Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states.

Abstract:

:Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most often active alcoholic cirrhosis, and also chronic active and viral hepatitis, and cryptogenic and biliary cirrhosis. Patients with benign extrahepatic biliary obstruction may have increased plasma CEA, the highest in patients with co-existent cholangitis and especially liver abscess. The liver appears to be essential for the metabolism and/or excretion of CEA. Hence, liver work-up is needed to assess any patient with an elevated CEA. A damaged liver may further augment elevated CEA levels due to cancer. The increased circulating CEA observed in some patients with active ulcerative colitis tends to correlate with severity and extent of disease and usually returns to normal with remission. CEA levels also may be mildly elevated in patients with pancreatitis and in adults with colonic polyps. Smoking may contribute to the increased CEA levels seen in patients with alcoholic liver disease and pancreatitis. Therefore, in interpreting mildy elevated circulating CEA levels in patients with GI tract diseases, one must consider benign as well as malignant etiologies.

journal_name

Cancer

journal_title

Cancer

authors

Loewenstein MS,Zamcheck N

doi

10.1002/1097-0142(197809)42:3+<1412::aid-cncr28204

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

1412-8

issue

3 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

42

pub_type

杂志文章,评审

相关文献

CANCER文献大全
  • C-cell disease of the thyroid gland in multiple endocrine neoplasia, type 2b.

    abstract::Multiple endocrine neoplasia, type 2b (MEN 2b) is a disorder characterized by C-cell disease of the thyroid gland (medullary carcinoma or C-cell hyperplasia, or both), pheochromocytoma, ganglioneuromatosis, and skeletal and connective tissue abnormalities. The medullary thyroid carcinoma (MTC) is bilateral and multice...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197912)44:6<2173::aid-cncr282044

    authors: Carney JA,Sizemore GW,Hayles AV

    更新日期:1979-12-01 00:00:00

  • Ganglioside composition of human neuroblastomas. Correlation with prognosis. A Pediatric Oncology Group Study.

    abstract::The ganglioside composition of neuroblastoma samples from 53 patients was determined. Tumor sites included the adrenals (15), and the thoracic (20), abdominal (15), and pelvic (3) areas. Age of the patients at the time of surgery ranged from 1 day to over 10 years and the Stage of the tumors from A to D. Differences i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851201)56:11<2640::aid-cncr282

    authors: Schengrund CL,Repman MA,Shochat SJ

    更新日期:1985-12-01 00:00:00

  • Plasma thyroid-stimulating hormone and thyroxine concentrations in breast cancer.

    abstract::Plasma TSH and thyroxine levels were measured in 74 early breast cancer patients and 53 with advanced disease, 77 patients with cancer arising in other organs and 67 healthy women of similar age. The mean plasma TSH levels were higher in the breast cancer cases than the other two groups; the difference was statistical...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197802)41:2<666::aid-cncr2820410

    authors: Rose DP,Davis TE

    更新日期:1978-02-01 00:00:00

  • Proportional mortality among alcoholics.

    abstract::To test the hypothesis that there is a positive association between chronic alcoholism and carcinoma of the pancreas, the mortality experience of 1382 chronic alcoholics was studied. Analysis was limited to a comparison of observed and expected proportional mortality of different causes of death in the 894 whites who ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197509)36:3<1077::aid-cncr282036

    authors: Monson RR,Lyon JL

    更新日期:1975-09-01 00:00:00

  • Viral oncolysate in the management of malignant melanoma. II. Clinical studies.

    abstract::Melanoma cell oncolysate, prepared with Newcastle disease virus, was administered as an immunostimulant to 13 patients with metastatic melanoma. The oncolysate was well tolerated. Six treated patients evidenced a decrease in the size of skin nodules or diseased lymph nodes. Visceral lesions were not favorably influenc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197708)40:2<680::aid-cncr2820400

    authors: Murray DR,Cassel WA,Torbin AH,Olkowski ZL,Moore ME

    更新日期:1977-08-01 00:00:00

  • Cardiac disease after mediastinal irradiation for seminoma.

