Abstract:
BACKGROUND:Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. Onycholysis may be precipitated by exposure to ultraviolet radiation. METHODS:The authors studied 91 patients who received paclitaxel and 187 patients who received doxorubicin. RESULTS:Onycholysis occurred in 5 of 21 patients who received > 6 courses of weekly paclitaxel, developing in the summer months in all 5 patients. It did not occur in patients who received fewer weekly paclitaxel courses or those who were treated every 3 weeks. Onycholysis did not occur in 187 patients who received doxorubicin. Review of the literature revealed that onycholysis is nearly exclusively associated with anthracycline and taxane therapy. CONCLUSIONS:Prolonged weekly paclitaxel, other taxanes, and anthracyclines cause onycholysis in some patients, which may be precipitated by exposure to sunlight. Patients receiving these drugs should protect their nails from sunlight.
journal_name
Cancerjournal_title
Cancerauthors
Hussain S,Anderson DN,Salvatti ME,Adamson B,McManus M,Braverman ASdoi
10.1002/(sici)1097-0142(20000515)88:10<2367::aid-csubject
Has Abstractpub_date
2000-05-15 00:00:00pages
2367-71issue
10eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(20000515)88:10<2367::AID-Cjournal_volume
88pub_type
杂志文章,评审相关文献
CANCER文献大全abstract::Tumor-bearing patients with breast cancer were assayed for their natural killer (NK) cell activity and for the function of activated cytotoxic T-cells, as assessed by lectin-dependent cellular cytotoxicity (LDCC). Tumor-bearing patients with breast cancer had a significant increase in NK activity and in LDCC, as compa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890515)63:10<1985::aid-cncr282
更新日期:1989-05-15 00:00:00
abstract::This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (> 3 fmol/mg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to hypophysectomy. E...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801215)46:12+<2838::aid-cncr28
更新日期:1980-12-15 00:00:00
abstract:BACKGROUND:Age-related disparities in colon cancer treatment exist, with older patients being less likely to receive recommended therapy. However, to the authors' knowledge, few studies to date have focused on receipt of surgery. The objective of the current study was to describe patterns of surgery in patients aged ≥ ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27765
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Endometrial cancer (EC) is the most common extraintestinal malignancy in Lynch syndrome (LS) and often is the sentinel malignancy, yet there is no consensus regarding LS-EC detection algorithms. In this study, the authors determined the efficacy of family/personal history and tumor morphology in predicting L...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26323
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The delivery of effective treatment for pediatric solid tumors poses a particular challenge to centers in middle-income countries (MICs) that already are vigorously addressing pediatric cancer. The objective of this study was to improve the current understanding of barriers to effective treatment of pediatri...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28339
更新日期:2014-01-01 00:00:00
abstract::Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891215)64:12<2515::aid-cncr282
更新日期:1989-12-15 00:00:00
abstract:BACKGROUND:Stomach cancer was a leading cause of cancer-related deaths early in the 20th century and has steadily declined over the last century in the United States. Although incidence and death rates are now low, stomach cancer remains an important cause of morbidity and mortality in black, Asian and Pacific Islander...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30881
更新日期:2017-12-15 00:00:00
abstract:BACKGROUND:Fortunately, primary malignant mucosal melanoma of the head and neck is a rare entity. A paucity of data elucidating the predictive factors as well as the unpredictable and aggressive biologic behavior of mucosal melanoma compound the vexing clinical situation. This review summarizes what the literature reve...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8<1373::aid-cn
更新日期:1997-10-15 00:00:00
abstract::Twenty-four patients who developed extramedullary disease during the course of Philadelphia chromosome-positive chronic myelogenous leukemia are described. The most frequent sites of extramedullary disease were lymph nodes (54%), bone (37%), and skin and soft tissue (29%). The appearance of extramedullary disease was ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870115)59:2<297::aid-cncr28205
更新日期:1987-01-15 00:00:00
abstract:BACKGROUND:Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 ha...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29499
更新日期:2015-09-15 00:00:00
abstract::Transforming growth factors (TGF) are polypeptides that stimulate anchorage-independent growth of various nontransformed cells in vitro. Transforming growth factors have been found in tumor extracts and in the urine of cancer patients. The specific questions of our study were whether TGF activity can be detected in ma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1832::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract::A bronchogenic tumor was removed from a 12-year-old girl. Histology showed a clear cell lesion with electron microscope features compatible with serous acinic cell origin. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197608)38:2<830::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract:BACKGROUND:Reports on lymphoid malignancy and its treatment in children infected with human immunodeficiency virus (HIV) are limited. METHODS:Antibodies to Epstein-Barr virus (EBV) were detected by indirect immunofluorescence. DNA was extracted from peripheral blood lymphocytes or biopsy specimens. Polymerase chain re...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940101)73:1<224::aid-cncr28207
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:: Patients with oral premalignant lesions (OPL) present with oral squamous cell carcinomas (OSCC) at a much higher rate than the general population. There are currently no useful markers that indicate specifically which OPLs are most likely to progress. Three small integrin binding ligands N-linked glycoprot...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24938
