Abstract:
:The effectiveness of combined modality therapy was studied in 29 patients with metastatic extradural spinal tumor who had had a previous diagnosis of malignancy. Dexamethasone was begun upon suspicion of the diagnosis in a dose of 40 mg daily. Following emergency myelography, in all patients without rapid progression, dexamethasone in combination with radiotherapy and chemotherapy, when appropriate, was instituted. If deterioration occurred, decompressive laminectomy was performed. Five ambulatory patients had neurological function preserved and the condition of seven nonambulatory patients was improved to ambulation at discharge with a combination of dexamethasone, radiation therapy, and chemotherapy. These were patients with prostatic carcinoma, Hodgkin's disease, or breast carcinoma. In five patients who failed medical therapy decompressive laminectomy was successful. In patients with metastatic bronchogenic carcinoma, nonsurgical therapy failed and all underwent surgical decompression with a favorable outcome in only two of 10 patients.
journal_name
Cancerjournal_title
Cancerauthors
Marshall LF,Langfitt TWdoi
10.1002/1097-0142(197711)40:5<2067::aid-cncr282040subject
Has Abstractpub_date
1977-11-01 00:00:00pages
2067-70issue
5eissn
0008-543Xissn
1097-0142journal_volume
40pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Breast cancers that are negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) (triple negative [TN]) have been associated with high-grade histology, aggressive clinical behavior, and poor survival. It has been determined that breast cancers that ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23243
更新日期:2008-02-15 00:00:00
abstract:BACKGROUND:Inferior vena cava obstruction (IVCO) is a poorly characterized complication of metastatic germ cell tumor (GCT). The authors identified 31 cases to describe the clinical features, radiologic findings, complications, and treatment of this clinical entity. METHODS:Patients with GCT and IVCO were identified f...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-02-15 00:00:00
abstract::A summary is presented of those organ specific enzyme assays traditionally used in evaluation of the patient with cancer. In addition, the use of certain serum enzymes such as gamma-glutamyl transpeptidase, phosphohexose isomerase or 5'-nucleotidase as aids in following the course of the disease, particularly in patie...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197601)37:1+<542::aid-cncr282037
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:The Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low radiation dose computed tomography (low-dose CT) in persons at high-risk for lung cancer. The authors report on the baseline screening experience. For full evaluation of screening, they await the ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20001201)89:11+<2474::aid-cncr26
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Because of the small number of cases (five) reported between 1929 and 1969 and a significant increase reported in the decade of the 1970s, the Familial Ovarian Cancer Registry was established in 1981 to study the occurrence of familial ovarian cancer in the United States. METHODS:Any woman (with or without ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820710214
更新日期:1993-01-15 00:00:00
abstract::Research trends on quality of life outcomes for cancer survivors are discussed. Epidemiologic data indicate that female cancer survivors, coming primarily from patient groups with gynecologic, breast, and colorectal cancers, will outnumber male survivors 3 to 1. Male survivors will come from the ranks of patient group...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19940815)74:4+<1484::aid-cncr282
更新日期:1994-08-15 00:00:00
abstract::The hematologic factors of 16 female patients with breast carcinoma who had received adjuvant chemotherapy with L-phenylalanine-based programs for two years were compared with those for 13 normal female volunteers of similar age. The findings include significant suppression of the mean hemoglobin level, of leukocyte c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820615)49:12<2455::aid-cncr282
更新日期:1982-06-15 00:00:00
abstract::Since single drug therapy of chronic lymphocytic leukemia (CLL) has not resulted in prolonged remissions of advanced disease, we initiated a program of combination chemotherapy, COP (cycloposphamide, vincristine sulfate, prednisone) for CLL patients with increasing adenopathy, spenomegaly, and/or signs of marrow failu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<1664::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract::The c-Met/hepatocyte growth factor receptor and its family members are known to promote cancer cell migration and invasion. Signaling within and beyond this pathway contributes to the systemic spread of metastases through induction of the epithelial-mesenchymal transition, a process also implicated in mediating resist...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.27965
更新日期:2013-05-15 00:00:00
abstract:BACKGROUND:Lesions that contain abundant myoepithelial cells may present as a diagnostic challenge in fine-needle aspiration (FNA) specimens. Potential diagnostic problems may arise due to morphologic heterogeneity of myoepithelial cell-rich lesions and difficulty in predicting malignancy in FNA specimens. An accurate ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20642
更新日期:2004-12-25 00:00:00
abstract::Activity of Poly (C) avid ribonuclease was estimated in sera of 129 patients with different malignancies. All patients had histologically verified carcinomas, normal renal function, and no signs of acute catabolic condition. Activity values were compared with those of normal subjects (U-test, Mann and Whitney) separat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840501)53:9<1927::aid-cncr2820
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Although several refinements have been reported for breast magnetic resonance imaging (MRI), there has been no uniform agreement by researchers on the optimal method. The authors report a simple and effective MRI method that incorporated the best qualities of other breast MRI methods yet eliminated the compl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010801)92:3<471::aid-cncr1345>
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:The overexpression of HER-2 occurs in a minority of patients with nonsmall cell lung carcinoma. Trastuzumab, which is a monoclonal antibody to HER-2, is an effective treatment in some women with breast carcinomas that overexpress HER-2, as demonstrated by immunohistochemistry. The objective of this Phase II ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.20950
更新日期:2005-04-15 00:00:00
