Abstract:
:Nutrients as therapy for patients with cancer are important as adjunctive therapy, i.e., adequate nutrition may be important for the success of whatever form of therapy is administered. Diets deficient in certain amino acids have some selectivity when tested against experimental tumors propagated in vivo. Such diets have had limited clinical trial and have been characterized by poor patient acceptance. Enzymes that produce deficiencies of certain amino acids, e.g., asparaginase, glutaminase, methioninase appear to offer a more reasonable approach to development of selective amino acid deficiencies in man. Trace metals in excessive amounts may be toxic or carcinogenic to the host. Two heavy metal salts, Cis-diamine dichloroplatinum and gallium nitrate, have recently been shown to have anti-neoplastic effects in man. There is no conclusive evidence that vitamins, administered in large doses, have significant antineoplastic effects although large doses of vitamin A, vitamin C, and vitamin B12 have been used for this purpose. In contrast, certain vitamin analogs such as folate antimetabolites can cause tumor regression and are useful clinical treatment. An enzyme, carboxypeptidase G1, by splitting naturally occurring folates, may also have promise as a method of producing enzymic folate deficiency.
journal_name
Cancerjournal_title
Cancerauthors
Bertino JRdoi
10.1002/1097-0142(197905)43:5+<2137::aid-cncr28204subject
Has Abstractpub_date
1979-05-01 00:00:00pages
2137-42issue
5 Suppleissn
0008-543Xissn
1097-0142journal_volume
43pub_type
杂志文章,评审相关文献
CANCER文献大全abstract::The authors retrospectively reviewed 50 episodes of spinal epidural tumor that occurred in 42 patients with metastatic prostate cancer and were treated with external-beam radiation. Treatment response was evaluated in terms of symptoms, neurologic status, and, in most cases, reduction of tumor on repeat myelography. A...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921101)70:9<2319::aid-cncr2820
更新日期:1992-11-01 00:00:00
abstract::Twenty-three leukemic children were studied prospectively to detect chronic effects of therapy. All patients received CNS prophylaxis, including 2400 R cranial irradiation, and intermittent maintenance therapy with intravenous methotrexate, cyclophosphamide and cytosine arabinoside. Neurologic symptoms were observed i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<853::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:The diagnosis of low-grade squamous intraepithelial lesion (LSIL), cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) was not included in the 2001 Bethesda System. It is used in some institutions to diagnose cases that fulfill criteria for both the diagnosis of LSIL and atypical squamous cell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncy.20004
更新日期:2009-04-25 00:00:00
abstract::Retinoblastoma should not be considered as the exceptional childhood cancer that shows dominant inheritance, but rather as the typical childhood cancer that embraces a prezygotic and postzygotic subgroup. Postzygotic cases are conceived as involving mutation as a first step too, but with the mutation in somatic rather...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3+<1022::aid-cncr28203
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:Because carcinomas of unknown primary origin are highly malignant tumors with a bad prognosis (median survival, 6-12 months) and no current optimal therapy, the authors designed a prospective dose-dense chemotherapy regimen with the objective of improving the results observed in patients who receive conventi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.10264
更新日期:2002-02-01 00:00:00
abstract::The establishment of a maturation-induction model using human colon cancer cells as targets is reported. Two colon carcinoma cell lines were established from human tumors; one line was heterogeneous and was cloned into two distant subpopulations. Cells from these lines and clones and cells from an established human co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:5+<1178::aid-cncr282
更新日期:1980-03-15 00:00:00
abstract::Hereditary adenomatosis of the colon and rectum (HACR) is associated with a wide variety of extracolonic manifestations. Two cases of neoplasia involving the adrenal gland are reported, one adenoma and one carcinoma. The literature relating these lesions to HACR and other syndromes of malignant and nonmalignant growth...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850501)55:9<2001::aid-cncr2820
更新日期:1985-05-01 00:00:00
abstract::In an article published in this issue of Cancer, D'Arcy et al link the incidence of cancer among recipients of solid organ transplantation (SOT) in the Scientific Registry of Transplant Recipients with data from regional and statewide cancer registries to examine cancer-specific mortality for common malignancies in SO...
