Expression of c-erbB-2 oncoprotein in gastric carcinoma. Immunoreactivity for c-erbB-2 protein is an independent indicator of poor short-term prognosis in patients with gastric carcinoma.


:Correlations of c-erbB-2 protein expression with clinical outcomes of gastric carcinomas were studied in 189 gastric carcinomas. There were 23 (12.2%) carcinomas with evidence of c-erbB-2 protein in which the reaction was localized to the cell membrane. There was no significant association between c-erbB-2 staining and the macroscopic or histologic type of the carcinomas. c-erbB-2-stained tumors were more likely to be associated with serosal invasion, nodal involvement, and peritoneal metastasis, than c-erbB-2-unstained ones. In addition, c-erbB-2 was stained in none of early gastric carcinomas. The 5-year survival rates of the c-erbB-2 protein-positive and the protein-negative group were 11% and 50%, respectively. When the c-erbB-2 tissue status and seven clinicopathologic variables as conventional prognostic factors were entered simultaneously into the Cox regression model, serosal invasion, hepatic metastasis, peritoneal metastasis, nodal status, and c-erbB-2 tissue status emerged as independent prognostic variables. The results suggested that c-erbB-2 protein expression might be enhanced in advanced stages during the progression of gastric carcinoma. In this particular group of patients, immunoreactivity for c-erbB-2 protein is an indicator of poor short-term prognosis.






Yonemura Y,Ninomiya I,Ohoyama S,Kimura H,Yamaguchi A,Fushida S,Kosaka T,Miwa K,Miyazaki I,Endou Y




Has Abstract,Author List Incomplete


1991-06-01 00:00:00














  • Prostate-specific antigen response after short-term hormone therapy plus external-beam radiotherapy and outcome in patients treated on Radiation Therapy Oncology Group study 9413.

    abstract:BACKGROUND:The objective of this study was to assess the impact of a prostate-specific antigen (PSA) complete response (PSA-CR), measured at the end of external-beam radiotherapy and short-term hormone therapy, on treatment outcomes. METHODS:The phase 3 Radiation Therapy Oncology Group 9413 trial, as part of its origi...


    pub_type: 杂志文章,随机对照试验


    authors: Cury FL,Hunt D,Roach M 3rd,Shipley W,Gore E,Hsu IC,Krisch RE,Seider MJ,Sandler H,Lawton C

    更新日期:2013-06-01 00:00:00

  • Role of the gallium scan in Hodgkin's disease.

    abstract::The reports of 240 gallium scans on 165 patients with Hodgkin's disease were reviewed to compare results with higher doses with those in earlier studies that employed lower doses. Tracer concentrations in specific sites were correlated with radiologic and pathologic reports and with the clinical courses of the patient...


    pub_type: 杂志文章


    authors: Hagemeister FB,Fesus SM,Lamki LM,Haynie TP

    更新日期:1990-03-01 00:00:00

  • Studies on translocation of immunoglobulins across intestinal epithelium.

    abstract::The issue of how immunoglobulins are transported across the intestinal epithelium into the gut lumen was examined by immunohistocytochemical techniques. IgA, IgM, IgG and secretory component (SC) in human small intestine at light and electron microscopic levels were localized by the peroxidase-labeled antibody techniq...


    pub_type: 杂志文章


    authors: Brown WR

    更新日期:1977-11-01 00:00:00

  • A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction.

    abstract:BACKGROUND:Patients with locoregional carcinoma of the esophagus or gastroesophageal junction have a poor survival rate after surgery. Preoperative chemotherapy or chemoradiotherapy has not improved the outcome for these patients. Our study was designed to assess the feasibility of preoperative induction combination ch...


    pub_type: 临床试验,杂志文章


    authors: Ajani JA,Komaki R,Putnam JB,Walsh G,Nesbitt J,Pisters PW,Lynch PM,Vaporciyan A,Smythe R,Lahoti S,Raijman I,Swisher S,Martin FD,Roth JA

    更新日期:2001-07-15 00:00:00

  • High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas.

    abstract:BACKGROUND:Soft tissue sarcomas (STSs) are heterogeneous neoplasms that have variable clinical outcome. Several clinical parameters and few molecular markers, including Ki-67 proliferative index, have been shown to correlate with patient prognosis. To the authors' knowledge, no definitive report exists to identify one ...


    pub_type: 杂志文章


    authors: Hoos A,Stojadinovic A,Mastorides S,Urist MJ,Polsky D,Di Como CJ,Brennan MF,Cordon-Cardo C

