Immune hemolytic anemia associated with streptococcal preparation OK-432.

Abstract:

:In the course of administration of an immunopotentiator, streptococcal agent OK-432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel of washed Group O erythrocyte samples. The eluated antibody was composed of monoclonal IgG1-lambda. Upon discontinuing the drug the patient's hemoglobin level increased slowly with concomitant normalization of the reticulocyte count. Although very rare, drug-induced immune hemolytic anemia should be included in the list of adverse effects of immunopotentiators. This is the first reported case of immune hemolytic anemia associated with OK-432.

journal_name

Cancer

journal_title

Cancer

authors

Nomura S,Kanoh T

doi

10.1002/1097-0142(19870415)59:8<1409::aid-cncr2820

subject

Has Abstract

pub_date

1987-04-15 00:00:00

pages

1409-11

issue

8

eissn

0008-543X

issn

1097-0142

journal_volume

59

pub_type

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