The MAPK pathway across different malignancies: a new perspective.

abstract：:Intravenous immunoglobulin (IVIG) has several potential uses in bone marrow transplantation. Most often IVIG is used to modify cytomegalovirus (CMV) infection or CMV-related interstitial pneumonia. It also is used to modify graft versus host disease (GVHD) and decrease infections other than CMV. Another use is to trea...

journal_title：Cancer

authors： Gale RP,Winston D

更新日期：1991-09-15 00:00:00

abstract：:In malignant melanoma, using Sephadex G-200 chromatography and polyacrylamide gel electrophoresis (PAGE), it has been possible to separate two types of skin reactive antigens. The first, found in Sephadex fraction II and PAGE region a appears specific for melanoma. Allogeneic extracts have produced positive reactions ...

journal_title：Cancer

authors： Hollinshead AC

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. MET...

journal_title：Cancer

authors： Hong H,Koch MO,Foster RS,Bihrle R,Gardner TA,Fyffe J,Ulbright TM,Eble JN,Cheng L

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:NR4A2, an orphan nuclear receptor essential in the generation of dopaminergic neurons, has been recently linked to inflammation and cancer. This study sought to identify the role of NR4A2 on chemoresistance and postoperative prognosis of gastric cancer (GC). METHODS:NR4A2 was transfected into GC cells to in...

journal_title：Cancer

authors： Han Y,Cai H,Ma L,Ding Y,Tan X,Chang W,Guan W,Liu Y,Shen Q,Yu Y,Zhang H,Cao G

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The combination of paclitaxel with cisplatin or carboplatin has become the preferred chemotherapy regimen in the treatment of epithelial ovarian carcinoma. Anthracyclines also have activity in this disease. We conducted a Phase II study by using the combination of paclitaxel, cisplatin, and epirubicin for th...

journal_title：Cancer

authors： Papadimitriou CA,Moulopoulos LA,Vlahos G,Voulgaris Z,Kiosses E,Georgoulias N,Gika D,Diakomanolis E,Michalas S,Dimopoulos MA

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:An association between fats and colorectal carcinoma has been suggested, but the epidemiologic evidence by type of dietary fat is far less clear. Colorectal carcinoma rates have been relatively low in Mediterranean countries compared with most other Western countries, but the components of the Mediterranean ...

journal_title：Cancer

authors： Braga C,La Vecchia C,Franceschi S,Negri E,Parpinel M,Decarli A,Giacosa A,Trichopoulos D

更新日期：1998-02-01 00:00:00

abstract：:From November 1987 to April 1989, 1000 women 40 years or older underwent screening vaginal sonography at the University of Kentucky Medical Center (Lexington, KY). Patients included in this investigation were all asymptomatic and had no known pelvic abnormalities. Each ovary was measured in three planes and ovarian vo...

journal_title：Cancer

authors： van Nagell JR Jr,Higgins RV,Donaldson ES,Gallion HH,Powell DE,Pavlik EJ,Woods CH,Thompson EA

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Cisplatin (CDDP) administration concomitant with radiotherapy (RT) for the treatment of locally advanced cervical cancer has evolved from an inpatient 5-day every 21-day regimen to a weekly outpatient regimen. This study was designed to test for differences in progression-free survival (PFS) and toxicity bet...

journal_title：Cancer

authors： Einstein MH,Novetsky AP,Garg M,Hailpern SM,Huang GS,Glueck A,Fields AL,Kalnicki S,Goldberg GL

更新日期：2007-01-01 00:00:00

abstract：:Some variant of mastectomy remains the mainstay of the treatment of the primary tumor for the vast majority of the 110,000 new cases of cancer of the breast which will be treated this year in the United States. Reconstruction of the breast after ablation for cancer has become an integral part of the therapeutic regime...

journal_title：Cancer

authors： Dinner MI,Dowden RV

更新日期：1984-02-01 00:00:00

abstract：:A case of osteosarcoma arising in the soft tissue of the larynx in an elderly man is presented with light and electron microscopic documentation. The patient developed chronic hoarseness and a recurring polypoid laryngeal tumor, causing acute airway obstruction. He was treated by total laryngectomy, but he died with m...

journal_title：Cancer

authors： Dahm LJ,Schaefer SD,Carder HM,Vellios F

更新日期：1978-11-01 00:00:00

abstract：:Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...

