Abstract:
:In the course of administration of an immunopotentiator, streptococcal agent OK-432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel of washed Group O erythrocyte samples. The eluated antibody was composed of monoclonal IgG1-lambda. Upon discontinuing the drug the patient's hemoglobin level increased slowly with concomitant normalization of the reticulocyte count. Although very rare, drug-induced immune hemolytic anemia should be included in the list of adverse effects of immunopotentiators. This is the first reported case of immune hemolytic anemia associated with OK-432.
journal_name
Cancerjournal_title
Cancerauthors
Nomura S,Kanoh Tdoi
10.1002/1097-0142(19870415)59:8<1409::aid-cncr2820subject
Has Abstractpub_date
1987-04-15 00:00:00pages
1409-11issue
8eissn
0008-543Xissn
1097-0142journal_volume
59pub_type
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