/m2 paclitaxel by 1-hour intravenous infusion weekly for 3 weeks,...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/cncr.11956

    authors: Vaughn DJ,Brown AW Jr,Harker WG,Huh S,Miller L,Rinaldi D,Kabbinavar F

    更新日期:2004-02-15 00:00:00

  • Predictors of invasion in patients with core-needle biopsy-diagnosed ductal carcinoma in situ and recommendations for a selective approach to sentinel lymph node biopsy in ductal carcinoma in situ.

    abstract:BACKGROUND:Among patients with core-needle biopsy (CNB)-diagnosed ductal carcinoma in situ (DCIS), the guidelines for the selection of patients to undergo sentinel lymph node (SLN) biopsy are not well defined, and many patients with no invasion undergo an unnecessary SLN biopsy. The objective of this study was to ident...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22216

    authors: Huo L,Sneige N,Hunt KK,Albarracin CT,Lopez A,Resetkova E

    更新日期:2006-10-15 00:00:00

  • The prognostic significance of ploidy analysis in operable breast cancer.

    abstract::The nuclear DNA content of 98 operable breast cancers was determined by flow cytometric analysis using paraffin-embedded tissue. All patients were on follow-up and failure of treatment or recurrences were identified. DNA ploidy data in the form of ploidy status and DNA index (DI) has been correlated with various clini...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911215)68:12<2612::aid-cncr282

    authors: Sharma S,Mishra MC,Kapur BM,Verma K,Nath I

    更新日期:1991-12-15 00:00:00

  • Multivariate analysis for histologic prognostic factors in soft tissue sarcomas.

    abstract::To investigate histologic prognostic factors in soft tissue sarcomas (STS), multivariate analysis was performed on 236 patients with complete clinical information. These included 141 males and 95 females with an age range from 1 to 85 years (median, 47.6 years). Histologically, malignant fibrous histiocytoma (33.5%) w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880901)62:5<994::aid-cncr28206

    authors: Tsujimoto M,Aozasa K,Ueda T,Morimura Y,Komatsubara Y,Doi T

    更新日期:1988-09-01 00:00:00

  • Differences in the diagnostic criteria used by Japanese and Western pathologists to diagnose colorectal carcinoma.

    abstract:BACKGROUND:In view of the many studies of early stage colorectal carcinoma from Japan, it is essential to know whether the criteria for the histologic diagnosis of colorectal carcinoma are similar in Japan and Western countries. METHODS:Eight expert pathologists from Japan (4), North America (2), and Europe (2) indivi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980101)82:1<60::aid-cncr

    authors: Schlemper RJ,Itabashi M,Kato Y,Lewin KJ,Riddell RH,Shimoda T,Sipponen P,Stolte M,Watanabe H

    更新日期:1998-01-01 00:00:00

  • X;6 translocation in a child with congenital acute lymphocytic leukemia.

    abstract::A case of congenital acute lymphoblastic leukemia (ALL) displayed an X;6 translocation. This is the third reported case of ALL with an X;6 translocation. In addition, two of the three ALL cases occurred during infancy, at ages 2 months and newborn, and both translocations involved the band q15-16 region of chromosome ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19920201)69:3<799::aid-cncr28206

    authors: Carney LA,Kinney JS,Higgins RR,Freeman AI,Hecht BK,Woods GM

    更新日期:1992-02-01 00:00:00

  • Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck.

    abstract:BACKGROUND:p53 plays a critical role in cellular anticancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of p53 results in an amino acid substitution and could influence p53 function. The authors hypothesized that p53 codon 72 polymorphism may b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25072

    authors: Li F,Sturgis EM,Chen X,Zafereo ME,Wei Q,Li G

    更新日期:2010-05-15 00:00:00

  • Randomized trial comparing cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) with rotational CMF, epirubicin and vincristine as primary chemotherapy in operable breast carcinoma.

    abstract:BACKGROUND:According to the overview of Early Breast Cancer Trialists' Collaborative Group, anthracycline containing regimens are superior to cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) as adjuvant chemotherapy for breast carcinoma, but no comparative information is available in terms of primary chemothera...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.10678

    authors: Cocconi G,Di Blasio B,Boni C,Bisagni G,Ceci G,Rondini E,Bella M,Leonardi F,Savoldi L,Camisa R,Bruzzi P

    更新日期:2002-07-15 00:00:00

  • Occult hepatitis B virus infection is associated with the development of hepatocellular carcinoma in chronic hepatitis C patients.

    abstract:BACKGROUND:Occult hepatitis B virus (HBV) infection frequently occurs in patients with HBV surface antigen (HBsAg)-negative chronic liver disease, and much evidence suggests that it is a risk factor for hepatocellular carcinoma (HCC) development. However, to the authors' knowledge, no follow-up study has been performed...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21702

    authors: Squadrito G,Pollicino T,Cacciola I,Caccamo G,Villari D,La Masa T,Restuccia T,Cucinotta E,Scisca C,Magazzu D,Raimondo G

    更新日期:2006-03-15 00:00:00

  • Prognostic factors for survival of patients with advanced urothelial tumors treated with methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy.

