Abstract:
:Interleukin-6 (IL-6) plays a major role in the response to injury or infection and is involved in the immune response, inflammation, and hematopoiesis. Its deregulation impacts numerous disease states, including many types of cancer. Consequently, modulating IL-6 may be an innovative therapeutic strategy in several diseases. A review of relevant published literature regarding IL-6 and its receptor was performed. In addition, a review of the relevance of this cytokine system to human illness, particularly in cancer, was undertaken. IL-6 is a pleiotropic cytokine that is involved in the physiology of virtually every organ system. Aberrant expression of this cytokine has been implicated in diverse human illnesses, most notably inflammatory and autoimmune disorders, coronary artery and neurologic disease, gestational problems, and neoplasms. In cancer, high levels of circulating IL-6 are observed in almost every type of tumor studied and predict a poor outcome. Furthermore, elevated IL-6 levels are associated strongly with several of the striking phenotypic features of cancer. Several molecules have been developed recently that target the biologic function of IL-6. Early results in the clinic suggest that this strategy may have a significant salutary impact on diverse tumors. The field of cytokine research has yielded a deep understanding of the fundamental role of IL-6 and its receptor in health and disease. Therapeutic targeting of IL-6 and its receptor in cancer has strong biologic rationale, and there is preliminary evidence suggesting that targeting of the IL-6 system may be beneficial in the treatment of cancer.
journal_name
Cancerjournal_title
Cancerauthors
Hong DS,Angelo LS,Kurzrock Rdoi
10.1002/cncr.22999subject
Has Abstractpub_date
2007-11-01 00:00:00pages
1911-28issue
9eissn
0008-543Xissn
1097-0142journal_volume
110pub_type
杂志文章,评审相关文献
CANCER文献大全abstract::Prognostic factors were evaluated in 109 soft tissue sarcomas of the extremities, walls of the trunk, head, and neck. All lesions were graded according to the systems proposed by the National Cancer Institute (NCI) and the French Federation of Cancer Centers (FNCLCC), and a correlation was found between tumor grade an...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19890401)63:7<1437::aid-cncr2820
更新日期:1989-04-01 00:00:00
abstract::Seventeen cases of malignant melanoma of soft parts (clear cell sarcoma) are reported. The patients ranged from 9 to 70 years of age, but 13 were between 10 and 40 years of age. There were eight male patients and nine female patients. The most common tumor location (seven patients) was the foot, followed by the area a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900115)65:2<367::aid-cncr28206
更新日期:1990-01-15 00:00:00
abstract::The report describes a clinical trial on conservative surgery in progress at the National Cancer Institute of Milan, Italy. The randomized clinical trial compares radical mastectomy with a more conservative procedure consisting of mammary resection plus axillary dissection plus radiotherapy. The resection comprises an...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197706)39:6<2822::aid-cncr282039
更新日期:1977-06-01 00:00:00
abstract::Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune activation and dysregulation resulting in extreme and often life-threatening inflammation. HLH has been well recognized in pediatric populations, and most current diagnostic and therapeutic guidelines are based on pediatric HLH. Recently there has...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.30826
更新日期:2017-09-01 00:00:00
abstract::The presence of receptors for estrogen, glucocorticoid and progesterone was determined in the cytosol of two breast angiosarcomas. Estrogen and glucocorticoid receptors were present in both of them. Progesterone receptors were present in one of the two tumors assayed. Occupied nuclear estrogen receptors have been foun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830601)51:11<2105::aid-cncr282
更新日期:1983-06-01 00:00:00
abstract::Between 1970 and 1989, 17 children with histologically malignant intracranial ependymomas received treatment at the University of Pennsylvania (Philadelphia, PA). Eleven were treated with prophylactic cranial or craniospinal irradiation plus a local boost (CS-XRT), five with local (L-XRT) irradiation only, and one was...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910601)67:11<2766::aid-cncr282
更新日期:1991-06-01 00:00:00
abstract::The clinical, patient-oriented focus of medicine and psychology is contrasted with the epidemiologic (public health) approach in assessing the role of life-style factors and health promotion in cancer research. The unifying host-agent-environment epidemiologic paradigm is applied to contemporary cancer prevention issu...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910201)67:3+<808::aid-cncr2820
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31395
更新日期:2018-07-01 00:00:00
abstract::Epidemiology and prognosis were analyzed in a consecutive, population-based series of 137 patients with malignant fibrous histiocytoma of soft tissue in the extremities and trunk wall, with a complete follow-up of minimum 3 years. All but one patient were treated by surgery in 28 cases combined with adjuvant radiother...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<499::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract::Thirty white and 15 black children with neuroblastoma were compared with respect to survival. Patient age and tumor stage at diagnosis were similar in the two groups, as was duration of symptoms prior to diagnosis. There was no significant difference between the white and black children in regard to median duration of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197509)36:3<1151::aid-cncr282036
更新日期:1975-09-01 00:00:00
abstract::This article reports on the diagnostic features, radiographic findings, staging, operative management, treatments, and treatment results for 95 children (mean age, 10 years) with paratesticular sarcoma; they were treated on the Intergroup Rhabdomyosarcoma Study (IRS) I and II protocols. Embryonal rhabdomyosarcoma (RMS...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19871101)60:9<2337::aid-cncr2820
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Melanoma is the most lethal form of skin cancer, with an estimated 68,130 new cases and 8700 deaths in the United States in 2010. The increasing incidence and high death rate associated with metastatic disease support the need to focus on prevention. The authors used data from the Women's Health Initiative (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27497
