The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases.

Abstract:

:This report documents, in seven infants younger than 2 years of age, a previously unrecognized association of a renal embryonal neoplasm (malignant rhabdoid tumor in six patients and a Wilms' tumor in one) with an embryonal primary tumor originating in the central nervous system. The neuroepithelial tumors included three cerebellar medulloblastomas, one pineoblastoma, one primitive neuroepithelial tumor (probably cerebral neuroblastoma), one malignant subependymal giant cell astrocytoma, and one cerebellar medulloepithelioma with divergent glial and neuronal differentiation. There is no evidence that this association is based on the selective neoplastic transformation of embryonal cells of similar histogenetic or cytogenetic origin. The relationship between these dissimilar, embryologically unrelated tumors remains enigmatic.

journal_name

Cancer

journal_title

Cancer

authors

Bonnin JM,Rubinstein LJ,Palmer NF,Beckwith JB

doi

10.1002/1097-0142(19841115)54:10<2137::aid-cncr282

subject

Has Abstract

pub_date

1984-11-15 00:00:00

pages

2137-46

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

54

pub_type

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