Participants in prospective, randomized clinical trials for resected non-small cell lung cancer have improved survival compared with nonparticipants in such trials.

Abstract:

:The survival of 78 patients with resected non-small cell lung cancer entered in prospective, randomized investigational trials is compared to that of a population-based group of control patients not included in such trials. The survival of trial patients is significantly better than that of controls (P less than 0.001). This survival advantage for trial participants is most apparent among late Stage I patients, and is observed after matching for known prognostic factors (i.e., primary tumor size, nodal status, tumor histology) and after adjusting in the analysis for age, sex, and the administration of radiation therapy. Several explanations for the improved outcome for trial patients are explored, including differences in preoperative evaluation, staging, surgical technique, placebo effects, and patient motivation. These results suggest the possibility that inclusion in these controlled cancer trials may have had an inherent advantage for all participants.

journal_name

Cancer

journal_title

Cancer

authors

Davis S,Wright PW,Schulman SF,Hill LD,Pinkham RD,Johnson LP,Jones TW,Kellogg HB Jr,Radke HM,Sikkema WW

doi

10.1002/1097-0142(19851001)56:7<1710::aid-cncr2820

subject

Has Abstract,Author List Incomplete

pub_date

1985-10-01 00:00:00

pages

1710-8

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

56

pub_type

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