journal_title:Cancer
pub_type: 评论,杂志文章
doi:10.1002/cncr.31963
更新日期:2019-03-15 00:00:00
abstract::Between July 1968 and December 1974, 53 patients with lung cancer were planned for preoperative irradiation and surgery. All patients were considered clinically marginally resectable because of advanced local disease, 4 Stage II patients, with limited pulmonary reserve and 49 Stage III patients. Most patients received...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<2040::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:Malignant lymphomas and solid tumors that mimic or are associated with epithelioid granulomas are widely recognized in surgical pathology, but have received little attention in the cytopathology literature. In this study the authors present their experience with six such cases in which the presence of granul...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980425)84:2<84::aid-cncr
更新日期:1998-04-25 00:00:00
abstract:BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970425)81:2<122::aid-cnc
更新日期:1997-04-25 00:00:00
abstract:BACKGROUND:Parathyroid hormone-related protein (PTHrP) is the predominant cause of humoral hypercalcemia of malignancy (HHM). METHODS:Using a PTHrP-specific monoclonal antibody (MoAb), 4B3, the authors investigated the immunohistochemical localization of PTHrP in formalin-fixed and paraffin-embedded sections of normal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930501)71:9<2803::aid-cncr2820
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:The growing number of individuals surviving childhood cancer has increased the awareness of adverse long-term sequelae. One of the most worrisome complications after cancer therapy is the development of second malignant neoplasms (SMNs). METHODS:The authors describe the incidence of solid organ SMN in survi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23860
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Rural residence has been associated with increased risk of late stage cancer diagnosis, but it is unknown if this is related to lower socioeconomic status (SES) of rural residents or to other factors. This study examined the impacts of SES and urban/rural status on colorectal cancer (CRC) stage at diagnosis ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22016
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:A randomized, multicenter trial, double-blind for antiandrogen therapy, compared the antiandrogens bicalutamide and flutamide, each combined with luteinizing hormone-releasing hormone analogue therapy (LHRH-A) in 813 patients with Stage D2 prostate carcinoma. An analysis of time to progression (median follow...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(sici)1097-0142(19961115)78:10<2164::aid-c
更新日期:1996-11-15 00:00:00
abstract::Our simple rapid autoradiography for 3H-thymidine (3H-TdR) labeling index (LI) of leukemic cells was introduced. Thirty-nine adult patients with acute nonlymphocytic leukemia were treated under a new protocol using 3H-TdR LI as a parameter and inserting a trial of partial synchronization by Ara-C. The success rate of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801115)46:10<2298::aid-cncr282
更新日期:1980-11-15 00:00:00
abstract:BACKGROUND:Tobacco assessment and cessation support are not routinely included in cancer care. An automated tobacco assessment and cessation program was developed to increase the delivery of tobacco cessation support for cancer patients. METHODS:A structured tobacco assessment was incorporated into the electronic heal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28440
更新日期:2014-02-15 00:00:00
abstract::The clinical course of 29 patients with idiopathic refractory sideroblastic anemia studied by us was reviewed. Four patients developed acute leukemia. We were able to find 27 out of 268 cases of idiopathic refractory sideroblastic anemia reported in the literature which terminated in acute leukemia. Nine of these were...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197908)44:2<724::aid-cncr2820440
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31873
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated. METHODS:A 34-item survey focusing on barriers to ped...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33075
更新日期:2020-09-15 00:00:00
abstract::The authors reviewed clinical features, surgical extent of resection, histologic parameters, and DNA content in 55 children with medulloblastomas and found that complete or near total resection, absence of tumor dissemination, tumor DNA aneuploidy, and low proliferative index correlated with a favorable clinical outco...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820690539
更新日期:1992-03-01 00:00:00
abstract::With increasing evidence that cancer patients respond immunologically to their cancers, it seemed interesting to investigate whether or not the course of the second cancer differed from that of the first. If we assume that, in analogy to mammary cancer in the mouse, the cells of human breast cancers carry shared antig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3<596::aid-cncr2820350
更新日期:1975-03-01 00:00:00
abstract::Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered intraperitoneally in combination with multidrug chemotherapy using methotrexate (M), vinblastine (V), doxorubicin (A), and cisplatin (C, or for the combination, MVAC) to C3H/He mice (5-week-old females) after experimental carcinoma, MBT...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920215)69:4<997::aid-cncr28206
更新日期:1992-02-15 00:00:00
abstract::CEA-like material was found in 51 of 62 primary human breast carcinomas and in only 2 of 12 fibroadenomas. Levels of carcinoma CEA-like material correlated weakly with cytoplasmic estradiol receptor levels, total cytosol estrogens, and cytosol progesterone. Levels of CEA-like material showed no significant correlation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830101)51:1<121::aid-cncr28205
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Full-scale implementation of lung cancer screening in the United States will increase detection of early stages. This study was aimed at assessing the capacity required for treating those cancers. METHODS:A well-established microsimulation model was extended with treatment data from the National Cancer Data...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32026
更新日期:2019-06-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the results of thyroid fine-needle aspiration (FNA) and to determine the reasons for the discrepancies between the cytologic and histologic diagnoses. METHODS:The authors evaluated the cytologic and histologic results of 133 FNAs obtained from 92 patients who underw...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970825)81:4<253::aid-cnc
更新日期:1997-08-25 00:00:00
abstract::There is now considerable interest in gastrointestinal stromal tumor (GIST) because it can be treated effectively with a targeted molecular agent. The majority of GISTs contain an activating mutation in the KIT protooncogene or, occasionally, in the platelet-derived growth factor-alpha (PDGFRA) gene. Five years ago, i...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.21419
更新日期:2005-11-01 00:00:00
abstract::A retrospective analysis of a series of 162 patients treated for isolated chest wall recurrence of breast cancer after mastectomy was undertaken. Cumulative survival, distant relapse-free survival, and freedom from local progression after 5 years from the diagnosis of recurrence were 34%, 28%, and 45% respectively. Fi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870715)60:2<240::aid-cncr28206
更新日期:1987-07-15 00:00:00
abstract:BACKGROUND:Breast cancer is the most common cancer and the second leading cause of cancer death among women in the United States; annual breast cancer deaths are exceeded only by those for lung cancer. METHODS:Data from the Surveillance, Epidemiology, and End Results (SEER) program registry of the National Cancer Inst...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Endometrial cancer (EC) is the most common extraintestinal malignancy in Lynch syndrome (LS) and often is the sentinel malignancy, yet there is no consensus regarding LS-EC detection algorithms. In this study, the authors determined the efficacy of family/personal history and tumor morphology in predicting L...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26323
更新日期:2012-02-01 00:00:00