Young age and outcome for women with early-stage invasive breast carcinoma.

Abstract:

BACKGROUND:Patients with invasive breast carcinoma who are ages 35-40 years or younger at the time of diagnosis have been found in several studies to have worse prognosis and higher local failure rates after breast-conserving therapy (BCT) compared with older patients. However, it is uncertain whether specific clinical, pathologic, or treatment factors affect these results, or whether mastectomy yields a better outcome. METHODS:Articles addressing how patient age at the time of diagnosis affects treatment outcome were identified through the MEDLINE and CancerLit databases and the reference lists of relevant articles. RESULTS:Young age was found to remain an independent risk factor for worse outcome after either BCT or mastectomy. Limited evidence did not demonstrate a superior outcome with mastectomy compared with BCT. Recent studies of BCT still reported young age to be associated with higher local recurrence rates compared with that for older patients, but their interpretation was hampered by inadequate margin assessment for ductal carcinoma in situ. Adjuvant chemotherapy has been found to improve local control rates substantially for young patients after BCT. CONCLUSIONS:To the authors' knowledge, there are insufficient data to determine whether young patients have superior long-term outcome if treated by mastectomy compared with BCT, or whether having truly uninvolved margins abrogates their increased risk of local failure after BCT. When meticulous attention is given to surgical techniques and margin status, it appears that young age at the time of diagnosis need not be a contraindication to BCT.

journal_name

Cancer

journal_title

Cancer

authors

Zhou P,Recht A

doi

10.1002/cncr.20523

subject

Has Abstract

pub_date

2004-09-15 00:00:00

pages

1264-74

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

101

pub_type

杂志文章,评审

相关文献

CANCER文献大全
  • Recurrence of early gastric cancer. Follow-up of 1475 patients and review of the Japanese literature.

    abstract:BACKGROUND:The outcome of surgical treatment for early gastric cancer (EGC) generally is considered to be satisfactory. Although a small percentage of patients experience disease recurrence, the absolute number of such instances is too small for assessment of risk factors. METHODS:The authors investigated the follow-u...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19931201)72:11<3174::aid-cncr282

    authors: Sano T,Sasako M,Kinoshita T,Maruyama K

    更新日期:1993-12-01 00:00:00

  • Clear cell carcinoma of the uterine endocervix with an in situ component.

    abstract::In the past all clear cell carcinomas of the female genital tract were thought to arise from mesonephric remnants. Recently increasing evidence has related their origin to müllerian rather than mesonephric epithelium. One of the main reasons that has been advanced to support their mesonephric origin has been their occ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197811)42:5<2435::aid-cncr282042

    authors: Hasumi K,Ehrmann RL

    更新日期:1978-11-01 00:00:00

  • Indicators of survival duration in ovarian cancer and implications for aggressiveness of care.

    abstract:BACKGROUND:Ovarian cancer patients frequently receive chemotherapy near the end of life. The purpose of the current study was to develop indicators that characterize those ovarian cancer patients who have a short life span. METHODS:The medical charts of deceased epithelial ovarian cancer patients were retrospectively ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.23391

    authors: von Gruenigen V,Daly B,Gibbons H,Hutchins J,Green A

    更新日期:2008-05-15 00:00:00

  • Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study.

    abstract:BACKGROUND:To eliminate cranial irradiation (CrRT)-related sequelae and to minimize the adverse impact of traumatic lumbar puncture (TLP) with blasts, the Taiwan Pediatric Oncology Group (TPOG) introduced a modified central nervous system (CNS)-directed regimen characterized by delayed triple intrathecal therapy (TIT) ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.31758

    authors: Yeh TC,Liang DC,Hou JY,Jaing TH,Lin DT,Yang CP,Peng CT,Hung IJ,Lin KH,Hsiao CC,Jou ST,Chiou SS,Chen JS,Wang SC,Chang TK,Wu KH,Sheen JM,Yen HJ,Chen SH,Lu MY,Li MJ,Chang TT,Huang TH,Chang YH,Chen SH,Yang Y

    更新日期:2018-12-01 00:00:00

  • Pleuropulmonary blastoma. The so-called pulmonary blastoma of childhood.

    abstract::The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells with blastematous qualities separ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19881015)62:8<1516::aid-cncr2820

    authors: Manivel JC,Priest JR,Watterson J,Steiner M,Woods WG,Wick MR,Dehner LP

    更新日期:1988-10-15 00:00:00

  • Dose-ranging antiemetic evaluation of the serotonin antagonist tropisetron in patients receiving anti-cancer chemotherapy.