    更新日期:2001-08-15 00:00:00

  • Combination chemotherapy and radiation therapy in the treatment of metastatic osteogenic sarcoma.

    abstract::Fourteen patients with 16 metastatic ostogenic sarcoma lesions were treated with high-dose methotrexate (HDMTX) with citrovorum factor rescue (CFR), adriamycin, and pulse high-dose cyclophosphamide combined with radiation therapy. Thirteen of 16 lesions responded. Responses consisted of relief of pain (6/6 patients) i...


    pub_type: 杂志文章


    authors: Rosen G,Tefft M,Martinez A,Cham W,Murphy ML

    更新日期:1975-03-01 00:00:00

  • Telomerase activity in benign and malignant cytologic fluids.

    abstract:BACKGROUND:Telomerase is a ribonucleoprotein that maintains telomeric base pair repeats at the ends of mammalian chromosomes during DNA replication. Telomerase is expressed in various human tumors, some normal tissues, and immortalized cell lines. The assay of telomerase activity has potential as an adjunct for cancer ...


    pub_type: 杂志文章


    authors: Mu XC,Brien TP,Ross JS,Lowry CV,McKenna BJ

    更新日期:1999-04-25 00:00:00

  • Childhood cancer in relation to parental race and ethnicity: a 5-state pooled analysis.

    abstract:BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...


    pub_type: 杂志文章


    authors: Chow EJ,Puumala SE,Mueller BA,Carozza SE,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Spector LG

    更新日期:2010-06-15 00:00:00

  • Reverse stage shift at a tertiary care center: escalating risk in men undergoing radical prostatectomy.

    abstract:BACKGROUND:The objective of this study was to evaluate changes in clinical and pathologic characteristics of prostate cancer in patients who underwent surgery at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). METHODS:The authors retrospect...


    pub_type: 杂志文章


    authors: Silberstein JL,Vickers AJ,Power NE,Fine SW,Scardino PT,Eastham JA,Laudone VP

    更新日期:2011-11-01 00:00:00

  • Bladder cancer as seen in giant histologic sections.

    abstract::Giant sections from cystectomy specimens in 45 cases of bladder cancer were examined microscopically after en bloc fixation and processing. There were 35 transitional cell, seven squamous cell, and three mixed transitional cell and squamous carcinomas. Broad front invasion was associated with papillary and superficial...


    pub_type: 杂志文章


    authors: Soto EA,Friedell GH,Tiltman AJ

    更新日期:1977-02-01 00:00:00

  • Basaloid squamous cell carcinoma of floor of mouth.

    abstract:BACKGROUND:Only five cases of basaloid squamous cell carcinoma (BSCC), a rare tumor of head and neck, have been reported to involve the floor of mouth. METHODS:Clinicopathologic and immunohistochemical features of eight BSCC of floor of mouth were studied to evaluate the significance of the basaloid features. RESULTS...


    pub_type: 杂志文章


    authors: Coppola D,Catalano E,Tang CK,Elfenbein IB,Harwick R,Mohr R

    更新日期:1993-10-15 00:00:00

  • High-dose combination chemotherapy with autologous bone marrow transplantation in adult solid tumors.

    abstract::In order to determine whether high-dose combination chemotherapy was active in chemotherapy resistant patients, 19 patients, (9 with small cell bronchogenic carcinoma, 6 with embryonal cell carcinoma, 2 with diffuse histiocytic lymphoma, 1 with Hodgkin's disease and 1 with chondrosarcoma), 18 of whom had had extensive...


    pub_type: 杂志文章


    authors: Spitzer G,Dicke KA,Litam J,Verma DS,Zander A,Lanzotti V,Valdivieso M,McCredie KB,Samuels ML

    更新日期:1980-06-15 00:00:00

  • Wide excision without radiation for desmoplastic melanoma.

    abstract:BACKGROUND:Adjuvant radiation has been proposed for the treatment of patients with desmoplastic melanoma, who reportedly have local recurrence rates as high as 40-60%. The authors investigated local recurrence rates at a tertiary referral center to determine the success of wide excision alone for patients with desmopla...


    pub_type: 杂志文章


    authors: Arora A,Lowe L,Su L,Rees R,Bradford C,Cimmino VC,Chang AE,Johnson TM,Sabel MS

    更新日期:2005-10-01 00:00:00

  • Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.

