Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature.


BACKGROUND:Hyalinizing clear cell carcinoma (HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is important to recognize the features of this unusual tumor. METHODS:The authors present 8 new, fully characterized cases of HCCC and systematically reviewed 44 other cases of HCCC reported in the English language literature from 1980 to 2008. Historic cases were reviewed, and available data regarding morphology, special stains, demographics, clinical presentation, radiographic findings, management, and outcomes were extracted. Data from the current series were compared with the earlier published literature. RESULTS:To the best of the authors' knowledge, this was the largest reviewed series of HCCC and included a total of 52 cases. The findings, which included key histologic features, clinical presentation, and outcome, generally were consistent with what was reported previously. However, the current review revealed that 25% of patients reported in the literature had metastatases at initial presentation, including 10 of 44 patients who had metastases to regional lymph nodes and 1 patient who had metastasis to the lung. The authors were unable to identify any specific histologic features that would predict this behavior. CONCLUSIONS:The current results indicated that HCCC is less indolent than was believed previously; therefore, regional lymph node dissection should be considered in conjunction with wide local excision for patients with HCC.






Solar AA,Schmidt BL,Jordan RC




Has Abstract


2009-01-01 00:00:00














  • Soft tissue sarcoma with additional anaplastic components. A clinicopathologic and immunohistochemical study of 27 cases.

    abstract::This clinicopathologic study concerns 27 cases of "dedifferentiated" soft tissue sarcoma (DSTS), including 14 liposarcomas, six leiomyosarcomas, five chondrosarcomas, and two rhabdomyosarcomas. In addition, the authors conducted an immunohistochemical survey of 23 cases and an electron microscopic examination of three...


    pub_type: 杂志文章


    authors: Hashimoto H,Daimaru Y,Tsuneyoshi M,Enjoji M

    更新日期:1990-10-01 00:00:00

  • Acute nonlymphocytic leukemia 5 years after treatment with cisplatin, vinblastine, and bleomycin for disseminated testicular cancer.

    abstract::The combination of cisplatin, vinblastine, and bleomycin (PVB) was used to treat a 25-year-old man for disseminated testicular germ cell cancer, leading to a complete remission. Acute nonlymphocytic leukemia (ANLL), resistant to chemotherapy, developed 5 years later. The secondary nature of this ANLL was corroborated ...


    pub_type: 杂志文章


    authors: van Imhoff GW,Sleijfer DT,Breuning MH,Anders GJ,Mulder NH,Halie MR

    更新日期:1986-03-01 00:00:00

  • Restoration of defective EAG-rosetting capacity of cancer patient neutrophils by levamisole.

    abstract::Levamisole, used in vitro at therapeutic concentrations, was found able to restore the defective Fc-receptor activity of cancer patient neutrophils. In addition, the drug prevented the inhibition of normal neutrophils Fc-receptor function by cancer patient sera. The neutrophil Fc-receptor function was also restored in...


    pub_type: 杂志文章


    authors: Patrone F,Dallegri F,Pistoia V,Ghio R,Sacchetti C

    更新日期:1985-04-15 00:00:00

  • Insular thyroid cancer: a population-level analysis of patient characteristics and predictors of survival.

    abstract:BACKGROUND:Insular thyroid cancer (ITC) is an uncommon, poorly differentiated thyroid malignancy. To date, there have been no population-level studies of the characteristics and outcomes of patients with ITC. METHODS:The authors used the Surveillance, Epidemiology, and End Results (SEER) database from 1999 to 2007 to ...


    pub_type: 杂志文章


    authors: Kazaure HS,Roman SA,Sosa JA

    更新日期:2012-07-01 00:00:00

  • Anticancer effects of arterial administration of the anticancer agent SMANCS with lipiodol on metastatic lymph nodes.

    abstract::A new method of arterially administering an oily anticancer agent was successfully established for the selective targeting of metastatic lymph nodes. A high molecular weight anticancer agent, a conjugate of copolymer (styrene maleic acid) to neocarzinostatin (SMANCS) was prepared in our laboratory and dissolved in a l...


    pub_type: 杂志文章


    authors: Ohtsuka N,Konno T,Miyauchi Y,Maeda H

    更新日期:1987-05-01 00:00:00

  • Polymorph phagocytosis by cancer cells in an endometrial adenoacanthoma.

    abstract::A case of endometrial adenoacanthoma is reported in which two histologically distinct populations of cells were identified in the primary tumor. The two cell types differed in that one had phagocytosed large numbers of polymorphonuclear leucocytes. A subsequent skin metastasis was composed entirely of cells capable of...


    pub_type: 杂志文章


    authors: Chandrasoma P

    更新日期:1980-05-01 00:00:00

  • Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Special reference to its detection by the polymerase chain reaction and in situ hybridization in 99 tumors, including a morphologic analysis.

