EphA2 overexpression is associated with angiogenesis in ovarian cancer.


BACKGROUND:EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. METHODS:After Institutional Review Board (IRB) approval, 77 invasive epithelial ovarian tumors were analyzed for CD31, EphA2, MMP-2, MMP-9, and MT1-MMP expression. RESULTS:The median age of the patients was 59 years (range, 34-83). EphA2 was overexpressed in 76% of tumors and was associated with advanced-stage disease (P < .001) and high-grade histology (P = .04). MVD was stratified into high (>12.7 vessels/high-power field [HPF]) versus low (






Lin YG,Han LY,Kamat AA,Merritt WM,Landen CN,Deavers MT,Fletcher MS,Urbauer DL,Kinch MS,Sood AK




Has Abstract


2007-01-15 00:00:00














  • Functional insulin receptors are overexpressed in thyroid tumors: is this an early event in thyroid tumorigenesis?

    abstract:BACKGROUND:Insulin receptor (IR), a member of the receptor tyrosine kinase family, is expressed in normal thyroid cells and affects thyroid cell proliferation and differentiation. METHODS:The authors measured IR content in benign and malignant thyroid tumors by three independent methods: a specific radioimmunoassay, 1...


    pub_type: 杂志文章


    authors: Frittitta L,Sciacca L,Catalfamo R,Ippolito A,Gangemi P,Pezzino V,Filetti S,Vigneri R

    更新日期:1999-01-15 00:00:00

  • Chemoimmunotherapy of metastatic large bowel cancer: nonspecific stimulation with BCG and levamisole.

    abstract::The administration of two chemoimmunotherapy programs to 103 consecutive patients with metastatic colorectal cancer resulted in improved survival for patients who achieved either objective tumor regressions or disease stabilization for more than 8 weeks. Objective tumor regression was observed in 47% of patients treat...


    pub_type: 杂志文章


    authors: Valdivieso M,Bedikian A,Burgess MA,Rodriguez V,Hersh EM,Bodey GP,Mavligit GM

    更新日期:1977-11-01 00:00:00

  • Assessing the impact of patient navigation: prevention and early detection metrics.

    abstract:BACKGROUND:The lack of comparable metrics to evaluate prevention and early detection patient navigation programs impeded the ability to identify best practices. METHODS:The Prevention and Early Detection Workgroup of the Patient Navigation Leadership Summit was charged with making recommendations for common clinical m...


    pub_type: 杂志文章,评审


    authors: Battaglia TA,Burhansstipanov L,Murrell SS,Dwyer AJ,Caron SE,Prevention and Early Detection Workgroup, National Patient Navigation Leadership Summit.

    更新日期:2011-08-01 00:00:00

  • Primary chemotherapy for obstructive jaundice caused by intermediate-grade non-Hodgkin lymphoma.

    abstract:BACKGROUND:Advanced non-Hodgkin lymphoma (NHL) usually is treated with doxorubicin-based combination chemotherapy. Because doxorubicin is excreted by the biliary route, many authorities recommend alternative initial interventions in patients with NHL causing obstructive jaundice. METHODS:The authors retrospectively re...


    pub_type: 杂志文章


    authors: Dudgeon DJ,Brower M

    更新日期:1993-05-01 00:00:00

  • Developing epidemic of melanoma in the Hispanic population of California.

    abstract:BACKGROUND:Hispanics comprise almost one-third of the population of California, are the most rapidly increasing racial/ethnic group in the state, and represent almost one-third of all Hispanics in the U.S. California has among the highest rates of melanoma in the world, yet little is known about trends in melanoma in i...


    pub_type: 杂志文章


    authors: Cockburn MG,Zadnick J,Deapen D

    更新日期:2006-03-01 00:00:00

  • Adenocarcinoid tumor of the colon arising in preexisting ulcerative colitis.

    abstract::Patients with ulcerative colitis are at increased risk of developing adenocarcinoma of the colon. The authors describe a patient whose colonic neoplasm demonstrated histologic characteristics of both an adenocarcinoma and a carcinoid tumor and which was pathologically identical to a appendiceal adenocarcinoid. Because...


