A clinical and pathological staging system for soft tissue sarcomas.

abstract：BACKGROUND:Patients with metastatic melanoma (MM) have very few therapy options. Based on reports of responses to paclitaxel and carboplatin (PC), 31 patients with MM were treated with PC. METHODS:Data regarding patients treated with PC were abstracted from medical records. Clinical outcomes as determined by the treat...

journal_title：Cancer

authors： Rao RD,Holtan SG,Ingle JN,Croghan GA,Kottschade LA,Creagan ET,Kaur JS,Pitot HC,Markovic SN

更新日期：2006-01-15 00:00:00

abstract：BACKGROUND:Human papillomaviruses (HPVs) commonly cause proliferative lesions of squamous epithelia, and infection with certain HPV types carries a high risk of malignant transformation, especially in the uterine cervix but also at other sites, including the esophagus. We used molecular techniques to detect and type HP...

journal_title：Cancer

authors： West AB,Soloway GN,Lizarraga G,Tyrrell L,Longley JB

更新日期：1996-06-15 00:00:00

abstract：BACKGROUND:Because of the small number of cases (five) reported between 1929 and 1969 and a significant increase reported in the decade of the 1970s, the Familial Ovarian Cancer Registry was established in 1981 to study the occurrence of familial ovarian cancer in the United States. METHODS:Any woman (with or without ...

journal_title：Cancer

authors： Piver MS,Baker TR,Jishi MF,Sandecki AM,Tsukada Y,Natarajan N,Mettlin CJ,Blake CA

更新日期：1993-01-15 00:00:00

abstract：BACKGROUND:We previously reported that a single prostate-specific antigen (PSA) measured at ages 44-50 was highly predictive of subsequent prostate cancer diagnosis in an unscreened population. Here we report an additional 7 years of follow-up. This provides replication using an independent data set and allows estimate...

journal_title：Cancer

authors： Lilja H,Cronin AM,Dahlin A,Manjer J,Nilsson PM,Eastham JA,Bjartell AS,Scardino PT,Ulmert D,Vickers AJ

更新日期：2011-03-15 00:00:00

abstract：:Blood was obtained on 36 occasions from 12 healthy adult volunteers and the polymorphonuclear leukocytes (PMNL) were separated. PMNL hexose monophosphate shunt activity of whole blood and ability of separated cells to phagocytize and kill E. coli were evaluated when the PMNL were incubated with normal pooled sera and ...

journal_title：Cancer

authors： Pickering LK,Ericsson CD,Kohl S

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Although almost half of all incidents of breast carcinoma occur in women age > or = 65 years, not enough is known about appropriate care for patients in this age group. The objective of the current study was to evaluate the role of breast conservation therapy in the management of breast carcinoma in women ag...

journal_title：Cancer

authors： Vlastos G,Mirza NQ,Meric F,Hunt KK,Kuerer HM,Ames FC,Ross MI,Buchholz TA,Hortobagyi GN,Singletary SE

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous cell carcinomas of gynecologic origin is largely unknown. METHO...

journal_title：Cancer

authors： Tait DL,MacDonald PC,Casey ML

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Aberrant methylation is a known cause of cancer initiation and/or progression. There are scant data on the genome-wide methylation pattern of nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and sporadic and hereditary NFPanNETs. METHODS:Thirty-three tissue samples were analyzed: they included sa...

journal_title：Cancer

authors： Tirosh A,Mukherjee S,Lack J,Gara SK,Wang S,Quezado MM,Keutgen XM,Wu X,Cam M,Kumar S,Patel D,Nilubol N,Tyagi MV,Kebebew E

更新日期：2019-04-15 00:00:00

abstract：:Correlations of c-erbB-2 protein expression with clinical outcomes of gastric carcinomas were studied in 189 gastric carcinomas. There were 23 (12.2%) carcinomas with evidence of c-erbB-2 protein in which the reaction was localized to the cell membrane. There was no significant association between c-erbB-2 staining an...

journal_title：Cancer

authors： Yonemura Y,Ninomiya I,Ohoyama S,Kimura H,Yamaguchi A,Fushida S,Kosaka T,Miwa K,Miyazaki I,Endou Y

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Lung carcinoma represents the most frequent cause of cancer death worldwide because of tumor metastases. The objective of the current study was to analyze the immunologic response during the progress of lung carcinoma metastasis. METHODS:The authors established two tumor cell lines that were derived from pr...

journal_title：Cancer

authors： So T,Takenoyama M,Ichiki Y,Mizukami M,So T,Hanagiri T,Sugio K,Yasumoto K