journal_title：Cancer

authors： Loewenstein MS,Zamcheck N

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Clear cell tumors of the thyroid gland in general are uncommon. Metastatic renal cell carcinoma (RCC) to the thyroid gland is a rare occurrence but must be considered in the differential diagnosis of a thyroid gland clear cell neoplasm to prevent misclassification, potentially resulting in inappropriate clin...

journal_title：Cancer

authors： Heffess CS,Wenig BM,Thompson LD

更新日期：2002-11-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered intraperitoneally in combination with multidrug chemotherapy using methotrexate (M), vinblastine (V), doxorubicin (A), and cisplatin (C, or for the combination, MVAC) to C3H/He mice (5-week-old females) after experimental carcinoma, MBT...

journal_title：Cancer

authors： Akaza H,Fukushima H,Koiso K,Aso Y

更新日期：1992-02-15 00:00:00

abstract：BACKGROUND:The treatment of metastatic renal cell carcinoma (RCC) with high-dose interleukin-2 (HD IL-2) has resulted in durable tumor regression in a minority of patients. The current study presents the authors' 20-year experience administering this immunotherapeutic agent. METHODS:Patients with metastatic RCC (n = 2...

journal_title：Cancer

authors： Klapper JA,Downey SG,Smith FO,Yang JC,Hughes MS,Kammula US,Sherry RM,Royal RE,Steinberg SM,Rosenberg S

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:Bortezomib is active in heavily pretreated multiple myeloma patients; the dose-limiting toxicity is peripheral neuropathy (PN). METHODS:The authors retrospectively reviewed the incidence, severity, and risk factors for PN in 78 patients who received bortezomib. The median age was 57 years (range, 33-80 year...

journal_title：Cancer

authors： Badros A,Goloubeva O,Dalal JS,Can I,Thompson J,Rapoport AP,Heyman M,Akpek G,Fenton RG

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:The objective of this analysis was to evaluate the role of autologous stem cell transplantation (ASCT) in prolonging disease free survival (DFS) and overall survival (OS) in patients with chronic myeloid leukemia (CML) who received autografts of Philadelphia chromosome (Ph) positive or Ph negative cell harve...

journal_title：Cancer

authors： Koziner B,Dengra C,Lucero G,Klein G,Cánepa C,Milovic V,Milone G,Robinson A,Cerutti I,Saporito G,Kusminsky G,Milone J,Bordone J,Lastiri F,Argentine Group of Bone Marrow Transplantation.

更新日期：2002-12-01 00:00:00

abstract：:The unique characteristics of tumor vasculature represent an attractive target that may be exploited by vascular-targeting anticancer agents. A promising strategy involves the selective disruption of established tumor blood vessels by tumor-vascular disrupting agents (tumor-VDAs), which exhibit antivascular activity, ...

journal_title：Cancer

authors： McKeage MJ,Baguley BC

更新日期：2010-04-15 00:00:00

abstract：BACKGROUND:Angiogenesis in individuals with various solid tumors has provided useful information on tumor progression and prognosis, and many examples of mast cell (MC) accumulation coupled with angiogenesis can be found in the literature. METHODS:Utilizing monoclonal antibodies for tryptase that are specific markers ...

journal_title：Cancer

authors： Takanami I,Takeuchi K,Naruke M

更新日期：2000-06-15 00:00:00

abstract：:The use of preoperative computed tomographic (CT) scans of the chest in carcinoma of the esophagus to associate preoperative staging with postoperative survival is controversial. Thirty-two patients who underwent esophagectomy and reconstruction were examined with respect to a variety of variables available on preoper...

journal_title：Cancer

authors： Lefor AT,Merino MM,Steinberg SM,Dwyer A,Roth JA,Flanagan M,Pass HI

更新日期：1988-10-01 00:00:00

abstract：:Peritoneal mesothelioma in a 61-year-old man, occurred 26 years after abdominal radiotherapy for a testicular seminoma. The patient had no history of asbestos exposure. After asbestos, radiation is the second most frequent defined cause of mesothelioma in North America, but the number of well-documented cases is small...

journal_title：Cancer

authors： Gilks B,Hegedus C,Freeman H,Fratkin L,Churg A

更新日期：1988-05-15 00:00:00

abstract：BACKGROUND:The authors hypothesized that comprehensive genomic profiling of advanced-stage cutaneous squamous cell carcinoma (cSCC) could identify genomic-derived drug targets of therapy for patients with conventional therapy-resistant disease. METHODS:Comprehensive genomic profiling of 315 cancer genes was applied to...

