Lack of effectiveness of radiotherapy combined with cisplatin in patients with locally advanced pancreatic carcinoma.

Abstract:

BACKGROUND:Cisplatin has been reported to enhance the cell-killing effect of radiation. The current study was conducted to evaluate the efficacy and toxicity of radiotherapy combined with cisplatin in patients with locally advanced pancreatic carcinoma. METHODS:Forty-one patients with pancreatic carcinoma that was unresectable but confined to the pancreatic region were treated with external beam radiation (50.4 grays [Gy] in 28 fractions over 5.5 weeks) and daily cisplatin (5 mg/m(2)/day as a 30-minute infusion just before each radiation fraction). Maintenance 5-fluorouracil (5-FU) (500 mg/m(2)) given once weekly was initiated 1 week after the completion of the chemoradiotherapy and continued until disease progression or unacceptable toxicity. RESULTS:Of the 41 patients, 31 (76%) completed the scheduled course of chemoradiotherapy. The median survival time was 7.7 months, and the 1-year survival rate was 36%. The median progression free survival time was 5.8 months. The first site of failure was distant metastases in 25 patients, locoregional recurrence in 6 patients, and both sites in 1 patient. The major toxicity was leukocytopenia and nausea/emesis. CONCLUSIONS:Radiotherapy with daily cisplatin appears to be inferior to conventional chemoradiotherapy using 5-FU in patients with locally advanced pancreatic carcinoma.

journal_name

Cancer

journal_title

Cancer

authors

Okusaka T,Okada S,Tokuuye K,Wakasugi H,Saisho H,Ishikawa O,Matsuno S,Sato T,Sato K,Non-surgical Treatment Group for Pancreatic Cancer in Japan.

doi

10.1002/1097-0142(20010401)91:7<1384::aid-cncr1142

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

1384-9

issue

7

eissn

0008-543X

issn

1097-0142

pii

10.1002/1097-0142(20010401)91:7<1384::AID-CNCR1142

journal_volume

91

pub_type

临床试验,杂志文章

相关文献

CANCER文献大全
  • Prospective evaluation of the prognostic relevance of molecular staging for urothelial carcinoma.

    abstract:BACKGROUND:Nearly 50% of urothelial carcinoma patients with lymph node-negative invasive cancers recur after radical surgery. In many cases, occult local or lymph node disease may be present but undetectable by current approaches. Reverse-transcriptase polymerase chain reaction (RT-PCR)-detectable mRNA of Uroplakin II ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.21953

    authors: Copp HL,Chin JL,Conaway M,Theodorescu D

    更新日期:2006-07-01 00:00:00

  • Prognostic implications of DNA histogram, DNA content, and histologic changes of regional lymph nodes in patients with lung cancer.

    abstract::Forty-six cases of resected lung cancer, including 20 cases at Stages I and II and 26 cases at Stage III (N2), were subdivided into two groups: a good prognosis group with a longer survival period and a poor prognosis group in which the patients died earlier of the cancer. From paraffin-embedded lymph node tissues of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910301)67:5<1370::aid-cncr2820

    authors: Ogawa J,Iwazaki M,Tsurumi T,Inoue H,Shohtsu A

    更新日期:1991-03-01 00:00:00

  • Hand-mirror variant of acute lymphoblastic leukemia. Evidence for early T-cell lineage in two cases by evaluation with monoclonal antibodies.

    abstract::Lymphoid cells from two patients with hand-mirror variant of acute lymphoblastic leukemia (ALL) were studied with various monoclonal antibodies in attempts to determine their derivation and differentiation. The predominant feature of the malignant bone marrow cells was strong reactivity with antibody 3A1, which stains...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850101)55:1<77::aid-cncr282055

    authors: Gramatzki M,Strong DM,Duval-Arnould B,Morstyn G,Schumacher HR

    更新日期:1985-01-01 00:00:00

  • Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications.

    abstract:BACKGROUND:Recent preclinical explorations strongly support the tumorigenic potential of bile on laryngopharyngeal mucosa. Herein, the authors describe, in bile-related human hypopharyngeal squamous cell carcinoma (HSCC), NF-κB-related messenger RNA (mRNA) and microRNA (miRNA) oncogenic phenotypes similar to those prev...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32369

    authors: Sasaki CT,Doukas SG,Costa J,Vageli DP

    更新日期:2019-10-15 00:00:00

  • Quantification of telomerase activity in sporadic colorectal carcinoma: association with tumor growth and venous invasion.

