Glandular cardiac myxomas. Histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation.

Abstract:

:Histologic, histochemical, immunocytochemical, and ultrastructural features of two cardiac myxomas containing glandular elements are reported. Glandular elements in both cases stained positively with both mucicarmine and periodic acid-Schiff reagent with diastase pretreatment (DPAS). Immunoperoxidase studies demonstrated positivity of the glandular cells for carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), and keratin. Factor VIII-related antigen (FVIIIAg) was identified only in cells lining vascular spaces. Electron microscopic study of one tumor demonstrated well-formed glands having basement membranes, junctional complexes, and apical secretory granules. These findings indicate the capacity for true epithelial differentiation of cardiac myxomas and have implications both as regards the histologic diagnosis of these tumors and their histogenesis.

journal_name

Cancer

journal_title

Cancer

authors

Goldman BI,Frydman C,Harpaz N,Ryan SF,Loiterman D

doi

10.1002/1097-0142(19870515)59:10<1767::aid-cncr282

subject

Has Abstract

pub_date

1987-05-15 00:00:00

pages

1767-75

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

59

pub_type

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