    pub_type: 杂志文章


    authors: Lyss AP,Thompson JJ,Glick JH

    更新日期:1981-08-01 00:00:00

  • Models in cytostatic chemotherapy.

    abstract::Models play a fundamental role in all sciences. Scientific theories can be understood as "intellectual models" of the relations and interrelations between the elements of the science. Such relational models consider the scientific topics as "systems," and may therefore be called "system models." The basic elements of ...


    pub_type: 杂志文章


    authors: Brock N,Schneider B

    更新日期:1984-09-15 00:00:00

  • Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy.

    abstract::Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologic...


    pub_type: 杂志文章


    authors: Hisa S,Morinaga S,Kobayashi Y,Ojima M,Chikaoka H,Sasano N

    更新日期:1985-06-15 00:00:00

  • Bronchogenic carcinoma and secondary aspergillosis--common yet unexplored: evaluation of the role of bronchoalveolar lavage-polymerase chain reaction and some nonvalidated serologic methods to establish early diagnosis.

    abstract:BACKGROUND:More cases of bronchogenic carcinoma have been reported in recent years, and these patients are more prone to secondary aspergillosis. However, the frequency of secondary aspergillosis in bronchogenic carcinoma still has not been defined clearly in the literature. METHODS:The current study population was co...


    pub_type: 杂志文章


    authors: Shahid M,Malik A,Bhargava R

    更新日期:2008-08-01 00:00:00

  • Pleuropulmonary blastoma. The so-called pulmonary blastoma of childhood.

    abstract::The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells with blastematous qualities separ...


    pub_type: 杂志文章,评审


    authors: Manivel JC,Priest JR,Watterson J,Steiner M,Woods WG,Wick MR,Dehner LP

    更新日期:1988-10-15 00:00:00

  • Synovial sarcoma of the neck: a followup study of 24 cases.

    abstract::This article reviews the clinicopathologic features and the biological behavior of 24 cases of synovial sarcoma that took origin from the cervical prevertebral connective tissue space and manifested as a retropharyngeal tumor or as a palpable mass in the anterior or posterior cervical triangle. The age of the 24 patie...


    pub_type: 杂志文章


    authors: Roth JA,Enzinger FM,Tannenbaum M

    更新日期:1975-04-01 00:00:00

  • Lack of frameshift mutations at coding mononucleotide repeats in hepatocellular carcinoma in Japanese patients.

    abstract:BACKGROUND:Microsatellite instability occurs frequently in hereditary nonpolyposis colorectal carcinoma, in sporadic gastrointestinal carcinoma, and in other tumors. In these tumors, slippage-related frameshift mutations have been detected at coding mononucleotide repeats in genes such as those for transforming growth ...


    pub_type: 杂志文章


    authors: Saeki A,Tamura S,Ito N,Kiso S,Matsuda Y,Yabuuchi I,Kawata S,Matsuzawa Y

    更新日期:2000-03-01 00:00:00

  • Pathologic stage III endometrial carcinoma. Prognostic factors and patterns of recurrence.

    abstract:BACKGROUND:This review was done to assess the outcomes and patterns of recurrence in a group of patients with Stage III endometrial carcinoma that might help guide adjuvant therapy. METHODS:A retrospective review was performed of 105 patients treated from 1970-1990 at three institutions. All patients underwent abdomin...


    pub_type: 杂志文章


    authors: Greven KM,Lanciano RM,Corn B,Case D,Randall ME

    更新日期:1993-06-01 00:00:00

  • Immune thrombocytopenic purpura and intravenous immunoglobulin.

    abstract::The observation, in 1980, of a rapid increase in platelet counts as a result of administration of intravenous immunoglobulin (IVIG) in a patient with immune thrombocytopenic purpura (ITP) was followed by clinical studies confirming the efficacy of this new treatment alternative in ITP. Simultaneously, new sensitive as...


    pub_type: 杂志文章,评审


    authors: Imbach P

    更新日期:1991-09-15 00:00:00

  • Stage III nodular lymphoreticular tumors (non-Hodgkin's lymphoma): results of central lymphatic irradiation.

    abstract::Since 1969, 29 previously untreated patients with Stage III nodular malignant lymphoreticular (MLT) have received total central lymphatic (TCL) irradiation. The volume irradiated included the entire abdomen, Waldeyer's ring, and preauricular nodes in addition to the usual regions encompassed by total nodal irradiation...


