Abstract:
:Fifteen malignant schwannomas were examined by light and electron microscopy. Five tumors arose in patients with neurofibromatosis and five were contiguous with a peripheral nerve (Group I). Five tumors met neither of these generally accepted diagnostic criteria but were light microscopically seen as compatible with malignant schwannoma when examined under light microscope (Group II). In the better differentiated areas of Group I lesions, long, overlapping, tightly packed cytoplasmic processes were parallel to homogeneous flocculent material, occasionally assuming a linear appearance suggesting basal lamina. In Group II, similar cytoplasmic processes were present but the extracellular material was less extensive and had a less obvious relationship to the plasma membrane. In neither group were fine intracytoplasmic filaments prominent. Malignant schwann cells are seldom as ultrastructurally differentiated as their benign counterparts. Nevertheless, within the context of well-studied light microscopy and the sampling error inherent in ultrastructural examination, electron microscopy can support the diagnosis of malignant schwannoma.
journal_name
Cancerjournal_title
Cancerauthors
Taxy JB,Battifora H,Trujillo Y,Dorfman HDdoi
10.1002/1097-0142(19810915)48:6<1381::aid-cncr2820subject
Has Abstractpub_date
1981-09-15 00:00:00pages
1381-91issue
6eissn
0008-543Xissn
1097-0142journal_volume
48pub_type
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