    abstract::One hundred twenty-four patients with seminoma (119 primary testis, five primary extragonadal) were treated between 1968 and 1984 at the Joint Center for Radiation Therapy. Fifty-seven of the 124 patients were treated with irradiation to the mediastinum as well as to an infradiaphragmatic field. One patient received s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870815)60:4<772::aid-cncr28206

    authors: Lederman GS,Sheldon TA,Chaffey JT,Herman TS,Gelman RS,Coleman CN

    更新日期:1987-08-15 00:00:00

  • Malignant peritoneal mesothelioma after remote abdominal radiation.

    abstract::Peritoneal mesothelioma in a 61-year-old man, occurred 26 years after abdominal radiotherapy for a testicular seminoma. The patient had no history of asbestos exposure. After asbestos, radiation is the second most frequent defined cause of mesothelioma in North America, but the number of well-documented cases is small...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19880515)61:10<2019::aid-cncr282

    authors: Gilks B,Hegedus C,Freeman H,Fratkin L,Churg A

    更新日期:1988-05-15 00:00:00

  • Findings from NSABP Protocol No. B-04: comparison of radical mastectomy with alternative treatments. II. The clinical and biologic significance of medial-central breast cancers.

    abstract::Findings from 1665 women with primary breast cancer, treated at 34 NSABP institutions in Canada and the United States, have failed to demonstrate that patients with medial-central tumors had a greater probability of developing distant metastases or dying than did those with lateral tumors despite the greater incidence...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19811015)48:8<1863::aid-cncr2820

    authors: Fisher B,Wolmark N,Redmond C,Deutsch M,Fisher ER

    更新日期:1981-10-15 00:00:00

  • Laparoscopy and biopsy in malignant liver disease.

    abstract::Laparoscopy is highly effective in diagnosing malignant liver disease, with overall accuracy in the 90% range. Up to 80% of the liver surface can be inspected, and biopsies can be directed with precision. A major advantage over scan guided percutaneous techniques is the ability to detect and biopsy lesions only a few ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Lightdale CJ

    更新日期:1982-12-01 00:00:00

  • Accelerated growth rates of recurrent hepatocellular carcinoma after liver transplantation.

    abstract::The growth rates of recurrent hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLTX) were estimated by calculating the tumor doubling time (TDT) in 20 patients. The mean TDT, calculated by multiple measurement of tumor size, was 44.3 +/- 11.3 days (mean +/- standard error) in 12 patients with pul...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911115)68:10<2095::aid-cncr282

    authors: Yokoyama I,Carr B,Saitsu H,Iwatsuki S,Starzl TE

    更新日期:1991-11-15 00:00:00

  • Chondrosarcoma of the foot. A case report and review of the literature.

    abstract::Chondrosarcoma of the foot is a very unusual entity. A case arising from a solitary osteocartilagenous exostosis is presented and the literature is reviewed and discussed. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197508)36:2<586::aid-cncr2820360

    authors: Lewis MM,Marcove RC,Bullough PG

    更新日期:1975-08-01 00:00:00

  • Hepatic arterial infusion of human recombinant tumor necrosis factor-alpha. An experimental study in dogs.

    abstract::Local and systemic toxicities associated with hepatic arterial infusion of human recombinant tumor necrosis factor (rTNF) were studied in healthy adult mongrel dogs. The animals received saline containing human serum albumin with or without rTNF (0.02, 0.2, or 2.0 mg/m2). Arteriograms were made, and blood samples were...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890601)63:11<2096::aid-cncr282

    authors: Ohkawa S,Wright KC,Mahajan H,Mavligit GM,Wallace S

    更新日期:1989-06-01 00:00:00

  • Prognostic value of DNA ploidy and c-erbB-2 oncoprotein overexpression in adenocarcinoma of Barrett's esophagus.

    abstract:BACKGROUND:During the last two decades, a rising incidence of adenocarcinoma of the esophagus has been observed in the Western world. The prognostic relevance of tumor-biological factors, such as DNA ploidy or c-erbB-2 overexpression, for overall survival following complete resection is still unknown. METHODS:In a ret...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940401)73:7<1785::aid-cncr2820

    authors: Nakamura T,Nekarda H,Hoelscher AH,Bollschweiler E,Harbeck N,Becker K,Siewert JR,Harbec N corrected to Harbeck N

    更新日期:1994-04-01 00:00:00

  • Combined BCG and irradiation treatment of skin metastases originating from malignant melanoma.

