Multicenter Phase II study of estramustine phosphate plus weekly paclitaxel in patients with androgen-independent prostate carcinoma.

Abstract:

BACKGROUND:The current study determined the efficacy and toxicity of weekly paclitaxel in combination with estramustine phosphate (EMP) in patients with androgen-independent prostate carcinoma (AIPC). METHODS:Patients with progressive AIPC received 90 mg/m2 paclitaxel by 1-hour intravenous infusion weekly for 3 weeks, followed by a 1-week treatment rest. Patients received 140 mg EMP orally 3 times daily on the day before, the day of, and the day after paclitaxel administration. Patients received 1 mg warfarin daily to prevent thromboembolism. RESULTS:Sixty-six patients with progressive AIPC received treatment at 29 centers. Forty-two percent of patients had a 50% decline in prostate-specific antigen (PSA; 95% confidence interval [CI], 30-54%). For 26 patients with bidimensionally measurable disease, the objective response rate was 15% (95% CI, 1-30%). The median time to disease progression was 6.3 months, and the median time to PSA progression was 11.4 months. The median survival period was 15.6 months. Grade 3-4 toxicities were uncommon and included thromboembolism (8%), anemia (3%), neutropenia (3%), and peripheral neuropathy (2%). There was one treatment-related death. CONCLUSIONS:This regimen of EMP plus weekly paclitaxel was an active and well tolerated treatment for patients with AIPC.

journal_name

Cancer

journal_title

Cancer

authors

Vaughn DJ,Brown AW Jr,Harker WG,Huh S,Miller L,Rinaldi D,Kabbinavar F

doi

10.1002/cncr.11956

subject

Has Abstract

pub_date

2004-02-15 00:00:00

pages

746-50

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

100

pub_type

临床试验,杂志文章,多中心研究

相关文献

CANCER文献大全
  • Evaluation of des-gamma-carboxy prothrombin as a marker protein of hepatocellular carcinoma.

    abstract::We measured des-gamma-carboxyglutamic acid prothrombin (protein induced by vitamin K absence or antagonist-Factor II: [PIVKA-II]) in plasmas of normal subjects, patients with thrombotic disease, those with hepatic disease including hepatocellular carcinoma, and those with carcinoma of other tissues, and compared the r...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891215)64:12<2546::aid-cncr282

    authors: Deyashiki Y,Nishioka Y,Takahashi K,Kosaka Y,Suzuki K

    更新日期:1989-12-15 00:00:00

  • The long-term effect of cisplatin on renal function.

    abstract::The long-term effect of cisplatin on renal function was studied in a follow-up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/m2 (range, 275-650 mg/m2). Prehydration with isotonic saline secured diures...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861115)58:10<2214::aid-cncr282

    authors: Fjeldborg P,Sørensen J,Helkjaer PE

    更新日期:1986-11-15 00:00:00

  • Codon 13 KRAS mutation predicts patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases.

    abstract:BACKGROUND:Investigations regarding the impact of tumor biology after surgical management of colorectal liver metastasis have focused largely on overall survival. We investigated the impact of codon-specific KRAS mutations on the rates and patterns of recurrence in patients after surgery for colorectal liver metastasis...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30085

    authors: Margonis GA,Kim Y,Sasaki K,Samaha M,Amini N,Pawlik TM

    更新日期:2016-09-01 00:00:00

  • Aggressive angiomyxoma: a clinicopathologic study of 29 female patients.

    abstract:BACKGROUND:Aggressive angiomyxoma is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females. Since its initial description in 1983, approximately 65 cases have been reported in the English literature. METHODS:The clinical and pathologic features of 29 cases of aggressive ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960701)78:1<79::AID-CNCR

    authors: Fetsch JF,Laskin WB,Lefkowitz M,Kindblom LG,Meis-Kindblom JM

    更新日期:1996-07-01 00:00:00

  • Hidden barriers between knowledge and behavior: the North Carolina prostate cancer screening and treatment experience.

    abstract:BACKGROUND:Prostate cancer (PC) mortality is much greater for African American than for Caucasian men. To identify patient factors that might account for some of this disparity, men within 6 months of diagnosis were surveyed about health attitudes and behavior. METHODS:Using Rapid Identification in the North Carolina ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22583

    authors: Talcott JA,Spain P,Clark JA,Carpenter WR,Do YK,Hamilton RJ,Galanko JA,Jackman A,Godley PA