    abstract:BACKGROUND:Activation of telomerase, a ribonucleoprotein enzyme complex that synthesizes telomere repeats, is associated with acquisition of unlimited cellular proliferation and is commonly detected in human cancer. Measurement of telomerase activity (TA) may provide important information as a diagnostic marker or a pr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(20000315)88:6<1304::aid-cn

    authors: Shoji Y,Yoshinaga K,Inoue A,Iwasaki A,Sugihara K

    更新日期:2000-03-15 00:00:00

  • Malignant mixed tumor of the vagina probably arising in mesonephric rests.

    abstract::An exceedingly rare tumor arising in the upper lateral vagina is described histologically, histochemically, and ultrastructurally. It is compared to the lesion reported by Okagaki et al. which is considered to represent the same type of tumor. Comparison with synovial sarcomas indicates that the lesion is similar, but...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197807)42:1<214::aid-cncr2820420

    authors: Shevchuk MM,Fenoglio CM,Lattes R,Frick HC 2nd,Richart RM

    更新日期:1978-07-01 00:00:00

  • Fine structural characterization of melanosomes in dysplastic nevi.

    abstract::This study characterized the fine structure of melanosomes in melanocytes of the dysplastic nevi in six cases with lentiginous melanocytic dysplasia and one case with epithelioid-cell melanocytic dysplasia, and compared that structure with those of common melanocytic nevi and malignant melanoma. It was found that: fin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850701)56:1<111::aid-cncr28205

    authors: Takahashi H,Horikoshi T,Jimbow K

    更新日期:1985-07-01 00:00:00

  • Analysis of the presenting features of adult acute leukemia: the French-American-British classification.

    abstract::The authors have performed a clinical and statistical analysis of the presenting features of adult acute leukemia classified according to the French-American-British (FAB) hematopathologic criteria. Observations were made on 70 variables of history, physical examination, and laboratory examination recorded for 195 pat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810515)47:10<2460::aid-cncr282

    authors: Burns CP,Armitage JO,Frey AL,Dick FR,Jordan JE,Woolson RF

    更新日期:1981-05-15 00:00:00

  • Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines.

    abstract:BACKGROUND:Vascular endothelial growth factor receptor-1 (VEGFR-1) is one of three receptor tyrosine kinases for VEGF, a key regulator of angiogenesis in cancer. Although VEGFRs initially were believed to be expressed exclusively on endothelial cells (ECs), recent studies have demonstrated the presence of VEGFR-1 on no...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21145

    authors: Wey JS,Fan F,Gray MJ,Bauer TW,McCarty MF,Somcio R,Liu W,Evans DB,Wu Y,Hicklin DJ,Ellis LM

    更新日期:2005-07-15 00:00:00

  • Reserpine and breast cancer.

    abstract::After a series of studies on the linkage of reserpine with breast cancer, both evidence and interpretation appeared to be in conflict. Our case-control survey of long-term, comprehensive records from the Kaiser Foundation Medical Care Program, on 108 hypertensive breast cancer cases and 324 hypertensive controls, matc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197802)41:2<761::aid-cncr2820410

    authors: Kodlin D,McCarthy N

    更新日期:1978-02-01 00:00:00

  • Isolated marrow lymphoma: an entity of possible T-cell derivation.

    abstract::Seven adults had a distinct clinicopathologic type of lymphoproliferative disorder of the bone marrow. All patients presented with weakness and pancytopenia; no evidence of gross extramedullary involvement was found. In 5 cases severe and prolonged bone marrow hypoplasia was associated with combination chemotherapy; 1...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801015)46:8<1767::aid-cncr2820

    authors: Barton JC,Conrad ME,Vogler LB,Parmley RT

    更新日期:1980-10-15 00:00:00

  • Applicability of randomized trials in radiation oncology to standard clinical practice.

    abstract:BACKGROUND:Randomized controlled trials (RCTs) are commonly used to inform clinical practice; however, it is unclear how generalizable RCT data are to patients in routine clinical practice. The authors of this report assessed the availability and applicability of randomized evidence guiding medical decisions in a cohor...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28149

    authors: Apisarnthanarax S,Swisher-McClure S,Chiu WK,Kimple RJ,Harris SL,Morris DE,Tepper JE

    更新日期:2013-08-15 00:00:00

  • Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma.

    abstract:BACKGROUND:The purpose of this article was to evaluate the utility of a pharmacokinetically modeled measure of regional contrast access, based on dynamic contrast-enhanced magnetic resonance imaging (MRI) studies after preoperative chemotherapy, as a predictor of disease free survival in osteosarcoma. METHODS:The kine...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Reddick WE,Wang S,Xiong X,Glass JO,Wu S,Kaste SC,Pratt CB,Meyer WH,Fletcher BD

    更新日期:2001-06-15 00:00:00

  • Significance of plasma PTH-rp in patients with hypercalcemia of malignancy treated with bisphosphonate.

