Bowenoid dysplasia of the vulva.

abstract：BACKGROUND:Sialyl-Tn (STn) represents an aberrantly glycosylated mucin epitope that is expressed in breast carcinoma and other adenocarcinomas and is an important factor in the development of novel immunotherapeutic approaches. The primary aim of the current study was to investigate the influence of STn expression on t...

journal_title：Cancer

authors： Kinney AY,Sahin A,Vernon SW,Frankowski RF,Annegers JF,Hortobagyi GN,Buzdar AU,Frye DK,Dhingra K

更新日期：1997-12-15 00:00:00

abstract：BACKGROUND:Sunitinib has replaced interferon (IFN) as a first-line standard of care in the treatment of metastatic renal cell carcinoma (RCC). This study aimed to determine overall survival and to confirm effectiveness in a population that includes poor prognosis patients. METHODS:Data were collected on all patients i...

journal_title：Cancer

authors： Heng DY,Chi KN,Murray N,Jin T,Garcia JA,Bukowski RM,Rini BI,Kollmannsberger C

更新日期：2009-02-15 00:00:00

abstract：BACKGROUND:This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS:Seventeen patients with extremity melanoma who underwent...

journal_title：Cancer

authors： Bartlett DL,Ma G,Alexander HR,Libutti SK,Fraker DL

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:The combination of a platinating agent and etoposide has induced responses in various pediatric tumors. The study estimated the maximum tolerated dose (MTD) of an oxaliplatin and etoposide regimen in children with recurrent solid tumors. METHODS:Oxaliplatin was administered on Day 1 and etoposide on Days 1 ...

journal_title：Cancer

authors： McGregor LM,Spunt SL,Santana VM,Stewart CF,Ward DA,Watkins A,Laningham FH,Ivy P,Furman WL,Fouladi M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Lung carcinoma usually is advanced at the time of presentation and frequently shows metastatic spread. In recent times, prognostic factors such as c-erbB-2 in patients with breast carcinoma have provided useful information and beneficial therapeutic targets. The objective of this study was to evaluate angiog...

journal_title：Cancer

authors： Toomey D,Smyth G,Condron C,Kay E,Conroy R,Foley D,Hong C,Hogan B,Toner S,McCormick P,Broe P,Kelly C,Bouchier-Hayes D

更新日期：2001-11-15 00:00:00

abstract：BACKGROUND:The objective of this study was to characterize chronic disease, health-related quality of life (HRQOL), emotional distress, and social attainment among long-term survivors of neuroblastoma. METHODS:Chronic health conditions among 136 ≥10-year neuroblastoma survivors (median age, 31.9 years; range, 20.2-54....

journal_title：Cancer

authors： Wilson CL,Brinkman TM,Cook C,Huang S,Hyun G,Green DM,Furman WL,Bhakta N,Ehrhardt MJ,Krasin MJ,Robison LL,Ness KK,Hudson MM

更新日期：2020-03-15 00:00:00

abstract：:Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...

journal_title：Cancer

authors： Rosen G,Caparros B,Huvos AG,Kosloff C,Nirenberg A,Cacavio A,Marcove RC,Lane JM,Mehta B,Urban C

更新日期：1982-03-15 00:00:00

abstract：:Without organized clinical trials, we are doomed to repeat our mistakes endlessly. There are many genuine conflicts of interest intrinsic to clinical research. Some of these arise from the necessity of admitting that we as physicians do not know the best way to treat every disease or each patient and that all treatmen...

journal_title：Cancer

authors： Hrushesky WJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the correlation between intratumoral blood flow as assessed by color Doppler ultrasound with stage, tumor grade, depth of invasion, and lymph node metastasis in endometrial carcinoma and determine its clinical usefulness. METHODS:Sixty-six patients with endometria...

journal_title：Cancer

authors： Cheng WF,Chen TM,Chen CA,Wu CC,Huang KT,Hsieh CY,Hsieh FJ

更新日期：1998-05-15 00:00:00

abstract：:The histologic types of lung cancer in 855 patients (747 men and 107 women) from three hospitals and one international study of insulation workers were evaluated. Of these, 196 cases had asbestos exposure. About one half of the cases were diagnosed from surgical slides and one half from autopsy slides. Squamous cell c...