    abstract:BACKGROUND:Gastric carcinoma with lymphoid stroma (GCLS) has been reported to have a more favorable prognosis than ordinary gastric carcinoma, however, the precise mechanism of the pathogenesis for GCLS remains unclear. METHODS:The authors analyzed 99 GCLS in 94 patients for Epstein-Barr virus (EBV) sequences using po...


    pub_type: 杂志文章


    authors: Nakamura S,Ueki T,Yao T,Ueyama T,Tsuneyoshi M

    更新日期:1994-05-01 00:00:00

  • The single palpable thyroid nodule: evaluation by 99mTc-pertechnetate imaging.

    abstract::The role of 99mTc-pertechnetate thyroid imaging in the preoperative assessment of patients with single palpable thyroid nodules was evaluated. The frequency of cancer in hypofunctional nodules was similar to that found in previous studies with 131I. The 99mTc-pertechnetate image allowed a reliable separation of pathol...


    pub_type: 杂志文章


    authors: Alderson PO,Sumner HW,Siegel BA

    更新日期:1976-01-01 00:00:00

  • The chemotherapy of Hodgkin's disease: past experiences and future directions.

    abstract::From the standpoint of chemotherapy, the first progress in the treatment of Hodgkin's disease was the identification of the activity of nitrogen mustard in the 1940's. The initial antitumor effect of the drug created a great excitement. However, when all patients later relapsed, there was subsequent dejection and skep...


    pub_type: 临床试验,历史文章,杂志文章,评审


    authors: DeVita VT Jr,Lewis BJ,Rozencweig M,Muggia FM

    更新日期:1978-08-01 00:00:00

  • Assessing the impact of patient navigation: prevention and early detection metrics.

    abstract:BACKGROUND:The lack of comparable metrics to evaluate prevention and early detection patient navigation programs impeded the ability to identify best practices. METHODS:The Prevention and Early Detection Workgroup of the Patient Navigation Leadership Summit was charged with making recommendations for common clinical m...


    pub_type: 杂志文章,评审


    authors: Battaglia TA,Burhansstipanov L,Murrell SS,Dwyer AJ,Caron SE,Prevention and Early Detection Workgroup, National Patient Navigation Leadership Summit.

    更新日期:2011-08-01 00:00:00

  • K-ras activation in colorectal tumors from patients with familial polyposis coli.

    abstract::K-ras gene mutation in colorectal tumors from patients with familial polyposis coli were investigated using oligonucleotide probes specific for a mutation at codon 12, 13, or 61 of the K-ras gene. The authors examined 22 colorectal carcinomas and 51 colorectal adenomas from 41 familial polyposis coli patients and obse...


    pub_type: 杂志文章


    authors: Sasaki M,Sugio K,Sasazuki T

    更新日期:1990-06-01 00:00:00

  • Primary chemotherapy for obstructive jaundice caused by intermediate-grade non-Hodgkin lymphoma.

    abstract:BACKGROUND:Advanced non-Hodgkin lymphoma (NHL) usually is treated with doxorubicin-based combination chemotherapy. Because doxorubicin is excreted by the biliary route, many authorities recommend alternative initial interventions in patients with NHL causing obstructive jaundice. METHODS:The authors retrospectively re...


    pub_type: 杂志文章


    authors: Dudgeon DJ,Brower M

    更新日期:1993-05-01 00:00:00

  • Quantification of telomerase activity in sporadic colorectal carcinoma: association with tumor growth and venous invasion.

    abstract:BACKGROUND:Activation of telomerase, a ribonucleoprotein enzyme complex that synthesizes telomere repeats, is associated with acquisition of unlimited cellular proliferation and is commonly detected in human cancer. Measurement of telomerase activity (TA) may provide important information as a diagnostic marker or a pr...


    pub_type: 杂志文章


    authors: Shoji Y,Yoshinaga K,Inoue A,Iwasaki A,Sugihara K

    更新日期:2000-03-15 00:00:00

  • The prognosis of patients with stage III melanoma. Prospective long-term study of 286 patients of the Fachklinik Hornheide.

    abstract:BACKGROUND:Prognostic factors for patients with stage III melanoma are still controversial. METHODS:Two hundred eighty-six patients with solitary cutaneous malignant melanoma of the skin in Stage III (International Union Against Cancer [UICC]) were followed up for as long as 11 years. RESULTS:Patients in risk group p...


    pub_type: 杂志文章


    authors: Drepper H,Biess B,Hofherr B,Hundeiker M,Lippold A,Otto F,Padberg G,Peters A,Wiebelt H

    更新日期:1993-02-15 00:00:00

  • 111Indium-bleomycin breast and axilla imaging.

