Abstract:
:The monitoring utility of serial patterns of a single marker (carcinoembryonic antigen) level and multiple marker (three carbohydrates-fucose, mannose and galactose) levels in patients with small cell carcinoma of the lung was investigated using a quantitative approach. A serial multiple regression (SMR) model was formulated to assess the disease response following the first to the tenth course of therapy and resulted in the multiple correlations ranging from 0.183 (NS)-0.706 (P less than 0.005) for CEA, and 0.502 (P less than 0.250)-0.760 (P less than 0.025) for three carbohydrates, respectively. The appraisal of these markers utilizing the SMR model points out that: (1) the serial levels of CEA greater than 5.0 ng/ml are significantly correlated with the disease course whereas the serial levels less than 5.0 ng/ml reflect the trend of variation in the disease course, but with less accuracy; and (2) the levels of three carbohydrates, any one elevated before and during therapy, are significantly correlated with the disease course.
journal_name
Cancerjournal_title
Cancerauthors
Woo KB,Waalkes P,Abeloff MD,Ettinger DS,McNitt KL,Gehrke CWdoi
10.1002/1097-0142(19811001)48:7<1633::aid-cncr2820subject
Has Abstractpub_date
1981-10-01 00:00:00pages
1633-42issue
7eissn
0008-543Xissn
1097-0142journal_volume
48pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:In less than a century, lung cancer has progressed from a medical curiosity to the most deadly of all malignant diseases on our planet. Because cigarette smoking is responsible for the existing global lung cancer epidemic, policy initiatives have focused almost exclusively on primary prevention. There is no ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20001201)89:11+<2422::aid-cncr16
更新日期:2000-12-01 00:00:00
abstract::The binding of soybean agglutinin (SBA) lectin to routinely processed surgical pathology material from cases of prostatic hyperplasia, atypical hyperplasia, and adenocarcinoma was studied using an immunoperoxidase technique. Positive staining was obtained in eight of eight cases of nodular hyperplasia, eight of eight ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890415)63:8<1583::aid-cncr2820
更新日期:1989-04-15 00:00:00
abstract::The following case report describes a 22-year-old healthy man, non-smoker, non-drinker, who developed a squamous cell carcinoma of the buccal mucosa. The appearance of this unusual tumor in an unexpected clinical setting was unexplained until it was discovered that the patient had a lifetime habit of chewing plastic m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197704)39:4<1686::aid-cncr282039
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Early-phase trials in patients with recurrent neuroblastoma historically used an objective "response" of measureable disease (Response Evaluation Criteria In Solid Tumors [RECIST], without bone/bone marrow assessment) to select agents for further study. Historical cohorts may be small and potentially biased;...
journal_title:Cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/cncr.30934
更新日期:2017-12-15 00:00:00
abstract::Radiotherapy was applied to 14 esophageal carcinomas with respiratory tract fistulas using various treatment regimens. Closure of the fistulas was observed in four cases after irradiation at a daily dose of 1.5 Gy. The period of closure was transient in two cases but long-term in the other two. One long-term closure c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890901)64:5<1026::aid-cncr2820
更新日期:1989-09-01 00:00:00
abstract::The histologic findings of five patients with clinically typical Bowenoid dysplasia (BD) allowed the authors to classify the vulvar and perineal biopsies of 18 patients under 40 years as BD and the vulvar biopsies of six patients under 40 years as squamous cell carcinoma in situ (CIS). The two best criteria for BD are...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821215)50:12<2910::aid-cncr282
更新日期:1982-12-15 00:00:00
abstract:BACKGROUND:Widespread disparities in care have been documented in women with gynecologic cancer in the United States. This study was designed to determine whether structural barriers to optimal care were present during the preoperative period for patients with gynecologic cancer. METHODS:A retrospective review was con...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29859
更新日期:2016-03-15 00:00:00
abstract:BACKGROUND:The purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes. METHODS:Immunohistochemical staining for Survivin was carried ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22521
更新日期:2007-03-15 00:00:00
abstract:BACKGROUND:To evaluate the hearing preservation rate and to determine its prognostic factors after gamma knife (GK) stereotactic radiosurgery (SRS) in patients with vestibular schwannoma, the authors used a prospective study design to analyze these patients. METHODS:Between December 1997 and January 2002, 25 patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21190
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:To identify the factors that contribute to poorer colon carcinoma survival rates for African Americans compared with Caucasians, the authors evaluated survival differences based on the histologic grade (differentiation) of the tumor. METHODS:All 169 African Americans and 229 randomly selected non-Hispanic C...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21021
更新日期:2005-05-15 00:00:00
abstract::Based on Church records for 15,500 California Mormons during 1968 to 1975 and for 55,000 Utah Mormons during 1970 and 1975, the ratio of age-adjusted death rates for religiously active Mormon males compared with U.S. white males is 38% for ages 35 to 64 years and 50% for ages 35 years and above. The remaining life exp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197810)42:4<1943::aid-cncr282042
更新日期:1978-10-01 00:00:00
abstract::New approaches are needed in the treatment of advanced breast cancer. In vitro studies have shown that recombinant tumor necrosis factor (TNF) is a growth inhibitor for the MCF-7, ZR-75-1, and BT-20 human breast cancer cell lines. Based on these considerations, the Southwest Oncology Group performed a Phase II trial o...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19911015)68:8<1694::aid-cncr2820
更新日期:1991-10-15 00:00:00
abstract:BACKGROUND:The purpose of the current study was to determine the prevalence of low bone mineral density (BMD) (ie, osteopenia) and identify factors associated with low BMD in young adult survivors of childhood acute lymphoblastic leukemia (ALL). METHODS:Dual energy x-ray absorptiometry was used to evaluate BMD in 74 r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23912
