Factors influencing survival of children with nonmetastatic neuroblastoma.

Abstract:

:A randomized study was designed to determine the effect of intermittent oral cyclophosphamide on the rate of metastases in children with localized and regional neuroblastoma. Secondary objectives of the study were to determine the value of the proposed staging system, to measure the influence of the peripheral lymphocyte count on prognosis, and to study the effect of the primary tumor site and regional node involvement. Since there was no difference in survival in the two groups of patients, whether or not they received chemotherapy, all 113 children were treated as a single group for the analysis of the secondary objectives. The proposed staging served as a good indicator of prognosis with a significant difference in survival seen between each of three stages. It was not possible to detect a significant influence by the three other prognostic variables studied, peripheral lymphocytes, primary site and regional node involvement. Small numbers in the various subgroups studied may account for the failure of differences to achieve statistical significance.

journal_name

Cancer

journal_title

Cancer

authors

Evans AE,Albo V,D'Angio GJ,Finklestein JZ,Leiken S,Santulli T,Weiner J,Hammond GD

doi

10.1002/1097-0142(197608)38:2<661::aid-cncr2820380

subject

Has Abstract

pub_date

1976-08-01 00:00:00

pages

661-6

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

38

pub_type

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