Abstract:
BACKGROUND:As androgen deprivation therapy (ADT) becomes a standard of treatment for men with recurrent or metastatic prostate cancer, evaluation of adverse effects associated with this treatment is needed. In this study, the authors evaluated the effect of ADT administered as monotherapy and in combination with local treatment on physical well-being in a longitudinal sample of men with prostate cancer. METHODS:Exposure to ADT was defined by 3 groups: local (local treatment only), combination (local treatment with adjuvant and/or neoadjuvant ADT), and primary ADT. Associations between exposure to ADT and physical well-being measured by self-reported health-related quality of life outcomes over time were evaluated by repeated measures analysis using mixed modeling. Estimates adjusted for various clinical and demographic variables are reported. RESULTS:A total of 2922 men, who completed both pretreatment and follow-up health-related quality of life assessment, were identified from the CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor) registry. During 24 months of follow-up, exposure to ADT was associated with worse physical well-being compared with local treatment at all time points (P < .001). Being exposed to ADT as primary therapy was associated with more severe declines compared with combination therapy. CONCLUSIONS:The potential consequence of decline in physical well-being in patients exposed to ADT has to be included in treatment decision making.
journal_name
Cancerjournal_title
Cancerauthors
Sadetsky N,Greene K,Cooperberg MR,Hubbard A,Carroll PR,Satariano Wdoi
10.1002/cncr.26064subject
Has Abstractpub_date
2011-10-01 00:00:00pages
4406-13issue
19eissn
0008-543Xissn
1097-0142journal_volume
117pub_type
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