Onycholysis as a complication of systemic chemotherapy: report of five cases associated with prolonged weekly paclitaxel therapy and review of the literature.

Abstract:

BACKGROUND:Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. Onycholysis may be precipitated by exposure to ultraviolet radiation. METHODS:The authors studied 91 patients who received paclitaxel and 187 patients who received doxorubicin. RESULTS:Onycholysis occurred in 5 of 21 patients who received > 6 courses of weekly paclitaxel, developing in the summer months in all 5 patients. It did not occur in patients who received fewer weekly paclitaxel courses or those who were treated every 3 weeks. Onycholysis did not occur in 187 patients who received doxorubicin. Review of the literature revealed that onycholysis is nearly exclusively associated with anthracycline and taxane therapy. CONCLUSIONS:Prolonged weekly paclitaxel, other taxanes, and anthracyclines cause onycholysis in some patients, which may be precipitated by exposure to sunlight. Patients receiving these drugs should protect their nails from sunlight.

journal_name

Cancer

journal_title

Cancer

authors

Hussain S,Anderson DN,Salvatti ME,Adamson B,McManus M,Braverman AS

doi

10.1002/(sici)1097-0142(20000515)88:10<2367::aid-c

subject

Has Abstract

pub_date

2000-05-15 00:00:00

pages

2367-71

issue

10

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(20000515)88:10<2367::AID-C

journal_volume

88

pub_type

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