journal_title：Cancer

authors： Auerbach O,Garfinkel L,Parks VR,Conston AS,Galdi VA,Joubert L

更新日期：1984-12-15 00:00:00

abstract：:Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyc...

journal_title：Cancer

authors： Kim TH,McLaren J,Alvarado CS,Wyly JB,Crocker I,Winn K,Singhapakdi S,Ragab A

更新日期：1989-05-15 00:00:00

abstract：:An exceedingly rare tumor arising in the upper lateral vagina is described histologically, histochemically, and ultrastructurally. It is compared to the lesion reported by Okagaki et al. which is considered to represent the same type of tumor. Comparison with synovial sarcomas indicates that the lesion is similar, but...

journal_title：Cancer

authors： Shevchuk MM,Fenoglio CM,Lattes R,Frick HC 2nd,Richart RM

更新日期：1978-07-01 00:00:00

abstract：:We detected cytoplasmic estrogen receptors (ER) in only 4 of 34 (12%) patients with malignant melanoma. The titers as assayed by the dextran-coated charcoal method were 3, 3, 4, and 5 fmol/mg, respectively. Our data indicate that the incidence of melanoma with detectable ER is low, which suggests that any potential cl...

journal_title：Cancer

authors： Creagan ET,Ingle JN,Woods JE,Pritchard DJ,Jiang NS

更新日期：1980-10-15 00:00:00

abstract：BACKGROUND:Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study of a stable liposomal doxor...

journal_title：Cancer

authors： Hong RL,Tseng YL

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the long-term survival and late toxicities of concurrent-adjuvant chemotherapy in patients with stage III through IVB nasopharyngeal carcinoma (NPC) from endemic regions of China. METHODS:Patients with stage III to IVB NPC were assigned randomly to receive radioth...

journal_title：Cancer

authors： Chen Y,Sun Y,Liang SB,Zong JF,Li WF,Chen M,Chen L,Mao YP,Tang LL,Guo Y,Lin AH,Liu MZ,Ma J

更新日期：2013-06-15 00:00:00

abstract：:Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger ...

journal_title：Cancer

authors： Brawn PN,Speights VO,Kuhl D,Riggs M,Spiekerman AM,McCord RG,Coffield KS,Stewart DT,Lind ML

更新日期：1991-10-01 00:00:00

abstract：:Renal cell carcinoma (RCC) has remained refractory to substantive change of its natural history despite intervention with a number of therapeutic modalities. Alpha interferons leukocyte interferon alpha [HuIFN-alpha (Le)] and lymphoblastoid interferon alpha [HuIFN-alpha (Ly)] initially were shown to produce regression...

journal_title：Cancer

authors： Neidhart JA

更新日期：1986-04-15 00:00:00

abstract：:Lobular carcinoma may arise within the epithelial component of fibroadenoma of the breast, as evidenced by 5 cases reported from the files of the Mayo Clinic and 21 cases cited in the literature. The 5 cases reported here occurred in a series of 4000 cases of fibroadenoma during a 43-year period. Lobular carcinoma is ...

journal_title：Cancer

authors： Buzanowski-Konakry K,Harrison EG Jr,Payne WS

更新日期：1975-02-01 00:00:00

abstract：:There are three principal disturbances in bone remodelling that occur in neoplasia affecting the skeleton. The first is an increase in bone turnover that in solid tumors may be confined to sites of metastases or be a generalized phenomenon, most likely related to the secretion of parathyroid hormone-related protein. I...

journal_title：Cancer

authors： Kanis JA,McCloskey EV

更新日期：1997-10-15 00:00:00

abstract：:Fourteen examples of intravenous leiomyomatosis in the FIP files were studied. Growth beyond the uterus occurred in 10 of the 14 examples, largely in vessels in the broad ligament and in uterine and iliac veins. Metastasis to the heart occurred in 1 example. The study provides evidence that is consistent with both the...