    abstract::111Indium-Bleomycin (111In-Blm), a new radiopharmaceutical, was administered intravenously to 37 patients with benign and malignant breast lesions. Early and delayed images of both the breasts and axillae were made, and results were correlated with physical examination, histopathology of the excised lesion, mammograph...


    pub_type: 杂志文章


    authors: Silverstein MJ,Verma RC,Greenfield L,Morton DL

    更新日期:1976-01-01 00:00:00

  • The role of radical surgery in the management of radiation recurrent and large volume prostate cancer.

    abstract::Twenty-two patients seen between 1975 and 1988 were analyzed who had surgical attempts to cure locally advanced prostate cancer by exenterative procedures or salvage surgery for radiation recurrent disease. Twelve patients (Group I) underwent either a salvage cystoprostatectomy or perineal prostatectomy for radiorecur...


    pub_type: 杂志文章


    authors: Moul JW,Paulson DF

    更新日期:1991-09-15 00:00:00

  • Contemporary prevalence of pretreatment urinary, sexual, hormonal, and bowel dysfunction: Defining the population at risk for harms of prostate cancer treatment.

    abstract:BACKGROUND:The authors investigated the prevalence of pretreatment urinary, sexual, hormonal, and bowel dysfunction in a contemporary, population-based prostate cancer cohort. They also explored the associations between baseline function and age, comorbidity, and timing of baseline survey completion with respect to tre...


    pub_type: 杂志文章


    authors: Resnick MJ,Barocas DA,Morgans AK,Phillips SE,Chen VW,Cooperberg MR,Goodman M,Greenfield S,Hamilton AS,Hoffman KE,Kaplan SH,Paddock LE,Stroup AM,Wu XC,Koyama T,Penson DF

    更新日期:2014-04-15 00:00:00

  • Hemolytic uremic syndrome after high dose chemotherapy with autologous stem cell support.

    abstract:BACKGROUND:Chemotherapy intensification may lead to new forms of toxicity such as hemolytic uremic syndrome. METHODS:Three patients are described who developed this complication 4 to 6 months after high dose chemotherapy followed by autologous stem cell support. The literature on this subject is reviewed. RESULTS:One...


    pub_type: 杂志文章,评审


    authors: van der Lelie H,Baars JW,Rodenhuis S,van Dijk MA,de Glas-Vos CW,Thomas BL,van Oers RH,von dem Borne AE

    更新日期:1995-12-01 00:00:00

  • Survivin expression is associated with bladder cancer presence, stage, progression, and mortality.

    abstract:BACKGROUND:The purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes. METHODS:Immunohistochemical staining for Survivin was carried ...


    pub_type: 杂志文章


    authors: Shariat SF,Ashfaq R,Karakiewicz PI,Saeedi O,Sagalowsky AI,Lotan Y

    更新日期:2007-03-15 00:00:00

  • Systemic giant-cell histiocytosis: report of a case and a review of the adult form of Letterer-Siwe disease.

    abstract::The multiple classifications of histiocytic disorders, and the lack of specificity in their application, have degraded the utility of such diagnostic terms as "Letterer-Siwe Disease" and "Malignant Histiocytosis". A case is presented of a systemic histiocytic proliferation with erythrophagocytosis and giant-cell forma...


    pub_type: 杂志文章,评审


    authors: Wolfson WL,Gossett T,Pagani J

    更新日期:1976-12-01 00:00:00

  • Intent and subsequent initiation of human papillomavirus vaccine among young cancer survivors.

    abstract:BACKGROUND:Despite an increased risk of subsequent human papillomavirus (HPV)-related malignancies, HPV vaccine initiation rates among cancer survivors remain critically low. The purpose of this study was to determine the relationship between HPV vaccine intent and subsequent vaccine initiation among cancer survivors b...


    pub_type: 杂志文章


    authors: Cherven B,Castellino SM,Chen Y,Wong FL,York JM,Wasilewski-Masker K,Hudson MM,Bhatia S,Klosky JL,Landier W

    更新日期:2019-11-01 00:00:00

  • Impact of changes to the American Joint Committee on Cancer T classification on outcome prediction in patients with oropharyngeal cancer.

    abstract:BACKGROUND:The efficacy of the current 6th edition of the American Joint Committee on Cancer (AJCC) tumor staging criteria in improving outcome prediction for patients with oropharyngeal cancer was analyzed. METHODS:From the database of the Department of Radiation Oncology at the University of Texas M. D. Anderson Can...


    pub_type: 杂志文章


    authors: Asper JA,Morrison WH,Rosenthal DI,Ahamad A,Ang KK,Garden AS

    更新日期:2006-05-01 00:00:00

  • Acclerated growth of testicular cancer after cytoreductive surgery.

