Pleuropulmonary blastoma. The so-called pulmonary blastoma of childhood.


:The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells with blastematous qualities separated by an uncommitted stroma. Focal rhabdomyosarcomatous, chondrosarcomatous, and liposarcomatous differentiation was observed. Epithelial components had bland cytologic features and probably represented entrapped benign epithelium and/or mesothelium. The prognosis for these patients was grave; seven patients died of their disease 5 months to 2 years after diagnosis. Two patients have survived disease-free for 10 and 12 years after diagnosis. Two recent cases are alive 14 and 32 months after diagnosis. This neoplasm constitutes a distinct entity which has been reported in the literature as pulmonary blastoma in children. It differs from pulmonary blastoma in adults because of its variable anatomic location, primitive embryonic-like blastema and stroma, absence of a carcinomatous component, and potential for sarcomatous differentiation. The designation of pleuropulmonary blastoma is suggested by the authors for these intrathoracic neoplasms of childhood rather than pulmonary blastoma for histogenetic and anatomic reasons. The clinicopathologic features, immunophenotypic and ultrastructural characteristics, possible histogenesis, and differential diagnosis of these neoplasms from other thoracopulmonary tumors in children serve as the basis for this report.






Manivel JC,Priest JR,Watterson J,Steiner M,Woods WG,Wick MR,Dehner LP




Has Abstract


1988-10-15 00:00:00














  • Transgenic models for the study of prostate cancer.

    abstract::Transgenic model systems provide tools for obtaining information that clarifies important relationships between genetic alterations and carcinogenesis. One such relationship is the induction of specific growth factor activities by dominantly acting oncogenes. Using a "transgenic organ" model referred to as mouse prost...


    pub_type: 杂志文章,评审


    authors: Thompson TC,Truong LD,Timme TL,Kadmon D,McCune BK,Flanders KC,Scardino PT,Park SH

    更新日期:1993-02-01 00:00:00

  • Comparative analysis of the sensitivity of endometrial cancer cells to epidermal growth factor and steroid hormones.

    abstract:BACKGROUND:Epidermal growth factor (EGF) and EGF-regulated processes play an important role in steroid signal transduction. Comparative analysis of EGF and steroid receptor expression and the sensitivity of early stages of proliferation induction, such as activation of phospholipid turnover to EGF and steroids, may pro...


    pub_type: 杂志文章


    authors: Gershtein ES,Shatskaya VA,Kostyleva OI,Ermilova VD,Kushlinsky NE,Krasil'nikov MA

    更新日期:1995-12-15 00:00:00

  • Imaging assessment of the responses of osteosarcoma patients to preoperative chemotherapy: angiography compared with thallium-201 scintigraphy.

    abstract:BACKGROUND:Assessment of the responses of osteosarcoma patients to preoperative chemotherapy is of clinical importance. The purpose of this study was to estimate the accuracy of angiography and thallium-201 scintigraphy, compared with histology, in assessing the responses of patients with osteosarcoma to preoperative c...


    pub_type: 杂志文章


    authors: Kunisada T,Ozaki T,Kawai A,Sugihara S,Taguchi K,Inoue H

    更新日期:1999-09-15 00:00:00

  • High-dose methotrexate in small cell lung cancer. Lack of efficacy in preventing CNS relapse.

    abstract::Few studies have incorporated high-dose methotrexate (MTX) with leucovorin rescue in the treatment of small cell lung cancer (SCLC). Potentially therapeutic levels of MTX can be achieved in the central nervous system (CNS) by systemic administration of high doses of this drug. Utilizing a combination chemotherapy prog...


    pub_type: 杂志文章


    authors: Neijstrom ES,Capizzi RL,Rudnick SA,Kirsch M,Delaney D,Kahn L,Lipper S,Carney C

    更新日期:1983-03-15 00:00:00

  • The role of tumor resection in the treatment of glioblastoma multiforme in adults.

    abstract:BACKGROUND:The therapeutic impact of tumor resection is poorly defined. Therefore the current study was conducted. METHODS:A retrospective, 2-institutional study was conducted (1991-1994) to compare the treatment results of stereotactic biopsy plus radiation therapy (99 patients; tumor dose: 60 gray [Gy]) with those o...


    pub_type: 杂志文章,多中心研究


    authors: Kreth FW,Berlis A,Spiropoulou V,Faist M,Scheremet R,Rossner R,Volk B,Ostertag CB

    更新日期:1999-11-15 00:00:00

  • Relationship of radioactive radon daughters and cigarette smoking in the genesis of lung cancer in uranium miners.