journal_title：Cancer

authors： Norris HJ,Parmley T

更新日期：1975-12-01 00:00:00

abstract：:Nine children with acute promyelocytic leukemia (APL) are presented. This series of children represents 7% of all acute leukemias and 21% of acute myelogenous leukemias seen during the same period at the Red Cross War Memorial Children's Hospital. These figures are much higher than the incidence quoted in other series...

journal_title：Cancer

authors： Gilbert RD,Karabus CD,Mills AE

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Patient navigation programs are emerging that aim to address disparities in clinical trial participation among medically underserved populations, including racial/ethnic minorities. However, there is a lack of consensus on the role of patient navigators within the clinical trial process as well as outcome me...

journal_title：Cancer

authors： Ghebre RG,Jones LA,Wenzel JA,Martin MY,Durant RW,Ford JG

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The incidence of rectal cancer in the United States in young patients is considered to be low. Underestimating this incidence may result in a failure to diagnose younger patients with rectal cancer in a timely manner. METHODS:The authors conducted a retrospective cohort study using Surveillance, Epidemiolog...

journal_title：Cancer

authors： Meyer JE,Narang T,Schnoll-Sussman FH,Pochapin MB,Christos PJ,Sherr DL

更新日期：2010-09-15 00:00:00

abstract：:The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point. This pathway is tightly regulated under normal conditions by phosphatases a...

journal_title：Cancer

authors： Burotto M,Chiou VL,Lee JM,Kohn EC

更新日期：2014-11-15 00:00:00

abstract：:The clinicopathologic features and response to therapy of 28 patients with non-Ewing's flat bone sarcoma treated at St. Jude Children's Research Hospital, Memphis, Tennessee, over a 25-year period were reviewed. Twenty-two patients had osteosarcoma, four malignant fibrous histiocytoma, one chondrosarcoma, and one fibr...

journal_title：Cancer

authors： Kellie SJ,Pratt CB,Parham DM,Fleming ID,Meyer WH,Rao BN

更新日期：1990-02-15 00:00:00

abstract：BACKGROUND:Radiation recall is a recurrence of acute toxicity within a previously quiescent radiation field that occurs with subsequent administration of chemotherapy. METHODS:A patient with acquired immune deficiency syndrome (AIDS)-related Kaposi sarcoma (KS) who had radiation recall is reported. The patient was par...

journal_title：Cancer

authors： Stelzer KJ,Griffin TW,Koh WJ

更新日期：1993-02-15 00:00:00

abstract：BACKGROUND:A clinicopathologic evaluation of clinical Stage I and II uterine sarcoma was done by the Gynecologic Oncology Group from 1979-1988. METHODS:After all eligibility criteria were met, 453 cases were evaluable and analyzed for prognostic factors. RESULTS:Of the 301 mixed mesodermal tumors (MMT), 167 were homo...

journal_title：Cancer

authors： Major FJ,Blessing JA,Silverberg SG,Morrow CP,Creasman WT,Currie JL,Yordan E,Brady MF

更新日期：1993-02-15 00:00:00

abstract：:The authors draw on the lessons highlighted in preceding articles in the current supplement to provide recommendations for cancer screening intervention research and to highlight some of the many questions that will require further investigation. ...

journal_title：Cancer

authors： Meissner HI,Vernon SW,Rimer BK,Wilson KM,Rakowski W,Briss PA,Smith RA

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Lesions that contain abundant myoepithelial cells may present as a diagnostic challenge in fine-needle aspiration (FNA) specimens. Potential diagnostic problems may arise due to morphologic heterogeneity of myoepithelial cell-rich lesions and difficulty in predicting malignancy in FNA specimens. An accurate ...

journal_title：Cancer

authors： Darvishian F,Lin O

更新日期：2004-12-25 00:00:00

abstract：:Fifteen oncocytic (oxyphilic granular cell) neoplasms of the salivary glands collected from three large university medical centers are presented. The histologic and ultrastructural criteria that characterize oncocytes are presented and electron micrographs of two of our cases are discussed. Included in the series are ...

journal_title：Cancer

authors： Gray SR,Cornog JL Jr,Seo IS

更新日期：1976-09-01 00:00:00