Abstract:
BACKGROUND:Although marital distress has been implicated in difficulties with adjustment to a breast cancer diagnosis, its long-term effects, especially on physical recovery, are unknown. METHODS:Longitudinal data from newly diagnosed breast cancer patients (N=100) who were married or cohabiting were used. Patients were assessed after diagnosis and surgery (baseline) and then reassessed every 4 or 6 months for the next 5 years. Women in stable, distressed relationships (n=28) were compared with those in stable, nondistressed relationships (n=72). Stress, health behavior, and health outcomes were examined using mixed-effects modeling. RESULTS:Overall, marital distress was associated with slowed recovery trajectories and poor outcomes. At baseline, both groups had equivalent, high levels of stress, but diverged thereafter. Stress declined more slowly for the Distressed group, and by 5 years it remained significantly higher. Differential reductions in physical activity were also observed. With regard to health, the Distressed group was found to have a slower recovery in performance status and more symptoms/signs of illness and treatment side effects through 3 years. Finally, all the effects were observed above and beyond reductions occurring with depressive symptomatology, which was significantly higher in the Distressed group. CONCLUSIONS:Marital distress is not only associated with worse psychologic outcomes for breast cancer survivors, but poorer health and a steeper decline in physical activity. These novel data demonstrate recovery trajectories for breast cancer survivors to be constrained for those also coping with ongoing difficulties in their marriage.
journal_name
Cancerjournal_title
Cancerauthors
Yang HC,Schuler TAdoi
10.1002/cncr.23964subject
Has Abstractpub_date
2009-01-01 00:00:00pages
217-28issue
1eissn
0008-543Xissn
1097-0142journal_volume
115pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract::Acute non-lymphocytic leukemia occurred in eight women following long-term treatment with Treosulfan (= dihydroxybusulfan) for ovarian carcinoma. The leukemia developed from 21 to 58 months (median 50 months) after the institution of chemotherapy. At the time when the leukemia appeared seven of the patients were in co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800101)45:1<19::aid-cncr282045
更新日期:1980-01-01 00:00:00
abstract::A patient is presented who developed a peritoneal malignant mesothelioma in association with severe persistent and recurrent diverticulitis. The case is unusual in that a spectrum of mesothelial proliferation was documented beginning initially as benign foci of mesothelial proliferation and passing through a stage of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810701)48:1<134::aid-cncr28204
更新日期:1981-07-01 00:00:00
abstract:BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(20010201)91:3<484::aid-cncr1026>
更新日期:2001-02-01 00:00:00
abstract::One hundred seventeen postmenopausal advanced breast cancer patients previously untreated with chemotherapy were randomized to receive: cyclophosphamide, methotrexate, and 5-fluorouracil (CMF), CMF and tamoxifen (TMX), and CMF and medroxyprogesterone (MAP). Treatments B and C induced a greater proportion of responses ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19851215)56:12<2745::aid-cncr282
更新日期:1985-12-15 00:00:00
abstract::We examined resected specimens from 40 cases of advanced rectal cancer to determine the extent of microtubular cancer nests and undifferentiated cancer cells (budding). We investigated the relationship between this budding and lymphatic invasion (ly), venous invasion (v), and lymph node metastasis (n), respectively. M...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890201)63:3<539::aid-cncr28206
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Spouses of cancer survivors are at an increased risk of poor mental health outcomes but are known to underuse supportive services. The objective of the current study was to determine how the health and health care use of cancer survivors were associated with depression and anxiety-related health care use in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33345
更新日期:2020-12-08 00:00:00
abstract:BACKGROUND:Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, the authors examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with the risk of total, low-grade, and high-grade prostate cancer. METHODS:Dat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24423
更新日期:2009-08-15 00:00:00
abstract::There is a growing body of basic science and epidemiologic evidence to support a research thrust to determine whether several natural or synthetic agents, given alone or together, can lower cancer incidence. Candidate agents include analogs of vitamin A and the vitamin A precursor, beta-carotene, vitamins C and E, and...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19870801)60:3+<650::aid-cncr2820
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Telomerase is a ribonucleoprotein that maintains telomeric base pair repeats at the ends of mammalian chromosomes during DNA replication. Telomerase is expressed in various human tumors, some normal tissues, and immortalized cell lines. The assay of telomerase activity has potential as an adjunct for cancer ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-04-25 00:00:00
abstract::Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL-N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4<1748::aid-cncr282040
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:The Danish Breast Cancer Cooperative Group (DBCG) 77B trial examined the relative efficacy of levamisole, single-agent oral cyclophosphamide, and the classic combination of cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) against no adjuvant systemic therapy in high-risk breast cancer patients. The a...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.24969
更新日期:2010-05-01 00:00:00
abstract::The monitoring utility of serial patterns of a single marker (carcinoembryonic antigen) level and multiple marker (three carbohydrates-fucose, mannose and galactose) levels in patients with small cell carcinoma of the lung was investigated using a quantitative approach. A serial multiple regression (SMR) model was for...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811001)48:7<1633::aid-cncr2820
更新日期:1981-10-01 00:00:00
abstract::Eleven patients with advanced soft tissue sarcoma were treated with whole body hyperthermia (41.8 degrees C-43.0 degrees C) for 2 hours, doxorubicin (45 mg/m2) at the beginning of peak temperature and cyclophosphamide (1000 mg/m2) 6 hours after doxorubicin. Warming was accomplished with a nylon and vinyl mesh water pe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840615)53:12<2585::aid-cncr282