abstract:BACKGROUND:Laryngeal cancer is the primary cause of death among patients with head and neck cancer in Argentina. Different prognostic factors have been incidentally dealt with in a number of articles, but there are few studies of prognostic variables, such as age, tobacco, and alcohol, using multifactorial analysis. M...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930415)71:8<2472::aid-cncr2820
更新日期:1993-04-15 00:00:00
abstract::To investigate the possible role of sex-hormone imbalance in hepatocellular carcinogenesis in male alcoholic cirrhotic patients, we determined plasma levels of testosterone (T), dihydrotestosterone (DHT), androstenedione (A), dehydroepiandrosterone (DHA), estrone (E1), estradiol (E2), and sex-hormone-binding globulin ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880815)62:4<760::aid-cncr28206
更新日期:1988-08-15 00:00:00
abstract::The natural history of the development of neoplasia in experimental systems may be separated into at least three different stages, those of initiation, promotion and progression. Evidence for such distinct stages has been demonstrated in at least half a dozen different experimental systems. The stage of promotion is t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820315)49:6<1206::aid-cncr2820
更新日期:1982-03-15 00:00:00
abstract::The records of 314 children with acute lymphocytic leukemia (ALL) were reviewed to determine the frequency, clinical and laboratory features; contributing factors; and prognosis of cyclophosphamide-induced hemorrhagic cystitis. Twenty-five well-documented cases of hemorrhagic cystitis were identified. While most of th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197511)36:5<1572::aid-cncr282036
更新日期:1975-11-01 00:00:00
abstract:BACKGROUND:Lung carcinoma usually is advanced at the time of presentation and frequently shows metastatic spread. In recent times, prognostic factors such as c-erbB-2 in patients with breast carcinoma have provided useful information and beneficial therapeutic targets. The objective of this study was to evaluate angiog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011115)92:10<2648::aid-cncr161
更新日期:2001-11-15 00:00:00
abstract::Survival of patients with chronic myeloid leukemia seen in the University of Colorado Leukemia Clinic were reviewed with respect to therapy. A total of 55 patients seen consecutively through mid 1980 were included in this study. Of these patients 30 were treated with busulfan, 14 were treated with hydroxyurea and 11 r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821101)50:9<1683::aid-cncr2820
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:The prognostic relevance of activated oncogenes and oncoproteins has not been well studied in papillary thyroid cancer, which is slow-growing, with only regional spread in most cases. Therefore, the influence of some protein markers and tumor cell proliferation on disease progress in a series of patients wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951101)76:9<1643::aid-cncr2820
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Sunitinib has replaced interferon (IFN) as a first-line standard of care in the treatment of metastatic renal cell carcinoma (RCC). This study aimed to determine overall survival and to confirm effectiveness in a population that includes poor prognosis patients. METHODS:Data were collected on all patients i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24051
更新日期:2009-02-15 00:00:00
abstract::This overview highlights the use of experimental models in selecting monoclonal antibodies and radiolabels with promise for clinical radioimmunotherapy, discusses some of the experimental therapeutic approaches being studies in these models, and reviews some of the limitations of animal models caused by the allometric...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19940201)73:3+<989::aid-cncr2820
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:The psychological adaptation to a cancer diagnosis is characterized by significant distress. Although distress levels in cancer patients have been reported to be the highest shortly after diagnosis and before treatment, few attempts have been made to study emotional adjustment during the diagnostic period of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10564
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a bro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25826
更新日期:2011-05-15 00:00:00
abstract::Low-dose continuous infusion 5-fluorouracil (LDCI-FU) was administered to 28 women with advanced breast carcinoma. Daily doses ranged from 175 to 250 mg/m2. The LDCI-FU was delivered continuously until the appearance of toxicity and was reinstituted at a 20% dose reduction after toxicity completely resolved. Patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890201)63:3<419::aid-cncr28206
更新日期:1989-02-01 00:00:00
abstract::Two siblings succumbed to glioblastoma multiforme, associated with hepatic focal nodular hyperplasia and cafe-au-lait spots. One sibling had syndactyly and multiple colonic polyps, while the other had an angiomatous malformation in the brain. Their mother died of myasthenia gravis. The findings suggest a hamartomatous...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<310::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract::Monozygotic twins developed gastric cancers that were found almost simultaneously. A 47-year-old man complained of nausea and vomiting; an upper gastrointestinal series and endoscopy revealed advanced gastric cancer invading the serosa. Palliative subtotal gastrectomy was performed. In his asymptomatic twin a gastric ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19881201)62:11<2430::aid-cncr282
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:The relationships between psychological and behavioral variables and patient outcomes after hematopoietic stem cell transplantation (HSCT) are not known definitively but have great potential importance, since this lifesaving procedure is used increasingly to treat a variety of malignancies. The objective of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20431
更新日期:2004-08-15 00:00:00
abstract::A series of 27 typical Krukenberg tumors of the ovary were analyzed. By definition, all examples were characterized by the presence of mucinous signet-ring carcinoma cells within a cellular, nonneoplastic ovarian stroma. The patients' ages ranged from 20-70 years; almost one-half were 40 years of age or younger. A pri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821201)50:11<2438::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract::A case of carcinoid tumor of the gallbladder associated with adenocarcinoma in a 56-year-old man is reported and a review of the literature is made. The tumor was a polypoid mass with a size of 5.5 X 4.0 X 2.8 cm. Histologically, the tumor showed carcinoid and adenocarcinoma with areas of mucous change. Tumor cells co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830515)51:10<1911::aid-cncr282
更新日期:1983-05-15 00:00:00