MAGE, BAGE, and GAGE gene expression in patients with esophageal squamous cell carcinoma and adenocarcinoma of the gastric cardia.

Abstract:

BACKGROUND:The MAGE, BAGE, and GAGE gene families code for distinct, tumor specific antigens that are recognized by cytotoxic T lymphocytes in the context of HLA molecules. The purpose of this study was to analyze MAGE, BAGE, and GAGE gene expression in the two major histologic types of esophageal carcinoma, squamous carcinoma (ESCc) and adenocarcinoma (CAc), and to correlate their expression patterns with the principal prognostic parameters and long term survival. METHODS:Gene expression was analyzed in surgical samples from 24 patients with ESCc and 24 patients with CAc by reverse transcriptase-polymerase chain reaction amplification (RT-PCR). None of the patients had received preoperative chemotherapy or radiotherapy, and all were followed until death or for a minimum of 4 years. RESULTS:Sixteen ESCc samples (67%) and 9 CAc samples (37.5%) expressed at least one of the genes under study. The expression of each MAGE gene in the two histologic types was not significantly different, with the exception of MAGE-4, which was expressed more in ESCc samples than in CAc samples. BAGE and GAGE expression was rather low and, in every case, was associated with the expression of at least one MAGE gene. CONCLUSIONS:In the group as a whole, and in both ESCc and CAc subgroups, no significant correlation emerged between the expression of any gene and prognostic parameters, such as pathologic tumor, lymph node, or disease stage. Nevertheless, BAGE or GAGE expression was related significantly to a poor prognosis, whereas the expression of MAGE genes (in the absence of BAGE and GAGE expression) was related significantly to a good prognosis.

journal_name

Cancer

journal_title

Cancer

authors

Zambon A,Mandruzzato S,Parenti A,Macino B,Dalerba P,Ruol A,Merigliano S,Zaninotto G,Zanovello P

subject

Has Abstract

pub_date

2001-05-15 00:00:00

pages

1882-8

issue

10

eissn

0008-543X

issn

1097-0142

pii

10.1002/1097-0142(20010515)91:10<1882::AID-CNCR121

journal_volume

91

pub_type

杂志文章

相关文献

CANCER文献大全
  • Development of postoperative intrathoracic chemo-thermotherapy for lung cancer with objective of improving local cure.

    abstract::From April 1985 through March 1988, 24 lung cancer patients with carcinomatous pleuritis were treated with a new combined treatment modality consisting of pulmonary resection and postoperative intrathoracic chemo-thermotherapy (PICT). They consisted of 15 male patients and nine female patients. A majority of the patie...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891001)64:7<1422::aid-cncr2820

    authors: Kodama K,Doi O,Tatsuta M,Kuriyama K,Tateishi R

    更新日期:1989-10-01 00:00:00

  • Factors influencing survival of children with nonmetastatic neuroblastoma.

    abstract::A randomized study was designed to determine the effect of intermittent oral cyclophosphamide on the rate of metastases in children with localized and regional neuroblastoma. Secondary objectives of the study were to determine the value of the proposed staging system, to measure the influence of the peripheral lymphoc...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197608)38:2<661::aid-cncr2820380

    authors: Evans AE,Albo V,D'Angio GJ,Finklestein JZ,Leiken S,Santulli T,Weiner J,Hammond GD

    更新日期:1976-08-01 00:00:00

  • Trichosporon sepsis and leukemia.

    abstract::Trichosporon cutaneum is a fungus known to cause superficial nodules over the distal third of hair shafts, mainly scalp hair, and to produce a clinical entity known as piedra. This superficial mycosis occurs mostly in temperate and tropical regions and is rarely seen in North America. Trichosporon cutaneum spesis is d...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197509)36:3<1106::aid-cncr282036

    authors: Rivera R,Cangir A

    更新日期:1975-09-01 00:00:00

  • A case of hepatocellular carcinoma associated with ossification. A case report.

    abstract::A 54-year-old man with hepatocellular carcinoma (HCC) of the typical trabecular pattern exhibiting unusual histologic features, both osteoid and bone formations, is reported. The tumor was associated with well-developed cirrhosis; thus, this may be different from mixed hepatic tumors of adults with bone formations bec...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860101)57:1<134::aid-cncr28205

    authors: Maeda M,Kanayama M,Uchida T,Hasumura Y,Takeuchi J

    更新日期:1986-01-01 00:00:00

  • Prognostic significance of serum osteoprotegerin levels in patients with bladder carcinoma.