更新日期:1984-06-15 00:00:00
abstract:BACKGROUND:Parathyroid hormone-related protein (PTHrP) has been shown to be the principal cause of humoral hypercalcemia associated with renal cell carcinoma (RCC). Recent studies have demonstrated that the amino-terminal region of PTHrP has growth factor-like activities, suggesting it may play a role in the developmen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990915)86:6<1028::aid-cn
更新日期:1999-09-15 00:00:00
abstract::Basal cell carcinomas (BCCs) obtained from 22 subjects undergoing microscopically controlled surgery were transplanted to 40 athymic (nude) mice. With no further immunosuppression of the mice, no tumor growth was noted in the first 14 attempts. When mice were further immunosuppressed with anti-lymphocyte serum (ALS) i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850801)56:3<519::aid-cncr28205
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling. These tumors most commonly occur in the stomach and small intestine and encompass a clinic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23216
更新日期:2008-02-01 00:00:00
abstract::Until recently the prognosis of childhood non-Hodgkin's lymphoma has been poor. A program of combination chemotherapy and involved area radiotherapy was instituted in the Department of Pediatrics at Roswell Park Memorial Institute in 1971. Thirty-one biopsy proven untreated children entered this study. There were 4 St...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<1997::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract::Flow cytometric measurements were done on 51 ovarian carcinoma specimens collected from consecutive patients in a prospective study. The ploidy status was related to the course of the disease. The tumors from 26 (52%) of 50 evaluable patients had DNA aneuploidy. Patients with diploid tumors were more often considered ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880301)61:5<971::aid-cncr28206
更新日期:1988-03-01 00:00:00
abstract::The diagnosis of brain metastasis from prostate carcinoma is rarely made antemortem, and has previously been reported only in patients with known extensive metastatic disease of long duration. A case of adenocarcinoma of the prostate presenting as a brain metastasis is described. Current concepts of metastatic spread ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841015)54:8<1723::aid-cncr2820
更新日期:1984-10-15 00:00:00
abstract:BACKGROUND:Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy allows the detailed imaging and FNA not only of both intramural and extramural structures and lesions of the gastrointestinal (GI) tract but also of various intraabdominal organs. Thus, EUS-FNA biopsy offers a novel opportunity to evaluate ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20498
更新日期:2004-10-25 00:00:00
abstract:BACKGROUND:In less than a century, lung cancer has progressed from a medical curiosity to the most deadly of all malignant diseases on our planet. Because cigarette smoking is responsible for the existing global lung cancer epidemic, policy initiatives have focused almost exclusively on primary prevention. There is no ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20001201)89:11+<2422::aid-cncr16
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Previous data from the National Cancer Data Base have examined time trends in stage of disease, treatment patterns, and survival for selected cancers. The most current (1993) data for breast carcinoma are described here. METHODS:Five Calls for Data have yielded a total of 508,724 breast cancer cases diagnos...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19961015)78:8<1838::aid-cn
更新日期:1996-10-15 00:00:00
abstract:BACKGROUND:It is unclear whether new treatment modalities have improved the survival of follicular lymphoma patients. Some data show that there has been no improvement in survival in the last 3 decades of the 20th century, whereas the results of recent retrospective studies suggest that evolving therapy has improved th...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.22649
更新日期:2007-05-15 00:00:00
abstract:BACKGROUND:The lack of comparable metrics to evaluate prevention and early detection patient navigation programs impeded the ability to identify best practices. METHODS:The Prevention and Early Detection Workgroup of the Patient Navigation Leadership Summit was charged with making recommendations for common clinical m...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26267
更新日期:2011-08-01 00:00:00
abstract::To investigate the possible implications of heterogeneity among the non-Hodgkin's lymphomas for bone marrow purging using complement-fixing monoclonal antibodies to lymphoma-associated antigens, a panel of large cell lymphoma cell lines of diverse phenotypes was treated with monoclonal antibodies DLC-48 and LN-1. An a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880315)61:6<1082::aid-cncr2820
更新日期:1988-03-15 00:00:00
abstract::Cases of childhood cancer (less than 15 years of age at diagnosis), diagnosed between 1960 and 1984, were obtained from the Hawaii Tumor Registry, a population-based Surveillance, Epidemiology, and End Results (SEER) participant covering the entire State of Hawaii. During the 25 years of data collection, cancer was di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891015)64:8<1758::aid-cncr2820
更新日期:1989-10-15 00:00:00
abstract::Conjugal tumors are rarely reported; but nevertheless, raise important questions of possible etiologic factors. In this report, the presentation of grade 2 gemistocytic astrocytomas in an unrelated married couple in their early thirties within 18 months of each other is described. In both cases the left frontal region...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850215)55:4<864::aid-cncr28205
更新日期:1985-02-15 00:00:00
abstract::An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<4072::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract:BACKGROUND:For patients with stage III through IVB head and neck squamous cell carcinoma (HNSCC), concurrent high-dose cisplatin plus radiation therapy is a widely accepted standard of care. HNSCC tumors that express high levels of vascular endothelial growth factor have been associated with a worse prognosis, and beva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27498
更新日期:2012-10-15 00:00:00
abstract::The efficacy of mitoxantrone in combination with vinblastine was assessed in 156 patients with metastatic breast cancer who had been treated previously with one or multiple chemotherapeutic regimens. Mitoxantrone was given by random assignment, either as a 10 mg/m2 single intravenous dose or in five consecutive daily ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19871015)60:8<1724::aid-cncr2820
更新日期:1987-10-15 00:00:00