    abstract::This article documents the study of 383 cases of lung cancer in uranium miners and presents for the first time the relationship of radioactive radon gas and cigarette smoking. There is evidence that alpha radiation from radon gas at exposure levels above 465 working level months (WLM) is a strong contributor to the de...


    pub_type: 杂志文章


    authors: Saccomanno G,Huth GC,Auerbach O,Kuschner M

    更新日期:1988-10-01 00:00:00

  • The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS.

    abstract:BACKGROUND:The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene resulting from the chromosome inversion inv(2)(p21;p23) recently was identified in nonsmall cell lung cancer (NSCLC). The authors of this study investigated the frequency, genetic and clinicopathologic prof...


    pub_type: 杂志文章


    authors: Wong DW,Leung EL,So KK,Tam IY,Sihoe AD,Cheng LC,Ho KK,Au JS,Chung LP,Pik Wong M,University of Hong Kong Lung Cancer Study Group.

    更新日期:2009-04-15 00:00:00

  • Cytologic examination of pancreatic juice for differential diagnosis of benign and malignant mucin-producing tumors of the pancreas.

    abstract:BACKGROUND:A new clinical type of pancreatic tumor, the mucin-producing tumor, has been recognized recently. However, it is not always easy to distinguish benign from malignant tumors preoperatively. In this study, three different methods of differentiating mucin-producing tumors of the pancreas were compared. METHODS...


    pub_type: 杂志文章


    authors: Uehara H,Nakaizumi A,Iishi H,Tatsuta M,Kitamra T,Okuda S,Ohigashi H,Ishikawa O,Takenaka A,Ishiguro S

    更新日期:1994-08-01 00:00:00

  • High-dose combination chemotherapy for acute nonlymphoblastic leukemia in adults.

    abstract::One hundred thirty-nine consecutive unselected adults with acute nonlymphoblastic leukemia were treated with a high-dose chemotherapeutic remission-induction regimen consisting of daunomycin (70 mg/m2 IV on days 1, 2, 3), cytosine arabinoside (100 mg/m2 IV every 12 hours), 6-thioguanine (100 mg/m2 orally every 12 hour...


    pub_type: 临床试验,杂志文章


    authors: Glucksberg H,Cheever MA,Farewell VT,Fefer A,Sale GE,Thomas ED

    更新日期:1981-09-01 00:00:00

  • Fournier's gangrene complicating aggressive therapy for hematologic malignancy.

    abstract::The authors describe two cases of Fournier's gangrene complicating aggressive therapy for hematologic malignancies. Fournier's gangrene is a fulminant necrotizing fasciitis of the scrotum and penis, often with an infectious etiology. Only one prior case has been reported in a patient receiving aggressive chemotherapy ...


    pub_type: 杂志文章


    authors: Berg A,Armitage JO,Burns CP

    更新日期:1986-06-15 00:00:00

  • Tissue components of weight loss in cancer patients. A new method of study and preliminary observations.

    abstract::A new approach using anthropometric, radiographic, biochemical, and ultrasonic methods allowed partition of body weight into fat, fat-free mass, skeletal muscle, and volume of heart, liver, kidneys, spleen, and tumor. These methods were used to evaluate body composition longitudinally in a pilot group of nine cancer p...


    pub_type: 杂志文章


    authors: Heymsfield SB,McManus CB

    更新日期:1985-01-01 00:00:00

  • Ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive irradiation. Correlation of pathologic parameters with outcome of treatment.

    abstract:BACKGROUND:To evaluate the pathologic characteristics of the primary tumor relative to local control, survival, and freedom from distant metastases, an analysis was performed of 172 patients with ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive breast ...


    pub_type: 杂志文章,多中心研究


    authors: Solin LJ,Yeh IT,Kurtz J,Fourquet A,Recht A,Kuske R,McCormick B,Cross MA,Schultz DJ,Amalric R

    更新日期:1993-04-15 00:00:00

  • Management of low-grade gliomas of the optic nerve and chiasm.

    abstract::Thirty-six patients were evaluated between 1965 and 1983 for glioma of the optic nerves and/or chiasm. Median follow-up was 10.2 years. Pathologic verification was obtained in 32 patients. Tumor initially confined to the optic nerve recurred in one of five patients after complete resection. The actuarial survival for ...


    pub_type: 杂志文章


    authors: Flickinger JC,Torres C,Deutsch M

    更新日期:1988-02-15 00:00:00

  • A phase 2 study of bevacizumab with cisplatin plus intensity-modulated radiation therapy for stage III/IVB head and neck squamous cell cancer.

