Abstract:
:The DNA stemline ploidy was assessed in paraffin-embedded, formalin-fixed primary tumor tissue from 68 patients with nonseminomatous germ cell cancer (NSCGT) clinical Stage I (CS I). Forty-three patients had a single aneuploid (greater than 1C) DNA stemline, whereas 24 patients had multiple aneuploid stemlines. In one tumor there was no evidence of an abnormal DNA stemline. Most DNA stemlines had DNA indices around the 3c value. In 13 patients there was a good correlation between the DNA stemline values observed in the primary tumor and in the retroperitoneal lymph node metastases. No correlation was found between the DNA index and the histologic subclassification or the metastatic behavior. The size of the S-phase fraction did not appear to be predictive of subclinical metastases. In CS I patients with NSCGT determination of DNA stemline values does not yield information of predictive or prognostic significance but may contribute to the understanding of the pathogenesis of NSCGT.
journal_name
Cancerjournal_title
Cancerauthors
Fosså SD,Nesland JM,Waehre H,Amellem O,Pettersen EOdoi
10.1002/1097-0142(19910401)67:7<1874::aid-cncr2820subject
Has Abstractpub_date
1991-04-01 00:00:00pages
1874-7issue
7eissn
0008-543Xissn
1097-0142journal_volume
67pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Survival trends provide a measure of improvement in detection and treatment over time. In the current study, updated childhood and adolescent cancer survival statistics are presented, overall and among demographic subgroups, including Hispanics, for whom to the authors' knowledge national rates have not been...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23866
更新日期:2008-11-01 00:00:00
abstract::Forty-six examples of carcinoma cuniculatum, a rare variant of squamous cell carcinoma of the skin, were studied by means of light and electron microscopy and immunoperoxidase techniques. The tumors usually presented as ulcerated, fungating, and polypoid masses with openings of sinus tracts onto the skin surface that ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820601)49:11<2395::aid-cncr282
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, little is known to date regarding the prognostic relevance of measuring serum levels of vascular endothelial growth factor (VEGF), a potent stimulator of angiogenesis, in patients with colon carcinoma who undergo surgery. METHODS:Preoperative and postoperative VEGF serum levels we...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11911
更新日期:2004-01-15 00:00:00
abstract::An unusually high association of other primary cancers (9.7%) was found during the analysis of 403 consecutive cases of carcinoma of the lung diagnosed at DGMC between 1960 and 1975. Incidence by stage included 17.3% for Stage I (75 cases) and 16.9% for Stage II (59 cases). Median survival by stage was not adversely a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197812)42:6<2887::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Rapid tumor growth is caused by angiogenesis factors, growth factors, etc. We previously reported a possible connection between nitric oxide (NO) and enhanced vascular permeability in solid tumor. In the present experiment, the role of NO in solid tumor pathology was further investigated in animal tumor. ME...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1598::AID-CN
更新日期:1996-04-15 00:00:00
abstract:BACKGROUND:The stabilization and nuclear translocation of beta-catenin are early events in the majority of sporadic colorectal carcinomas (CRC). beta-catenin up-regulates c-Myc and cyclin D1, which antagonize the association of the cyclin-dependent kinase (Cdk) inhibitor, p27(kip1), with Cdk2, thus allowing cell cycle ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10986
更新日期:2002-12-15 00:00:00
abstract::Light microscopic, immunocytochemical and ultrastructural studies were performed on chondrosarcomas which contained a second, noncartilagenous mesenchymal component. Attention was focused on the nonchondroid portion of each tumor in an attempt to elucidate the histogenesis of this mixed variant of chondrosarcoma. The ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860715)58:2<287::aid-cncr28205
更新日期:1986-07-15 00:00:00
abstract:BACKGROUND:The health-related functioning of patients with cancer is compromised by several factors, including the disease process, treatment, and the various symptoms that are produced by both disease and treatment. This study was designed to specify the relationship between patients' pain severity and their self-repo...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:The authors hypothesized that the outcomes for young patients who present with primary osteosarcoma of flat bones or secondary osteosarcoma after other primary malignancies are similar because the sites of these tumors rarely makes them amenable to complete surgical resection. METHODS:The authors reviewed t...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-09-15 00:00:00
abstract::Meningeal carcinomatosis can appear with a variety of neurologic signs and symptoms. Alterations in respiratory control have not been reported in this syndrome or in neurologic syndromes associated with systemic cancer. The authors report on a case of documented leptomeningeal carcinoma from breast cancer presenting a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810301)47:5<982::aid-cncr28204
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1231::aid-cn
更新日期:1998-09-15 00:00:00
abstract::We present a case with the unusual association of Graves' disease and functioning pulmonary metastases of follicular thyroid carcinoma. Unlike other reports of thyroid cancer and thyrotoxicosis, this patient's hyperthyroidism was related to a hyperfunctioning primary thyroid neoplasm and not merely to large amounts of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197905)43:5<1885::aid-cncr282043
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:Based on the 1998 Patient Care Evaluation (PCE) from the American College of Surgeons National Cancer Data Base (NCDB), the authors described contemporary nationwide patterns of prostate carcinoma presentation, diagnosis, and staging. METHODS:The authors reviewed 54,212 cases from the 1998 PCE. Demographics...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11635
更新日期:2003-09-15 00:00:00
abstract::The relationship between DNA content, clinicopathologic findings, and patient survival in synovial sarcoma was investigated. Patient age at diagnosis (P less than 0.001), tumor size (P less than 0.001), and ploidy status (P less than 0.003) correlated significantly with patient survival. A marginally significant corre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900515)65:10<2295::aid-cncr282