    abstract::Between February 1983 and February 1986, 132 patients with advanced urothelial tract tumors were treated with methotrexate, vinblastine, Adriamycin (doxorubicin), and cisplatin (M-VAC) chemotherapy. Analysis of prognostic factors for survival of the first 92 patients was undertaken using the Cox proportional hazards m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910315)67:6<1525::aid-cncr2820

    authors: Geller NL,Sternberg CN,Penenberg D,Scher H,Yagoda A

    更新日期:1991-03-15 00:00:00

  • Correlation of chromosome abnormalities with clinical characteristics in thyroid lymphoma.

    abstract::Karyotypes from seven patients with thyroid lymphoma were studied before treatment. When the cytogenetic results were correlated with the clinical data, it became evident that there are two distinct groups of patients with thyroid lymphoma. In a group of patients with solely numerical abnormalities the disease is asso...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890301)63:5<873::aid-cncr28206

    authors: Taniwaki M,Nishida K,Misawa S,Takino T,Abe T,Aozasa K,Katagiri S,Yonezawa T,Matsuzuka F,Kuma K

    更新日期:1989-03-01 00:00:00

  • Image cytometric classification of premalignant breast disease in fine needle aspirates.

    abstract::Image cytometry for the classification of fine needle aspirate (FNA) biopsies was evaluated in samples from 39 women. Eighteen of them had benign lesions, seven had premalignant lesions, nine had carcinoma in situ, and five had carcinoma. The term, premalignant, here refers to lesions with an increased risk of develop...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880701)62:1<114::aid-cncr28206

    authors: King EB,Chew KL,Duarte L,Hom JD,Mayall BH,Miller TR,Petrakis NL

    更新日期:1988-07-01 00:00:00

  • Intraoperative radiation therapy adjuvant to resection in the treatment of pancreatic cancer.

    abstract:BACKGROUND:Local recurrence is the most frequent site of failure after resection for pancreatic cancer. Tolerance, local control, and survival obtained by the association of resection and intraoperative radiation therapy (IORT) were reported. METHODS:Between June 1985 and March 1993, 90 resections for pancreatic cance...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940615)73:12<2930::aid-cncr282

    authors: Zerbi A,Fossati V,Parolini D,Carlucci M,Balzano G,Bordogna G,Staudacher C,Di Carlo V

    更新日期:1994-06-15 00:00:00

  • The long-term effect of cisplatin on renal function.

    abstract::The long-term effect of cisplatin on renal function was studied in a follow-up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/m2 (range, 275-650 mg/m2). Prehydration with isotonic saline secured diures...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861115)58:10<2214::aid-cncr282

    authors: Fjeldborg P,Sørensen J,Helkjaer PE

    更新日期:1986-11-15 00:00:00

  • Prognostic value of CD44 isoform expression in thymic epithelial neoplasms.

    abstract:BACKGROUND:Many histologic classifications of thymic epithelial tumors have been reported to date, but to the authors' knowledge, none of them closely reflect the clinical behavior or prognosis of the tumor. Therefore, it is necessary to establish a biologic marker for thymic epithelial tumors. Variants of CD44 may be ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21046

    authors: Sonobe S,Miyamoto H,Nobukawa B,Izumi H,Futagawa T,Ishikawa N,Yamazaki A,Uekusa T,Abe H,Suda K

    更新日期:2005-05-15 00:00:00

  • Occupation and lung cancer risk. An analysis by histologic subtypes.

    abstract::The relationships between cigarette smoking, occupational exposures, dietary vitamin A and lung cancer is explored in a case-control study. The study is based on 1002 primary lung cancers among white men and 1119 white male controls between 35 and 79 years of age admitted to Roswell Park Memorial Institute from 1957 t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850815)56:4<910::aid-cncr28205

    authors: Vena JE,Byers TE,Cookfair D,Swanson M

    更新日期:1985-08-15 00:00:00

  • Growth inhibitory effects of paclitaxel on human epithelioid sarcoma in vitro: heterogeneity of response and the multidrug resistance phenotype.

    abstract:BACKGROUND:Epithelioid sarcoma is a highly malignant soft tissue tumor that is largely resistant to conventional chemotherapy and radiotherapy. Because paclitaxel has been proven to be effective in other human malignancies refractory to conventional chemotherapy, the authors analyzed the in vitro growth inhibitory effe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(20000401)88:7<1614::aid-cn

    authors: Reinecke P,Knopf C,Schmitz M,Schneider EM,Gabbert HE,Gerharz CD

    更新日期:2000-04-01 00:00:00

  • An immunohistochemical analysis for cancer of the esophagus using monoclonal antibodies specific for modified nucleosides.

    abstract:BACKGROUND:Modified nucleosides such as 1-methyl-adenosine and pseudouridine exist as minute components of transfer ribonucleic acid (tRNA) and are excreted in the urine in large amounts in the presence of malignancy. Although use of these modified nucleosides as tumor markers has long been studied and many reports hav...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931215)72:12<3571::aid-cncr282

    authors: Masuda M,Nishihira T,Itoh K,Mizugaki M,Ishida N,Mori S

    更新日期:1993-12-15 00:00:00