    更新日期:2007-04-15 00:00:00

  • Sulphomucin-secreting intestinal metaplasia in the human gastric mucosa. An association with intestinal-type gastric carcinoma.

    abstract::Sixty-three gastrectomy specimens (21 with early intestinal type carcinoma, 21 with early diffuse carcinoma, and 21 with benign nonneoplastic lesions) were examined histochemically to determine the distribution of intestinal metaplasia (IM), particularly the sulphomucin-secreting type (Type IIB IM). The frequency and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900815)66:4<689::aid-cncr28206

    authors: Matsukuma A,Mori M,Enjoji M

    更新日期:1990-08-15 00:00:00

  • Parathyroid hormone-related protein expression in gynecic squamous carcinoma cells.

    abstract:BACKGROUND:The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous cell carcinomas of gynecologic origin is largely unknown. METHO...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940301)73:5<1515::aid-cncr2820

    authors: Tait DL,MacDonald PC,Casey ML

    更新日期:1994-03-01 00:00:00

  • Periosteal osteosarcoma: a single-institution experience.

    abstract:BACKGROUND:Periosteal osteosarcoma is a rare variant of osteosarcoma. Wide surgical removal is the mainstay of treatment, but controversy remains about the role of chemotherapy. The objective of this study was to review and analyze the clinical and treatment-related factors that influence the survival of patients with ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25718

    authors: Cesari M,Alberghini M,Vanel D,Palmerini E,Staals EL,Longhi A,Abate M,Ferrari C,Balladelli A,Ferrari S

    更新日期:2011-04-15 00:00:00

  • Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study.

    abstract:BACKGROUND:Most gynecologists determine therapy based on current International Society of Gynecologic Pathologists (ISGP)/World Health Organization classification of endometrial hyperplasia, the reproducibility of which has been questioned. The Gynecologic Oncology Group (GOG) initiated a protocol to assess the efficac...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.21649

    authors: Zaino RJ,Kauderer J,Trimble CL,Silverberg SG,Curtin JP,Lim PC,Gallup DG

    更新日期:2006-02-15 00:00:00

  • Cancer burden in the aged: an epidemiologic and demographic overview.

    abstract::Sixty percent of all cancer occurs in persons aged > or =65 years. This article provides an overview of aspects of the burden of cancer in the elderly, highlighting certain demographic and epidemiologic data. It served as a frame of reference for participants in the Oncology Geriatric Education Retreat, San Juan, Puer...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Yancik R

    更新日期:1997-10-01 00:00:00

  • Gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists.

    abstract:BACKGROUND:The current study was conducted to examine gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists. METHODS:The participants included a convenience sample of 178 oncologists from Israel (52 of whom were women) and Canada (48 of whom were women). Oncol...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30236

    authors: Granek L,Krzyzanowska MK,Nakash O,Cohen M,Ariad S,Barbera L,Levy R,Ben-David M

    更新日期:2016-12-01 00:00:00

  • Nutrients, vitamins and minerals as therapy.

    abstract::Nutrients as therapy for patients with cancer are important as adjunctive therapy, i.e., adequate nutrition may be important for the success of whatever form of therapy is administered. Diets deficient in certain amino acids have some selectivity when tested against experimental tumors propagated in vivo. Such diets h...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197905)43:5+<2137::aid-cncr28204

    authors: Bertino JR

    更新日期:1979-05-01 00:00:00

  • Quality-of-life outcomes for men with prostate carcinoma detected by screening.

    abstract:BACKGROUND:There is limited information on outcomes of prostate carcinoma treatments given to screened patient populations for whom cancer is usually detected at an earlier stage. METHODS:The authors conducted a cross-sectional evaluation of quality-of-life outcomes for men with prostate carcinoma detected in screenin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Smith DS,Carvalhal GF,Schneider K,Krygiel J,Yan Y,Catalona WJ

    更新日期:2000-03-15 00:00:00

  • Lung carcinoma arising in bronchopulmonary sequestration.

