Effects of hepatic arterial yttrium 90 glass microspheres in dogs.

Abstract:

:A 22-micron glass microsphere called TheraSphere (Theragenics Corp., Atlanta, GA) has been developed in which yttrium 89 oxide is incorporated into the glass matrix and is activated by neutron bombardment to form the beta-emitting isotope yttrium 90 (Y 90) before using the spheres as radiotherapeutic vehicles. The injection of up to 12 times (on a liver weight basis) the anticipated human dose of nonradioactive TheraSphere into the hepatic arteries of dogs was well tolerated and produced clinically silent alterations within centrolobular areas. The hepatic arterial (HA) injection of radioactive TheraSphere also produced portal changes similar to those observed in humans after external beam therapy. While the extent of damage increased with the delivered dose, radiation exposures in excess of 30,000 cGy did not cause total hepatic necrosis and were compatible with survival. No microspheres distributed to the bone marrow and absolutely no myelosuppression was encountered in any animal. Proposed hepatic exposures to humans of 5000 to 10,000 cGy by means of these microspheres, therefore, would appear to be feasible and tolerable. Radiotherapeutic microsphere administration preceded by regional infusion of a radiosensitizing agent and/or immediately following the redistribution of blood flow toward intrahepatic tumor by vasoactive agents can potentially yield a synergistic, highly selective attack on tumors confined to the liver.

journal_name

Cancer

journal_title

Cancer

authors

Wollner I,Knutsen C,Smith P,Prieskorn D,Chrisp C,Andrews J,Juni J,Warber S,Klevering J,Crudup J

doi

10.1002/1097-0142(19880401)61:7<1336::aid-cncr2820

subject

Has Abstract,Author List Incomplete

pub_date

1988-04-01 00:00:00

pages

1336-44

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

61

pub_type

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