journal_title：Cancer

authors： Al-Rohil RN,Tarasen AJ,Carlson JA,Wang K,Johnson A,Yelensky R,Lipson D,Elvin JA,Vergilio JA,Ali SM,Suh J,Miller VA,Stephens PJ,Ganesan P,Janku F,Karp DD,Subbiah V,Mihm MC,Ross JS

更新日期：2016-01-15 00:00:00

abstract：:Lymphocytic and plasmocytic infiltration surrounding a malignant tumor probably represents an immunologic response of the host directed against the neoplasm. It has been documented that lymphocytic infiltration has a favorable effect on prognosis in a number of human tumor systems, including cutaneous melanoma. In the...

journal_title：Cancer

authors： Lang JR,Davidorf FH,Baba N

更新日期：1977-11-01 00:00:00

abstract：:Two hundred ninety-three patients with Stage IB carcinoma of the uterine cervix were treated by intracavitary irradiation followed by radical hysterectomy and pelvic lymph node dissection in the 3-year period 1970 to 1972, inclusive. Preoperative lymphography was performed and intraoperative films were taken to obtain...

journal_title：Cancer

authors： Kjorstad KE,Kolbenstvedt A,Strickert T

更新日期：1984-11-15 00:00:00

abstract：BACKGROUND:At the time of diagnosis of colorectal carcinoma, 2-3% of patients are likely to be harboring brain metastases, and another 10% of patients will develop brain lesions during the course of their disease. The purpose of this study was to examine the clinical course of a group of patients with metastatic brain ...

journal_title：Cancer

authors： Wroński M,Arbit E

更新日期：1999-04-15 00:00:00

abstract：BACKGROUND:It has been postulated that different biologic characteristics of a tumor might account for at least a portion of the disparity in breast cancer survival for patients across racial and ethnic groups. The hormone receptor status of breast tumors is one characteristic with prognostic significance. Results of s...

journal_title：Cancer

authors： Gapstur SM,Dupuis J,Gann P,Collila S,Winchester DP

更新日期：1996-04-15 00:00:00

abstract：:From January, 1973, to June, 1976, 226 patients with palpable ovarian masses were evaluated preoperatively by lymphography. Histology showed 166 cases of malignant epithelial tumors, 26 benign tumors, and 34 malignant special tumors (not included in this report). Furthermore, the group of patients included 99 recurren...

journal_title：Cancer

authors： Musumeci R,Banfi A,Bolis G,Candiani GB,De Palo G,Di Re F,Lucina L,Lattuada A,Mangioni C,Mattioli G,Natale N

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:The treatment of patients with hepatocellular carcinoma (HCC) presents a major challenge, because associated cirrhosis limits the choice of chemotherapeutic agents. However, the abundant vascularity of HCC presents an attractive target for antiangiogenic therapy that potentially may be tolerated by cirrhotic...

journal_title：Cancer

authors： Patt YZ,Hassan MM,Lozano RD,Nooka AK,Schnirer II,Zeldis JB,Abbruzzese JL,Brown TD

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:Axillary reverse mapping (ARM) is a novel technique to preserve upper extremity lymphatics that may reduce the incidence of lymphedema after axillary lymph node dissection. Early reports have suggested that ARM lymph nodes do not contain metastatic disease from breast cancer; however, these studies were cond...

journal_title：Cancer

authors： Bedrosian I,Babiera GV,Mittendorf EA,Kuerer HM,Pantoja L,Hunt KK,Krishnamurthy S,Meric-Bernstam F

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Assessment of prognostic markers in breast cancer independent of the axillary lymph node status is of major concern for the application of adjuvant treatment regimens. The current treatment decision is based mainly on the axillary lymph node status. Because of improved screening methods, the number and propo...

journal_title：Cancer

authors： Friedrichs K,Gluba S,Eidtmann H,Jonat W

更新日期：1993-12-15 00:00:00

abstract：BACKGROUND:A phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA1/2-mutated (BRCA+) cohort and a wild-type BRCA (BRCA-) cohort. The aims were to determine t...

journal_title：Cancer

authors： O'Reilly EM,Lee JW,Lowery MA,Capanu M,Stadler ZK,Moore MJ,Dhani N,Kindler HL,Estrella H,Maynard H,Golan T,Segal A,Salo-Mullen EE,Yu KH,Epstein AS,Segal M,Brenner R,Do RK,Chen AP,Tang LH,Kelsen DP

更新日期：2018-04-01 00:00:00