    abstract:BACKGROUND:Tropisetron (ICS 205-930) antagonizes the serotonin type 3 receptor and has antiemetic activity in animals given cisplatin. Its mean serum half-life in 11.1 hours. METHODS:In this dose-ranging trial, 22 patients undergoing anti-cancer chemotherapy received 24 courses of a single intravenous infusion of trop...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930101)71:1<226::aid-cncr28207

    authors: Pisters KM,Kris MG,Tyson LB,Clark RA,Gralla RJ

    更新日期:1993-01-01 00:00:00

  • Immunostimulation with intrapleural BCG as adjuvant therapy in resected non-small cell lung cancer. The Ludwig Lung Cancer Study Group (LLCSG).

    abstract::A prospective randomized trial was performed to evaluate the role of adjuvant local immunostimulation with bacillus Calmette-Guérin (BCG) in resected Stage I and Stage II non-small cell bronchogenic carcinoma. The patients were stratified according to extent of resection and surgical stage, and randomized to treatment...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19861201)58:11<2411::aid-cncr282

    authors:

    更新日期:1986-12-01 00:00:00

  • Reverse stage shift at a tertiary care center: escalating risk in men undergoing radical prostatectomy.

    abstract:BACKGROUND:The objective of this study was to evaluate changes in clinical and pathologic characteristics of prostate cancer in patients who underwent surgery at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). METHODS:The authors retrospect...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26132

    authors: Silberstein JL,Vickers AJ,Power NE,Fine SW,Scardino PT,Eastham JA,Laudone VP

    更新日期:2011-11-01 00:00:00

  • The genetics of childhood cancer.

    abstract::Retinoblastoma should not be considered as the exceptional childhood cancer that shows dominant inheritance, but rather as the typical childhood cancer that embraces a prezygotic and postzygotic subgroup. Postzygotic cases are conceived as involving mutation as a first step too, but with the mutation in somatic rather...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197503)35:3+<1022::aid-cncr28203

    authors: Knudson AG Jr

    更新日期:1975-03-01 00:00:00

  • A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment.

    abstract:BACKGROUND:Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor of the vascular endothelial growth factor receptors 1 through 3 (VEGFR1-VEGFR3), fibroblast growth factor receptors 1 through 4 (FGFR1-FGFR4), platelet-derived growth factor receptor α (PDGFRα), ret proto-oncogene (RET), and v-kit Hardy-Zuckerman...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29395

    authors: Cabanillas ME,Schlumberger M,Jarzab B,Martins RG,Pacini F,Robinson B,McCaffrey JC,Shah MH,Bodenner DL,Topliss D,Andresen C,O'Brien JP,Ren M,Funahashi Y,Allison R,Elisei R,Newbold K,Licitra LF,Sherman SI,Ball DW

    更新日期:2015-08-15 00:00:00

  • Infants younger than 1 year of age with rhabdomyosarcoma.

    abstract::Of a total of 1561 patients registered in the Intergroup Rhabdomyosarcoma Study (IRS) as of May 1983, 78 patients (5%) were younger than 1 year of age. These infants did not differ from the older children (1-20 years of age) in male/female ratio, clinical grouping, or survival rates. Infants younger than 1 year of age...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861215)58:12<2606::aid-cncr282

    authors: Ragab AH,Heyn R,Tefft M,Hays DN,Newton WA Jr,Beltangady M

    更新日期:1986-12-15 00:00:00

  • Meningeal carcinomatosis in breast cancer presenting as central hypoventilation: a case report with a brief review of the literature.

    abstract::Meningeal carcinomatosis can appear with a variety of neurologic signs and symptoms. Alterations in respiratory control have not been reported in this syndrome or in neurologic syndromes associated with systemic cancer. The authors report on a case of documented leptomeningeal carcinoma from breast cancer presenting a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810301)47:5<982::aid-cncr28204

    authors: Marcus FS,Dandolos EM,Friedman MA

    更新日期:1981-03-01 00:00:00

  • Treatment of patients with lymphomas of the uterus or cervix with combination chemotherapy and radiation therapy.

    abstract:BACKGROUND:Primary lymphomas of the uterus or cervix are so rare that treatment series of single institutions consist of very small numbers of patients, making standard treatment difficult to define. The outcome of patients treated with a combination of chemotherapy and radiation therapy was analyzed for all but patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950501)75:9<2392::aid-cncr2820

    authors: Stroh EL,Besa PC,Cox JD,Fuller LM,Cabanillas FF

    更新日期:1995-05-01 00:00:00

  • Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study.

