Transbronchial lung biopsy in the diagnosis of lymphangitic carcinomatosis.


:The clinical diagnosis of lymphangitic carcinomatosis of the lung has generally been confirmed by open lung or transthoracic needle biopsy, precedures with significant morbidity and mortality, particularly in patients with respiratory insufficiency. We present six cases of lymphangitic carcinomatosis diagnosed by transbronchial biopsy. Autopsy confirmation was obtained in 4 patients and ultrastructural confirmation of intralymphatic location of tumor in one. The diffuse bronchial and peribronchial lymphatic involvement demonstrated here suggests that this relatively noninvasive technique should be the procedure of choice in the diagnosis of lymphangitic carcinomatosis of the lung.






Aranda C,Sidhu G,Sasso LA,Adams FV




Has Abstract


1978-10-01 00:00:00














  • Phase II study of pentostatin in advanced T-cell lymphoid malignancies: update of an M.D. Anderson Cancer Center series.

    abstract:BACKGROUND:The goal of the current study was to assess the toxicity, safety, and efficacy of pentostatin in patients with T-cell lymphoid malignancies. METHODS:Patients were eligible if they had biopsy-proven T-cell lymphoma or leukemia and failure to respond to previous therapy or an expected complete response rate t...


    pub_type: 临床试验,杂志文章


    authors: Tsimberidou AM,Giles F,Duvic M,Fayad L,Kurzrock R

    更新日期:2004-01-15 00:00:00

  • An integrated analysis of germline and somatic, genetic and epigenetic alterations at 9p21.3 in glioblastoma.

    abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most prevalent and deadly brain tumor. A variety of germline and somatic, genetic and epigenetic alterations at 9p21.3, which encode CDKN2A/CDKN2B tumor suppressor genes, have been isolatedly reported to be associated with GBM risk and prognosis. METHODS:To obtain a comp...


    pub_type: 杂志文章


    authors: Feng J,Kim ST,Liu W,Kim JW,Zhang Z,Zhu Y,Berens M,Sun J,Xu J

    更新日期:2012-01-01 00:00:00

  • A study of drug-induced kinetic perturbations in the marrow of a patient with neuroblastoma.

    abstract::The kinetic perturbations induced by vincristine, cyclophosphamide, and adriamycin were studied in the bone marrow of a patient with neuroblastoma. Serial marrow samples were studied by dual parameter (Coulter volume and DNA content), flow cytometry, and radioautography, and findings were correlated with cytomorpholog...


    pub_type: 杂志文章


    authors: Shackney SE,Bunn PA,Ford SS,Erickson B,Ross WE,Levine AS

    更新日期:1980-03-01 00:00:00

  • Flow cytometric analysis of nuclear DNA content in esophageal cancer. Aneuploidy as an index for highly malignant potential.

    abstract::Flow cytometric analysis of nuclear DNA content was performed on excised malignant tissue of the esophagus. The DNA ploidy pattern was compared with a variety of histologic parameters and the subsequent clinical course to determine whether or not this pattern is associated with the mode of malignant potentiality. Of t...


    pub_type: 杂志文章


    authors: Kaketani K,Saito T,Kobayashi M

    更新日期:1989-08-15 00:00:00

  • Circumscribed carcinoma of the uterine cervix, with marked lymphocytic infiltration.

    abstract::The present study was carried out to investigate a distinctive type of carcinoma of the uterine cervix categorized under the designation as circumscribed carcinoma with lymphocytic infiltration. Grossly this carcinoma is characterized by defined circumscription with a superficial ulceration. A microscropic feature cha...


    pub_type: 杂志文章


    authors: Hasumi K,Sugano H,Sakamoto G,Masubuchi K,Kubo H

    更新日期:1977-06-01 00:00:00

  • Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of Ch

    abstract:BACKGROUND:The objective of this study was to evaluate the long-term survival and late toxicities of concurrent-adjuvant chemotherapy in patients with stage III through IVB nasopharyngeal carcinoma (NPC) from endemic regions of China. METHODS:Patients with stage III to IVB NPC were assigned randomly to receive radioth...


    pub_type: 杂志文章,随机对照试验


    authors: Chen Y,Sun Y,Liang SB,Zong JF,Li WF,Chen M,Chen L,Mao YP,Tang LL,Guo Y,Lin AH,Liu MZ,Ma J