    pub_type: 杂志文章


    authors: Cox JD,Komaki R,Kun LE,Wilson JF,Greenberg M

    更新日期:1981-05-01 00:00:00

  • Restaging surgery for women with borderline ovarian tumors: results of a French multicenter study.

    abstract:BACKGROUND:The purpose of the current study was to examine the surgical management of women with borderline ovarian tumors and the adequacy of initial staging according to the guidelines of the International Federation of Gynecology and Obstetrics; to evaluate the impact of restaging operations; and to identify risk fa...


    pub_type: 杂志文章,多中心研究


    authors: Fauvet R,Boccara J,Dufournet C,David-Montefiore E,Poncelet C,Daraï E

    更新日期:2004-03-15 00:00:00

  • Intraoperative radiotherapy for intracranial malignancies. A pilot study.

    abstract::Intraoperative radiotherapy (IOR) or "direct view" irradiation permits the delivery of a single exposure of high-energy electrons to a surgically exposed tumor. Surgical exposure permits physical retraction of normal uninvolved tissues away from the IOR beam as well as the accurate assessment of the target volume. IOR...


    pub_type: 杂志文章


    authors: Goldson AL,Streeter OE Jr,Ashayeri E,Collier-Manning J,Barber JB,Fan KJ

    更新日期:1984-12-01 00:00:00

  • Racial disparities in recurrence among patients with early-stage endometrial cancer: is recurrence increased in black patients who receive estrogen replacement therapy?

    abstract:BACKGROUND:Population-based studies suggest that, because of inequalities in treatment, black women with localized endometrial cancer have shorter survival compared with white women. The objective of the current investigation was to determine whether there is a racial disparity in outcome between black patients and whi...


    pub_type: 杂志文章


    authors: Maxwell GL,Tian C,Risinger JI,Hamilton CA,Barakat RR,Gynecologic Oncology Group Study.

    更新日期:2008-09-15 00:00:00

  • Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.

    abstract:BACKGROUND:The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule. METHODS:The authors randomly assigned 215 men who h...


    pub_type: 杂志文章,随机对照试验


    authors: Viani GA,Viana BS,Martin JE,Rossi BT,Zuliani G,Stefano EJ

    更新日期:2016-07-01 00:00:00

  • The quantitative Gleason score improves prostate cancer risk assessment.

    abstract:BACKGROUND:In the current study, the authors propose the quantitative Gleason score (qGS), a modification of the current Gleason grading system for prostate cancer, based on the weighted average of Gleason patterns present in the pathology specimen. They hypothesize that the qGS can improve prostate cancer risk stratif...


    pub_type: 杂志文章


    authors: Reese AC,Cowan JE,Brajtbord JS,Harris CR,Carroll PR,Cooperberg MR

    更新日期:2012-12-15 00:00:00

  • Wilms' tumor: prognostic factors for patients without metastases at diagnosis: results of the National Wilms' Tumor Study.

    abstract::Multivariate statistical analyses are used to evaluate a wide range of factors in predicting relapse and survival for 429 children enrolled in the National Wilms' Tumor Study. Anaplastic or sarcomatous histology, specimen weight over 250 grams, positive regional lymph nodes, treatment with only a single drug and age o...


    pub_type: 杂志文章


    authors: Breslow NE,Palmer NF,Hill LR,Buring J,D'Angio GJ

    更新日期:1978-04-01 00:00:00

  • Prognostic impact of discordant results from cytogenetics and flow cytometry in patients with acute myeloid leukemia undergoing hematopoietic cell transplantation.

    abstract:BACKGROUND:Cytogenetics and multicolor flow cytometry (MFC) are useful tools for monitoring outcome of treatment in acute myeloid leukemia (AML). However, no data are available regarding the meaning of results when the 2 tests do not agree. METHODS:The authors of this report analyzed 1464 pairs of concurrent cytogenet...


    pub_type: 杂志文章


    authors: Fang M,Storer B,Wood B,Gyurkocza B,Sandmaier BM,Appelbaum FR

    更新日期:2012-05-01 00:00:00

  • Concomitant conjugal gliomas with similar histologic features.