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:Neuropilins (NRPs) are characterized as coreceptors of vascular endothelial growth factor (VEGF). In the current study, the authors assessed the expression of NRPs, VEGF, and vascular endothelial growth factor receptors (VEGFRs), as well as VEGF-induced cell proliferation, in pancreatic carcinoma cell lines ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20634
更新日期:2004-11-15 00:00:00
abstract:BACKGROUND:The Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low radiation dose computed tomography (low-dose CT) in persons at high-risk for lung cancer. The authors report on the baseline screening experience. For full evaluation of screening, they await the ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20001201)89:11+<2474::aid-cncr26
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Monoclonal antibodies have not been evaluated in metastasizing endocrine tumors, even though these lesions may induce severe morbidity of hormone excess in absence of considerable tumor burden. METHODS:A murine monoclonal antibody of the IgG2a subtype was generated by immunization with dispersed tumor cells...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19940301)73:5<1346::aid-cncr2820
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:The goal of the current study was to assess the toxicity, safety, and efficacy of pentostatin in patients with T-cell lymphoid malignancies. METHODS:Patients were eligible if they had biopsy-proven T-cell lymphoma or leukemia and failure to respond to previous therapy or an expected complete response rate t...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11899
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:Screening for and the aggressive treatment of prostate carcinoma are controversial, but they are nevertheless being practiced in the U.S. Current clinical studies of the effectiveness of screening will take years to complete. Meanwhile, screening for prostate carcinoma is already having an effect on society....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971101)80:9<1857::aid-cn
更新日期:1997-11-01 00:00:00
abstract::The case of a man who developed a leiomyosarcoma in association with a surgically created arteriovenous fistula is reported. This unusual complication of a dialysis fistula is the first reported case of a leiomyosarcoma occurring in a surgically created fistula. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830715)52:2<390::aid-cncr28205
更新日期:1983-07-15 00:00:00
abstract:BACKGROUND:Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop resistance and cardiac and steroid t...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.10946
更新日期:2002-11-15 00:00:00
abstract::Few studies have incorporated high-dose methotrexate (MTX) with leucovorin rescue in the treatment of small cell lung cancer (SCLC). Potentially therapeutic levels of MTX can be achieved in the central nervous system (CNS) by systemic administration of high doses of this drug. Utilizing a combination chemotherapy prog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830315)51:6<1056::aid-cncr2820
更新日期:1983-03-15 00:00:00
abstract:BACKGROUND:False-positive cancer screening results may affect a patient's willingness to obtain future screening. METHODS:The authors conducted logistic regression analysis of 450,484 person-years of electronic medical records (2006-2015) in 92,405 individuals aged 50 to 75 years. Exposures were false-positive breast,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31271
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The authors evaluated the efficacy of adjuvant chemotherapy with 5-fluorouracil (5-FU) plus doxorubicin in gastric carcinoma after D2-3 curative resection. They also evaluated the effect of dose-related factors (delivered total dose/m(2), actual dose intensity [ADI], relative dose intensity [RDI]) of this re...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010601)91:11<2016::aid-cncr122
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS:Seventeen patients with extremity melanoma who underwent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971201)80:11<2084::aid-c
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Based on previous data demonstrating a potentially synergistic interaction between tamoxifen and cisplatin in metastatic melanoma therapy, a Phase II study was performed to assess the activity of tamoxifen, etoposide, mitoxantrone, and cisplatin (TEMP) in patients with metastatic breast carcinoma. METHODS:F...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19961101)78:9<1906::aid-cn
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine if pelvic computed tomography (CT) should routinely be appended to abdominal CT in the workup of patients with breast carcinoma. METHODS:The abdominal-pelvic CTs of 139 breast carcinoma patients (195 exams) were reviewed. Scans were grouped by indication and whether pel...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Poor enrollment of adolescents and young adults (AYAs) (ages 15-39 years) onto cancer clinical trials (CCTs) may contribute to inferior survival gains compared with children. In this study, the authors assessed whether differences in CCT availability would explain lower CCT enrollment for early AYAs (eAYAs) ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31127
更新日期:2018-03-01 00:00:00
abstract::The prognostic significance of histologic tumor grade has been evaluated in 1537 women entered into the Ludwig Trials I-IV of adjuvant therapy for node-positive breast cancer. Tumor grade was determined on histologic review of primary tumor sections by two central review pathologists using a modification of the Bloom ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19861215)58:12<2662::aid-cncr282
更新日期:1986-12-15 00:00:00
abstract::Over the last decade, new cytotoxic treatments and targeted therapies have altered treatment paradigms for patients with metastatic non-small cell lung cancer (NSCLC). We sought to analyze the impact of histology and biomarker selection criteria on outcomes of clinical trials in metastatic NSCLC reported over the last...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28956
更新日期:2014-12-15 00:00:00
abstract::This report documents, in seven infants younger than 2 years of age, a previously unrecognized association of a renal embryonal neoplasm (malignant rhabdoid tumor in six patients and a Wilms' tumor in one) with an embryonal primary tumor originating in the central nervous system. The neuroepithelial tumors included th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841115)54:10<2137::aid-cncr282
更新日期:1984-11-15 00:00:00
abstract:BACKGROUND:Louisiana is one of the few Southern states that enacted the Medicaid expansion of the Patient Protection and Affordable Care Act (ACA). To the authors' knowledge, the issue of how this has affected the breast cancer landscape in Louisiana is unknown. The authors have postulated that ACA expansion had a posi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33265
更新日期:2020-11-03 00:00:00