    更新日期:2013-06-15 00:00:00

  • Granulocytic sarcoma of the cervix as a primary manifestation: case without overt leukemic features for 26 months.

    abstract::A case of granulocytic sarcoma involving the uterine cervix as primary manifestation without evidence of leukemia is presented. It was followed by neurological symptoms 19 months later and a right breast mass 26 months after the initial cervical lesion, but still with no evidence of leukemia. Two years and four months...


    pub_type: 杂志文章


    authors: Seo IS,Hull MT,Pak HY

    更新日期:1977-12-01 00:00:00

  • Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature.

    abstract:BACKGROUND:Hyalinizing clear cell carcinoma (HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is import...


    pub_type: 杂志文章,评审


    authors: Solar AA,Schmidt BL,Jordan RC

    更新日期:2009-01-01 00:00:00

  • Intraosseous well-differentiated osteosarcoma.

    abstract::A series of 27 patients with intramedullary osteogenic sarcomas that were so well-differentiated histologically as to be confused with benign lesions was studied. Of the 27 patients, 14 were females and 13 were males, and most were adults. The tibia and femur were involved commonly. Roentgenographically, the tumors sh...


    pub_type: 杂志文章


    authors: Unni KK,Dahlin DC,McLeod RA,Pritchard DJ

    更新日期:1977-09-01 00:00:00

  • Non-Hodgkin's lymphoma in children.

    abstract::Until recently the prognosis of childhood non-Hodgkin's lymphoma has been poor. A program of combination chemotherapy and involved area radiotherapy was instituted in the Department of Pediatrics at Roswell Park Memorial Institute in 1971. Thirty-one biopsy proven untreated children entered this study. There were 4 St...


    pub_type: 杂志文章


    authors: Brecher ML,Sinks LF,Thomas RR,Freeman AI

    更新日期:1978-05-01 00:00:00

  • Probably benign lesions at breast magnetic resonance imaging: preliminary experience in high-risk women.

    abstract:BACKGROUND:The purpose of the current study was to determine the frequency of 'probably benign' interpretations at breast magnetic resonance (MR) imaging screening of high-risk women and the frequency of subsequent malignancy in these women. METHODS:The authors performed a retrospective review of the records of 367 as...


    pub_type: 杂志文章


    authors: Liberman L,Morris EA,Benton CL,Abramson AF,Dershaw DD

    更新日期:2003-07-15 00:00:00

  • The relation of flow cytometry to clinical and biologic characteristics in women with node negative primary breast cancer.

    abstract::Flow cytometry (FC) analysis including DNA index (ploidy status) and cell kinetics (%S and %S + G2/M) was done on frozen tissue of the primary lesions of 101 women with node negative (N-) breast cancer who were studied prospectively. Currently, 19% (19/101) of the patients have recurred. No significant relations have ...


    pub_type: 杂志文章


    authors: Muss HB,Kute TE,Case LD,Smith LR,Booher C,Long R,Kammire L,Gregory B,Brockschmidt JK

    更新日期:1989-11-01 00:00:00

  • Telomerase activity in benign and malignant cytologic fluids.

    abstract:BACKGROUND:Telomerase is a ribonucleoprotein that maintains telomeric base pair repeats at the ends of mammalian chromosomes during DNA replication. Telomerase is expressed in various human tumors, some normal tissues, and immortalized cell lines. The assay of telomerase activity has potential as an adjunct for cancer ...


    pub_type: 杂志文章


    authors: Mu XC,Brien TP,Ross JS,Lowry CV,McKenna BJ

    更新日期:1999-04-25 00:00:00

  • Ureteral obstruction in patients with breast cancer.

    abstract::Six breast cancer patients were treated recently for renal insufficiency secondary to neoplasic involvement of the ureters. This complication usually occurs in long standing hormonal-dependent breast cancer with bone metastases. Diagnosis was performed by abdominal echography. Ureteral catheterization or percutaneous ...


    pub_type: 杂志文章


    authors: Recloux P,Weiser M,Piccart M,Sculier JP

    更新日期:1988-05-01 00:00:00

  • Toxicity of very high dose nitrosourea administration.

