Levamisole in primary breast cancer. A controlled study in conjunction with l-phenylalanine mustard.

abstract：:Almost all patients with prostatic cancer will eventually escape the control of the first-line endocrine therapy and relapse. This escape is attributed to selecting and/or cloning preexisting or de novo appearing hormone-independent or resistant cell lines and occurs in most patients after a median time of 12 to 18 mo...

journal_title：Cancer

authors： Mahler C,Denis L

更新日期：1992-07-01 00:00:00

abstract：:CEA-like material was found in 51 of 62 primary human breast carcinomas and in only 2 of 12 fibroadenomas. Levels of carcinoma CEA-like material correlated weakly with cytoplasmic estradiol receptor levels, total cytosol estrogens, and cytosol progesterone. Levels of CEA-like material showed no significant correlation...

journal_title：Cancer

authors： Duffy MJ,O'Connell M,O'Sullivan F,McKenna B,Allen MA,McDonnell L

更新日期：1983-01-01 00:00:00

abstract：:Prostate cancer is the most common male malignancy and the second or third leading cause of cancer death among men in the West. The descriptive epidemiology of prostate cancer suggests that it is a preventable disease. Prevention has the theoretical advantage of not only saving lives, but also reduce the morbidity of ...

journal_title：Cancer

authors： Fleshner N,Zlotta AR

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Cancer patients with single tumors live longer today due to earlier detection and improved treatment methods. For this reason, the authors see more patients who develop a second primary tumor. The etiology of the second tumor can be the same as the first, whether treatment-induced or unknown. The prognoses o...

journal_title：Cancer

authors： Robinson E,Segal R,Struminger L,Faraggi D,El'ad-Yarum R,Mekori T

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:We sought to determine the impact of radical nephrectomy case volume, hospital size, and geographic region on immediate surgical outcomes for patients undergoing radical nephrectomy in academic centers across the country. METHODS:The University HealthSystem Consortium (UHC) Clinical Data Base was queried fo...

journal_title：Cancer

authors： Mitchell RE,Lee BT,Cookson MS,Barocas DA,Duke Herrell S,Clark PE,Smith JA,Chang SS

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Male patients with oral and oropharyngeal cancer are known to have high risk of concomitant esophageal cancer developing. Thus, mass screening programs are pursued to detect such esophageal cancer early, and in a mass screening trial of patients with early oral and oropharyngeal cancer, the efficacy of Lugol...

journal_title：Cancer

authors： Ina H,Shibuya H,Ohashi I,Kitagawa M

更新日期：1994-04-15 00:00:00

abstract：:Ninety-five malignant tumors in the submandibular gland, the sublingual gland, and the minor salivary glands seen in a 25-year period were reviewed. The patients were retrospectively staged using the Union Internationale Contre le Cancer (UICC) classification. The most frequent tumor was adenoid cystic carcinoma, foll...

journal_title：Cancer

authors： Andersen LJ,Therkildsen MH,Ockelmann HH,Bentzen JD,Schiødt T,Hansen HS

更新日期：1991-12-01 00:00:00

abstract：:An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...

journal_title：Cancer

authors： Nakakuma K,Tashiro S,Uemura K,Takayama K

更新日期：1983-10-15 00:00:00

abstract：BACKGROUND:Although Kaposi sarcoma (KS) initially was described over a century ago, its biology remains enigmatic and conflicting. Whereas the classic type occurs mainly in older men of Mediterranean or Eastern European backgrounds and is not linked to impairment of the host immune response, iatrogenic and human immuno...

journal_title：Cancer

authors： Iscovich J,Boffetta P,Franceschi S,Azizi E,Sarid R

更新日期：2000-02-01 00:00:00

abstract：:A case report is presented, believed to be the first documented example of pleomorphic rhabdomyosarcoma developing in the larynx of a child. A review of the literature then follows, with evaluation of the epidemiology, treatment options, and survival of patients with this disease. Cure of this malignancy is more likel...

