Costs of cancer along the care continuum: What we can expect based on recent literature.


BACKGROUND:Cancer costs should be discussed by patients and providers, but information is not readily available. Results from recently published studies (in the last 5 years) on direct and indirect cancer costs may help guide these discussions. METHODS:The authors reviewed studies published between 2013 and 2017 that reported direct health care costs and indirect (productivity losses) costs. The annual mean total and net costs of cancer were summarized for all payers and for survivors only by age (ages 18-64 and ≥65 years), by phase of care (initial [ie, 12 months from diagnosis], continuing, and end-of-life [ie, 12 months before death]), or for recently diagnosed (within 1-2 years of diagnosis) and longer term survivors. RESULTS:For all payers combined, costs for cancers like breast, prostate, colorectal, and lung cancers were $20,000 to $100,000 in the initial phase, $1000 to $30,000 annually in the continuing phase, and ≥$60,000 in the end-of-life phase. Annual out-of-pocket costs to recently diagnosed survivors were >$1000 for medical care and time costs, approximately $2000 for productivity losses, and from $2500 to >$4000 for employment disability, depending on age. For longer term survivors, the cost of medical care was approximately $1500 for older survivors and $747 for younger survivors, time costs were $831 to $955 for older survivors and $459 to $630 for younger survivors, and productivity losses were approximately $800. Disability among long-term survivors was similar to that among short-term survivors. Limitations of the reviewed studies included older data and under-representation of higher cost cancers. CONCLUSIONS:Frequently updated cost information for all cancer types is needed to guide discussions of anticipated short-term and long-term cancer-related costs with survivors. Cancer 2018;000:000-000. © 2018 American Cancer Society.






Pisu M,Henrikson NB,Banegas MP,Yabroff KR




Has Abstract


2018-11-01 00:00:00














  • Adjuvant chemotherapy in lung cancer: review and prospects.

    abstract::The results of trials testing combined surgery and chemotherapy in lung cancer are reviewed. Fifteen adjuvant trials using various chemotherapeutic agents were analyzed to determine reasons for their lack of success. Current trials with adjuvant therapy in lung cancer are briefly outlined. In addition, analysis of the...


    pub_type: 临床试验,杂志文章,评审


    authors: Legha SS,Muggia FM,Carter SK

    更新日期:1977-04-01 00:00:00

  • Supratentorial gangliogliomas: histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years.

    abstract:BACKGROUND:Supratentorial gangliogliomas (GGs) are rare tumors of the central nervous system and are commonly associated with chronic seizures. To date, only case reports and small series of patients with short-term follow-up have been available for the assessment of the potential of GGs to recur and progress. METHODS...


    pub_type: 杂志文章


    authors: Luyken C,Blümcke I,Fimmers R,Urbach H,Wiestler OD,Schramm J

    更新日期:2004-07-01 00:00:00

  • The prognostic significance of lymphocytic infiltration in malignant melanoma of the choroid.

    abstract::Lymphocytic and plasmocytic infiltration surrounding a malignant tumor probably represents an immunologic response of the host directed against the neoplasm. It has been documented that lymphocytic infiltration has a favorable effect on prognosis in a number of human tumor systems, including cutaneous melanoma. In the...


    pub_type: 杂志文章


    authors: Lang JR,Davidorf FH,Baba N

    更新日期:1977-11-01 00:00:00

  • Acute promyelocytic leukemia. A childhood cluster.

    abstract::Nine children with acute promyelocytic leukemia (APL) are presented. This series of children represents 7% of all acute leukemias and 21% of acute myelogenous leukemias seen during the same period at the Red Cross War Memorial Children's Hospital. These figures are much higher than the incidence quoted in other series...


    pub_type: 杂志文章


    authors: Gilbert RD,Karabus CD,Mills AE

    更新日期:1987-03-01 00:00:00

  • Risk of venous thromboembolism in patients with non-Hodgkin lymphoma surviving blood or marrow transplantation.

    abstract:BACKGROUND:Patients with non-Hodgkin lymphoma (NHL) have an increased risk of venous thromboembolism (VTE), particularly when they are receiving treatment. Blood or marrow transplantation (BMT) is recommended for relapsed/refractory NHL, and the risk of VTE after these patients undergo BMT is uncertain. METHODS:Patien...


    pub_type: 杂志文章


    authors: Gangaraju R,Chen Y,Hageman L,Wu J,Francisco L,Kung M,Ness E,Parman M,Weisdorf DJ,Forman SJ,Arora M,Armenian SH,Bhatia S