    abstract::We report a case of inadvertent administration of over twice the usual dose of methyl-CCNU. The patient exhibited an early onset of bone marrow suppression. Profound pancytopenia, including lymphopenia, persisted for over seven weeks, Although early recovery started at about five weeks. Permanent marrow damage was ind...


    pub_type: 杂志文章


    authors: Breeden JH,Vollmer JT,Twomey PL

    更新日期:1982-11-01 00:00:00

  • Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.

    abstract:BACKGROUND:To identify potential genetic markers for severe oxaliplatin-induced chronic peripheral neuropathy (OXCPN), the authors performed a genome-wide association analysis of patients with colon cancer who received oxaliplatin-based chemotherapy. METHODS:This was a prospective study in which DNA was purified in pe...


    pub_type: 杂志文章


    authors: Won HH,Lee J,Park JO,Park YS,Lim HY,Kang WK,Kim JW,Lee SY,Park SH

    更新日期:2012-06-01 00:00:00

  • Early detection of malignancy in ulcerative colitis. A flow-cytometric DNA study.

    abstract::The cellular DNA content in colorectal biopsies from 51 patients with chronic ulcerative colitis has been studied with flow-cytometric technique. The DNA pattern has been related to the duration of the disease, and to histopathology. Aneuploid cell lines were found in eight patients, two of which had histopathological...


    pub_type: 杂志文章


    authors: Hammarberg C,Slezak P,Tribukait B

    更新日期:1984-01-15 00:00:00

  • Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resista

    abstract:BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...


    pub_type: 杂志文章


    authors: Mathieu A,Remmelink M,D'Haene N,Penant S,Gaussin JF,Van Ginckel R,Darro F,Kiss R,Salmon I

    更新日期:2004-10-15 00:00:00

  • Genetic testing for colorectal carcinoma susceptibility: focus group responses of individuals with colorectal carcinoma and first-degree relatives.

    abstract:BACKGROUND:Colorectal carcinoma (CRC) may be the most frequent form of hereditary cancer. Genetic counseling and testing for heritable CRC is a promising approach for reducing the high incidence and mortality rates associated with the disease. Patients with CRC or those with at least one family member with the disease ...


    pub_type: 杂志文章


    authors: Kinney AY,DeVellis BM,Skrzynia C,Millikan R

    更新日期:2001-01-01 00:00:00

  • Correlation of chromosome abnormalities with clinical characteristics in thyroid lymphoma.

    abstract::Karyotypes from seven patients with thyroid lymphoma were studied before treatment. When the cytogenetic results were correlated with the clinical data, it became evident that there are two distinct groups of patients with thyroid lymphoma. In a group of patients with solely numerical abnormalities the disease is asso...


    pub_type: 杂志文章


    authors: Taniwaki M,Nishida K,Misawa S,Takino T,Abe T,Aozasa K,Katagiri S,Yonezawa T,Matsuzuka F,Kuma K

    更新日期:1989-03-01 00:00:00

  • Core imprint cytology of screen-detected breast lesions is predictive of the histologic results.

    abstract:BACKGROUND:In multidisciplinary assessment clinics for screen-detected breast lesions, onsite cytopathologists provide immediate results of fine-needle aspiration biopsies (FNABs) and this information is used for patient counseling and treatment planning. Such consultation is not possible for the increasing proportion ...


    pub_type: 杂志文章


    authors: Farshid G,Pieterse S

    更新日期:2006-06-25 00:00:00

  • The risk for cancer among children of women who underwent in vitro fertilization.

    abstract:BACKGROUND:The possible association between ovarian carcinoma and ovulation-inducing drugs has led to renewed interest in the potential carcinogenic risks of these drugs. In vitro fertilization (IVF) has been linked to multiple pregnancies and possibly congenital malformations. However, to the authors' knowledge the as...


    pub_type: 杂志文章


    authors: Lerner-Geva L,Toren A,Chetrit A,Modan B,Mandel M,Rechavi G,Dor J

    更新日期:2000-06-15 00:00:00

  • True hermaphrodite with multiple gonadal neoplasms: report of a case with cytogenetic study.

    abstract::On account of the functioning bigonads, true hermaphrodites show a wide range of morphological anomalies. The patient under discussion had an ovary on one side and an ovotestis on the other side; both of them functioned to some extent to produce a rudimentary uterus, fallopian tubes and a few Woolfian remnants. The ad...