    abstract:BACKGROUND:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays an important role in the process of lymphocyte-mediated cytotoxicity against malignant cells. Osteoprotegerin (OPG) is a soluble decoy receptor for TRAIL, and circulating OPG has been implicated in the protection of cells from TRAIL-mediat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20550

    authors: Mizutani Y,Matsubara H,Yamamoto K,Nan Li Y,Mikami K,Okihara K,Kawauchi A,Bonavida B,Miki T

    更新日期:2004-10-15 00:00:00

  • Antibody response to Epstein-Barr virus Rta protein in patients with nasopharyngeal carcinoma: a new serologic parameter for diagnosis.

    abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is associated closely with Epstein-Barr virus (EBV). The authors previously reported that an EBV immediate-early gene, BRLF1, was expressed frequently in NPC tumors, and a significant elevation in immunoglobulin G (IgG) antibodies directed against BRLF1 gene product Rta was det...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011001)92:7<1872::aid-cncr1704

    authors: Feng P,Chan SH,Soo MY,Liu D,Guan M,Ren EC,Hu H

    更新日期:2001-10-01 00:00:00

  • The equivalence and difference between the English and Chinese versions of two major, cancer-specific, health-related quality-of-life questionnaires.

    abstract:BACKGROUND:English and Chinese are two of the most widely used primary languages in the world. Patients in many cancer centers have a variety of ethnic backgrounds and primary languages. The comparability of version 4 of the English and Chinese versions of the Functional Assessment of Cancer Therapy-General (FACT-G) an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20681

    authors: Cheung YB,Thumboo J,Goh C,Khoo KS,Che W,Wee J

    更新日期:2004-12-15 00:00:00

  • Once weekly total and subtotal skin electron beam therapy for Kaposi's sarcoma.

    abstract::Although Kaposi's sarcoma (KS) usually appears with solitary skin lesions, in a large percentage of these patients the disease progresses eventually to involve large extensive segments of the skin. In the past, the most frequently used approach is the irradiation of isolated lesions as they arose, hence the so-called ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810215)47:4<640::aid-cncr28204

    authors: Nisce LZ,Safai B,Poussin-Rosillo H

    更新日期:1981-02-15 00:00:00

  • Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: the Japanese Association for Research on the Thymus Database Study.

    abstract:BACKGROUND:The efficacy of postoperative radiotherapy (PORT) for thymic epithelial tumors is still controversial. Using the Japanese Association for Research on the Thymus (JART) database, this study was aimed at clarifying the efficacy of PORT for Masaoka stage II and III thymic carcinoma and thymoma. METHODS:The JAR...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29166

    authors: Omasa M,Date H,Sozu T,Sato T,Nagai K,Yokoi K,Okamoto T,Ikeda N,Tanaka F,Maniwa Y,Japanese Association for Research on the Thymus.

    更新日期:2015-04-01 00:00:00

  • Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer.

    abstract::The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy. Response (PR + CR) was obtained in 14 patients (40%) of a median duration of five months. Among the 14 responding patients, 10 were resistant to previous endocrine th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800715)46:2<253::aid-cncr28204

    authors: Mouridsen HT,Kristensen D,Nielsen JH,Dombernowsky P

    更新日期:1980-07-15 00:00:00

  • Current and future status of adjuvant therapy for breast cancer.

    abstract::Adjuvant systemic treatments have greatly improved the prognosis of women with early breast cancer. Combination chemotherapy and, for patients with oestrogen receptor-positive (ER+) tumours, endocrine treatment has been found to reduce the frequency of relapse and improve survival. New adjuvant strategies include the ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11124

    authors: Coleman RE

    更新日期:2003-02-01 00:00:00

  • Ultrastructural observations on the histogenesis of alveolar rhabdomyosarcoma.

    abstract::Ultrastructural examination of an alveolar rhabdomyosarcoma revealed that the bulk of the tumor was composed of small polygonal cells containing polyribosomes, short strands of rough endoplasmic reticulum, and variable amounts of glycogen; the cells were joined by small desmosome-like structures. Similar cells, as wel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197804)41:4<1355::aid-cncr282041

    authors: Churg A,Ringus J

    更新日期:1978-04-01 00:00:00

  • HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia.

    abstract:BACKGROUND:Chronic myeloid leukemia (CML) may progress to blast phase (BP) at the rate of 1% to 1.5% per year. With the use of single-agent tyrosine kinase inhibitors, median overall survival ranges between 7 and 11 months. METHODS:The outcome was analyzed for 42 patients with lymphoid BP-CML who were treated with hyp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28433

    authors: Strati P,Kantarjian H,Thomas D,O'Brien S,Konoplev S,Jorgensen JL,Luthra R,Abruzzo L,Jabbour E,Quintas-Cardama A,Borthakur G,Faderl S,Ravandi F,Cortes J