    abstract::Surgical removal of bulky metastases of non-seminomatous germ-cell testicular cancer has been advocated as an adjuvant to chemotherapy in patients whose disease probably is too extensive to be cured by chemotherapy or surgery alone. However, in 8 of our patients, cytoreductive surgery was followed by a sudden and dram...


    pub_type: 杂志文章


    authors: Lange PH,Hekmat K,Bosl G,Kennedy BJ,Fraley EE

    更新日期:1980-03-15 00:00:00

  • A population-based study of prevalence of complementary methods use by cancer survivors: a report from the American Cancer Society's studies of cancer survivors.

    abstract:BACKGROUND:The use of complementary methods (CMs) is widespread and increasing in the United States. Most literature on CM use among cancer survivors focuses on the treatment period, whereas only a few studies address use further along the cancer continuum. METHODS:This study analyzed the prevalence and the medical an...


    pub_type: 杂志文章


    authors: Gansler T,Kaw C,Crammer C,Smith T

    更新日期:2008-09-01 00:00:00

  • MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy.

    abstract:BACKGROUND:The authors are interested in identifying molecular markers that can aid in the diagnosis of adrenocortical carcinoma (ACC). The aim of this study was to identify microRNAs (miRNAs or miRs) that are differentially expressed in malignant adrenocortical tumors as compared with benign tumors and assess their po...


    pub_type: 杂志文章


    authors: Patterson EE,Holloway AK,Weng J,Fojo T,Kebebew E

    更新日期:2011-04-15 00:00:00

  • Clinical and pathologic features of follicular large cell (nodular histiocytic) lymphoma.

    abstract::Clinicopathologic correlations were made in 50 patients with follicular large cell (FLC) lymphoma to better define the influence of a variety of clinical and pathologic features on survival and the potential for continuous freedom from disease. The 5- and 10-year actuarial survivals for the entire group of patients ar...


    pub_type: 杂志文章


    authors: Horning SJ,Weiss LM,Nevitt JB,Warnke RA

    更新日期:1987-04-15 00:00:00

  • DNA flow cytometric analysis of serous ovarian tumors of low malignant potential.

    abstract:BACKGROUND:Ovarian serous tumors of low malignant potential (STLMP) occasionally progress; a small percentage of patients die of the tumor. There is no known way to predict which tumors will progress. METHODS:Forty STLMP were analyzed by DNA flow cytometry and compared with 26 serous carcinomas. RESULTS:Forty percent...


    pub_type: 杂志文章


    authors: Seidman JD,Norris HJ,Griffin JL,Hitchcock CL

    更新日期:1993-06-15 00:00:00

  • Diabetes in relation to Barrett's esophagus and adenocarcinomas of the esophagus: A pooled study from the International Barrett's and Esophageal Adenocarcinoma Consortium.

    abstract:BACKGROUND:Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. METHODS:Data were harmonized across 13 studies in the International Barrett's and Esophageal Adenocarcinoma Consortium, comprising 2309 esophageal adenocarcinom...


    pub_type: 杂志文章


    authors: Petrick JL,Li N,Anderson LA,Bernstein L,Corley DA,El Serag HB,Hardikar S,Liao LM,Liu G,Murray LJ,Rubenstein JH,Schneider JL,Shaheen NJ,Thrift AP,van den Brandt PA,Vaughan TL,Whiteman DC,Wu AH,Zhao WK,Gammon MD,Coo

    更新日期:2019-12-01 00:00:00

  • Prognostic value of the plasminogen activation system in patients with gastric carcinoma.

    abstract:BACKGROUND:Patients with gastric cancer have a poor prognosis and can be cured by surgery only if the cancer is detected in an early stage. Extended surgery, down staging with chemotherapy before operation, and new postoperative treatments are recent approaches to increase survival rates. Categorizing patients' prognos...


    pub_type: 杂志文章


    authors: Ganesh S,Sier CF,Heerding MM,van Krieken JH,Griffioen G,Welvaart K,van de Velde CJ,Verheijen JH,Lamers CB,Verspaget HW

    更新日期:1996-03-15 00:00:00

  • A survival-stratification model of human colorectal carcinomas with beta-catenin and p27kip1.

    abstract:BACKGROUND:The stabilization and nuclear translocation of beta-catenin are early events in the majority of sporadic colorectal carcinomas (CRC). beta-catenin up-regulates c-Myc and cyclin D1, which antagonize the association of the cyclin-dependent kinase (Cdk) inhibitor, p27(kip1), with Cdk2, thus allowing cell cycle ...


    pub_type: 杂志文章


    authors: Cheah PY,Choo PH,Yao J,Eu KW,Seow-Choen F

    更新日期:2002-12-15 00:00:00