    pub_type: 杂志文章


    authors: Radharrishnan S,Sivaraman L,Natarajan PS

    更新日期:1978-12-01 00:00:00

  • Comparative genomic hybridization of esophageal squamous cell carcinoma: correlations between chromosomal aberrations and disease progression/prognosis.

    abstract:BACKGROUND:Esophageal carcinoma is a major cause of cancer-related deaths among males in Taiwan. However, to date, the genetic alterations that accompany this lethal disease are not understood. METHODS:Chromosomal aberrations of 46 samples of esophageal squamous cell carcinoma (EC-SCC) were analyzed by comparative gen...


    pub_type: 杂志文章


    authors: Yen CC,Chen YJ,Chen JT,Hsia JY,Chen PM,Liu JH,Fan FS,Chiou TJ,Wang WS,Lin CH

    更新日期:2001-12-01 00:00:00

  • Late regrowth of pituitary adenomas after irradiation and/or surgery. Hazard function analysis.

    abstract::A retrospective analysis was performed on all patients with pituitary adenomas treated at the Radiation Oncology Center, Mallinckrodt Institute of Radiology, St. Louis, Missouri. Of 210 patients treated from April 1954 through December 1982, 70 were treated with radiotherapy alone (RT), 121 received immediate postoper...


    pub_type: 杂志文章


    authors: Grigsby PW,Simpson JR,Fineberg B

    更新日期:1989-04-01 00:00:00

  • Delivery of comprehensive cancer care at Kaiser Permanente.

    abstract:BACKGROUND:Kaiser Permanente (KP) is a large health maintenance organization (HMO) operating in 14 states and caring for 8,000,000 members in hundreds of facilities staffed by thousands of physicians and support personnel. Cancer care is provided to these KP members as part of the health care package. METHODS:KP insur...


    pub_type: 杂志文章


    authors: Glass A

    更新日期:1998-05-15 00:00:00

  • Prognostic evaluation of DNA flow cytometric and histopathologic parameters of colorectal cancer.

    abstract:BACKGROUND:The clinical value of DNA flow cytometry of colorectal cancer is unclear. The purpose of this retrospective study was to evaluate the relationship between tumor flow cytometry, histopathologic parameters, and survival. METHODS:Flow cytometry was performed on paraffin embedded specimens from 653 patients who...


    pub_type: 杂志文章


    authors: Tang R,Ho YS,You YT,Hsu KC,Chen JS,Changchien CR,Wang JY

    更新日期:1995-11-15 00:00:00

  • Diagnostic accuracy of fine-needle aspiration biopsy is determined by physician training in sampling technique.

    abstract:BACKGROUND:Fine-needle aspiration biopsy (FNAB) has been used with variable success as a diagnostic test for benign and malignant breast lesions. The goal of this study was to examine the effects of training physicians in the fine-needle aspiration sampling-technique on the diagnostic accuracy of FNAB of palpable breas...


    pub_type: 杂志文章


    authors: Ljung BM,Drejet A,Chiampi N,Jeffrey J,Goodson WH 3rd,Chew K,Moore DH 2nd,Miller TR

    更新日期:2001-08-25 00:00:00

  • Improving prognosis of glioblastoma in the 21st century: who has benefited most?

    abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults. Temozolomide was rapidly incorporated into first-line treatment following the publication of the pivotal European Organization for Research and Treatment of Cancer-National Cancer Institute of Canada phase 3 trial in 2005. Howe...


    pub_type: 杂志文章


    authors: Lawrence YR,Mishra MV,Werner-Wasik M,Andrews DW,Showalter TN,Glass J,Shen X,Symon Z,Dicker AP

    更新日期:2012-09-01 00:00:00

  • Cancer chemoprevention.

    abstract::Encouraging results from several recent trials have increased interest in the potential of chemoprevention in reducing the incidence of cancer. Treatment with 13-cis-retinoic acid has reversed oral leukoplakia, a premalignant lesion, and prevented the development of second primary carcinomas of the head and neck. Tamo...


    pub_type: 杂志文章,评审


    authors: Itri LM

    更新日期:1993-12-01 00:00:00