Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity.

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) complicating cirrhosis has a high intrahepatic recurrence rate after treatment by surgical resection or percutaneous ethanol injection (PEI). In this study, certain clinical, biochemical, and pathologic parameters were evaluated as risk factors for intrahepatic tumor recurrence...

journal_title：Cancer

authors： Pompili M,Rapaccini GL,de Luca F,Caturelli E,Astone A,Siena DA,Villani MR,Grattagliano A,Cedrone A,Gasbarrini G

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Pancreatic-duodenal homeobox 1 (PDX-1) is a transcription factor that regulates embryologic pancreas development and insulin expression in the adult islet; however, it is overexpressed in many types of cancer, including pancreatic cancer. The purpose of this study was to investigate the role of PDX-1 in tumo...

journal_title：Cancer

authors： Liu SH,Patel S,Gingras MC,Nemunaitis J,Zhou G,Chen C,Li M,Fisher W,Gibbs R,Brunicardi FC

更新日期：2011-02-15 00:00:00

abstract：:Five cases of primary intestinal lymphoma are described. The main clinical features included abdominal pain, diarrhea, and marked weight loss, together with radiologic and some laboratory findings suggestive of malabsorption. Laparatomy perfomed in four cases revealed dilatation of the small intestine, with mesenteric...

journal_title：Cancer

authors： Shahid MJ,Alami SY,Nassar VH,Balikian JB,Salem AA

更新日期：1975-03-01 00:00:00

abstract：BACKGROUND:Medulloblastomas are small cell embryonal tumors of the cerebellum found predominantly in children, only slightly more than half of whom survive. Predicting favorable outcome has been difficult, and improved stratification clearly is required to avoid both undertreatment and overtreatment. Patients currently...

journal_title：Cancer

authors： Eberhart CG,Kepner JL,Goldthwaite PT,Kun LE,Duffner PK,Friedman HS,Strother DR,Burger PC

更新日期：2002-01-15 00:00:00

abstract：BACKGROUND:The authors previously identified sperm protein 17 (Sp17) as being expressed in patients with multiple myeloma. The restricted expression of Sp17 in normal tissue makes it an ideal target for tumor vaccine. In the current study, the authors extended their research to include ovarian carcinoma. METHODS:A pai...

journal_title：Cancer

authors： Chiriva-Internati M,Wang Z,Salati E,Timmins P,Lim SH

更新日期：2002-05-01 00:00:00

abstract：:There is a growing body of basic science and epidemiologic evidence to support a research thrust to determine whether several natural or synthetic agents, given alone or together, can lower cancer incidence. Candidate agents include analogs of vitamin A and the vitamin A precursor, beta-carotene, vitamins C and E, and...

journal_title：Cancer

authors： Malone WF,Kelloff GJ,Pierson H,Greenwald P

更新日期：1987-08-01 00:00:00

abstract：:One hundred thirty patients with histologically verified primary fibrosarcoma of bone, unassociated with any pre-existent benign bone condition, were treated at Memorial Sloan-Kettering Cancer Center between 1918 and 1973. This series of cases represents approximately 5% of primary malignant bone tumors treated in our...

journal_title：Cancer

authors： Huvos AG,Higinbotham NL

更新日期：1975-03-01 00:00:00

abstract：:The nitroblue tetrazolium test (NBT) was evaluated in 111 patients with cancer. Patients were placed into control and "presumed infected" groups. The mean NBT score for the control group, 6.3, was significantly greater than the mean for a group of normal volunteers, 3.1, but the mean score for the "presumed infected" ...

journal_title：Cancer

authors： Lehane DE,Watson S,Lane M

更新日期：1975-05-01 00:00:00

abstract：:This paper presents an overview of factors, attitudes, and beliefs that may influence the adoption of cancer prevention and detection strategies by health-care providers and the public. Health-care practitioners require education about prevention and detection approaches to health care and the social variations in the...

journal_title：Cancer

authors： Fink DJ,Sheehan HE

更新日期：1988-06-01 00:00:00

abstract：:In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use before 20 years of age was significantly associated with higher tumor cell proliferative activity, as indicated by a higher S-phase fraction (SPF), and a higher fraction of DNA aneuploid tumors, compared with later or never users (P ...