    abstract:BACKGROUND:Hypercalcemia of malignancy (HM) is one of the commonest metabolic complications associated with cancer. Plasma parathyroid hormone-related peptide (PTH-rp) is known to cause hypercalcemia in the vast majority of patients with HM. METHODS:Fifty-two patients with HM were treated with a single infusion of 60 ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940415)73:8<2223::aid-cncr2820

    authors: Wimalawansa SJ

    更新日期:1994-04-15 00:00:00

  • Nephrotoxicity of nitrosoureas.

    abstract::Irreversible and progressive renal parenchymal damage and functional impairment occurred in the majority of patients receiving at least six courses (200 mg/m2 of BCNU and/or methyl CCNU at eight-week intervals) of nitrosoureas for therapy of malignant brain tumors. Seventeen of 18 patients who received at least six co...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810915)48:6<1328::aid-cncr2820

    authors: Schacht RG,Feiner HD,Gallo GR,Lieberman A,Baldwin DS

    更新日期:1981-09-15 00:00:00

  • Guideline-concordant cancer care and survival among American Indian/Alaskan Native patients.

    abstract:BACKGROUND:American Indians/Alaskan Natives (AI/ANs) have the worst 5-year cancer survival of all racial/ethnic groups in the United States. Causes for this disparity are unknown. The authors of this report examined the receipt of cancer treatment among AI/AN patients compared with white patients. METHODS:This was a r...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28683

    authors: Javid SH,Varghese TK,Morris AM,Porter MP,He H,Buchwald D,Flum DR,Collaborative to Improve Native Cancer Outcomes (CINCO).

    更新日期:2014-07-15 00:00:00

  • Prognostic significance of Wilms tumor gene (WT1) mRNA expression in soft tissue sarcoma.

    abstract:BACKGROUND:There have been several recent reports that Wilms tumor gene (WT1) mRNA is overexpressed in many types of neoplasms, and those results suggested that WT1 has oncogenic properties. The objective of the current study was to evaluate the prognostic significance of WT1 mRNA expression in patients with soft tissu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21861

    authors: Sotobori T,Ueda T,Oji Y,Naka N,Araki N,Myoui A,Sugiyama H,Yoshikawa H

    更新日期:2006-05-15 00:00:00

  • The impact of age, treatment, and symptoms on the physical and mental health of cancer patients. A longitudinal perspective.

    abstract:BACKGROUND:To describe continuing care and rehabilitation needs of cancer patients, a longitudinal design (6 months) was performed among patients 50 years of age and older with solid tumors. The study examined how age, type of treatment, site of cancer, and symptom experience affect physical functioning and their menta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941001)74:7+<2128::aid-cncr282

    authors: Given CW,Given BA,Stommel M

    更新日期:1994-10-01 00:00:00

  • Cyclophosphamide therapy and interstitial pulmonary fibrosis.

    abstract::Intersitial pneumonia and pulmonary fibrosis developed in a 72-year-old man during therapy with cyclophosphamide, vincristine, and prednisone. After extensive investigations, including an open lung biopsy, cyclophosphamide appeared to be the cause of the pulmonary disease. Complete disappearance of tachypnea and the p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197610)38:4<1542::aid-cncr282038

    authors: Patel AR,Shah PC,Rhee HL,Sassoon H,Rao KP

    更新日期:1976-10-01 00:00:00

  • Should extrapulmonary small cell cancer be managed like small cell lung cancer?

    abstract:BACKGROUND:The aim of this study was to determine if extrapulmonary small cell carcinomas (EPSCC) should be managed using protocols similar to those for small cell lung cancer (SCLC). METHODS:Treatment strategies, survival, patterns of failure, and prognostic factors for patients with EPSCC were analyzed retrospective...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24858

    authors: Brennan SM,Gregory DL,Stillie A,Herschtal A,Mac Manus M,Ball DL

    更新日期:2010-02-15 00:00:00

  • Young age and outcome for women with early-stage invasive breast carcinoma.

    abstract:BACKGROUND:Patients with invasive breast carcinoma who are ages 35-40 years or younger at the time of diagnosis have been found in several studies to have worse prognosis and higher local failure rates after breast-conserving therapy (BCT) compared with older patients. However, it is uncertain whether specific clinical...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.20523

    authors: Zhou P,Recht A

    更新日期:2004-09-15 00:00:00

  • Rehabilitation of persons with central nervous system tumors.

    abstract::A tumor that affects the central nervous system can have a dramatic impact on the individual affected, as well as his or her family and friends. The tumor, regardless of extent or location, may affect the physical, social, vocational, and emotional capabilities of the individual. Basic aspects of rehabilitation for pa...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(20010815)92:4+<1029::aid-cncr141

    authors: Kirshblum S,O'Dell MW,Ho C,Barr K

    更新日期:2001-08-15 00:00:00

  • A novel arterial infusion chemotherapy for the treatment of patients with advanced pancreatic carcinoma after vascular supply distribution via superselective embolization.