    abstract::A squamous cell carcinoma arising in intralobar bronchopulmonary sequestration of the right lower lobe is described in a 69-year-old man. One other reported case was found. Other complications of bronchopulmonary sequestration include nonspecific infections and tuberculosis. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197907)44:1<334::aid-cncr2820440

    authors: Bell-Thomson J,Missier P,Sommers SC

    更新日期:1979-07-01 00:00:00

  • Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial.

    abstract::This study concerns 75 patients with squamous cell carcinoma of the oral cavity who were patients at the Gustave-Roussy Institute between December 1966 and July 1973. These patients were divided into two groups. The first group was comprised of 39 patients who underwent elective radical neck dissection; nodal involvem...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19800715)46:2<386::aid-cncr28204

    authors: Vandenbrouck C,Sancho-Garnier H,Chassagne D,Saravane D,Cachin Y,Micheau C

    更新日期:1980-07-15 00:00:00

  • Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity.

    abstract:BACKGROUND:Oral leukoplakia is a premalignant lesion, but the genetic changes in the foci of early cancerization in leukoplakia have not been studied. METHODS:Loss of heterozygosity (LOH) was successively investigated in 13 cases in the leukoplakia and foci of early cancerization in the same leukoplakia. The authors m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011101)92:9<2349::aid-cncr1582

    authors: Jiang WW,Fujii H,Shirai T,Mega H,Takagi M

    更新日期:2001-11-01 00:00:00

  • Fine-needle aspiration biopsy of granulocytic sarcoma: a clinicopathologic study of 27 cases.

    abstract:BACKGROUND:Because of morphologic similarities, the differential diagnosis of granulocytic sarcoma (GS) in fine-needle aspiration (FNA) specimens includes non-Hodgkin or Hodgkin lymphoma, extramedullary hematopoiesis, poorly differentiated carcinoma, and infection. METHODS:Twenty-six FNAs and 1 pleural effusion fluid ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Suh YK,Shin HJ

    更新日期:2000-12-25 00:00:00

  • Plasma immunoglobulin levels in patients with breast cancer.

    abstract::The plasma levels of the immunoglobulins IgA, IgG and IgM have been measured in 55 patients with benign breast disease, 28, 68 and 22 patients with early breast cancer one day before, 10-14 days after and three-six months after mastectomy, respectively, and 35 normal healthy control women. The mean levels of IgA, IgG ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197705)39:5<2190::aid-cncr282039

    authors: Wang DY,Goodwin PR,Bulbrook RD,Hayward JL

    更新日期:1977-05-01 00:00:00

  • Adjuvant chemotherapy for advanced nasopharyngeal carcinoma in childhood.

    abstract::Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyc...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19890515)63:10<1922::aid-cncr282

    authors: Kim TH,McLaren J,Alvarado CS,Wyly JB,Crocker I,Winn K,Singhapakdi S,Ragab A

    更新日期:1989-05-15 00:00:00

  • Maryland's Special Populations Network. A model for cancer disparities research, education, and training.

    abstract::The unequal burden of cancer in minority and underserved communities nationally and in Maryland is a compelling crisis. The Maryland Special Populations Cancer Research Network (MSPN) developed an infrastructure covering Maryland's 23 jurisdictions and Baltimore City through formal partnerships between the University ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22158

    authors: Baquet CR,Mack KM,Mishra SI,Bramble J,Deshields M,Datcher D,Savoy M,Brooks SE,Boykin-Brown S,Hummel K

    更新日期:2006-10-15 00:00:00

  • The value of ultrasonic imaging and CT scanning in planning the radiotherapy for prostatic carcinoma.

    abstract::Forty-four consecutive patients with potentially curable carcinoma of the prostate were localized with an Old Delft Simulator with the methods described by Bagshaw. The isocenter and the treatment portal were marked on the skin of the patient. Subsequently, the adequacy of the portal was checked by ultrasonography and...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800215)45:4<724::aid-cncr28204

    authors: Lee DJ,Leibel S,Shiels R,Sanders R,Siegelman S,Order S

    更新日期:1980-02-15 00:00:00

  • BCG immunotherapy of bladder cancer: inhibition of tumor recurrence and associated immune responses.