    abstract:BACKGROUND:Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In the current study, we described the prevalence of sedentary behaviors in survivors of ALL...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31162

    authors: Howell CR,Wilson CL,Ehrhardt MJ,Partin RE,Kaste SC,Lanctot JQ,Pui CH,Robison LL,Hudson MM,Ness KK

    更新日期:2018-03-01 00:00:00

  • Prognostic value of the plasminogen activation system in patients with gastric carcinoma.

    abstract:BACKGROUND:Patients with gastric cancer have a poor prognosis and can be cured by surgery only if the cancer is detected in an early stage. Extended surgery, down staging with chemotherapy before operation, and new postoperative treatments are recent approaches to increase survival rates. Categorizing patients' prognos...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19960315)77:6<1035::aid-cn

    authors: Ganesh S,Sier CF,Heerding MM,van Krieken JH,Griffioen G,Welvaart K,van de Velde CJ,Verheijen JH,Lamers CB,Verspaget HW

    更新日期:1996-03-15 00:00:00

  • Malignant mixed tumor of salivary origin: a clinicopathologic study of 146 cases.

    abstract::A 30-year Memorial Hospital experience with 146 patients with malignant mixed tumor is reviewed. These comprised 5% of 2,743 patients who were treated for salivary neoplasms from 1939 through 1968. The tumors arose in the parotid gland in 108 patients, submaxillary gland in 23 patients, mucus or so-called minor saliva...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197702)39:2<388::aid-cncr2820390

    authors: Spiro RH,Huvos AG,Strong EW

    更新日期:1977-02-01 00:00:00

  • Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood.

    abstract::Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3 partial remissions...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197903)43:3<1089::aid-cncr282043

    authors: Lobel JS,O'Brien RT,McIntosh S,Aspnes GT,Capizzi RL

    更新日期:1979-03-01 00:00:00

  • Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background.

    abstract:BACKGROUND:A novel pancreatic carcinoma cell line, FAMPAC, was identified from investigation of poorly differentiated pancreatic adenocarcinoma cells found in a patient with a familial predisposition to pancreatic carcinoma. A gene responsible for familial pancreatic carcinoma has not been identified to date. METHODS:...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20193

    authors: Eisold S,Ryschich E,Linnebacher M,Giese T,Nauheimer D,Wild A,Bartsch DK,Büchler MW,Schmidt J

    更新日期:2004-05-01 00:00:00

  • The fine structure of astroblastoma.

    abstract::An astroblastoma in the cerebrum was investigated with the electron microscope. A distinctive feature of the tumor was the radial arrangement of astrocytic cells around the blood vessels. The blood vessels in the tumor commonly exhibited fenestrated endothelial cells. The endothelium was generally surrounded by lamell...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850215)55:4<745::aid-cncr28205

    authors: Kubota T,Hirano A,Sato K,Yamamoto S

    更新日期:1985-02-15 00:00:00

  • Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C. A long term follow-up study after histologic diagnosis.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) occurs more frequently in patients with hepatitis C virus (HCV)-related chronic liver disease than those with hepatitis B virus-related disease. It is important to assess the factors affecting the development of HCC. METHODS:A long term follow-up study involving patients with ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Aizawa Y,Shibamoto Y,Takagi I,Zeniya M,Toda G

    更新日期:2000-07-01 00:00:00

  • Effect of human leukocyte interferon on malignant brain tumors.

    abstract::The antitumor effect of human leukocyte interferon was investigated on ten patients with malignant brain tumor. In eight cases of primary tumor, IFN alone was administered when their recurrent sign was evident. A dose of 3 X 10(6) IU or 1 X 10(6) IU of IFN was injected intramuscularly two or three times a week in high...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830601)51:11<1976::aid-cncr282

    authors: Hirakawa K,Ueda S,Nakagawa Y,Suzuki K,Fukuma S,Kita M,Imanishi J,Kishida T

    更新日期:1983-06-01 00:00:00

  • Transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation.

    abstract:BACKGROUND:Transitional cell carcinoma (TCC) is rare in the female genital tract. Although it is most common in the ovary, small series of cases in the cervix have been reported, with isolated cases described in the fallopian tube, adnexa uteri, and endometrium. METHODS:Eight cases of primary TCC involving the endomet...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Lininger RA,Ashfaq R,Albores-Saavedra J,Tavassoli FA

    更新日期:1997-05-15 00:00:00

  • Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma.

    abstract:BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10899

    authors: Ozaki Y,Kontani K,Hanaoka J,Chano T,Teramoto K,Tezuka N,Sawai S,Fujino S,Yoshiki T,Okabe H,Ohkubo I