    abstract::Conjugal tumors are rarely reported; but nevertheless, raise important questions of possible etiologic factors. In this report, the presentation of grade 2 gemistocytic astrocytomas in an unrelated married couple in their early thirties within 18 months of each other is described. In both cases the left frontal region...


    pub_type: 杂志文章


    authors: Tupchong L,Levison DA,Jones AE

    更新日期:1985-02-15 00:00:00

  • Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial.

    abstract::To assess the efficacy and safety of Adriamycin (Adria Laboratories, Columbus, OH) in inoperable hepatocellular carcinoma (HCC), 60 patients were randomized to receive Adriamycin 60 to 75 mg/m2 at 3-week intervals and 46 patients to receive no antitumor therapy. The median survival rate of the Adriamycin group was 10....


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lai CL,Wu PC,Chan GC,Lok AS,Lin HJ

    更新日期:1988-08-01 00:00:00

  • Radiofrequency field-induced thermal cytotoxicity in cancer cells treated with fluorescent nanoparticles.

    abstract:BACKGROUND:Nonionizing radiation, such as radiofrequency field and near infrared laser, induces thermal cytotoxicity in cancer cells treated with gold nanoparticles. Quantum dots are fluorescent semiconducting nanoparticles that were hypothesized to induce similar injury after radiofrequency field irradiation. METHODS...


    pub_type: 杂志文章


    authors: Glazer ES,Curley SA

    更新日期:2010-07-01 00:00:00

  • Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas.

    abstract:BACKGROUND:Previous studies have shown that low levels of p27(Kip1), an inhibitor of G1 cyclin-dependent kinases, are associated with high aggressiveness and poor prognosis in a variety of cancers. Decreased levels of p27 are caused, at least in part, by acceleration of the rate of its ubiquitin-mediated degradation. I...


    pub_type: 杂志文章


    authors: Hershko D,Bornstein G,Ben-Izhak O,Carrano A,Pagano M,Krausz MM,Hershko A

    更新日期:2001-05-01 00:00:00

  • Combined chemotherapy and surgery in breast cancer: a review.

    abstract::The current results of trials testing combined surgery and chemotherapy in patients with breast cancer is reviewed. Information concerning eight trials utilizing nine single-agent regimens was obtained. The results at this time are conflicting. There appear to be differences among the regimens utilized in the various ...


    pub_type: 杂志文章,评审


    authors: Tormey DC

    更新日期:1975-09-01 00:00:00

  • Consideration of comorbidity in risk stratification prior to prostate biopsy.

    abstract:BACKGROUND:Previously, the patient-reported Total Illness Burden Index for Prostate Cancer (TIBI-CaP) questionnaire and/or the physician-reported Charlson Comorbidity Index (CCI) have provided assessments of competing comorbidity during treatment decisions for patients with prostate cancer. In the current study, the au...


    pub_type: 杂志文章


    authors: Liss MA,Billimek J,Osann K,Cho J,Moskowitz R,Kaplan A,Szabo RJ,Kaplan SH,Greenfield S,Dash A

    更新日期:2013-07-01 00:00:00

  • Radiographic evaluation of metastatic melanoma.

    abstract::Malignant melanoma can potentially involve any organ system in the body once it metastasizes beyond the regional lymph nodes. A survey of the radiographic and associated clinical manifestations of metastatic melanoma is presented. The findings from 74 autopsies of patients who died of metastatic melanoma are included....


    pub_type: 杂志文章


    authors: Meyer JE

    更新日期:1978-07-01 00:00:00

  • Resting and activity energy expenditure during total parenteral nutrition in rats with methylcholanthrene-induced sarcoma.

    abstract::Tumor weight, carcass weight, nitrogen balance, energy balance, resting energy expenditure (REE), and activity energy expenditure (AEE) were measured in normal Fischer 344 rats, free-feeding Fischer 344 rats with methylcholanthrene-induced sarcoma (TB-FF), and similar tumor-bearing rats supported with total parenteral...


    pub_type: 杂志文章


    authors: Popp MB,Brennan MF,Morrison SD

    更新日期:1982-03-15 00:00:00