Transbronchial lung biopsy in the diagnosis of lymphangitic carcinomatosis.


:The clinical diagnosis of lymphangitic carcinomatosis of the lung has generally been confirmed by open lung or transthoracic needle biopsy, precedures with significant morbidity and mortality, particularly in patients with respiratory insufficiency. We present six cases of lymphangitic carcinomatosis diagnosed by transbronchial biopsy. Autopsy confirmation was obtained in 4 patients and ultrastructural confirmation of intralymphatic location of tumor in one. The diffuse bronchial and peribronchial lymphatic involvement demonstrated here suggests that this relatively noninvasive technique should be the procedure of choice in the diagnosis of lymphangitic carcinomatosis of the lung.






Aranda C,Sidhu G,Sasso LA,Adams FV




Has Abstract


1978-10-01 00:00:00














  • Prognostic importance of histologic grading in papillary thyroid carcinoma.

    abstract:BACKGROUND:The influence of various clinicopathologic features on survival of patients with papillary thyroid carcinoma has been examined. In particular, histologic grade, which was obtained by a combined assessment of nuclear atypia, tumor necrosis, and vascular invasion (VAN score) was studied. According to this, his...


    pub_type: 杂志文章


    authors: Akslen LA

    更新日期:1993-11-01 00:00:00

  • BCG immunotherapy of bladder cancer: inhibition of tumor recurrence and associated immune responses.

    abstract::Fifty-one patients with confirmed bladder cancer have enrolled in a prospective evaluation of BCG immunotherapy. Following resection of existing tumors, patients were stratified according to tumor grade and number of previous recurrences and randomly assigned to control or BCG treatment groups. Immunotherapy consisted...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lamm DL,Thor DE,Winters WD,Stogdill VD,Radwin HM

    更新日期:1981-07-01 00:00:00

  • Breast conservation therapy in the United States following the 1990 National Institutes of Health Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma.

    abstract:BACKGROUND:A National Institutes of Health (NIH) Consensus Development Conference on the treatment of patients with early stage invasive breast carcinoma, held in June 1990, recommended breast conservation therapy for the majority of women with Stage I or II breast carcinoma. The authors evaluated the national use of b...


    pub_type: 杂志文章


    authors: Lazovich D,Solomon CC,Thomas DB,Moe RE,White E

    更新日期:1999-08-15 00:00:00

  • Extremity and trunk desmoid tumors: a multifactorial analysis of outcome.

    abstract:BACKGROUND:The natural history of desmoid tumors remains an enigma. Previous reports attempting to identify their biology have included recurrent and primary tumors as well as tumors from both intra- and extra-abdominal sites. The purpose of this study was to analyze patients with primary extremity and trunk desmoid tu...


    pub_type: 杂志文章


    authors: Merchant NB,Lewis JJ,Woodruff JM,Leung DH,Brennan MF

    更新日期:1999-11-15 00:00:00

  • Are older breast carcinoma survivors willing to take hormone replacement therapy?

    abstract:BACKGROUND:Breast carcinoma survivors are the largest segment of the expanding cancer survivor community. As a result, there has been increasing discussion of the safety and efficacy of hormone replacement therapy for women with a past history of breast carcinoma. Little is known about the willingness of older breast c...


    pub_type: 杂志文章


    authors: Ganz PA,Greendale GA,Kahn B,O'Leary JF,Desmond KA

    更新日期:1999-09-01 00:00:00

  • Randomized phase 2 trial of erlotinib in combination with high-dose celecoxib or placebo in patients with advanced non-small cell lung cancer.

    abstract:BACKGROUND:Cyclooxygenase 2 (COX-2)-dependent signaling represents a potential mechanism of resistance to therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regul...


    pub_type: 杂志文章,随机对照试验


    authors: Reckamp KL,Koczywas M,Cristea MC,Dowell JE,Wang HJ,Gardner BK,Milne GL,Figlin RA,Fishbein MC,Elashoff RM,Dubinett SM

    更新日期:2015-09-15 00:00:00

  • Oncologic imaging. Staging and follow-up of renal and adrenal carcinoma.

    abstract::Computed tomography (CT) has emerged from the 1980s to play a dominant role in the pretreatment staging of renal and adrenal carcinomas. For detection, definition (staging), and determination of resectability or recurrence, CT with intravenous contrast enhancement, and more recently, magnetic resonance imaging (MRI) w...