    abstract:BACKGROUND:Patients with American Joint Committee on Cancer Stage IV advanced pancreatic carcinoma have been treated by systemic chemotherapy, intraarterial chemotherapy, radiation therapy, and multidisciplinary treatment using a combination of these. However, the outcome has not always been satisfactory. In the curren...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Homma H,Doi T,Mezawa S,Takada K,Kukitsu T,Oku T,Akiyama T,Kusakabe T,Miyanishi K,Niitsu Y

    更新日期:2000-07-15 00:00:00

  • Prophylactic cranial irradiation in limited-stage small cell lung cancer.

    abstract:BACKGROUND:The role of prophylactic cranial irradiation (PCI) for patients with limited-stage small cell lung cancer (LSSCLC) remains a controversial issue. This study evaluated PCI in patients with LSSCLC who achieved a complete response to initial chemotherapy. METHODS:A retrospective case study of all nonprotocol p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950315)75:6<1302::aid-cncr2820

    authors: Liengswangwong V,Bonner JA,Shaw EG,Foote RL,Frytak S,Richardson RL,Creagan ET,Eagan RT,Su JQ

    更新日期:1995-03-15 00:00:00

  • Ethical communication in clinical trials. Issues faced by data managers in obtaining informed consent.

    abstract:BACKGROUND:Informed consent has been proposed as the optimal method for ensuring the ethical entry of patients into clinical trials. However, it is known that problems with informed consent exist from the perspective of both patients and physicians. This has led to the suggestion that a third party, such as a research ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10994

    authors: Loh WY,Butow PN,Brown RF,Boyle F

    更新日期:2002-12-01 00:00:00

  • Pulmonary metastases in children and young adults with differentiated thyroid cancer.

    abstract:BACKGROUND:The prognostic significance and optimal care of children with differentiated thyroid cancer and pulmonary metastases are not well established. METHODS:Of 209 patients younger than 25 years of age who were treated at University of Texas M. D. Anderson Cancer Center between 1960 and 1990 and for whom there wa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930215)71:4<1348::aid-cncr2820

    authors: Vassilopoulou-Sellin R,Klein MJ,Smith TH,Samaan NA,Frankenthaler RA,Goepfert H,Cangir A,Haynie TP

    更新日期:1993-02-15 00:00:00

  • Intrahepatic mitomycin C as a salvage treatment for patients with hepatic metastases from colorectal carcinoma.

    abstract::Sixty-four evaluable patients with hepatic metastases from colorectal carcinoma, who did not have evidence of extrahepatic disease, were treated with intrahepatic (IH) mitomycin C (M) after disease progression or intolerance to treatment with IH fluorodeoxyuridine (FUDR). Eleven patients (17%) had a partial response (...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891201)64:11<2203::aid-cncr282

    authors: Schneider A,Kemeny N,Chapman D,Niedzwiecki D,Oderman P

    更新日期:1989-12-01 00:00:00

  • Total RNA yield and microarray gene expression profiles from fine-needle aspiration biopsy and core-needle biopsy samples of breast carcinoma.

    abstract:BACKGROUND:Gene expression profiling should be applicable to needle biopsy samples if microarray technology is to become practically useful for clinical research or management of breast carcinoma. This study compared gene expression profiles derived from fine-needle aspiration biopsy (FNAB) and from core needle biopsy ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11435

    authors: Symmans WF,Ayers M,Clark EA,Stec J,Hess KR,Sneige N,Buchholz TA,Krishnamurthy S,Ibrahim NK,Buzdar AU,Theriault RL,Rosales MF,Thomas ES,Gwyn KM,Green MC,Syed AR,Hortobagyi GN,Pusztai L

    更新日期:2003-06-15 00:00:00

  • Hematogenous metastases to the stomach. A review of 67 cases.

    abstract::Metastatic tumors to the mucosa of the stomach are unusual occurrences that can cause clinical and pathologic problems in diagnosis. The authors report 67 cases from the files of the Veterans Administration Center at Houston. Ten cases were found on endoscopic biopsy and 57 at necropsy. Each patient endoscopically eva...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900401)65:7<1596::aid-cncr2820

    authors: Green LK

    更新日期:1990-04-01 00:00:00

  • Estimates of lead time and length bias in a breast cancer screening program.

    abstract::Assume that the benefit of screening for breast cancer with a combination of mammography and a clinical examination is measured by comparing the five-year survival rate of women detected by screening to the five-year survival rate of women surface clinically with breast cancer, e.g., to the survival rate of women repo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800815)46:4<844::aid-cncr28204

    authors: Shwartz M

    更新日期:1980-08-15 00:00:00