    更新日期:2019-12-15 00:00:00

  • Racial disparities in postmastectomy breast reconstruction: National trends in utilization from 2005 to 2014.

    abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...


    pub_type: 杂志文章


    authors: Epstein S,Tran BN,Cohen JB,Lin SJ,Singhal D,Lee BT

    更新日期:2018-07-01 00:00:00

  • A Phase II trial of gemcitabine for metastatic neuroendocrine tumors.

    abstract:BACKGROUND:Treatment with traditional cytotoxic chemotherapy regimens containing streptozocin or dacarbazine has resulted in only marginal benefit for patients with metastatic neuroendocrine tumors. The use of these regimens has been further limited by their potential toxicity. Gemcitabine is generally well tolerated a...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Kulke MH,Kim H,Clark JW,Enzinger PC,Lynch TJ,Morgan JA,Vincitore M,Michelini A,Fuchs CS

    更新日期:2004-09-01 00:00:00

  • Pulmonary rhabdomyosarcoma with isolated small bowel metastasis. A report of a case with immunohistochemical and ultrastructural studies.

    abstract::A unique case of pulmonary rhabdomyosarcoma with an isolated, symptomatic small bowel metastasis is presented. The tumor affected the middle lobe, and was treated with a right pneumonectomy. Eleven months after the operation, an isolated small bowel metastasis, which produced intestinal obstruction, was resected. The ...


    pub_type: 杂志文章


    authors: Avagnina A,Elsner B,De Marco L,Bracco AN,Nazar J,Pavlovsky H

    更新日期:1984-05-01 00:00:00

  • Thymoma and the nephrotic syndrome: a report of a case.

    abstract::A 48-year-old male presented with the nephrotic syndrome 3 years after resection and irradiation of a thymoma. Renal biopsy revealed membranous glomerulonephritis by electron microscopy. IgA, IgG, and C3 deposition were present in the glomerular basement membrane by immunofluorescence. There was no evidence of other a...


    pub_type: 杂志文章


    authors: Posner MR,Prout MN,Berk S

    更新日期:1980-01-15 00:00:00

  • Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management.

    abstract::Adenoid cystic carcinoma (ACC) of the breast is a rare histologic type of breast cancer associated with a good prognosis. A woman who earlier had a pulmonary metastasis surgically resected 6 years postmastectomy developed clinically symptomatic bleeding from a renal metastasis 12 years postmastectomy. An atypical angi...


    pub_type: 杂志文章


    authors: Herzberg AJ,Bossen EH,Walther PJ

    更新日期:1991-09-01 00:00:00

  • Automated analysis of mammographic densities and breast carcinoma risk.

    abstract:BACKGROUND:There is considerable evidence that one of the strongest risk factors for breast carcinoma can be assessed from the mammographic appearance of the breast. However, the magnitude of the risk factor and the reliability of the prediction depend on the method of classification. Subjective classification requires...


    pub_type: 杂志文章


    authors: Byng JW,Yaffe MJ,Lockwood GA,Little LE,Tritchler DL,Boyd NF

    更新日期:1997-07-01 00:00:00

  • Disappearance of the predictive value of prognostic variables in childhood acute lymphoblastic leukemia: a report from Childrens Cancer Study Group.

    abstract::The identification of important prognostic factors at diagnosis of childhood leukemia has been very useful in explaining the marked differences in disease outcome. After a complete remission is achieved, it is interesting to determine whether the ability to maintain a complete remission and the patient's survival cont...


    pub_type: 杂志文章


    authors: Sather H,Coccia P,Nesbit M,Level C,Hammond D

    更新日期:1981-07-15 00:00:00

  • The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma.

    abstract:BACKGROUND:The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant...


    pub_type: 杂志文章


    authors: Gatalica Z,Lele SM,Rampy BA,Norris BA

    更新日期:2000-03-15 00:00:00

  • The effect of disease and treatment-related factors on biopsy results after prostate brachytherapy: implications for treatment optimization.

    abstract:BACKGROUND:Posttreatment prostate biopsy is a method of assessing local control after irradiation for prostate carcinoma. An analysis of the effect of disease- and treatment-related factors on biopsy results after prostate brachytherapy was performed to aid in patient selection and treatment optimization. METHODS:Two ...


    pub_type: 杂志文章


    authors: Stock RG,Stone NN,Kao J,Iannuzzi C,Unger P

    更新日期:2000-10-15 00:00:00

  • Toxicity and efficacy of combined radioimmunotherapy and bevacizumab in a mouse model of medullary thyroid carcinoma.