    pub_type: 杂志文章,评审


    authors: McClennan BL

    更新日期:1991-02-15 00:00:00

  • Long-term results of simple and radical nephrectomy for renal cell carcinoma.

    abstract::From 1974 to 1983, simple and radical nephrectomies were performed at the Chaim Sheba Medical Center (Tel Hashomer, Israel) for renal cell carcinoma. The authors reviewed 109 cases that were followed for a period ranging from 5 to 14 years. Simple nephrectomy was performed in 55 patients, and 54 patients underwent rad...


    pub_type: 杂志文章


    authors: Ramon J,Goldwasser B,Raviv G,Jonas P,Many M

    更新日期:1991-05-15 00:00:00

  • Prognostic significance of histologic parameters of soft tissue sarcomas.

    abstract:BACKGROUND AND METHODS:A univariate and multivariate analysis for the correlation between histomorphologic factors and prognosis was made using data from 1116 patients with soft tissue sarcoma, including 1005 cases available with complete histologic and follow-up data. RESULTS:The overall 5-year survival rate was 43.6...


    pub_type: 杂志文章


    authors: Hashimoto H,Daimaru Y,Takeshita S,Tsuneyoshi M,Enjoji M

    更新日期:1992-12-15 00:00:00

  • Colorectal carcinoma cell production of transforming growth factor beta decreases expression of endothelial cell vascular endothelial growth factor receptor 2.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) signaling is a target for antiangiogenic cancer therapy. The authors have previously observed that up to 40% of vessels in colorectal carcinoma (CRC) tumors are negative for VEGF receptor 2 (VEGFR2) expression. Differential activity of transforming growth factor beta...


    pub_type: 杂志文章


    authors: Kuczynski EA,Viloria-Petit AM,Coomber BL

    更新日期:2011-12-15 00:00:00

  • Why do men choose one treatment over another?: a review of patient decision making for localized prostate cancer.

    abstract::Treatment choices for localized prostate cancer appear to vary widely, although it is unclear whether this variation is a result of patient values or other factors. The authors conducted a systematic review of the literature, identifying 70 articles that focused on prostate cancer decision making. Studies suggest that...


    pub_type: 杂志文章


    authors: Zeliadt SB,Ramsey SD,Penson DF,Hall IJ,Ekwueme DU,Stroud L,Lee JW

    更新日期:2006-05-01 00:00:00

  • P21WAF1/CIP1 messenger RNA expression in hepatitis B, C virus-infected human hepatocellular carcinoma tissues.

    abstract:BACKGROUND:The primary objective of this study was to clarify the significance of p21WAF1/CIP1(p21) gene expression in the tumorgenicity of hepatitis B virus (HBV) and hepatitis C virus (HCV) infected human hepatocelluar carcinoma (HCC). METHODS:The authors performed Northern blot hybridization to compare the p21 mess...


    pub_type: 杂志文章


    authors: Kobayashi S,Matsushita K,Saigo K,Urashima T,Asano T,Hayashi H,Ochiai T

    更新日期:2001-06-01 00:00:00

  • Does endoscopic follow-up improve the outcome of patients with benign gastric ulcers and gastric cancer?

    abstract::This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed...


    pub_type: 杂志文章


    authors: Eckardt VF,Giessler W,Kanzler G,Bernhard G

    更新日期:1992-01-15 00:00:00

  • Adjuvant 5-fluorouracil plus doxorubicin in D2-3 resected gastric carcinoma: 15-year experience at a single institute.

    abstract:BACKGROUND:The authors evaluated the efficacy of adjuvant chemotherapy with 5-fluorouracil (5-FU) plus doxorubicin in gastric carcinoma after D2-3 curative resection. They also evaluated the effect of dose-related factors (delivered total dose/m(2), actual dose intensity [ADI], relative dose intensity [RDI]) of this re...


    pub_type: 临床试验,杂志文章


    authors: Jeung HC,Rha SY,Noh SH,Min JS,Kim BS,Chung HC

    更新日期:2001-06-01 00:00:00

  • Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial.

    abstract::To assess the efficacy and safety of Adriamycin (Adria Laboratories, Columbus, OH) in inoperable hepatocellular carcinoma (HCC), 60 patients were randomized to receive Adriamycin 60 to 75 mg/m2 at 3-week intervals and 46 patients to receive no antitumor therapy. The median survival rate of the Adriamycin group was 10....