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:In 1991, the Italian Association for Pediatric Hematology-Oncology and the National Council of Research (CNR) initiated an Italian Cooperative Study (SE 91-CNR Protocol) with the main objective of improving the overall survival (SUR) and the event free survival (EFS) of children and young adults with localiz...

journal_title：Cancer

authors： Rosito P,Mancini AF,Rondelli R,Abate ME,Pession A,Bedei L,Bacci G,Picci P,Mercuri M,Ruggieri P,Frezza G,Campanacci M,Paolucci G

更新日期：1999-08-01 00:00:00

abstract：:Ten patients with metastatic osteosarcoma were treated at the Joint Center for Radiation Therapy, the Sidney Farber Cancer Institute, and the Children's Hospital Medical Center from 1973 to 1976. Patients were treated with an aggressive multimodality approach with included surgery, chemotherapy, and radiation therapy....

journal_title：Cancer

authors： Weichselbaum RR,Cassady JR,Jaffe N,Filler RM

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:The authors investigated how lymphopenia and low serum albumin levels correlate with the prognosis of patients with carcinoma of unknown primary (CUP). METHODS:Univariate and multivariate prognostic factor analyses were conducted in a population of 317 consecutive patients with CUP who were evaluated at the...

journal_title：Cancer

authors： Seve P,Ray-Coquard I,Trillet-Lenoir V,Sawyer M,Hanson J,Broussolle C,Negrier S,Dumontet C,Mackey JR

更新日期：2006-12-01 00:00:00

abstract：:Twenty-six cases of anaplastic thyroid tumor were investigated and reclassified using immunoperoxidase techniques. Sections of the neoplasms were stained immunohistologically for the following thyroid associated antigens: (1) thyroglobulin, which shows a positive reaction with follicular cells of the thyroid; (2) calc...

journal_title：Cancer

authors： Shvero J,Gal R,Avidor I,Hadar T,Kessler E

更新日期：1988-07-15 00:00:00

abstract：:A clinicopathologic study of 48 cases of pleomorphic lipoma from the files of the Armed Forces Institute of Pathology reveals that this tumor occurs principally in males (83%) in the fifth to seventh decades (mean 57 years) and shows a predilection for the posterior neck, shoulder, and back. Typically, the lesion appe...

journal_title：Cancer

authors： Shmookler BM,Enzinger FM

更新日期：1981-01-01 00:00:00

abstract：:The author reviewed the question of late side effects of cancer treatment. A late side effect was defined as an unwanted and deleterious effect observed for the first time 12 months or longer after treatment. In a survey of articles published by The New England Journal of Medicine and The Lancet from 1968 to 1988, nin...

journal_title：Cancer

authors： Boivin JF

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:The recurrence or mortality rate of axillary lymph node-negative invasive breast cancer has been associated with the tumor S-phase fraction, which is measured by DNA flow cytometry. Because many of the studies that established this association were performed using frozen, pulverized tumor specimens, this ass...

journal_title：Cancer

authors： Merkel DE,Winchester DJ,Goldschmidt RA,August CZ,Wruck DM,Rademaker AW

更新日期：1993-09-15 00:00:00

abstract：BACKGROUND:To the authors' knowledge there are few data that correlate the expression of the epidermal growth factor receptor (EGFR) with the outcome of patients who have breast carcinoma and are treated with anthracycline chemotherapy. METHODS:Pretreatment tumor tissue samples were available from 82 patients who had ...

journal_title：Cancer

authors： Buchholz TA,Tu X,Ang KK,Esteva FJ,Kuerer HM,Pusztai L,Cristofanilli M,Singletary SE,Hortobagyi GN,Sahin AA

更新日期：2005-08-15 00:00:00

abstract：BACKGROUND:Although < 1% of men present with prostate-specific antigen (PSA)-negative prostate carcinoma, in that they have serum PSA levels much lower than the tumor burden would suggest, such patients represent a management dilemma. To the authors' knowledge, little information exists in the literature regarding patt...

journal_title：Cancer

authors： Birtle AJ,Freeman A,Masters JR,Payne HA,Harland SJ,BAUS Section of Oncology Cancer Registry.