journal_title：Cancer

authors： Dodd-o JM,Wieneke KF,Rosman PM

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:The management of children with hypothalamic (H) and/or chiasmatic (C) tumors remains controversial. We evaluated the impact of clinical and neuroimaging parameters and primary therapy on overall (OS) and progression-free (PFS) survival and on neuroendocrine and neurocognitive outcome in children with H and/...

journal_title：Cancer

authors： Fouladi M,Wallace D,Langston JW,Mulhern R,Rose SR,Gajjar A,Sanford RA,Merchant TE,Jenkins JJ,Kun LE,Heideman RL

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Breast carcinoma is one of the leading causes of excess mortality rates in Harlem, an inner-city neighborhood with the highest mortality rates and worst life expectancy in New York City. This study reports the results of a breast carcinoma screening and diagnostic program in Harlem. METHODS:Retrospective re...

journal_title：Cancer

authors： Liberman L,Freeman HP,Chandra S,Stein AL,McCord C,Godfrey D,Dershaw DD

更新日期：2002-07-01 00:00:00

abstract：:The mitogen-activated protein kinase/extracellular signal-regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point. This pathway is tightly regulated under normal conditions by phosphatases a...

journal_title：Cancer

authors： Burotto M,Chiou VL,Lee JM,Kohn EC

更新日期：2014-11-15 00:00:00

abstract：BACKGROUND:Despite the characteristic histopathologic appearance of alveolar soft-part sarcoma (ASPS), its histogenesis remains unclear, and cytogenetic analysis of ASPS is limited to eight cases so far because of the extreme rarity of this disease. METHODS:The authors document a cytogenetic study of a primary case of...

journal_title：Cancer

authors： Joyama S,Ueda T,Shimizu K,Kudawara I,Mano M,Funai H,Takemura K,Yoshikawa H

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:DFP-10917, a deoxycytidine nucleoside analogue, has a unique mechanism of action resulting in leukemic cell death when administered for prolonged periods at low doses. The current phase 1/2 study investigated the safety, maximum tolerated dose, and evidence of antileukemic activity for DFP-10917 administered...

journal_title：Cancer

authors： Kantarjian HM,Jabbour EJ,Garcia-Manero G,Kadia TM,DiNardo CD,Daver NG,Borthakur G,Jain N,Waukau JB,Kwari MI,Ravandi F,Anderson BD,Iizuka K,Jin C,Zhang C,Plunkett WK

更新日期：2019-05-15 00:00:00

abstract：:The hepatic histopathology was studied in 125 patients with Hodgkin's disease to determine whether there are any features other than Reed-Sternberg (RS) cells that might aid in the diagnosis of hepatic involvement by the neoplastic process. Liver biopsy specimens from 41 patients with Hodgkin's disease in the liver we...

journal_title：Cancer

authors： Dich NH,Goodman ZD,Klein MA

更新日期：1989-11-15 00:00:00

abstract：BACKGROUND:Recent scientific advances provide the opportunity to identify women in the general population at increased breast cancer risk and to offer effective early detection and disease prevention interventions. METHODS:A pedigree assessment tool (PAT) was designed to identify women in primary care settings who are...

journal_title：Cancer

authors： Hoskins KF,Zwaagstra A,Ranz M

更新日期：2006-10-15 00:00:00

abstract：BACKGROUND:p53 plays a critical role in cellular anticancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of p53 results in an amino acid substitution and could influence p53 function. The authors hypothesized that p53 codon 72 polymorphism may b...

journal_title：Cancer

authors： Li F,Sturgis EM,Chen X,Zafereo ME,Wei Q,Li G

更新日期：2010-05-15 00:00:00

abstract：BACKGROUND:Older adults are an important audience for smoking cessation programs. Over 4.5 million older adults (older than 65) continue to smoke, and the majority are long term, heavy smokers. There is evidence that smoking cessation programs tailored to older smokers can be effective. American Cancer Society (ACS) ma...

journal_title：Cancer

authors： Rimer BK,Orleans CT

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...