    abstract:BACKGROUND:Paclitaxel currently is administered by prolonged intravenous infusion because of the occurrence of severe hypersensitivity reactions in patients in early clinical trials. However, intensive premedication probably is more important in eliminating allergic reactions than is the length of infusion. The authors...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hainsworth JD,Greco FA

    更新日期:1994-08-15 00:00:00

  • Randomized controlled study of chemoimmunotherapy of acute myelogenous leukemia (AML) in adults with Nocardia rubra cell-wall skeleton and irradiated allogeneic AML cells.

    abstract::The effect of immunotherapy with Nocardia rubra cell-wall skeleton (N-CWS) on remission duration and survival of adults with acute myelogenous leukemia (AML) was studied in a prospective randomized controlled study. After having been induced into complete remission and having been consolidated, 73 patients were random...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ohno R,Nakamura H,Kodera Y,Ezaki K,Yokomaku S,Oguma S,Kubota Y,Shibata H,Ogawa N,Masaoka T

    更新日期:1986-04-15 00:00:00

  • Surviving cancer.

    abstract::Research trends on quality of life outcomes for cancer survivors are discussed. Epidemiologic data indicate that female cancer survivors, coming primarily from patient groups with gynecologic, breast, and colorectal cancers, will outnumber male survivors 3 to 1. Male survivors will come from the ranks of patient group...


    pub_type: 杂志文章,评审


    authors: Andersen BL

    更新日期:1994-08-15 00:00:00

  • Head and neck squamous cell carcinoma in patients aged > or = 80 years: patterns of care and survival.

    abstract:BACKGROUND:Scarce data exist concerning the outcome of very elderly patients with head and neck squamous cell carcinoma (HNSCC). METHODS:The clinical files of 316 patients aged > or = 80 years with HNSCC who were included in the authors' hospital database between 1987 and 2006 were reviewed retrospectively. RESULTS:A...


    pub_type: 杂志文章


    authors: Italiano A,Ortholan C,Dassonville O,Poissonnet G,Thariat J,Benezery K,Vallicioni J,Peyrade F,Marcy PY,Bensadoun RJ

    更新日期:2008-12-01 00:00:00

  • Complications from treatment for prostate carcinoma among men in the Detroit area.

    abstract:BACKGROUND:Aggressive treatment of early stage prostate carcinoma (PC) is limited primarily to two modalities: radical prostatectomy (RP) and external beam radiation therapy (RT). The authors conducted a population-based study of Detroit area men with localized PC to determine the outcome of bowel, urinary, and sexual ...


    pub_type: 杂志文章


    authors: Schwartz K,Bunner S,Bearer R,Severson RK

    更新日期:2002-07-01 00:00:00

  • T classification and clivus margin as risk factors for determining locoregional control by radiotherapy of nasopharyngeal carcinoma.

    abstract:BACKGROUND:The purpose of this study was to determine risk factors that affect locoregional control of nasopharyngeal carcinoma (NPC) after radiotherapy. Computed tomography (CT) is utilized for radiotherapy planning and for identifying high risk anatomic areas. METHODS:Between April 1990 and December 1993, 40 consecu...


    pub_type: 杂志文章


    authors: Jian JJ,Cheng SH,Prosnitz LR,Tsai SY,Tsai MJ,Huang AT

    更新日期:1998-01-15 00:00:00

  • Cost effectiveness of proton therapy compared with photon therapy in the management of pediatric medulloblastoma.

    abstract:BACKGROUND:Proton therapy has been a hotly contested issue in both scientific publications and lay media. Proponents cite the modality's ability to spare healthy tissue, but critics claim the benefit gained from its use does not validate its cost compared with photon therapy. The objective of this study was to evaluate...


    pub_type: 杂志文章


    authors: Mailhot Vega RB,Kim J,Bussière M,Hattangadi J,Hollander A,Michalski J,Tarbell NJ,Yock T,MacDonald SM

    更新日期:2013-12-15 00:00:00

  • Phase I and pharmacokinetic study of a stable, polyethylene-glycolated liposomal doxorubicin in patients with solid tumors: the relation between pharmacokinetic property and toxicity.

    abstract:BACKGROUND:Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study of a stable liposomal doxor...


    pub_type: 临床试验,杂志文章


    authors: Hong RL,Tseng YL

    更新日期:2001-05-01 00:00:00

  • A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis.

    abstract::Ninety-two cases of granulosa cell tumor of the ovary have been studied. The clinical and pathologic data from this group were similar to that obtained in previous series. Because of the long natural history of many granulosa cell tumors, crude death rates over a relatively short period give little indication of the t...


    pub_type: 杂志文章


    authors: Fox H,Agrawal K,Langley FA

    更新日期:1975-01-01 00:00:00

  • Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer.

    abstract:BACKGROUND:Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to ...


    pub_type: 杂志文章,多中心研究


    authors: Ali SM,Carney WP,Esteva FJ,Fornier M,Harris L,Köstler WJ,Lotz JP,Luftner D,Pichon MF,Lipton A,Serum HER-2\/neu Study Group.

