Abstract:
BACKGROUND:The importance of the bone marrow microenvironment in multiple myeloma is receiving increasing attention. Recent studies have suggested the importance of cytokine production and cell-cell contact by bone marrow stromal cells in the survival of myeloma cells. METHODS:In the current study, the authors examined bone marrow mesenchymal progenitor cell (MPC) cultures derived from eight multiple myeloma patients (mean age, 58 years) and nine normal donors (mean age, 61 years), with emphasis on cell surface antigens, cytokine, and growth factor expression. RESULTS:The authors have found, based on analysis of cellular receptors, growth factors, and cytokine expression, that myeloma MPCs are phenotypically and functionally distinguishable from normal donor MPCs. Immunofluorescence analysis of MPC monolayers shows that myeloma MPC cultures expressed reduced cell surface vascular cell adhesion molecule-1 and fibronectin, in contrast with the strong expression found on normal donor MPCs. Furthermore, a subset of myeloma MPCs strongly express intracellular receptor for hyaluronan-mediated motility, whereas normal MPCs do not. Cytokine expression in bone marrow MPC cultures was examined by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay. Bone marrow MPCs constitutively express interleukin (IL)-1beta, IL-6, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage (GM)-CSF, stem cell factor (SCF), and tumor necrosis factor (TNF)-alpha. In comparison to normal MPCs, multiple myeloma MPCs express increased basal levels of IL-1beta and TNF-alpha. In vitro exposure of MPC cultures to dexamethasone resulted in the down-regulation of IL-6, G-CSF, and GM-CSF in both normal and myeloma MPC cultures. However, dexamethasone treatment significantly increased expression of SCF-1 in myeloma MPCs. CONCLUSIONS:In myeloma, bone marrow stromal cells provide paracrine factors, through cytokine production and cell-cell contact, which play a role in plasma cell growth and survival. The authors' data indicate differences in bone marrow MPCs, which may be biologically relevant to the growth and survival of myeloma plasma cells.
journal_name
Cancerjournal_title
Cancerauthors
Wallace SR,Oken MM,Lunetta KL,Panoskaltsis-Mortari A,Masellis AMdoi
10.1002/1097-0142(20010401)91:7<1219::aid-cncr1122subject
Has Abstractpub_date
2001-04-01 00:00:00pages
1219-30issue
7eissn
0008-543Xissn
1097-0142pii
10.1002/1097-0142(20010401)91:7<1219::AID-CNCR1122journal_volume
91pub_type
杂志文章相关文献
CANCER文献大全abstract::A retrospective study is reported of 120 consecutive cases of patients presenting with brain metastases as the primary sign of their malignancy. Primary site was found in 62 patients (53 while alive and 9 at postmortem examination) and remained unknown in 58. Lung was the most frequent primary site (45% of known sites...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850815)56:4<880::aid-cncr28205
更新日期:1985-08-15 00:00:00
abstract:BACKGROUND:The mortality of patients with colorectal carcinoma depends mainly upon subsequent liver metastasis even after curative operation. However, it is very difficult to predict the incidence of liver metastasis by analyzing conventional tumor markers or pathologic findings. In the current study, the authors exami...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1729::AID-CN
更新日期:1996-04-15 00:00:00
abstract:BACKGROUND:A retrospective clinicopathologic study was performed to identify the influence of diagnostic and therapeutic procedures on the outcomes of patients with the follicular variant of papillary thyroid carcinoma (FVPTC). METHODS:The results of 37 patients with FVPTC were compared with those of 37 randomly selec...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940115)73:2<424::aid-cncr28207
更新日期:1994-01-15 00:00:00
abstract:BACKGROUND:It remains unclear whether health-related quality of life (HRQoL) measurements from patients and staff can be combined with medical data to predict survival in patients with terminal cancer. METHODS:The correlations between survival and potential health-related quality-of-life (HRQoL) prognostic variables w...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.20472
更新日期:2004-09-01 00:00:00
abstract::Fifteen oncocytic (oxyphilic granular cell) neoplasms of the salivary glands collected from three large university medical centers are presented. The histologic and ultrastructural criteria that characterize oncocytes are presented and electron micrographs of two of our cases are discussed. Included in the series are ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197609)38:3<1306::aid-cncr282038
更新日期:1976-09-01 00:00:00
abstract:BACKGROUND:The use of complementary methods (CMs) is widespread and increasing in the United States. Most literature on CM use among cancer survivors focuses on the treatment period, whereas only a few studies address use further along the cancer continuum. METHODS:This study analyzed the prevalence and the medical an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23659
