Electron microscopy in the diagnosis of malignant schwannoma.

Abstract:

:Fifteen malignant schwannomas were examined by light and electron microscopy. Five tumors arose in patients with neurofibromatosis and five were contiguous with a peripheral nerve (Group I). Five tumors met neither of these generally accepted diagnostic criteria but were light microscopically seen as compatible with malignant schwannoma when examined under light microscope (Group II). In the better differentiated areas of Group I lesions, long, overlapping, tightly packed cytoplasmic processes were parallel to homogeneous flocculent material, occasionally assuming a linear appearance suggesting basal lamina. In Group II, similar cytoplasmic processes were present but the extracellular material was less extensive and had a less obvious relationship to the plasma membrane. In neither group were fine intracytoplasmic filaments prominent. Malignant schwann cells are seldom as ultrastructurally differentiated as their benign counterparts. Nevertheless, within the context of well-studied light microscopy and the sampling error inherent in ultrastructural examination, electron microscopy can support the diagnosis of malignant schwannoma.

journal_name

Cancer

journal_title

Cancer

authors

Taxy JB,Battifora H,Trujillo Y,Dorfman HD

doi

10.1002/1097-0142(19810915)48:6<1381::aid-cncr2820

subject

Has Abstract

pub_date

1981-09-15 00:00:00

pages

1381-91

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

48

pub_type

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