    更新日期:2014-02-01 00:00:00

  • A retrospective study of 370 borderline tumors of the ovary treated at the Norwegian Radium Hospital from 1970 to 1982. A review of clinicopathologic features and treatment modalities.

    abstract:METHODS:Three-hundred seventy patients with borderline tumors treated between 1970 and 1982 at the Norwegian Radium Hospital were analyzed retrospectively for clinicopathologic features, treatment, and survival characteristics. RESULTS:One hundred seventy-eight patients had mucinous tumors, 174 patients had serous tum...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930301)71:5<1810::aid-cncr2820

    authors: Kaern J,Tropé CG,Abeler VM

    更新日期:1993-03-01 00:00:00

  • Interleukin-2-induced lung permeability is mediated by leukotriene B4.

    abstract::Interleukin (IL)-2 therapy leads to respiratory dysfunction due to increased vascular permeability. This study examines the role of the chemoattractant, immunomodulator, and permeability-promoting agent leukotriene (LT) B4 in this setting. Sheep with chronic lung lymph fistulae were given IL-2, 10(5) U/kg as an IV bol...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19901201)66:11<2357::aid-cncr282

    authors: Klausner JM,Goldman G,Skornick Y,Valeri R,Inbar M,Shepro D,Hechtman HB

    更新日期:1990-12-01 00:00:00

  • The identification of patient-specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild-type melanomas.

    abstract:BACKGROUND:Increasing knowledge of cancer genomes has triggered the development of specific targeted inhibitors, thus providing a valuable therapeutic pool. METHODS:In this report, the authors analyze the presence of targetable alterations in 136 tumor samples from 92 patients with melanoma using a comprehensive appro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31843

    authors: Appenzeller S,Gesierich A,Thiem A,Hufnagel A,Jessen C,Kneitz H,Regensburger M,Schmidt C,Zirkenbach V,Bischler T,Schilling B,Siedel C,Goebeler ME,Houben R,Schrama D,Gehrig A,Rost S,Maurus K,Bargou R,Rosenwald A,Sch

    更新日期:2019-02-15 00:00:00

  • Interleukin-6 and its receptor in cancer: implications for translational therapeutics.

    abstract::Interleukin-6 (IL-6) plays a major role in the response to injury or infection and is involved in the immune response, inflammation, and hematopoiesis. Its deregulation impacts numerous disease states, including many types of cancer. Consequently, modulating IL-6 may be an innovative therapeutic strategy in several di...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22999

    authors: Hong DS,Angelo LS,Kurzrock R

    更新日期:2007-11-01 00:00:00

  • Nephrotoxicity of nitrosoureas.

    abstract::Irreversible and progressive renal parenchymal damage and functional impairment occurred in the majority of patients receiving at least six courses (200 mg/m2 of BCNU and/or methyl CCNU at eight-week intervals) of nitrosoureas for therapy of malignant brain tumors. Seventeen of 18 patients who received at least six co...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810915)48:6<1328::aid-cncr2820

    authors: Schacht RG,Feiner HD,Gallo GR,Lieberman A,Baldwin DS

    更新日期:1981-09-15 00:00:00

  • Factors predicting long-term survival for metastatic breast cancer patients treated with high-dose chemotherapy and bone marrow support.

    abstract:BACKGROUND:Poor prognosis of Stage IV breast cancer patients have at best a 10% 3-year survival rate with conventional chemotherapy. Dose-intensive chemotherapy improved survival rates for some of these patients. METHODS:All patients were Stage IV estrogen receptor-negative or estrogen receptor-positive hormonal refra...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19940415)73:8<2157::aid-cncr2820

    authors: Dunphy FR,Spitzer G,Fornoff JE,Yau JC,Huan SD,Dicke KA,Buzdar AU,Hortobagyi GN

    更新日期:1994-04-15 00:00:00

  • Adjuvant chemotherapy in lung cancer: review and prospects.

    abstract::The results of trials testing combined surgery and chemotherapy in lung cancer are reviewed. Fifteen adjuvant trials using various chemotherapeutic agents were analyzed to determine reasons for their lack of success. Current trials with adjuvant therapy in lung cancer are briefly outlined. In addition, analysis of the...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,评审

    doi:10.1002/1097-0142(197704)39:4<1415::aid-cncr282039

    authors: Legha SS,Muggia FM,Carter SK

    更新日期:1977-04-01 00:00:00

  • Intravascular bronchioloalveolar tumor.