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Previous investigators have detected shifts to lower stages at diagnosis for renal cell carcinoma and prostate cancer. The authors investigated whether a similar pattern is seen for urothelial carcinomas of the bladder, ureter, and renal pelvis and sought to identify changes in cancer grade and survival tren...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24147
更新日期:2009-04-01 00:00:00
abstract::Amyloid as defined by positive Congo red green birefringence and STB red birefringence was observed in the stroma of a tubular carcinoma of minor salivary gland origin. The amyloid exhibited additional histochemical characteristics of immunamyloid, viz., positive DMAB-nitrate and DC-reactions and spontaneous autofluor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<1836::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:A multicenter trial was conducted to determine the efficacy and toxicity of escalating dosages of liposomal tretinoin (all-trans-retinoic acid) administered once or three times weekly in patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma. METHODS:Seventy-six patients with acqu...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.11009
更新日期:2002-12-15 00:00:00
abstract:BACKGROUND:Biological aging pathways accelerated by cancer treatments may be a mechanism for cognitive impairment in cancer survivors. The goal of the current study was to examine whether indicators of biological aging, namely elevated levels of DNA damage, reduced telomerase enzymatic activity, and shorter peripheral ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31777
更新日期:2019-01-15 00:00:00
abstract:BACKGROUND:Although Kaposi sarcoma (KS) initially was described over a century ago, its biology remains enigmatic and conflicting. Whereas the classic type occurs mainly in older men of Mediterranean or Eastern European backgrounds and is not linked to impairment of the host immune response, iatrogenic and human immuno...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Metastatic renal cell cancer is associated with poor long-term survival and has no cure. Traditional clinical endpoints are best supplemented by patient-reported outcomes designed to assess symptoms and function. Normative data was obtained on the National Comprehensive Cancer Network-Functional Assessment o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27688
更新日期:2013-01-15 00:00:00
abstract:BACKGROUND:Breast cancer advocacy movements, driven by advocate-led civil society organizations (CSOs), have proven to be a powerful force for the advancement of cancer control in high-income countries (HICs). However, although patient advocacy movements are growing in low-income and middle-income countries (LMICs) in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32852
更新日期:2020-05-15 00:00:00
abstract::This is a statistical analysis of the use of mammography in the symptomatic patient. Eighty-eight percent of women older than 50 years who had a palpable cancer of the breast had a positive mammogram; only 57% of women younger than 51 years of age had a positive mammogram. When the cancer presented as nipple discharge...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890401)63:7<1412::aid-cncr2820
更新日期:1989-04-01 00:00:00
abstract::Mixed cellularity Hodgkin's disease and diffuse non-Hodgkin's lymphoma, mixed cell type, occurred consecutively in a husband and wife. Both patients demonstrated monoclonal IgM gammopathies. The unusual nature and possible significance of these findings are discussed. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860115)57:2<277::aid-cncr28205
更新日期:1986-01-15 00:00:00
abstract:BACKGROUND:Adenocarcinomas of the appendix represent a heterogeneous disease depending on the presence of mucinous histology, histologic grade, and stage. In the current study, the authors sought to explore the interplay of these factors with systemic chemotherapy in a large population data set. METHODS:Patients in th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29744
更新日期:2016-01-15 00:00:00
abstract::The etiology of cancer resembles that of many other diseases in that multiple factors may be required. Because of this, the role or viruses in the etiology of human cancers is especially difficult to assess. When animal tumor systems were used as models, the roles of various predisposing characteristics in virus oncog...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197707)40:1+<419::aid-cncr282040
更新日期:1977-07-01 00:00:00
abstract::In the course of administration of an immunopotentiator, streptococcal agent OK-432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870415)59:8<1409::aid-cncr2820
更新日期:1987-04-15 00:00:00
abstract::In contrast with the expectations of the authors and with reports suggesting a decline in risk for scrotal cancer, Connecticut Tumor Registry data neither showed detectable decrease in risk over the 45-year-period for all 95 scrotal malignancies nor for the 71 epithelial cancers. The age distribution of scrotal cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840801)54:3<596::aid-cncr28205
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Stenotrophomonas maltophilia is responsible for an increasing number of infections, especially in hospitalized patients. Therapy options are limited and trimethoprim/sulfamethoxazole (TMP/SMX) is often the main treatment option for this infection. In the current study, the risk factors were determined for th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22705
更新日期:2007-06-15 00:00:00
abstract:BACKGROUND:The head and neck region is one of the most common locations of rhabdomyosarcoma. Salivary gland involvement is usually secondary to advanced disease, and presentation as a primary salivary gland tumor is very rare. METHODS:Three cases of rhabdomyosarcoma presenting as parotid masses, in 2 boys (ages 3 and ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-08-25 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) play a crucial role in carcinogenesis; however, it largely remains unclear whether miRNAs in gastric juice, which is specific for gastric tissues, can be used as biomarkers for gastric cancer. The objective of the current study was to investigate the feasibility of using gastric juice miRN...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27903
更新日期:2013-05-01 00:00:00