    abstract::Treatment with BCG (Bacillus Calmette-Guérin) followed by irradiation was attempted to improve response to therapy by cutaneous metastases from malignant skin melanomas. Both agents were applied in low doses, known to cause minimal side effects. Nineteen patients, divided into three groups, entered the clinical trial....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820915)50:6<1100::aid-cncr2820

    authors: Plesnicar S,Rudolf Z

    更新日期:1982-09-15 00:00:00

  • Disparities in participation in cancer clinical trials in the United States : a symptom of a healthcare system in crisis.

    abstract::Disparities in minorities' representation in cancer clinical trials have been shown only in adult populations, which suggest that the main causes of these disparities relate to health system-based barriers, including issues of poverty (lack of insurance), poor access to trials, and an inadequate number of clinical tri...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23201

    authors: Colon-Otero G,Smallridge RC,Solberg LA Jr,Keith TD,Woodward TA,Willis FB,Dunn AN

    更新日期:2008-02-01 00:00:00

  • Risk factors for primary central nervous system lymphoma: a case-control study.

    abstract:BACKGROUND:The incidence of primary central nervous system lymphoma (PCNSL) has increased over time in both immunocompetent and immunodeficient individuals. The reasons for the increase among immunocompetent patients are unclear. METHODS:The authors conducted a case-control study of PCNSL at the Mayo Clinic based on c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Schiff D,Suman VJ,Yang P,Rocca WA,O'Neill BP

    更新日期:1998-03-01 00:00:00

  • Expression of c-myc oncogene product and ras family oncogene products in various human malignant lymphomas defined by immunohistochemical techniques.

    abstract::The authors studied the expression of c-myc and ras family oncogene products in 43 cases of malignant lymphoma (ML) using the immunoperoxidase method. Unfixed frozen sections of lymph nodes from four patients with Hodgkin's disease and 39 with non-Hodgkin's lymphoma, together with normal lymph nodes, were studied by t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881115)62:10<2085::aid-cncr282

    authors: Mitani S,Sugawara I,Shiku H,Mori S

    更新日期:1988-11-15 00:00:00

  • Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature.

    abstract:BACKGROUND:Hyalinizing clear cell carcinoma (HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is import...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.23974

    authors: Solar AA,Schmidt BL,Jordan RC

    更新日期:2009-01-01 00:00:00

  • Cervical cancer incidence in the United States in the US-Mexico border region, 1998-2003.

    abstract:BACKGROUND:Cervical cancer mortality rates have declined in the United States, primarily because of Papanicolaou testing. However, limited information is available about the incidence of the disease in the US-Mexico border region, where some of the poorest counties in the United States are located. This study was under...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23748

    authors: Coughlin SS,Richards TB,Nasseri K,Weiss NS,Wiggins CL,Saraiya M,Stinchcomb DG,Vensor VM,Nielson CM

    更新日期:2008-11-15 00:00:00

  • Nucleolar organizer regions in precancerous and cancerous lesions of the bronchus.

    abstract::Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910115)67:2<472::aid-cncr28206

    authors: Abe S,Ogura S,Kunikane H,Suko N,Watanabe N,Nakajima I,Kawakami Y,Inoue K

    更新日期:1991-01-15 00:00:00

  • Role of stromal-derived cytokines and growth factors in bone metastasis.

    abstract:BACKGROUND:Interactions between bone marrow-derived cytokines, growth factors, and tumors play a critical role in both the homing of tumors to the bone and the development of bone metastasis. Bone is a storehouse of latent growth factors produced by stromal cells and osteoblasts that, when activated during osteoclastic...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11148

    authors: David Roodman G

    更新日期:2003-02-01 00:00:00

  • Gender representation of cancer patients in medical treatment and psychosocial survivorship research: changes over three decades.

    abstract:BACKGROUND:Prior studies raise concern about gender bias in cancer research, including insufficient inclusion of women or men, or studying women and men differently. The 1993 National Institutes of Health Revitalization Act aimed to eliminate gender bias in medicine. To examine changes in medical and psychological lite...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27432

    authors: Hoyt MA,Rubin LR

    更新日期:2012-10-01 00:00:00

  • Evaluation of cervical cancer by computed tomography: current status.