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:This study assessed the impact of surgical, histopathologic and patient-related factors on the risks of local and distant recurrence and overall survival for patients with stages I through IIIA nonsmall cell lung carcinoma (NSCLC) undergoing definitive resection with or without adjuvant chemotherapy. METHOD...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24133
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:DFP-10917, a deoxycytidine nucleoside analogue, has a unique mechanism of action resulting in leukemic cell death when administered for prolonged periods at low doses. The current phase 1/2 study investigated the safety, maximum tolerated dose, and evidence of antileukemic activity for DFP-10917 administered...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31923
更新日期:2019-05-15 00:00:00
abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28196
更新日期:2013-09-01 00:00:00
abstract::A 22-micron glass microsphere called TheraSphere (Theragenics Corp., Atlanta, GA) has been developed in which yttrium 89 oxide is incorporated into the glass matrix and is activated by neutron bombardment to form the beta-emitting isotope yttrium 90 (Y 90) before using the spheres as radiotherapeutic vehicles. The inj...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880401)61:7<1336::aid-cncr2820
更新日期:1988-04-01 00:00:00
abstract::Nine years after biopsy and radiation therapy for an extramedullary plasmacytoma of the nasal cavity, a 64-year-old man developed locally recurrent tumor. Repeat biopsy revealed tumor identical in hematoxylin and eosin stain (H & E) appearance to that found originally, leading to the diagnosis of recurrent extramedull...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870701)60:1<88::aid-cncr282060
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:The authors analyzed the secretion of extracellular matrix-degrading proteinases, including urinary-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2, gelatinase A), and MMP-9 (gelatinase B), by short term primary cultures of epithelial ovarian carcinoma cells derived from primary ovarian ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971015)80:8<1457::aid-cn
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:The bone destruction in myeloma patients is largely responsible for the clinical features of the disease. However, only recently has attention focused on identifying and developing drugs targeted specifically at the osteolysis. Receptor activator of NF-kappaB ligand (RANKL), macrophage inflammatory protein (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11133
更新日期:2003-02-01 00:00:00
abstract::Poor drug compliance may cause a decreased survival of children with malignancies. Children who fail to take their medications are not receiving optimum amounts of chemotherapy and suboptimal therapy causes a shortened survival in children with cancer. This is a study of prednisone compliance in 52 children with cance...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197901)43:1<169::aid-cncr2820430
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Hispanic Americans have been shown to receive fewer cancer screening procedures than nonminority populations. Although lack of insurance or a regular source of care appear to be important determinants, cultural factors also have been suggested. This study examines whether Hispanic patients receive cancer scr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010101)91:1+<257::aid-cncr15>3
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The authors previously identified sperm protein 17 (Sp17) as being expressed in patients with multiple myeloma. The restricted expression of Sp17 in normal tissue makes it an ideal target for tumor vaccine. In the current study, the authors extended their research to include ovarian carcinoma. METHODS:A pai...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10506
更新日期:2002-05-01 00:00:00
abstract::Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920901)70:5<1194::aid-cncr2820
更新日期:1992-09-01 00:00:00
abstract::Compliance in oncology clinic attendance was prospectively evaluated over a 12-month period at Harlem Hospital Center, an inner city municipal facility serving a predominantly black population. One hundred patients were followed (97 blacks, 2 Hispanics, 1 white) with an average age of 60 years. There were 41 men and 5...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860801)58:3<793::aid-cncr28205
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Systematic symptom assessment is not routinely performed in pediatric oncology. The objectives of the current study were to characterize the symptoms of pediatric oncology outpatients and evaluate agreement between patient and proxy reports and the association between children's ratings and oncologists' trea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29597
更新日期:2015-11-15 00:00:00
abstract:BACKGROUND:Despite improvements in survival rates, cancer treatments have significant side effects that affect the quality of life of children and their families. When an ill child cannot self-report symptoms (eg, he or she is too ill), caregiver (parent) reporting becomes critical. This study evaluates the validity an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33389
更新日期:2020-12-17 00:00:00
abstract::Two patients fulfilled the clinical and hematologic criteria for B-cell acute lymphoblastic leukemia: the malignant cells had L3 morphology, bore B-cell markers, and carried the specific t(8;14) translocation. The leukemic cells of one patient were tetrasomic for 1q, and those of the other patient showed several separ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840701)54:1<48::aid-cncr282054
更新日期:1984-07-01 00:00:00
abstract::Malignant schwannomas with rhabdomyoblastic differentiation have been termed malignant "Triton" tumors (MTT). To define the natural history of MTT, we have analyzed our experience (9 cases, the largest series reported) in combination with the 27 previously described in the literature (total 36 cases). This study was i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850601)55:11<2543::aid-cncr282
更新日期:1985-06-01 00:00:00
abstract:METHODS:Between 1983 and 1989, 42 patients with Stage II, III, and IV, node-negative, squamous cell head and neck cancer were treated with concurrent 5-fluorouracil, cisplatin, and radiation therapy. Two courses of chemotherapy with 30 Gy of concurrent radiation therapy were to be followed in all patients by definitive...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19921201)70:11<2685::aid-cncr282
更新日期:1992-12-01 00:00:00