Abstract:
:The survival of 78 patients with resected non-small cell lung cancer entered in prospective, randomized investigational trials is compared to that of a population-based group of control patients not included in such trials. The survival of trial patients is significantly better than that of controls (P less than 0.001). This survival advantage for trial participants is most apparent among late Stage I patients, and is observed after matching for known prognostic factors (i.e., primary tumor size, nodal status, tumor histology) and after adjusting in the analysis for age, sex, and the administration of radiation therapy. Several explanations for the improved outcome for trial patients are explored, including differences in preoperative evaluation, staging, surgical technique, placebo effects, and patient motivation. These results suggest the possibility that inclusion in these controlled cancer trials may have had an inherent advantage for all participants.
journal_name
Cancerjournal_title
Cancerauthors
Davis S,Wright PW,Schulman SF,Hill LD,Pinkham RD,Johnson LP,Jones TW,Kellogg HB Jr,Radke HM,Sikkema WWdoi
10.1002/1097-0142(19851001)56:7<1710::aid-cncr2820subject
Has Abstract,Author List Incompletepub_date
1985-10-01 00:00:00pages
1710-8issue
7eissn
0008-543Xissn
1097-0142journal_volume
56pub_type
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