    更新日期:2008-09-15 00:00:00

  • The significance of microscopic invasive cancer in endoscopically removed polyps of the large bowel. A clinicopathologic study of 51 cases.

    abstract::A clinicopathologic study of 51 patients with endoscopically removed large bowel polyps showing histologic evidence of malignancy, either focally, to a massive extent, or comprising the entire polyp, revealed only one absolute finding capable of predicting residual disease, namely, the presence of cancer at the resect...


    pub_type: 杂志文章


    authors: Lipper S,Kahn LB,Ackerman LV

    更新日期:1983-11-01 00:00:00

  • The usefulness of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) and a comparison of (18)F-FDG-pet with (67)gallium scintigraphy in the evaluation of lymphoma: relation to histologic subtypes based on the World Health Organization c

    abstract:BACKGROUND:Although studies comparing conventional imaging modalities with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) for the detection of lymphoma and although the relations between (18)F-FDG-PET and histologic types were reported previously, most studies were not systematic and involved rel...


    pub_type: 杂志文章


    authors: Tsukamoto N,Kojima M,Hasegawa M,Oriuchi N,Matsushima T,Yokohama A,Saitoh T,Handa H,Endo K,Murakami H

    更新日期:2007-08-01 00:00:00

  • Prostate carcinoma presentation, diagnosis, and staging: an update form the National Cancer Data Base.

    abstract:BACKGROUND:Based on the 1998 Patient Care Evaluation (PCE) from the American College of Surgeons National Cancer Data Base (NCDB), the authors described contemporary nationwide patterns of prostate carcinoma presentation, diagnosis, and staging. METHODS:The authors reviewed 54,212 cases from the 1998 PCE. Demographics...


    pub_type: 杂志文章


    authors: Miller DC,Hafez KS,Stewart A,Montie JE,Wei JT

    更新日期:2003-09-15 00:00:00

  • Thoracoscopy in pleural malignant mesothelioma: a prospective study of 188 consecutive patients. Part 1: Diagnosis.

    abstract:BACKGROUND:To compare the diagnostic value of thoracoscopic biopsy, fluid cytology, and Abrams needle biopsy, the authors analyzed prospectively the records of 188 patients with malignant pleural mesothelioma examined between 1973 and 1990. Symptoms were pleural effusion in 173 patients, empyema in 1, spontaneous pneum...


    pub_type: 临床试验,杂志文章


    authors: Boutin C,Rey F

    更新日期:1993-07-15 00:00:00

  • Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group.

    abstract:BACKGROUND:This study sought to investigate biological/clinicopathological characteristics of neuroblastoma, undifferentiated subtype (NBUD). METHODS:This study examined 157 NBUD cases filed at the Children's Oncology Group Neuroblastoma Pathology Reference Laboratory, and survival rates of the patients were analyzed ...


    pub_type: 杂志文章


    authors: Wang LL,Suganuma R,Ikegaki N,Tang X,Naranjo A,McGrady P,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Shimada H

    更新日期:2013-10-15 00:00:00

  • Predictors and outcomes of surgeons' referral of older breast cancer patients to medical oncologists.

    abstract:BACKGROUND:Older women are less likely than younger women to receive definitive care for a new diagnosis of breast cancer, but the reasons are not well understood. Although coordination of referral among specialists is an important component of quality of care, it has not been studied as a factor that contributes to ob...


    pub_type: 杂志文章


    authors: Thwin SS,Fink AK,Lash TL,Silliman RA

    更新日期:2005-09-01 00:00:00

  • Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer.

    abstract:BACKGROUND:The purpose of this study was to characterize insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R) expression in patients with nonsmall cell lung cancer (NSCLC). METHODS:A total of 459 patients who underwent curative resection of NSCLC were studied (median follow-up duration, 4.01 years)...


    pub_type: 杂志文章


    authors: Kim JS,Kim ES,Liu D,Lee JJ,Solis L,Behrens C,Lippman SM,Hong WK,Wistuba II,Lee HY

    更新日期:2012-05-01 00:00:00