Abstract:
:The clinical course of 29 patients with idiopathic refractory sideroblastic anemia studied by us was reviewed. Four patients developed acute leukemia. We were able to find 27 out of 268 cases of idiopathic refractory sideroblastic anemia reported in the literature which terminated in acute leukemia. Nine of these were well described. The overall incidence of acute leukemia is 10%. In an attempt to identify the risk factors for the development of acute leukemia, the clinical and laboratory features of this group of thirteen well-described cases which terminated in acute leukemia were compared to the remaining 25 of our cases which did not undergo leukemic transformation. The patients who died of acute leukemia tended to have a more severe anemia, a lower reticulocyte count, and increased transfusion requirement, and thrombocytopenia. Thrombocytosis appears to be a relatively good prognostic sign.
journal_name
Cancerjournal_title
Cancerauthors
Cheng DS,Kushner JP,Wintrobe MMdoi
10.1002/1097-0142(197908)44:2<724::aid-cncr2820440subject
Has Abstractpub_date
1979-08-01 00:00:00pages
724-31issue
2eissn
0008-543Xissn
1097-0142journal_volume
44pub_type
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