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Although protein expressions of glucocorticoid receptor (GR), estrogen receptors (ERα and ERβ), progesterone receptor A (PgR-A), and androgen receptor (AR) were shown to play roles in the growth and differentiation of normal thymus and thymic tumors, to the authors' knowledge their association with patient c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26061
更新日期:2011-10-01 00:00:00
abstract::Epidermoid cancer accounts for 81% of the malignancies of the vulva. Although the etiology has not been delineated, chronic vulvitis is associated with cancer in almost one-third of the patients. The staging system should utilize the most precise and accurate parameters delineated for improved treatment. A new staging...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<587::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Although pediatric cancer mortality and survival have improved in the United States over the past 40 years, differences exist by age, race/ethnicity, cancer site, and economic status. To assess progress, this study examined recent mortality and survival data for individuals younger than 20 years. METHODS:Ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33080
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Breast cancers that are negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) (triple negative [TN]) have been associated with high-grade histology, aggressive clinical behavior, and poor survival. It has been determined that breast cancers that ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23243
更新日期:2008-02-15 00:00:00
abstract::The clinicopathologic features and response to therapy of 28 patients with non-Ewing's flat bone sarcoma treated at St. Jude Children's Research Hospital, Memphis, Tennessee, over a 25-year period were reviewed. Twenty-two patients had osteosarcoma, four malignant fibrous histiocytoma, one chondrosarcoma, and one fibr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900215)65:4<1011::aid-cncr2820
更新日期:1990-02-15 00:00:00
abstract:BACKGROUND:The results of a Phase II study of concurrent chemotherapy and accelerated fractionation radiation therapy followed by surgical resection for patients with both adenocarcinoma and squamous cell carcinoma of the esophagus are presented. Pretreatment and postinduction staging were correlated with pathologic fi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-09-15 00:00:00
abstract:BACKGROUND:Hyperglycemia is often observed in medically ill patients. Previous studies have shown that patients with hyperglycemia during induction therapy for acute lymphoblastic leukemia develop more infections and have shorter disease-free survival. The authors hypothesized that hyperglycemia may be associated with ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22777
更新日期:2007-07-01 00:00:00
abstract::An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831015)52:8<1470::aid-cncr2820
更新日期:1983-10-15 00:00:00
abstract:BACKGROUND:China's lung cancer (LC) burden plays a pivotal role in the global cancer epidemic. Comparing LC burden and population attributable fractions (PAFs) of risk factors between China and other countries/regions is essential to inform effective intervention. The Global Burden of Disease (GBD) study provides a uni...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33078
更新日期:2020-09-15 00:00:00
abstract::Eighty-seven previously untreated patients with pathologic Stage IA, II (A or B), or IIIA Hodgkin's disease were randomized over a 48-month period to receive either megavoltage extended field radiotherapy alone or megavoltage radiotherapy limited to involved lymph node sites (including at least an upper mantle field) ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197504)35:4<1055::aid-cncr282035
更新日期:1975-04-01 00:00:00
abstract::A system for staging the clinical status of patients with soft tissue sarcomas is presented, based on the clinical characteristics of the primary tumor (size, extension), the involvement of lymph nodes, the presence of metastases, and the grade of the tumor. This represents the TNM system with grade of tumor (G) added...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4<1562::aid-cncr282040
更新日期:1977-10-01 00:00:00
abstract::Adrenal cortical carcinoma is an uncommon neoplasm in children. Only a handful of congenital adrenal cortical carcinoma cases have been described. A newborn who had metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions) is described. This patient underwent surgical resection of the right adrenal ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880801)62:3<507::aid-cncr28206