    abstract:BACKGROUND:For patients with stage III through IVB head and neck squamous cell carcinoma (HNSCC), concurrent high-dose cisplatin plus radiation therapy is a widely accepted standard of care. HNSCC tumors that express high levels of vascular endothelial growth factor have been associated with a worse prognosis, and beva...


    pub_type: 杂志文章


    authors: Fury MG,Lee NY,Sherman E,Lisa D,Kelly K,Lipson B,Carlson D,Stambuk H,Haque S,Shen R,Kraus D,Shah J,Pfister DG

    更新日期:2012-10-15 00:00:00

  • Non-Hodgkin's lymphoma in children. A comparative study of two modalities of therapy.

    abstract::Eighty-six children with non-Hodgkin's lymphoma were studied from 1964 to January 31, 1975. Seventy-six percent of the 43 patients in the nonprotocol group had far advanced disease, and 76% had Rappaport's diffuse histology. Only 11% of these patients survived free of disease. The second group of 43 patients received ...


    pub_type: 杂志文章


    authors: Wollner N,Burchenal JH,Lieberman PH,Exelby P,D'Angio G,Murphy ML

    更新日期:1976-01-01 00:00:00

  • Cancer of the urinary bladder in blacks and whites. A case-control study.

    abstract::Racial differences in the risk of cancer of the urinary bladder associated with cigarette smoking and alcohol consumption were examined in a study of 1663 cases (1534 whites and 129 blacks) and 4930 controls matched 3:1 by sex, race, and age to the cases. Significant increases in cancer risk associated with cigarette ...


    pub_type: 杂志文章


    authors: Harris RE,Chen-Backlund JY,Wynder EL

    更新日期:1990-12-15 00:00:00

  • Adenoma of parotid gland with sebaceous and oncocytic features.

    abstract::A parotid tumor having sebaceous differentiation and a particular histologic picture previously undescribed is reported. The tumor showed features of an adenolymphoma but almost completely lacked a lymphoid component. Sebaceous differentiation was seen in the epithelium of many cysts. Additionally, groups of oxyphilic...


    pub_type: 杂志文章


    authors: Cameron WR,Stenram U

    更新日期:1979-04-01 00:00:00

  • Fine-needle aspiration biopsy cytology of malignant neoplasms of the sinonasal tract.

    abstract:BACKGROUND:Primary and metastatic malignancies that originate in the sinonasal tract are rare and histologically diverse. The role of fine-needle aspiration biopsy (FNAB) and the cytomorphologic features of these tumors have not been specifically addressed. METHODS:The authors reviewed 22 cytology cases (20 FNABs, 1 s...


    pub_type: 杂志文章


    authors: Helsel JC,Bardales RH,Mukunyadzi P

    更新日期:2003-04-25 00:00:00

  • Central nervous system prophylaxis in adults with acute lymphoblastic leukemia: current and emerging therapies.

    abstract::Central nervous system (CNS) recurrence continues to be a significant complication in the treatment of adult patients with acute lymphoblastic leukemia (ALL). Preventing CNS recurrence has been a therapeutic challenge and has not been addressed critically in many clinical trials. Adult studies modeled on childhood ALL...


    pub_type: 杂志文章,评审


    authors: Jabbour E,Thomas D,Cortes J,Kantarjian HM,O'Brien S

    更新日期:2010-05-15 00:00:00

  • Anterior chemotherapy in esophageal cancer.

    abstract::Front loading chemotherapy using methotrexate (200 mg/m2) alone or methotrexate (200 mg/m2) with cisplatin (20 mg/m2 daily for 5 days) was used in epidermoid carcinoma of esophagus. Evaluation after two courses showed objective response of 50% or greater in 48% of patients with methotrexate alone. Response rate was in...


    pub_type: 杂志文章


    authors: Advani SH,Saikia TK,Swaroop S,Ramakrishnan G,Nair CN,Dinshaw KA,Sharma S,Vyas JJ,Desai PB

    更新日期:1985-10-01 00:00:00

  • Dose-ranging antiemetic evaluation of the serotonin antagonist tropisetron in patients receiving anti-cancer chemotherapy.

    abstract:BACKGROUND:Tropisetron (ICS 205-930) antagonizes the serotonin type 3 receptor and has antiemetic activity in animals given cisplatin. Its mean serum half-life in 11.1 hours. METHODS:In this dose-ranging trial, 22 patients undergoing anti-cancer chemotherapy received 24 courses of a single intravenous infusion of trop...


    pub_type: 杂志文章


    authors: Pisters KM,Kris MG,Tyson LB,Clark RA,Gralla RJ

    更新日期:1993-01-01 00:00:00

  • Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles.