journal_title：Cancer

authors： Olsson H,Ranstam J,Baldetorp B,Ewers SB,Fernö M,Killander D,Sigurdsson H

更新日期：1991-03-01 00:00:00

abstract：:Aggressive nutritional support of the cancer patient undergoing treatment has become widespread standard practice. In order to evaluate the effect of total parenteral nutrition (TPN) on protein metabolism, 11 patients with localized squamous cell carcinoma of the distal esophagus were studied in the postabsorptive sta...

journal_title：Cancer

authors： Burt ME,Stein TP,Schwade JG,Brennan MF

更新日期：1984-03-15 00:00:00

abstract：:The mechanisms of biochemical modulation of 5-fluorouracil (5-FU) cytotoxicity by folinic acid (FA) have been elucidated, and the clinical use of this combination has improved response rates and survival in patients with metastatic colorectal cancer. Recently, Phase II trials also showed potential synergism between al...

journal_title：Cancer

authors： Bukowski RM,Inoshita G,Yalavarthi P,Murthy S,Gibson V,Budd GT,Sergi JS,Bauer L,Prestifilippo J

更新日期：1992-02-15 00:00:00

abstract：:Six patients with Hodgkin's disease who developed idiopathic thrombocytopenic purpura (ITP) are presented. In contrast to prior cases reported in the literature, none of these patients developed recurrent Hodgkin's disease at the time of or subsequent to their thrombocytopenia, with follow-up data available up to 10 y...

journal_title：Cancer

authors： Cohen JR

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Although axillary lymph node metastasis is one of the most important prognostic determinants of breast carcinoma prognoses, the reasons why tumors vary in their capability to produce for axillary metastases remain unclear. METHODS:The authors used data from the nationwide Patient Care Evaluation (PCE) surve...

journal_title：Cancer

authors： Gann PH,Colilla SA,Gapstur SM,Winchester DJ,Winchester DP

更新日期：1999-10-15 00:00:00

abstract：:During the past 30 years, changes in the treatment of children and adolescents with cancer have led to substantial improvements in survival. Although treatment-related factors have been shown to impact subsequent health status and quality of life, there is limited information on survivors who are now two or more decad...

journal_title：Cancer

authors： Robison LL,Green DM,Hudson M,Meadows AT,Mertens AC,Packer RJ,Sklar CA,Strong LC,Yasui Y,Zeltzer LK

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:The objective of this study was to compare the quality of life (QOL) of younger (< or =50 years) versus older (>50 years) women on recent completion of treatment of breast carcinoma. METHODS:Data reported herein were obtained from a baseline assessment of 304 breast carcinoma patients. These patients were e...

journal_title：Cancer

authors： Wenzel LB,Fairclough DL,Brady MJ,Cella D,Garrett KM,Kluhsman BC,Crane LA,Marcus AC

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...

journal_title：Cancer

authors： Park MS,Patel SR,Ludwig JA,Trent JC,Conrad CA,Lazar AJ,Wang WL,Boonsirikamchai P,Choi H,Wang X,Benjamin RS,Araujo DM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Radiation therapy plays a major role in the management of patients with either locally recurrent or metastatic carcinoma of the prostate. RESULTS:In 23 patients with isolated postprostatectomy local recurrences treated with doses of 60-65 Gy, 17 (74%) had tumor control, and 45% survived relapse-free for 5 y...

journal_title：Cancer

authors： Perez CA,Cosmatos D,Garcia DM,Eisbruch A,Poulter CA

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Although prostate carcinoma is not widely recognized as a familial cancer, familial aggregation of this disease has been shown in some retrospective case-control studies. To study familial prostate cancer in Sweden, a population-based cohort study was performed, that attempted to avoid possible bias connecte...

journal_title：Cancer

authors： Grönberg H,Damber L,Damber JE

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:In the United States, detection of squamous carcinoma in situ (CIS) by screening has led to reduced rates for invasive squamous carcinoma and lower mortality. Adenocarcinoma in situ (AIS) rates also have increased, but invasive cervical adenocarcinoma rates have not declined similarly. To make inferences abo...

journal_title：Cancer

authors： Sherman ME,Wang SS,Carreon J,Devesa SS

更新日期：2005-03-15 00:00:00

abstract：:Glutamine may be an essential dietary component, especially for the support of intestinal mucosal growth and function. This study evaluated the effects of a glutamine-enriched elemental diet, administered before whole-abdominal radiation on gut glutamine metabolism, mucosal morphometrics, and bacterial translocation. ...