    更新日期:2002-11-01 00:00:00

  • Results of a multicenter, randomized, double-blind phase 2/3 study of lenalidomide in the treatment of pretreated relapsed or refractory metastatic malignant melanoma.

    abstract:BACKGROUND:The results of an international, multicenter, randomized, double-blind, controlled study assessing the efficacy and safety of lenalidomide treatment in patients with refractory stage IV metastatic malignant melanoma are reported. METHODS:The study compared treatment with lenalidomide (25 mg/d on Days 1-21 o...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.24686

    authors: Eisen T,Trefzer U,Hamilton A,Hersey P,Millward M,Knight RD,Jungnelius JU,Glaspy J

    更新日期:2010-01-01 00:00:00

  • Computed tomography scan-driven selection of treatment for retroperitoneal liposarcoma histologic subtypes.

    abstract:BACKGROUND:Well differentiated (WD) and dedifferentiated (DD) retroperitoneal liposarcoma (RPLS) have distinct biologic behaviors. Consequently, the therapeutic approaches for these tumors differ and mandate an accurate preoperative diagnosis. The authors of this report evaluated whether computed tomography (CT) can be...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.24045

    authors: Lahat G,Madewell JE,Anaya DA,Qiao W,Tuvin D,Benjamin RS,Lev DC,Pollock RE

    更新日期:2009-03-01 00:00:00

  • Multivariate analysis for histologic prognostic factors in soft tissue sarcomas.

    abstract::To investigate histologic prognostic factors in soft tissue sarcomas (STS), multivariate analysis was performed on 236 patients with complete clinical information. These included 141 males and 95 females with an age range from 1 to 85 years (median, 47.6 years). Histologically, malignant fibrous histiocytoma (33.5%) w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880901)62:5<994::aid-cncr28206

    authors: Tsujimoto M,Aozasa K,Ueda T,Morimura Y,Komatsubara Y,Doi T

    更新日期:1988-09-01 00:00:00

  • Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries.

    abstract:BACKGROUND:Endometrial cancer (EC) is the most common extraintestinal malignancy in Lynch syndrome (LS) and often is the sentinel malignancy, yet there is no consensus regarding LS-EC detection algorithms. In this study, the authors determined the efficacy of family/personal history and tumor morphology in predicting L...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26323

    authors: Ryan P,Mulligan AM,Aronson M,Ferguson SE,Bapat B,Semotiuk K,Holter S,Kwon J,Kalloger SE,Gilks CB,Gallinger S,Pollett A,Clarke BA

    更新日期:2012-02-01 00:00:00

  • Maternal and perinatal characteristics in relation to neuroblastoma.

    abstract:BACKGROUND:Neuroblastoma is the most common malignancy among infants, but risk factors remain poorly understood. Because most patients present in the first few years of life, it has been hypothesized that prenatal and perinatal exposures may contribute to the pathogenesis of neuroblastoma. METHODS:A population-based c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22486

    authors: Chow EJ,Friedman DL,Mueller BA

    更新日期:2007-03-01 00:00:00

  • Clinical behavior of recurrent hormone receptor-positive breast cancer by adjuvant endocrine therapy within the Breast International Group 1-98 clinical trial.

    abstract:BACKGROUND:Endocrine therapy resistance is a major cause of distant recurrence (DR) in hormone receptor-positive breast cancer. This study evaluated differences in survival after DR in patients treated with different adjuvant endocrine therapy regimens in the Breast International Group (BIG) 1-98 trial. METHODS:BIG 1-...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33318

    authors: Leone JP,Cole BF,Regan MM,Thürlimann B,Coates AS,Rabaglio M,Giobbie-Hurder A,Gelber RD,Ejlertsen B,Harvey VJ,Neven P,Láng I,Bonnefoi H,Wardley A,Goldhirsch A,Di Leo A,Colleoni M,Vaz-Luis I,Lin NU

    更新日期:2020-12-08 00:00:00

  • Malignant peripheral neuroectodermal tumors. A retrospective analysis of 42 patients.

    abstract::The clinical presentation of the disease and the results of treatment in 42 patients with malignant peripheral neuroectodermal tumors (MPNT) entered into the Cooperative Ewing's, soft tissue, and neuroblastoma trials of the German Society of Pediatric Oncology were retrospectively analyzed. Within the Ewing's sarcoma ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880115)61:2<349::aid-cncr28206

    authors: Jürgens H,Bier V,Harms D,Beck J,Brandeis W,Etspüler G,Gadner H,Schmidt D,Treuner J,Winkler K

    更新日期:1988-01-15 00:00:00