Abstract:
:Adrenal cortical carcinoma is an uncommon neoplasm in children. Only a handful of congenital adrenal cortical carcinoma cases have been described. A newborn who had metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions) is described. This patient underwent surgical resection of the right adrenal primary, but no further treatment was given. Hemihypertrophy developed in this patient by 2 months of age, and at 4 months of age spontaneous regression of all skin nodules and central nervous system (CNS) lesions was observed. Follow-up at 1 year shows the patient to be alive, well, and disease-free. Evaluation of the tumor included DNA ploidy analysis that showed the tumor to be polyploid, a pattern recently associated with nonmetastasizing adrenal cortical neoplasm. The observation of apparent metastatic disease that regressed spontaneously highlights the prognostic value of DNA ploidy analysis and raises the possibility of an adrenal tumor with properties similar to those of Stage IV-S neuroblastoma.
journal_name
Cancerjournal_title
Cancerauthors
Saracco S,Abramowsky C,Taylor S,Silverman RA,Berman BWdoi
10.1002/1097-0142(19880801)62:3<507::aid-cncr28206subject
Has Abstractpub_date
1988-08-01 00:00:00pages
507-11issue
3eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
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