journal_title：Cancer

authors： Klimberg VS,Souba WW,Dolson DJ,Salloum RM,Hautamaki RD,Plumley DA,Mendenhall WM,Bova FJ,Khan SR,Hackett RL

更新日期：1990-07-01 00:00:00

abstract：:Progress in the treatment of pancreatic cancer in the past several decades has been very modest. Several new agents with activity against this disease have been identified. Of these, gemcitabine appears to be the most promising when used in combination with other drugs. Gemcitabine and cisplatin combinations have been...

journal_title：Cancer

authors： Philip PA

更新日期：2002-08-15 00:00:00

abstract：BACKGROUND:Radioimmunotherapy with radiolabeled monoclonal antibodies to CD20 produces a high response rate in patients with recurring non-Hodgkin lymphoma (NHL), but the durability of those remissions is not well defined. METHODS:Data on patients with recurring NHL treated with yttrium Y 90 ibritumomab tiuxetan in 4 ...

journal_title：Cancer

authors： Witzig TE,Molina A,Gordon LI,Emmanouilides C,Schilder RJ,Flinn IW,Darif M,Macklis R,Vo K,Wiseman GA

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The objective of this study was to assess the impact of a prostate-specific antigen (PSA) complete response (PSA-CR), measured at the end of external-beam radiotherapy and short-term hormone therapy, on treatment outcomes. METHODS:The phase 3 Radiation Therapy Oncology Group 9413 trial, as part of its origi...

journal_title：Cancer

authors： Cury FL,Hunt D,Roach M 3rd,Shipley W,Gore E,Hsu IC,Krisch RE,Seider MJ,Sandler H,Lawton C

更新日期：2013-06-01 00:00:00

abstract：:High tissue concentrations of human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) were revealed by radioimmunoassay in a hepatic tumor which was surgically removed from a two-year, eight-month-old boy manifesting sexual precocity. Histologically the tumor showed an embryonal type hepatoblastoma admixed with...

journal_title：Cancer

authors： Morinaga S,Yamaguchi M,Watanabe I,Kasai M,Ojima M,Sasano N

更新日期：1983-05-01 00:00:00

abstract：:We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was greater than 100 U/g of tissue, a valu...

journal_title：Cancer

authors： Ettinger DS,Rosenshein NB,Parmley TH,Mendelsohn G,Baylin SB

更新日期：1980-05-15 00:00:00

abstract：:A 44-year-old patient with histologically proven bilateral ulcerated lymph node metastases from a carcinoma of the penis was treated by sequenced combined chemotherapy and radical irradiation. Methotrexate and bleomycin were administered at weekly intervals for 5 weeks, followed by radiation with a split-course coning...

journal_title：Cancer

authors： Abratt RP

更新日期：1984-10-15 00:00:00

abstract：:The histopathology of 43 cases of carcinoma in the extrahepatic bile ducts was reported. All four cases of noninfiltrating carcinoma were papillary or polypoid in gross shape. Only one of the eight cases of papillary or polypoid cancers penetrated beyond the fibromuscular layer of the bile ducts, while most cases of n...

journal_title：Cancer

authors： Kozuka S,Tsubone M,Hachisuka K

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Multimodality treatment has dramatically improved the outcome of patients with Ewing sarcoma. However, there appears to be little information concerning treatment-related complications in patients who are long-term survivors. METHODS:Forty-one patients with Ewing sarcoma who were treated between 1960-1980 a...

journal_title：Cancer

authors： Fuchs B,Valenzuela RG,Inwards C,Sim FH,Rock MG

更新日期：2003-12-15 00:00:00

abstract：BACKGROUND:The authors evaluated the effects of taxol, a microtubular inhibitor, as a possible radiation sensitizer on the human leukemic cell line (HL-60). Taxol acts as a mitotic inhibitor, blocking cells in the G2M-phase of the cell cycle. The differential radiation sensitivity of cells in various phases of the cell...

journal_title：Cancer

authors： Choy H,Rodriguez FF,Koester S,Hilsenbeck S,Von Hoff DD

更新日期：1993-06-01 00:00:00