    abstract:BACKGROUND:Obesity is considered a risk factor for breast cancer. Modifying life styles that reduce obesity offers the potential for prevention and improved outcomes from cancer. The effects of obesity and breast cancer among African-American women and Hispanic women have been explored in a limited number of studies. T...


    pub_type: 杂志文章


    authors: Sarkissyan M,Wu Y,Vadgama JV

    更新日期:2011-08-15 00:00:00

  • Efficacy of ondansetron against nausea and vomiting caused by dacarbazine-containing chemotherapy.

    abstract:BACKGROUND AND METHODS:The antiemetic activity of ondansetron (Zofran, Glaxo Pharmaceuticals, Research Triangle Park, NC) was evaluated in 25 patients with recurrent melanoma who were treated sequentially with dacarbazine (DTIC), vinblastine, and cisplatin. The antiemetic regimen included ondansetron alone in 11 patien...


    pub_type: 杂志文章


    authors: Legha SS,Hodges C,Ring S

    更新日期:1992-10-01 00:00:00

  • Effects of health insurance and race on breast carcinoma treatments and outcomes.

    abstract:BACKGROUND:The authors hypothesized that insurance payer and race would influence the care and outcomes for patients with breast carcinoma. METHODS:The authors examined treatments and adjusted risk of death (through 1997) for all incident cases of breast carcinoma occurring in Florida in 1994 (n = 11,113) by using sta...


    pub_type: 杂志文章


    authors: Roetzheim RG,Gonzalez EC,Ferrante JM,Pal N,Van Durme DJ,Krischer JP

    更新日期:2000-12-01 00:00:00

  • Prognostic significance of HER-2/neu oncoprotein expression in node-positive breast cancer. The influence of the pattern of immunostaining and adjuvant therapy.

    abstract:BACKGROUND:The influence of HER-2/neu on prognosis of breast cancer is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in patients receiving or no...


    pub_type: 杂志文章,多中心研究


    authors: Têtu B,Brisson J

    更新日期:1994-05-01 00:00:00

  • Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes.

    abstract:BACKGROUND:Salivary gland carcinomas (SGCs) are a rare malignancy with unknown etiology. The objective of the current study was to identify genetic variants modifying the risk of SGC and its major subtypes: adenoid cystic carcinoma and mucoepidermoid carcinoma. METHODS:The authors conducted a genome-wide association s...


    pub_type: 杂志文章,收录出版


    authors: Xu L,Tang H,Chen DW,El-Naggar AK,Wei P,Sturgis EM

    更新日期:2015-07-15 00:00:00

  • Relationship of glycolytic enzyme activities and response of breast cancer patients to chemotherapy: A preliminary report.

    abstract::Activities of glucosephosphate isomerase, lactate dehydrogenase, and NADP-isocitrate dehydrogenase were significantly elevated in breast cancer specimens from patients who responded favorably to combination cytotoxic chemotherapy regimens compared with those in carcinomas from patients failing to respond to the same c...


    pub_type: 杂志文章


    authors: Hilf R,Savlov ED,Rector WD,Wittliff JL

    更新日期:1976-08-01 00:00:00

  • Expression of carbohydrate antigens in human pulmonary adenocarcinoma.

    abstract:BACKGROUND:The altered and anomalous expression of carbohydrate antigens (CA) occur in patients with lung carcinomas. METHODS:To investigate the relationship between prognosis and immunohistochemical findings of CA in serum and pulmonary adenocarcinomas (PA), PA specimens surgically resected from 102 patients were stu...


    pub_type: 杂志文章


    authors: Kawai T,Suzuki M,Kase K,Ozeki Y

    更新日期:1993-09-01 00:00:00

  • Understanding the impact of breast reconstruction on the surgical decision-making process for breast cancer.

    abstract:BACKGROUND:Reconstruction is rarely incorporated into the decision-making process for surgical breast cancer treatment. We examined the importance of knowing about reconstruction to patients' surgical decision-making for breast cancer. METHODS:We surveyed women aged < or =79 years with breast cancer (N = 1844) who wer...


    pub_type: 杂志文章


    authors: Alderman AK,Hawley ST,Waljee J,Mujahid M,Morrow M,Katz SJ

    更新日期:2008-02-01 00:00:00

  • Ascertainment of postprostatectomy radiotherapy for prostate cancer in the Surveillance, Epidemiology, and End Results database.

    abstract:BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data are frequently used to examine receipt of adjuvant radiotherapy (RT), but to the authors' knowledge the accuracy of data regarding second-course treatments is unknown. METHODS:Using SEER-Medicare-linked data, the authors identified a cohort of men who ...


    pub_type: 杂志文章


    authors: Wang K,Sheets NC,Basak R,Chen RC

    更新日期:2016-10-01 00:00:00