Abstract:
:Histologic, histochemical, immunocytochemical, and ultrastructural features of two cardiac myxomas containing glandular elements are reported. Glandular elements in both cases stained positively with both mucicarmine and periodic acid-Schiff reagent with diastase pretreatment (DPAS). Immunoperoxidase studies demonstrated positivity of the glandular cells for carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), and keratin. Factor VIII-related antigen (FVIIIAg) was identified only in cells lining vascular spaces. Electron microscopic study of one tumor demonstrated well-formed glands having basement membranes, junctional complexes, and apical secretory granules. These findings indicate the capacity for true epithelial differentiation of cardiac myxomas and have implications both as regards the histologic diagnosis of these tumors and their histogenesis.
journal_name
Cancerjournal_title
Cancerauthors
Goldman BI,Frydman C,Harpaz N,Ryan SF,Loiterman Ddoi
10.1002/1097-0142(19870515)59:10<1767::aid-cncr282subject
Has Abstractpub_date
1987-05-15 00:00:00pages
1767-75issue
10eissn
0008-543Xissn
1097-0142journal_volume
59pub_type
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