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lai CL,Wu PC,Chan GC,Lok AS,Lin HJ

    更新日期:1988-08-01 00:00:00

  • Spinal cord compression in breast cancer.

    abstract::Myelography was performed on 78 patients with breast cancer who had signs or symptoms compatible with spinal cord compression. Of 42 patients (54%) with extradural defects, 21 (50%) had a complete block. All patients with positive myelograms (M+) had a positive bone scan and 41 of 42 (97%) had positive skeletal x-rays...


    pub_type: 杂志文章


    authors: Harrison KM,Muss HB,Ball MR,McWhorter M,Case D

    更新日期:1985-06-15 00:00:00

  • Thyroid-associated antigens in routinely embedded carcinomas. Possibilities and limitations studied in 116 cases.

    abstract::Routinely embedded tumors (116 cases) were screened immunohistochemically for the thyroid-associated antigens, thyroglobulin and calcitonin, and for carcinoembryonic antigen (CEA). Also the influence of different fixatives, decalcification, and embedding procedures were studied. All follicular and papillary carcinomas...


    pub_type: 杂志文章


    authors: Logmans SC,Jöbsis AC

    更新日期:1984-07-15 00:00:00

  • Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma.

    abstract::Based on laboratory studies showing enhanced cytotoxicity of floxuridine (FUDR) when used with high doses of leucovorin (LV), a pilot study of FUDR and LV through an implantable pump was initiated for the treatment of hepatic metastases from colorectal cancer. The highest dose of LV that could be administered, taking ...


    pub_type: 杂志文章


    authors: Kemeny N,Cohen A,Bertino JR,Sigurdson ER,Botet J,Oderman P

    更新日期:1990-06-01 00:00:00

  • Adrenocortical carcinoma: clinical and laboratory observations.

    abstract:BACKGROUND:The clinical features and natural history of adrenocortical carcinoma are highly dependent on the type of center reporting their experience. Observations from oncology services suggest a high incidence of nonfunctioning tumors, whereas reports from endocrine clinics emphasize excessive corticoid and androgen...


    pub_type: 杂志文章,评审


    authors: Wajchenberg BL,Albergaria Pereira MA,Medonca BB,Latronico AC,Campos Carneiro P,Alves VA,Zerbini MC,Liberman B,Carlos Gomes G,Kirschner MA

    更新日期:2000-02-15 00:00:00

  • Intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal.

    abstract:BACKGROUND:The purpose of this study was to compare outcomes in patients with anal canal squamous cell carcinoma (SCCA) who were treated with definitive chemoradiotherapy by either intensity-modulated radiation therapy (IMRT) or conventional radiotherapy (CRT). METHODS:Forty-six patients who received definitive chemor...


    pub_type: 杂志文章


    authors: Bazan JG,Hara W,Hsu A,Kunz PA,Ford J,Fisher GA,Welton ML,Shelton A,Kapp DS,Koong AC,Goodman KA,Chang DT

    更新日期:2011-08-01 00:00:00

  • Complementary therapies in palliative cancer care.

    abstract:BACKGROUND:Complementary medicine has become an important aspect of palliative cancer care. This overview is primarily aimed at providing guidance to clinicians regarding some commonly used complementary therapies. METHODS:Several complementary therapies were identified as particularly relevant to palliative cancer ca...


    pub_type: 杂志文章,评审


    authors: Ernst E

    更新日期:2001-06-01 00:00:00

  • Variations in gastric cancer care: a trend beyond racial disparities.

    abstract:BACKGROUND:Race is associated with patterns of presentation and survival outcomes of gastric cancer in the United States. However, the impact of race on the receipt of guideline-recommended care is not well characterized. By using current recommendations, the authors examined the association between race and guideline-...


    pub_type: 杂志文章


    authors: Al-Refaie WB,Gay G,Virnig BA,Tseng JF,Stewart A,Vickers SM,Tuttle TM,Feig BW

    更新日期:2010-01-15 00:00:00

  • Decreasing incidence of late-stage breast cancer after the introduction of organized mammography screening in Italy.

    abstract:BACKGROUND:After the introduction of a mammography screening program, the incidence of late-stage breast cancer is expected to decrease. The objective of the current study was to evaluate variations in the total incidence of breast cancer and in the incidence of breast cancers with a pathologic tumor (pT) classificatio...


    pub_type: 杂志文章


    authors: Foca F,Mancini S,Bucchi L,Puliti D,Zappa M,Naldoni C,Falcini F,Gambino ML,Piffer S,Sanoja Gonzalez ME,Stracci F,Zorzi M,Paci E,IMPACT Working Group.

