Abstract:
BACKGROUND:Patients with metachronous multiple colorectal carcinomas have been reported to have a higher frequency of a family history of colorectal carcinoma, associated colorectal adenomas, and extracolonic malignancies. These clinicopathologic factors also are considered to be related to the development of metachronous multiple colorectal carcinomas after surgery for colorectal carcinoma. In this article, the authors investigated whether genetic markers such as microsatellite instability (MSI) were helpful in predicting the development of metachronous multiple colorectal carcinomas. METHODS:Between 1990-1997, 312 colorectal carcinoma patients underwent yearly surveillance colonoscopy after surgery. Among these patients, there were 19 with nonfamilial colorectal carcinoma in whom metachronous multiple colorectal carcinomas were diagnosed during the yearly surveillance colonoscopy. A control group was comprised of 28 patients who did not demonstrate either synchronous or metachronous carcinomas over a period of > or =5 years. Six microsatellite markers (D2S123, D3S1029, D3S1611, TP53, Mfd26, and Mfd36) were used to determine MSI by polymerase chain reaction. RESULTS:The frequency of MSI positive cases was significantly higher in patients with sporadic metachronous multiple colorectal carcinomas than in those with a single carcinoma (17/19 [89%] vs. 4/28 [14%]; P<0.0001). In tumors occurring in the distal colon and rectum, the percentage of MSI positive carcinomas was significantly higher in the patients with metachronous multiple carcinomas than in those with a single carcinoma (13/15 [87%] vs. 0/19 [0%]; P<0.0001). No such difference was observed in the proximal colon. CONCLUSIONS:Based on the findings of the current study, the analysis of MSI in sporadic carcinomas of the distal colon and rectum may be helpful in predicting the development of metachronous multiple colorectal carcinomas.
journal_name
Cancerjournal_title
Cancerauthors
Masubuchi S,Konishi F,Togashi K,Okamoto T,Senba S,Shitoh K,Kashiwagi H,Kanazawa K,Tsukamoto Tsubject
Has Abstractpub_date
1999-05-01 00:00:00pages
1917-24issue
9eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19990501)85:9<1917::AID-CNjournal_volume
85pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling. These tumors most commonly occur in the stomach and small intestine and encompass a clinic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23216
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Forty-eight patients with resected Stages IIA and IIB melanoma were immunized with two tumor antigen epitope peptides derived from gp100(209-217) (210M) (IMDQVPSFV) and tyrosinase(368-376) (370D) (YMDGTMSQV) emulsified with incomplete Freund's adjuvant (IFA). Patients were assigned randomly to receive either...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.11045
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Studies of colorectal adenocarcinoma (CRC) indicate a higher mortality rate for African Americans compared with Caucasians in the United States. In the current study, the authors evaluated the racial differences in survival based on tumor location and pathologic stage between African-American patients and Ca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20337
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Treatment outcomes were analyzed for retromolar trigone squamous cell carcinoma. METHODS:Between June 1966 and August 2003, 99 patients were treated with radiotherapy alone (35 patients) or radiotherapy combined with surgery (64 patients). Followup ranged from 0.2 to 23.8 years (median, 3.3 yrs). All living...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21038
更新日期:2005-06-01 00:00:00
abstract::The present study was carried out to investigate a distinctive type of carcinoma of the uterine cervix categorized under the designation as circumscribed carcinoma with lymphocytic infiltration. Grossly this carcinoma is characterized by defined circumscription with a superficial ulceration. A microscropic feature cha...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197706)39:6<2503::aid-cncr282039
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:The authors established the genotype frequencies of cytochrome P450 (CYP1A1/MspI, CYP2E1/PstI, and CYP2E1/DraI), glutathione-S-transferase (GSTM1 and GSTT1), and p53 (exon 4/AcclI and intron 3/16-base pair duplication) gene polymorphisms in cervical carcinoma patients and controls and evaluated the associati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000501)88:9<2082::aid-cn
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Colorectal carcinoma (CRC) may be the most frequent form of hereditary cancer. Genetic counseling and testing for heritable CRC is a promising approach for reducing the high incidence and mortality rates associated with the disease. Patients with CRC or those with at least one family member with the disease ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010101)91:1<57::aid-cncr8>3.0.