    abstract::Fifty-one patients with confirmed bladder cancer have enrolled in a prospective evaluation of BCG immunotherapy. Following resection of existing tumors, patients were stratified according to tumor grade and number of previous recurrences and randomly assigned to control or BCG treatment groups. Immunotherapy consisted...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19810701)48:1<82::aid-cncr282048

    authors: Lamm DL,Thor DE,Winters WD,Stogdill VD,Radwin HM

    更新日期:1981-07-01 00:00:00

  • Dose escalation of gemcitabine concomitant with radiation and cisplatin for nonsmall cell lung cancer: a phase 1-2 study.

    abstract:BACKGROUND:The current study was conducted to evaluate the maximum tolerable dose of weekly gemcitabine administered simultaneously with radiation and cisplatin in patients with locally advanced nonsmall cell lung cancer (NSCLC). METHODS:Patients with stage IIIA/B NSCLC received concurrently 63 grays radiation and 20 ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25366

    authors: Momm F,Kaden M,Tannock I,Schumacher M,Hasse J,Henke M

    更新日期:2010-10-15 00:00:00

  • Mesothelioma following Wilms' tumor in childhood.

    abstract::A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840715)54:2<367::aid-cncr28205

    authors: Antman KH,Ruxer RL Jr,Aisner J,Vawter G

    更新日期:1984-07-15 00:00:00

  • Acute and delayed nausea and emesis control in pediatric oncology patients.

    abstract:BACKGROUND:To the authors' knowledge there is little information available regarding the effectiveness of standard antiemetic therapy among cancer patients who receive emetogenic chemotherapy in clinical practice, especially in the pediatric population. The current study was undertaken to determine the effectiveness of...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21631

    authors: Holdsworth MT,Raisch DW,Frost J

    更新日期:2006-02-15 00:00:00

  • Adherence to endocrine therapy including ovarian suppression: A large observational cohort study of US women with early breast cancer.

    abstract:BACKGROUND:Recent clinical trials support adding ovarian suppression (OS) to oral endocrine therapy (ET) for premenopausal women with early breast cancer. The adoption of OS among real-world populations and the impact of OS on ET adherence have not been evaluated. METHODS:This study examined a retrospective, observati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33367

    authors: Reeder-Hayes KE,Mayer SE,Lund JL

    更新日期:2021-01-28 00:00:00

  • Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors.

    abstract:BACKGROUND:Inhibition of the hedgehog signaling pathway (HHSP) for the treatment of locally advanced basal cell carcinoma (BCC) and metastatic BCC (mBCC) has produced promising results. Typically, mBCC is not taken into consideration during the workup of a patient with multifocal metastatic disease who has a history of...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.27532

    authors: Weiss GJ,Korn RL

    更新日期:2012-11-01 00:00:00

  • Adjuvant therapy in prostatic cancer.

    abstract:BACKGROUND:Prostatic cancer is an unusual malignancy because, commonly, it is slowly progressive and occurs at an age where the patient's life expectancy is short as a result of considerable competing mortality rates from other diseases. In addition, the place of radical surgery, i.e., radical prostatectomy is still no...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930201)71:3+<992::aid-cncr2820

    authors: Smith PH,Parmar MK

    更新日期:1993-02-01 00:00:00

  • Analgesics and cancer of the renal pelvis in New South Wales.

    abstract::A lifetime history of analgesics and tobacco consumption was obtained by a questionnaire completed at interview from 67 patients with carcinoma of the renal pelvis (40 women, 27 men) and 180 control subjects drawn from two sources, friends of patients and persons attending a health screening clinic. Regular consumptio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820615)49:12<2617::aid-cncr282

    authors: McCredie M,Ford JM,Taylor JS,Stewart JH

    更新日期:1982-06-15 00:00:00

  • Uveal melanoma: From diagnosis to treatment and the science in between.

    abstract::Melanomas of the choroid, ciliary body, and iris of the eye are collectively known as uveal melanomas. These cancers represent 5% of all melanoma diagnoses in the United States, and their age-adjusted risk is 5 per 1 million population. These less frequent melanomas are dissimilar to their more common cutaneous melano...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.29727

    authors: Chattopadhyay C,Kim DW,Gombos DS,Oba J,Qin Y,Williams MD,Esmaeli B,Grimm EA,Wargo JA,Woodman SE,Patel SP

    更新日期:2016-08-01 00:00:00