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor (EGF) and EGF-regulated processes play an important role in steroid signal transduction. Comparative analysis of EGF and steroid receptor expression and the sensitivity of early stages of proliferation induction, such as activation of phospholipid turnover to EGF and steroids, may pro...

journal_title：Cancer

authors： Gershtein ES,Shatskaya VA,Kostyleva OI,Ermilova VD,Kushlinsky NE,Krasil'nikov MA

更新日期：1995-12-15 00:00:00

abstract：:The authors observed the clinical course of 24 women with surgically removed prolactinomas for a mean postoperative interval of 62 months. The frequency of late tumor recurrence and probable factors responsible for the recurrence were investigated. Hyperprolactinemia recurred in 4 of 13 patients with microadenomas (31...

journal_title：Cancer

authors： Parl FF,Cruz VE,Cobb CA,Bradley CA,Aleshire SL

更新日期：1986-06-15 00:00:00

abstract：BACKGROUND:A clinicopathologic evaluation of clinical Stage I and II uterine sarcoma was done by the Gynecologic Oncology Group from 1979-1988. METHODS:After all eligibility criteria were met, 453 cases were evaluable and analyzed for prognostic factors. RESULTS:Of the 301 mixed mesodermal tumors (MMT), 167 were homo...

journal_title：Cancer

authors： Major FJ,Blessing JA,Silverberg SG,Morrow CP,Creasman WT,Currie JL,Yordan E,Brady MF

更新日期：1993-02-15 00:00:00

abstract：:The authors administered high-dose chemotherapy with cyclophosphamide, BCNU (carmustine) and VP-16 (etoposide) plus autologous bone marrow transplantation (ABMT) to 22 adult patients with relapsed acute leukemia in second or subsequent remission. The marrow was not treated ex vivo. The long-term, disease-free survival...

journal_title：Cancer

authors： Spinolo JA,Dicke KA,Horwitz LJ,Jagannath S,McCredie K,Estey E,Kantarjian H,Zander AR,Keating M,Spitzer G

更新日期：1990-08-15 00:00:00

abstract：:Serum CEA levels were determined serially by the Hansen Z gel technique on 41 patients with carcinoma of the esophagus and compared to 276 controls. Seventy percent of patients with carcinomas of the esophagus had elevated CEA levels. CEA levels greater than 10.0 ng/ml after therapy correlated with significantly short...

journal_title：Cancer

authors： Alexander JC Jr,Chretien PB,Dellon AL,Synder J

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:In addition to possessing many physiologic functions, human growth hormone-1 (GH1) has been shown in recent in vitro and in vivo experiments to induce malignant disease, including breast carcinoma. The authors investigated the association of breast carcinoma with genetic polymorphisms in the GH1 gene in the ...

journal_title：Cancer

authors： Ren Z,Cai Q,Shu XO,Cai H,Cheng JR,Wen WQ,Gao YT,Zheng W

更新日期：2004-07-15 00:00:00

abstract：BACKGROUND:The 5-year survival rate of patients with submucosal (sm) esophageal carcinoma continues to be much worse than that with intramucosal (m) lesions. The reasons are unclear, but matrix metalloproteinases (MMPs) and membrane type matrix metalloproteinases (MT-MMPs) are known to be involved in degradation of ext...

journal_title：Cancer

authors： Ohashi K,Nemoto T,Nakamura K,Nemori R

更新日期：2000-05-15 00:00:00

abstract：BACKGROUND:This study aimed to determine the potential diagnostic value of migration-inhibitory factor (MIF) for gastric cancer in patients presenting with dyspepsia and its prognostic value for gastric cancer. METHODS:A cohort of 97 patients with histologically confirmed gastric adenocarcinoma and 222 patients with d...

journal_title：Cancer

authors： Xia HH,Yang Y,Chu KM,Gu Q,Zhang YY,He H,Wong WM,Leung SY,Yuen ST,Yuen MF,Chan AO,Wong BC

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Male urethral cancer is a rare neoplasm, with the published literature consisting of small single-institution retrospective series. As such, there is no objective analysis of prognostic factors and treatment outcome. The author sought to use the population-based Surveillance, Epidemiology, and End Results (S...

journal_title：Cancer

authors： Rabbani F

更新日期：2011-06-01 00:00:00

abstract：:Epidemiologic and laboratory data suggest that cervical cancer typically arises from a series of causal steps. Each step can be studied separately in the hope of better etiologic understanding and improved cancer prevention. The earliest identified etiologic step is infection of young women with specific types of vene...

journal_title：Cancer

authors： Schiffman MH,Brinton LA

更新日期：1995-11-15 00:00:00

abstract：:Three patients had supratentorial malignant brain tumors 7 to 9 years after prophylactic central nervous system (CNS) treatment for acute lymphocytic leukemia or malignant T-cell lymphoma. Therapy was administered at the age of 3 to 8 years and included cranial irradiation (total dose, 1800 to 2400 cGy) and intratheca...

journal_title：Cancer

authors： Brüstle O,Ohgaki H,Schmitt HP,Walter GF,Ostertag H,Kleihues P

更新日期：1992-05-01 00:00:00