journal_title：Cancer

authors： Truica CI,Hansen CH,Garvin DF,Meehan KR

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:The incidence of metastasis to the thyroid gland in autopsy series varies from 1.25% to 24%. Metastasis to the thyroid gland is usually considered a terminal event, and the effectiveness of conventional treatment has been questioned. The authors assessed the effects of current methods of diagnosis and treatm...

journal_title：Cancer

authors： Nakhjavani MK,Gharib H,Goellner JR,van Heerden JA

更新日期：1997-02-01 00:00:00

abstract：:Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive pot...

journal_title：Cancer

authors： Varughese RS,Lam WS,Marican AABH,Viganeshwari SH,Bhave AS,Syn NL,Wang J,Wong AL,Kumar AP,Lobie PE,Lee SC,Sethi G,Goh BC,Wang L

更新日期：2019-06-01 00:00:00

abstract：:Common myths about nutrition education and care of cancer patients are debunked and realities are discussed. First, frequently held misconceptions of nonspecialized health professionals are considered. These include the myths that diet change in the population will be rapid now that dietary guidelines to prevent cance...

journal_title：Cancer

authors： Dwyer J

更新日期：1986-10-15 00:00:00

abstract：:Ninety-five patients with non-oat cell lung cancer underwent resection of all apparent disease and were followed for a minimum of 36 months. Incidence of recurrence was 34% in 47 patients with N0 disease, 65% in 32 patients with N1 disease, and 81.3% in 16 patients with N2 disease (P less than 0.02 and P less than 0.0...

journal_title：Cancer

authors： Iascone C,DeMeester TR,Albertucci M,Little AG,Golomb HM

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:PD-L1 (programmed death ligand 1, B7-H1) is a cell surface glycoprotein that can impair T-cell function. PD-L1 is aberrantly expressed by multiple human malignancies and has been shown to carry a highly unfavorable prognosis in patients with kidney cancer. The role of PD-L1 was evaluated as a mechanism for l...

journal_title：Cancer

authors： Inman BA,Sebo TJ,Frigola X,Dong H,Bergstralh EJ,Frank I,Fradet Y,Lacombe L,Kwon ED

更新日期：2007-04-15 00:00:00

abstract：BACKGROUND:Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous...

journal_title：Cancer

authors： Zhang Y,Sturgis EM,Huang Z,Zafereo ME,Wei Q,Li G

更新日期：2012-01-15 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor-C (VEGF-C) plays an important role in lymphangiogenesis and activates VEGF receptor-3 (VEGFR-3). Lymphatic spread is an important prognostic factor in patients with lung adenocarcinoma. The aim of the current study was to determine whether the expression of VEGF-C and VEGFR...

journal_title：Cancer

authors： Kojima H,Shijubo N,Yamada G,Ichimiya S,Abe S,Satoh M,Sato N

更新日期：2005-10-15 00:00:00

abstract：BACKGROUND:Patients with Stage I Grade 1 endometrial carcinoma have an excellent prognosis and a 10-year survival rate of more than 90%. In every clinical series, however, a few patients in this group have recurrence and die of their disease. METHODS:The authors reviewed 80 patients with Stage I Grade 1 endometrial ca...

journal_title：Cancer

authors： Tornos C,Silva EG,el-Naggar A,Burke TW

更新日期：1992-08-15 00:00:00

abstract：:Fatigue has been described as the most common, most debilitating side effect of cancer treatment and is frequently reported as a long-term complication of treatment as well. Despite the prevalence of fatigue and its profoundly negative effect on patients' quality of life, little is known about the specific mechanisms ...

journal_title：Cancer

authors： Mock V

更新日期：2001-09-15 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GISTs) historically were grouped with leiomyosarcomas (LMSs) based on their morphologic similarities; however, recently, GIST was established unequivocally as a distinct type of sarcoma based on its molecular features and response to imatinib treatment. METHODS:To gain furth...

journal_title：Cancer

authors： Ylipää A,Hunt KK,Yang J,Lazar AJ,Torres KE,Lev DC,Nykter M,Pollock RE,Trent J,Zhang W

更新日期：2011-01-15 00:00:00