    更新日期:2013-06-01 00:00:00

  • Angioinvasive plasma cell granulomas of the lung.

    abstract::A series of eight plasma cell granulomas of the lung were examined. Their clinical, pathologic, and immunohistochemical characteristics as well as the ultrastructural features of one case are in agreement with those found in the literature. One patient died after a surgical intervention complicated by invasion of pulm...


    pub_type: 杂志文章


    authors: Warter A,Satge D,Roeslin N

    更新日期:1987-02-01 00:00:00

  • Historical time to disease progression and progression-free survival in patients with recurrent/refractory neuroblastoma treated in the modern era on Children's Oncology Group early-phase trials.

    abstract:BACKGROUND:Early-phase trials in patients with recurrent neuroblastoma historically used an objective "response" of measureable disease (Response Evaluation Criteria In Solid Tumors [RECIST], without bone/bone marrow assessment) to select agents for further study. Historical cohorts may be small and potentially biased;...


    pub_type: 杂志文章,meta分析,评审


    authors: London WB,Bagatell R,Weigel BJ,Fox E,Guo D,Van Ryn C,Naranjo A,Park JR

    更新日期:2017-12-15 00:00:00

  • Tumor suppressor activity and inactivation of galanin receptor type 2 by aberrant promoter methylation in head and neck cancer.

    abstract:BACKGROUND:There is accumulating evidence that galanin receptors (GALRs) may be tumor suppressors in head and neck squamous cell carcinoma (HNSCC). Promoter methylation status and gene expression were assessed in a large panel of head and neck primary tumors, based on the hypothesis that cytosine-guanine dinucleotide (...


    pub_type: 杂志文章


    authors: Misawa Y,Misawa K,Kanazawa T,Uehara T,Endo S,Mochizuki D,Yamatodani T,Carey TE,Mineta H

    更新日期:2014-01-15 00:00:00

  • Does hormone treatment added to radiotherapy improve outcome in locally advanced prostate cancer?: meta-analysis of randomized trials.

    abstract:BACKGROUND:To quantify the magnitude of benefit of the addition of hormone treatment (HT) to exclusive radiotherapy for locally advanced prostate cancer, a literature-based meta-analysis was conducted. METHODS:Event-based relative risks (RR) with 95% confidence intervals (CIs) were derived through a random-effect mode...


    pub_type: 杂志文章,meta分析


    authors: Bria E,Cuppone F,Giannarelli D,Milella M,Ruggeri EM,Sperduti I,Pinnarò P,Terzoli E,Cognetti F,Carlini P

    更新日期:2009-08-01 00:00:00

  • Recurrence of early gastric cancer. Follow-up of 1475 patients and review of the Japanese literature.

    abstract:BACKGROUND:The outcome of surgical treatment for early gastric cancer (EGC) generally is considered to be satisfactory. Although a small percentage of patients experience disease recurrence, the absolute number of such instances is too small for assessment of risk factors. METHODS:The authors investigated the follow-u...


    pub_type: 杂志文章,评审


    authors: Sano T,Sasako M,Kinoshita T,Maruyama K

    更新日期:1993-12-01 00:00:00

  • High-dose combination chemotherapy with autologous bone marrow transplantation in adult solid tumors.

    abstract::In order to determine whether high-dose combination chemotherapy was active in chemotherapy resistant patients, 19 patients, (9 with small cell bronchogenic carcinoma, 6 with embryonal cell carcinoma, 2 with diffuse histiocytic lymphoma, 1 with Hodgkin's disease and 1 with chondrosarcoma), 18 of whom had had extensive...


    pub_type: 杂志文章


    authors: Spitzer G,Dicke KA,Litam J,Verma DS,Zander A,Lanzotti V,Valdivieso M,McCredie KB,Samuels ML

    更新日期:1980-06-15 00:00:00

  • Advances in medical imaging for cancer diagnosis and treatment.

    abstract::Over the last several decades, significant "new eyes" have been developed that improve the diagnosis, treatment, planning, and monitoring of human cancer: computer tomography (CT), magnetic resonance imaging (MRI) and spectroscopy (MRS), single photon emission computed tomography (SPECT), and positron emission tomogra...


    pub_type: 杂志文章,评审


    authors: Wagner HN Jr,Conti PS

    更新日期:1991-02-15 00:00:00