更新日期:1990-05-15 00:00:00
abstract::Low-dose continuous infusion 5-fluorouracil (LDCI-FU) was administered to 28 women with advanced breast carcinoma. Daily doses ranged from 175 to 250 mg/m2. The LDCI-FU was delivered continuously until the appearance of toxicity and was reinstituted at a 20% dose reduction after toxicity completely resolved. Patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890201)63:3<419::aid-cncr28206
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Cell cycle proteins are important markers in predicting tumor behavior in urothelial carcinoma of the bladder. The objectives of this study were 1) to determine the expression levels of some of those markers in a series of patients with bladder carcinoma, 2) to define their value in distinguishing T1a (minim...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20306
更新日期:2004-06-01 00:00:00
abstract::The case of a 71-year-old woman who developed generalized weakness, lymphadenopathy, and a skin rash during methyldopa therapy is described. The prompt disappearance of symptoms following the discontinuation of the drug implicates it in the initial triggering of the abnormal lymphoid proliferation. Shortly thereafter,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197811)42:5<2322::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract::Recent follow-up studies of patients with mammary carcinoma treated with breast-conserving primary radiotherapy identified a triad of pathologic features significantly associated with local treatment failure. These unfavorable characteristics of the primary tumor were: poor or undifferentiated nuclear grade; intraduct...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860401)57:7<1415::aid-cncr2820
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:The malignant biological behavior of small-sized lung adenocarcinomas remains obscure, although understanding this feature is important for selecting appropriate treatment. In the current study, the authors evaluated malignancy grades of small adenocarcinomas using fluorodeoxyglucose-positron emission tomogr...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.25244
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:As androgen deprivation therapy (ADT) becomes a standard of treatment for men with recurrent or metastatic prostate cancer, evaluation of adverse effects associated with this treatment is needed. In this study, the authors evaluated the effect of ADT administered as monotherapy and in combination with local ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26064
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the bre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951201)76:11<2260::aid-cncr282
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:There is global variation in the onset of hepatocellular carcinoma (HCC). The objective of the current study was to investigate the impact of country of birth on age at the time of HCC diagnosis in the United States. METHODS:Incident HCC cases diagnosed between 2000 and 2012 in the Surveillance, Epidemiolog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30246
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge there are few data that correlate the expression of the epidermal growth factor receptor (EGFR) with the outcome of patients who have breast carcinoma and are treated with anthracycline chemotherapy. METHODS:Pretreatment tumor tissue samples were available from 82 patients who had ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21217
更新日期:2005-08-15 00:00:00
abstract:BACKGROUND:Primary T-cell lymphomas of the central nervous system are uncommon neoplasms. METHODS:A case of a primary central nervous system T-cell lymphoma in a 66-year-old female who died 8 months after surgery is described. The biopsy specimen was evaluated by routine histology, immunohistochemistry, flow cytometry...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950415)75:8<2180::aid-cncr2820
更新日期:1995-04-15 00:00:00
abstract::Five cases of primary intestinal lymphoma are described. The main clinical features included abdominal pain, diarrhea, and marked weight loss, together with radiologic and some laboratory findings suggestive of malabsorption. Laparatomy perfomed in four cases revealed dilatation of the small intestine, with mesenteric...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3<848::aid-cncr2820350
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, there are few studies to date regarding colorectal cancer (CRC) beliefs, knowledge, and screening among multiple Asian American populations, who are reported to have lower CRC screening rates compared with white individuals. The current study was performed to assess knowledge and b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31216
更新日期:2018-04-01 00:00:00
abstract::Disease that is known to have extended beyond the prostatic capsule is unlikely to be cured by radical surgical excision, although the primary tumor may be controlled by external irradiation. The development of progressive (metastatic) disease is common and may be retarded by hormonal therapy. The timing of such treat...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930201)71:3+<1074::aid-cncr282
更新日期:1993-02-01 00:00:00
abstract::Treatment with BCG (Bacillus Calmette-Guérin) followed by irradiation was attempted to improve response to therapy by cutaneous metastases from malignant skin melanomas. Both agents were applied in low doses, known to cause minimal side effects. Nineteen patients, divided into three groups, entered the clinical trial....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820915)50:6<1100::aid-cncr2820
更新日期:1982-09-15 00:00:00
abstract::Two hundred seventy-nine consecutive patients with Stage II osteogenic sarcoma of the appendicular skeleton treated between 1976 and 1986 were studied to identify predictors of long-term survival. Survival was 77% and 73% at 5 and 10 years, respectively, with continuously disease-free survival being 70% and 69%. On un...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920201)69:3<698::aid-cncr28206
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Recently, a highly sensitive fluorescent imaging technique was developed for the real-time identification of hepatic tumors. The authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer. METHODS:Forty-nine consecutive patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26594
更新日期:2012-06-01 00:00:00