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:To define the clinicopathologic and prognostic features of patients with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) in North America, standard criteria were used to identify patients with ATLL. METHODS:Statistical analyses used included descriptive stati...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25147
更新日期:2010-07-15 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinoma (NPC) is associated closely with Epstein-Barr virus (EBV). The authors previously reported that an EBV immediate-early gene, BRLF1, was expressed frequently in NPC tumors, and a significant elevation in immunoglobulin G (IgG) antibodies directed against BRLF1 gene product Rta was det...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011001)92:7<1872::aid-cncr1704
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:The current study was performed to determine whether neuropsychologic functioning differs in breast cancer survivors 6 months after the completion of adjuvant treatment compared with women without cancer. METHODS:Participants were 187 women who were diagnosed with ductal carcinoma in situ or stage I or stag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24192
更新日期:2009-04-15 00:00:00
abstract::A randomized study was designed to determine the effect of intermittent oral cyclophosphamide on the rate of metastases in children with localized and regional neuroblastoma. Secondary objectives of the study were to determine the value of the proposed staging system, to measure the influence of the peripheral lymphoc...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197608)38:2<661::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract::Preoperative evaluation should focus on techniques that either preclude surgery entirely, alter the planned operation either preoperatively or intraoperatively, or suggest the need for preoperative adjuvant therapy. The presence of a synchronous colonic neoplasia should be excluded by colonoscopy or air-contrast bariu...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920901)70:3+<1328::aid-cncr282
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Many trials submitted to scientific meetings are not reported in peer-reviewed journals. Results may vary substantially and the lack of final publication constitutes a form of reporting bias. The authors sought to determine the presentation and publication rates of Phase I trials submitted to a major oncolog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21337
更新日期:2005-10-01 00:00:00
abstract::The aims of this study were as follows: to confirm that the presence of estrogen (ER) and progesterone (PgR) receptors is an indicator of clinical behavior of human breast cancer independent of other known prognostic factors; to seek clinical correlates of those receptor values that best predict the overall disease ev...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860315)57:6<1171::aid-cncr2820
更新日期:1986-03-15 00:00:00
abstract:BACKGROUND:Recently, adenomatous hyperplasia (AH) of the liver, a sizable parenchymal nodule in the cirrhotic liver, has been considered a preneoplastic lesion in human hepatocarcinogenesis. METHODS:The authors evaluated cell proliferative activity by immunostaining for proliferating cell nuclear antigen (PCNA) in AH ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920801)70:3<591::aid-cncr28207
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Although caspase recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) and CARD9 play important roles in lymphocyte activation, the significance of CARMA1 and CARD9 in the pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma remains to be elucidated. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21421
更新日期:2005-11-01 00:00:00
abstract::Forty-five patients with advanced non-small cell lung cancer (NSCLC), with progressive inoperable tumors were treated. Twenty-three patients were of "limited" stage. Six patients had received previous thoracic radiotherapy. Patients with central nervous system (CNS) metastases, Karnofsky scores of less than 30 or more...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880101)61:1<14::aid-cncr282061
更新日期:1988-01-01 00:00:00
abstract::Between August 1978 and November 1981, 33 boys with acute lymphocytic leukemia (ALL) (26 non-T, 7 T-cell) younger than 16 years underwent bilateral wedge testicular biopsies at the time of initial diagnosis. Seven (4 non-T, 3 T-cell) demonstrated focal leukemic infiltrates. Rebiopsy after successful induction therapy ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860301)57:5<1038::aid-cncr2820
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:In Japan, where liver transplantation has not been used to treat patients with hepatocellular carcinoma (HCC), percutaneous ethanol injection (PEI) has been employed for those with small HCCs that are not amenable to surgical resection. In the current study, the authors evaluated PEI as a treatment for HCC p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19991101)86:9<1682::aid-cn
更新日期:1999-11-01 00:00:00