Adjuvant chemotherapy for advanced nasopharyngeal carcinoma in childhood.

Abstract:

:Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyclophosphamide (7 mg/kg; days 1 through 5). This combination chemotherapy was given for 12 to 24 months after completion of radiation therapy. The radiation doses to the primary sites ranged from 6000 cGy to a maximum of 6800 cGy. The radiation doses for neck prophylaxis ranged from 4500 cGy to a total of 5000 cGy. Involved sites were irradiated to at least an additional boost of 1000 cGy. One patient had an external dose 6000 cGy to the primary site boosted with brachytherapy of 3000 cGy at the surface of an ovoid. After chemotherapy myelosuppression occurred in all patients and was tolerable. All seven patients are surviving, six disease-free, for 22 months to 12 years (median, 4 years). This study suggests that the combination of radiation therapy and chemotherapy as used here has acceptable toxicity and is effective and further suggests that children with nasopharyngeal carcinoma, even in its advanced stage at diagnosis, may be curable.

journal_name

Cancer

journal_title

Cancer

authors

Kim TH,McLaren J,Alvarado CS,Wyly JB,Crocker I,Winn K,Singhapakdi S,Ragab A

doi

10.1002/1097-0142(19890515)63:10<1922::aid-cncr282

subject

Has Abstract

pub_date

1989-05-15 00:00:00

pages

1922-6

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

63

pub_type

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