Abstract:
BACKGROUND:The current study determined the efficacy and toxicity of weekly paclitaxel in combination with estramustine phosphate (EMP) in patients with androgen-independent prostate carcinoma (AIPC). METHODS:Patients with progressive AIPC received 90 mg/m2 paclitaxel by 1-hour intravenous infusion weekly for 3 weeks, followed by a 1-week treatment rest. Patients received 140 mg EMP orally 3 times daily on the day before, the day of, and the day after paclitaxel administration. Patients received 1 mg warfarin daily to prevent thromboembolism. RESULTS:Sixty-six patients with progressive AIPC received treatment at 29 centers. Forty-two percent of patients had a 50% decline in prostate-specific antigen (PSA; 95% confidence interval [CI], 30-54%). For 26 patients with bidimensionally measurable disease, the objective response rate was 15% (95% CI, 1-30%). The median time to disease progression was 6.3 months, and the median time to PSA progression was 11.4 months. The median survival period was 15.6 months. Grade 3-4 toxicities were uncommon and included thromboembolism (8%), anemia (3%), neutropenia (3%), and peripheral neuropathy (2%). There was one treatment-related death. CONCLUSIONS:This regimen of EMP plus weekly paclitaxel was an active and well tolerated treatment for patients with AIPC.
journal_name
Cancerjournal_title
Cancerauthors
Vaughn DJ,Brown AW Jr,Harker WG,Huh S,Miller L,Rinaldi D,Kabbinavar Fdoi
10.1002/cncr.11956subject
Has Abstractpub_date
2004-02-15 00:00:00pages
746-50issue
4eissn
0008-543Xissn
1097-0142journal_volume
100pub_type
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