更新日期:2001-01-01 00:00:00
abstract::A hybrid radiofrequency heating system previously reported to produce highly focused heating patterns at less than or equal to 10 cm depth in phantom models was utilized to selectively heat hypervascular, heat resistant rabbit V-2 tumors implanted in the left hindlimb. Spheroidal heating patterns 3 to 4 cm in diameter...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850315)55:6<1172::aid-cncr2820
更新日期:1985-03-15 00:00:00
abstract::A case of bronchial mucoepidermoid carcinoma is reported, the presentation of which was as cutaneous metastases. Histologic, histochemical, and ultrastructural features of the neoplasm are described, and the literature pertaining to bronchial mucoepidermoid carcinoma is reviewed. This case illustrates the potential fo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861201)58:11<2556::aid-cncr282
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Bisphosphonates currently are the most important class of antiresorptive agents used in the treatment of metabolic bone diseases, including tumor-associated osteolysis and hypercalcemia, Paget's disease, and osteoporosis. These compounds have high affinity for calcium and therefore target to bone mineral, wh...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20000615)88:12+<2961::aid-cncr12
更新日期:2000-06-15 00:00:00
abstract:BACKGROUND:Examination was performed on pathologic material from patients enrolled in the National Surgical Adjuvant Breast Project (NSABP) protocol B-18, in which the clinical effects of preoperative (preop) and postoperative (postop) doxorubicin and cyclophosphamide (AC) were compared. METHODS:Of the total number of...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.10741
更新日期:2002-08-15 00:00:00
abstract::Between 1957 and February 1981, 782 patients received cytotoxic chemotherapy for gestational trophoblastic tumors (GTT) in the Department of Medical Oncology, Charing Cross Hospital (London, England). Sixty-nine (8.8%) patients had central nervous system (CNS) metastases. Thirty-three of them (48%) presented with CNS ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:A study was undertaken to evaluate results of surgery and radiotherapy (RT) for high-risk extracranial chondrosarcomas. METHODS:Between 1986 and 2006, 60 patients underwent surgery and RT for extracranial high-risk chondrosarcoma. Preoperative RT (median, 50 gray [Gy]) and postoperative RT (median, 60 Gy) w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25806
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The authors examined the "real-world" effectiveness of rituximab (R) maintenance therapy (R-maintenance) compared with observation after R-based induction therapy in patients with previously untreated follicular lymphoma (FL) in the United States. METHODS:The National LymphoCare Study is a prospective, mult...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28659
更新日期:2014-06-15 00:00:00
abstract:BACKGROUND:Programmed death 1 (PD-1) signaling in the tumor microenvironment dampens immune responses to cancer, and blocking this axis induces antitumor effects in several malignancies. Clinical studies of PD-1 blockade are only now being initiated in pediatric patients, and little is known regarding programmed death-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30724
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. METHODS:After Institutio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22415
更新日期:2007-01-15 00:00:00
abstract:BACKGROUND:Since the introduction of the TNM residual tumor (R) classification, the involvement of resection margins has been defined either as a microscopic (R1) or a macroscopic (R2) demonstration of tumor directly at the resection margin ("tumor transected"). METHODS:The recognition of the importance of the circumf...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24320
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:A new clinical type of pancreatic tumor, the mucin-producing tumor, has been recognized recently. However, it is not always easy to distinguish benign from malignant tumors preoperatively. In this study, three different methods of differentiating mucin-producing tumors of the pancreas were compared. METHODS...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3<826::aid-cncr28207
更新日期:1994-08-01 00:00:00
abstract::Peripheral B- and T-lymphocyte counts were studied in 50 patients before they received any therapy for their conditions: 16 had carcinoma of the breast; 8 soft tissue sarcoma; and 26, benign disease. Among 11 males, the six patients with advanced soft tissue sarcoma had significantly lower percentages of T lymphocytes...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197708)40:2<667::aid-cncr2820400
更新日期:1977-08-01 00:00:00
abstract::Management of testis cancer in children differs from that in adults due to the histological types and varying tolerances to chemotherapy agents. Embryonal adrenocarcinoma (endodermal sinus tumor, Teilum's tumor) is a tumor of infancy and young children and less aggressive than other testis cancers. Most cases require ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.1980.45.s7.1803
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND AND METHODS:The antiemetic activity of ondansetron (Zofran, Glaxo Pharmaceuticals, Research Triangle Park, NC) was evaluated in 25 patients with recurrent melanoma who were treated sequentially with dacarbazine (DTIC), vinblastine, and cisplatin. The antiemetic regimen included ondansetron alone in 11 patien...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921001)70:7<2018::aid-cncr2820
更新日期:1992-10-01 00:00:00
abstract::Breast cancer tissue from 12 male patients was evaluated for the presence of estrogen receptors (ER), and at least 10 of 12 were found to be high in ER (ER+). A combination of previously published cases and our own experience indicates that 80% of patients (37/47) have ER+ tumors. This incidence of ER positivity in me...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810101)47:1<134::aid-cncr28204
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, the long term follow-up of patients with carcinoma in situ of the urinary bladder is limited. METHODS:The authors studied 138 patients diagnosed with urothelial carcinoma in situ of the bladder at the Mayo Clinic between 1972-1979. All the histologic slides were reviewed and fulfi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::In a cohort of 254,417 male Swedish farmers (4,330,717 person-years) the incidence of cancer of the respiratory organs was compared to a reference cohort of 1,725,845 men (30,131,664 person-years) employed in other economic activities than agriculture or forestry. In the study cohort 1450 cases of cancer in the respir...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880301)61:5<1055::aid-cncr2820
更新日期:1988-03-01 00:00:00
abstract::The European Organization for Research on Treatment of Cancer (EORTC) trial 20781, concerning osteosarcoma of the limbs is reported. After definitive treatment of the primary tumor with amputation or irradiation, adjuvant treatment was given, randomized into either 9 months of chemotherapy according to a modified Rose...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19880301)61:5<1024::aid-cncr2820
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Although flow cytometric DNA analysis has been recognized to be a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus, the biologic significance of DNA aneuploidy remains to be elucidated. METHODS:Twenty-five patients with squamous cell carcinoma of the esophagus who under...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:This study was undertaken to determine whether the use of intermediate dose methotrexate in combination with vinblastine, doxorubicin, and cisplatin as first-line therapy increases the proportion of major responders and overall survival in patients with unresectable or metastatic transitional cell carcinoma ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19990301)85:5<1145::aid-cn
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:The aims of this study were to compare human epidermal growth factor receptor 2 (HER2) results between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and to investigate the clinicopathological characteristics and outcomes according to their results. METHODS:Using consecutive tissu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26406
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:The presence of tumor cells in peritoneal washing cytology specimens taken during surgery affects the staging of many gynecologic malignancies. Peritoneal washings are often collected routinely, even in cases of presumed benign disease. This study was designed to address whether evaluation of these specimens...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19991025)87:5<259::aid-cnc
更新日期:1999-10-25 00:00:00
abstract:BACKGROUND:Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of solid organ transplantation. Histologic heterogeneity and a lack of treatment standards have made evaluating clinical outcomes in specific patient populations difficult. This systematic literature review investigated the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31339
更新日期:2018-06-01 00:00:00