    abstract::A 17-year-old girl was operated for a solitary well-circumscribed pulmonary parenchymal tumor and reoperated ten times for multiple recurrent similar pulmonary tumors during 24 years. Histologic examination revealed the so-called intravascular bronchioloalveolar tumor (IVBAT) in all instances. The patient died from pn...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19871115)60:10<2471::aid-cncr282

    authors: Miettinen M,Collan Y,Halttunen P,Maamies T,Vilkko P

    更新日期:1987-11-15 00:00:00

  • Can immunohistochemical markers and mitotic rate improve prognostic precision in patients with primary melanoma?

    abstract:BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19990601)85:11<2391::aid-c

    authors: Ostmeier H,Fuchs B,Otto F,Mawick R,Lippold A,Krieg V,Suter L

    更新日期:1999-06-01 00:00:00

  • Evaluation of radiation effect, tumor differentiation, and prostate specific antigen staining in sequential prostate biopsies after external beam radiotherapy for patients with prostate carcinoma.

    abstract:BACKGROUND:Sequential systematic biopsies after radiotherapy (RT) for prostate carcinoma were evaluated with respect to radiation effect, tumor differentiation, and prostate specific antigen (PSA) staining, and these histopathologic parameters were correlated with local outcome. METHODS:Since 1990, transrectal ultraso...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Crook JM,Bahadur YA,Robertson SJ,Perry GA,Esche BA

    更新日期:1997-01-01 00:00:00

  • Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors.

    abstract:BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25255

    authors: Rausch SM,Clark MM,Patten C,Liu H,Felten S,Li Y,Sloan J,Yang P

    更新日期:2010-09-01 00:00:00

  • Prostate cancer risk in the Swedish AMORIS study: the interplay among triglycerides, total cholesterol, and glucose.

    abstract:BACKGROUND:In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose. METHODS:A cohort (n = 200,660) based on 4 groups of men, according to age at cohort entry, with TG, TC, and glucose me...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25758

    authors: Van Hemelrijck M,Garmo H,Holmberg L,Walldius G,Jungner I,Hammar N,Lambe M

    更新日期:2011-05-15 00:00:00

  • Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival.

    abstract::Breast cancer specimens from 600 women were assayed for estrogen receptors (ER) using an immunocytochemical assay (ICA) employing the monoclonal antiestrophilin antibody H222 Sp gamma. Results showed significant correlation with biochemical ER determinations as well as with tumor grade and menopausal status. In 449 ca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901015)66:8<1663::aid-cncr2820

    authors: Pertschuk LP,Kim DS,Nayer K,Feldman JG,Eisenberg KB,Carter AC,Rong ZT,Thelmo WL,Fleisher J,Greene GL

    更新日期:1990-10-15 00:00:00

  • A standard dose of radiation for "microscopic disease" is not appropriate.

    abstract::Elective irradiation of sites of potential occult tumor spread is often part of a patient's radiation therapy program. The required radiation dose (D) depends on the probability that occult disease exists (P(occ)), the number of sites at risk (A), the number of tumor clonogens present (Ni), their radiation sensitivity...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901215)66:12<2498::aid-cncr282

    authors: Marks LB

    更新日期:1990-12-15 00:00:00

  • Present and future projects of the International Breast Cancer Study Group.

    abstract::The International Breast Cancer Study Group (formerly the Ludwig Group) has conducted nine clinical trials since 1978 (see the Appendix for participants and authors). Biologic hypotheses related to the combined use of chemotherapy and endocrine therapy in women with operable breast cancer were tested. Questions of tim...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3+<1139::aid-cncr282

    authors: Goldhirsch A,Gelber RD,Castiglione M,Price KN,Rudenstam CM,Lindtner J,Collins J,Senn HJ,Brunner KW,Galligioni E

    更新日期:1994-08-01 00:00:00

  • Positive impact of the Patient Protection and Affordable Care Act Medicaid expansion on Louisiana women with breast cancer.

    abstract:BACKGROUND:Louisiana is one of the few Southern states that enacted the Medicaid expansion of the Patient Protection and Affordable Care Act (ACA). To the authors' knowledge, the issue of how this has affected the breast cancer landscape in Louisiana is unknown. The authors have postulated that ACA expansion had a posi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33265

    authors: Chu QD,Li T,Hsieh MC,Yi Y,Gibbs JF,Lyons JM 3rd,Wu XC

    更新日期:2020-11-03 00:00:00

  • Staging of cerebral hemispheric tumors.

    abstract::There is currently no adequate staging system for cerebral astrocytomas. A scheme for acquiring data that can be used to stage cerebral hemisphere tumors is suggested. This data base, in conjunction with treatment and survival information, may be useful in the management of childhood hemispheric tumors. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851001)56:7+<1784::aid-cncr282

    authors: Edwards MS,Klein DM

    更新日期:1985-10-01 00:00:00