    abstract:BACKGROUND:Significant antitumor effects were previously observed with radioimmunotherapy (RIT) using an anti-carcinoembryonic antigen (CEA) monoclonal antibody (F6) labeled with iodine-131 in medullary thyroid cancer (MTC)-bearing nude mice. Nevertheless, no complete response was achieved. Because angiogenesis is crit...


    pub_type: 杂志文章


    authors: Salaun PY,Bodet-Milin C,Frampas E,Oudoux A,Saï-Maurel C,Faivre-Chauvet A,Barbet J,Paris F,Kraeber-Bodéré F

    更新日期:2010-02-15 00:00:00

  • Cognitive performance in survivors of breast cancer and markers of biological aging.

    abstract:BACKGROUND:Biological aging pathways accelerated by cancer treatments may be a mechanism for cognitive impairment in cancer survivors. The goal of the current study was to examine whether indicators of biological aging, namely elevated levels of DNA damage, reduced telomerase enzymatic activity, and shorter peripheral ...


    pub_type: 杂志文章


    authors: Carroll JE,Van Dyk K,Bower JE,Scuric Z,Petersen L,Schiestl R,Irwin MR,Ganz PA

    更新日期:2019-01-15 00:00:00

  • Familial risk of breast cancer by dynamic, accumulative, and static definitions of family history.

    abstract:BACKGROUND:Familial breast cancer risk studies usually overlook the dynamic nature of family history. METHODS:The authors assessed the effect of incorporating the timing of cancer diagnosis events into the assessment of familial risks of breast cancer in first-degree and second-degree relatives in a nationwide cohort ...


    pub_type: 杂志文章


    authors: Mukama T,Kharazmi E,Sundquist K,Sundquist J,Brenner H,Fallah M

    更新日期:2020-06-15 00:00:00

  • Hepatic veno-occlusive disease due to DTIC.

    abstract::A case of fulminant hepatic failure leading to death in a patient receiving DTIC for metastatic melanoma is presented. Autopsy revealed widespread centrilobular necrosis secondary to a veno-occlusive process. There was no evidence of a similar process in other organs, and common causes of similar pathology were ruled ...


    pub_type: 杂志文章


    authors: Asbury RF,Rosenthal SN,Descalzi ME,Ratcliffe RL,Arseneau JC

    更新日期:1980-05-15 00:00:00

  • Cytology of myoepithelial carcinoma of the salivary gland.

    abstract:BACKGROUND:Myoepithelial carcinoma, also know as malignant myoepithelioma, is rare in the salivary gland, and its cytologic features have rarely been reported. DESIGN:Four cases of myoepithelial carcinoma with cytology were retrieved from the archives of the Pathology Departments of two academic institutes. In three c...


    pub_type: 杂志文章


    authors: Chhieng DC,Paulino AF

    更新日期:2002-02-25 00:00:00

  • Manual dissection of adenocarcinoma of the lower third of the rectum specimens for detection of lymph node metastases smaller than 5 mm.

    abstract:BACKGROUND:The question of whether manual dissection when searching for metastatic lymph nodes from rectal cancer (less than 5 mm) is a reliable method remains controversial. METHODS:We examined 50 consecutive cases of primary adenocarcinoma of the rectum treated with a sphincter-sparing total rectum resection, total ...


    pub_type: 杂志文章


    authors: Andreola S,Leo E,Belli F,Bufalino R,Tomasic G,Lavarino C,Baldini MT,Meroni E

    更新日期:1996-02-15 00:00:00

  • Cytogenetic studies of chronic myelocytic leukemia in children and adolescents.

    abstract::In a 3 1/2 year cytogenetic study of 107 leukemia patients diagnosed in childhood and adloescence, 8 presented with chronic myelogenous leukemia (CML). Seven of the 8 had chromosomal abnormalities. Six had the Ph1 chromosome; 5 had the usual 9;22 translocation. Two patients had involvement with chromosome 15; one had ...


    pub_type: 杂志文章


    authors: Hays T,Morse H,Peakman D,Rose B,Robinson A

    更新日期:1979-07-01 00:00:00

  • Sinusoidal hematolymphoid malignancy ("malignant histiocytosis") presenting as atypical sinusoidal proliferation. A study of nine cases.

    abstract::A number of cases of sinusoidal hematolymphoid malignancy ("malignant histiocytosis") in which early lymph node biopsies have not allowed clear separation from benign histiocytic disorders have been observed. Nine such cases in which only a follow-up lymph node biopsy documented their malignant nature are reported. Se...


    pub_type: 杂志文章


    authors: Weiss LM,Azzi R,Dorfman RF,Warnke RA

    更新日期:1986-10-15 00:00:00

  • Preoperative chemotherapy treatment of breast cancer--a review.