    abstract::In the evaluation of cervical cancer, computed tomography (CT) is used primarily to stage advanced tumors and evaluate for recurrence. Because of reports that CT imaging lacks sensitivity and specificity in the detection of primary tumors and metastatic lesions, its use in these applications has been limited, but rece...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11684

    authors: Pannu HK,Fishman EK

    更新日期:2003-11-01 00:00:00

  • Therapy of meningeal melanocytomas.

    abstract:BACKGROUND:Meningeal melanocytomas are rare, benign central nervous system lesions with a high probability of recurrence. To the authors' knowledge, approximately 100 cases have been reported since 1972, when the entity first was described. In the current study, four therapies were compared with regard to local control...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20296

    authors: Rades D,Schild SE,Tatagiba M,Molina HA,Alberti W

    更新日期:2004-06-01 00:00:00

  • Chromosome abnormalities in bilateral breast carcinomas. Cytogenetic evaluation of the clonal origin of multiple primary tumors.

    abstract:BACKGROUND:Although acquired somatic mutations presumably are crucial in carcinogenesis, nothing is known about the chromosome aberrations of bilateral breast carcinomas. METHODS:Eighteen specimens from 16 bilateral carcinomas were analyzed cytogenetically. The banding analysis was supplemented with fluorescence in si...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950715)76:2<250::aid-cncr28207

    authors: Pandis N,Teixeira MR,Gerdes AM,Limon J,Bardi G,Andersen JA,Idvall I,Mandahl N,Mitelman F,Heim S

    更新日期:1995-07-15 00:00:00

  • Pathomorphologic evaluation of pulmonary radiofrequency ablation: proof of cell death is characterized by DNA fragmentation and apoptotic bodies.

    abstract:BACKGROUND:Radiofrequency (RF) ablation is an increasingly applied technique. Promising results of hepatic RF ablation raised expectations of its capabilities for treatment of primary and secondary lung tumors. Because of different thermal and electrical properties of lung tissue, compared with liver tissue, a simple a...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.23882

    authors: Clasen S,Krober SM,Kosan B,Aebert H,Fend F,Bomches A,Claussen CD,Pereira PL

    更新日期:2008-12-01 00:00:00

  • Cognitive effects of hormone therapy in men with prostate cancer: a review.

    abstract:BACKGROUND:Men who receive androgen-deprivation therapy (ADT) for prostate cancer experience several side effects from this treatment. A few recent studies have examined the cognitive implications of ADT and how they impact a patient's treatment decision-making, occupational pursuits, and quality of life. For this repo...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.23658

    authors: Nelson CJ,Lee JS,Gamboa MC,Roth AJ

    更新日期:2008-09-01 00:00:00

  • Testis cancer. Ichthyosis constitutes a significant risk factor.

    abstract::Testis cancer and ichthyosis are both relatively rare diseases. Hence the finding of six individuals with both these conditions in a small population with testicular cancer is highly conspicuous and indicates some kind of connection among such persons. Despite the identical clinical appearances of their ichthyoses, th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910201)67:3<730::aid-cncr28206

    authors: Lykkesfeldt G,Bennett P,Lykkesfeldt AE,Micic S,Rørth M,Skakkebaek NE,Svenstrup B

    更新日期:1991-02-01 00:00:00

  • The pathophysiology of undernutrition in the child with cancer.

    abstract::The physiologic consequences of malnutrition in children with cancer are reviewed. It is stressed that the child with cancer has a nutritional state that is no different from the average population from which the child comes. What little malnutrition is seen is calorie malnutrition. The physiologic consequences are th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861015)58:8+<1874::aid-cncr282

    authors: van Eys J

    更新日期:1986-10-15 00:00:00

  • Potential impact on tumor control and organ preservation with cisplatin and 5-fluorouracil for patients with advanced tumors of the paranasal sinuses and nasal fossa. A prospective pilot study.

    abstract:METHODS:Twelve patients with advanced epithelial nonadenocarcinoma of the paranasal sinuses and nasal fossa were treated with three cycles of cisplatin (100 mg/m2, day 1) and 5-fluorouracil (1000 mg/m2/24 hours on days 1-5 by continuous infusion), followed by preoperative external radiation therapy of 48 Gy and limited...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19921201)70:11<2615::aid-cncr282

    authors: Björk-Eriksson T,Mercke C,Petruson B,Ekholm S

    更新日期:1992-12-01 00:00:00