Abstract:
:Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR in the nucleus were normal epithelium 1.2 +/- 0.1 (mean +/- SD), atypical squamous metaplasia (borderline lesion) 2.2 +/- 0.5, carcinoma in situ 3.8 +/- 0.6, and microinvasive squamous cell carcinoma 4.8 +/- 1.1. There was a highly significant difference between the Ag-NOR numbers in the atypical squamous metaplasia and those in the carcinoma in situ (P less than 0.01). The Ag-NOR staining is a useful technique for the differential diagnosis of difficult borderline lesions in the bronchial epithelium.
journal_name
Cancerjournal_title
Cancerauthors
Abe S,Ogura S,Kunikane H,Suko N,Watanabe N,Nakajima I,Kawakami Y,Inoue Kdoi
10.1002/1097-0142(19910115)67:2<472::aid-cncr28206subject
Has Abstractpub_date
1991-01-15 00:00:00pages
472-75issue
2eissn
0008-543Xissn
1097-0142journal_volume
67pub_type
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