    abstract::Despite proven benefits of neoadjuvant chemotherapy in patients with locally advanced, invasive breast cancer, no regimen is recommended as the treatment of choice. Neoadjuvant chemotherapy regimens encompass single-agent and combination therapy and sequential treatment. For this report, the author reviewed the litera...


    pub_type: 杂志文章,评审


    authors: Buzdar AU

    更新日期:2007-12-01 00:00:00

  • Stereotactic radiosurgery for multiple brain metastases from breast carcinoma.

    abstract:BACKGROUND:The current study analyzed the feasibility and outcome of stereotactic radiosurgery (SRS) for treatment of brain metastases from breast carcinoma. METHODS:During an 8-year period, 151 patients with a combined total of 620 brain metastases from breast carcinoma underwent 197 outpatient SRS procedures. Sixty-...


    pub_type: 临床试验,杂志文章


    authors: Muacevic A,Kreth FW,Tonn JC,Wowra B

    更新日期:2004-04-15 00:00:00

  • Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study.

    abstract:BACKGROUND:Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In the current study, we described the prevalence of sedentary behaviors in survivors of ALL...


    pub_type: 杂志文章


    authors: Howell CR,Wilson CL,Ehrhardt MJ,Partin RE,Kaste SC,Lanctot JQ,Pui CH,Robison LL,Hudson MM,Ness KK

    更新日期:2018-03-01 00:00:00

  • Recurrence of early gastric cancer. Follow-up of 1475 patients and review of the Japanese literature.

    abstract:BACKGROUND:The outcome of surgical treatment for early gastric cancer (EGC) generally is considered to be satisfactory. Although a small percentage of patients experience disease recurrence, the absolute number of such instances is too small for assessment of risk factors. METHODS:The authors investigated the follow-u...


    pub_type: 杂志文章,评审


    authors: Sano T,Sasako M,Kinoshita T,Maruyama K

    更新日期:1993-12-01 00:00:00

  • Adjuvant 5-fluorouracil plus doxorubicin in D2-3 resected gastric carcinoma: 15-year experience at a single institute.

    abstract:BACKGROUND:The authors evaluated the efficacy of adjuvant chemotherapy with 5-fluorouracil (5-FU) plus doxorubicin in gastric carcinoma after D2-3 curative resection. They also evaluated the effect of dose-related factors (delivered total dose/m(2), actual dose intensity [ADI], relative dose intensity [RDI]) of this re...


    pub_type: 临床试验,杂志文章


    authors: Jeung HC,Rha SY,Noh SH,Min JS,Kim BS,Chung HC

    更新日期:2001-06-01 00:00:00

  • Radiotherapy or surgery for head and neck squamous cell cancer: establishing the baseline for hypopharyngeal carcinoma?

    abstract:BACKGROUND:The authors compared the survival outcomes of radiotherapy+/-salvage surgery to surgery+/-postoperative radiotherapy for patients with squamous cell cancer of the hypopharynx. There was no evidence beyond observational studies and no consensus on the which treatment is most effective for this patient group. ...


    pub_type: 杂志文章


    authors: Hall SF,Groome PA,Irish J,O'Sullivan B

    更新日期:2009-12-15 00:00:00

  • Everolimus in combination with octreotide long-acting repeatable in a first-line setting for patients with neuroendocrine tumors: an ITMO group study.

    abstract:BACKGROUND:Preclinical and clinical studies suggest synergistic activity between somatostatin analogues and mammalian target of rapamycin inhibitors. The activity and safety of everolimus was assessed in combination with octreotide long-acting repeatable (LAR) in patients with neuroendocrine tumors (NETs) of gastroente...


    pub_type: 杂志文章,多中心研究


    authors: Bajetta E,Catena L,Fazio N,Pusceddu S,Biondani P,Blanco G,Ricci S,Aieta M,Pucci F,Valente M,Bianco N,Mauri CM,Spada F

    更新日期:2014-08-15 00:00:00

  • Prolymphocytic leukemia: treatment with combination chemotherapy to include doxorubicin.

    abstract::Prolymphocytic leukemia (PL) is a clinically distinct leukemic disorder. Cytochemical and surface marker characteristics help to differentiate PL from other types of leukemia, including chronic lymphocytic leukemia (CLL). In contrast to patients with CLL, those with PL frequently require early therapeutic intervention...


    pub_type: 杂志文章


    authors: Taylor HG,Butler WM,Rhoads J,Karcher DS,Detrick-Hooks B

    更新日期:1982-04-15 00:00:00