Hand-mirror variant of acute lymphoblastic leukemia. Evidence for early T-cell lineage in two cases by evaluation with monoclonal antibodies.

Abstract:

:Lymphoid cells from two patients with hand-mirror variant of acute lymphoblastic leukemia (ALL) were studied with various monoclonal antibodies in attempts to determine their derivation and differentiation. The predominant feature of the malignant bone marrow cells was strong reactivity with antibody 3A1, which stains the majority of normal T-cells and is apparently present on all T-ALL cells. In addition, a less intense binding was observed with antibody 4F2, which reacts with activated or rapidly dividing cells, and antibody 10.2, which reacts with all thymocytes and most peripheral T-cells. Most other antibodies with a wide variety of specificities were not reactive or, in the case of a few anti-T-cell antibodies showed, by fluorescence-activated cell sorter analysis only weak staining on some cells. Sequential bone marrow studies in one patient, before and during treatment with chemotherapy, revealed a reduction of 3A1-positive cells, concordant with a decrease of malignant cells in the marrow. When involved lymph nodes, peripheral blood, or marrow were studied, similar reactivity patterns were found in all locations. The data obtained suggest that in both patients with hand-mirror variant of ALL, the malignant lymphoid cells were immature cells of early T-lymphocyte lineage. The relation of phenotype by monoclonal antibody analysis to hand-mirror morphologic type and biologic function is discussed.

journal_name

Cancer

journal_title

Cancer

authors

Gramatzki M,Strong DM,Duval-Arnould B,Morstyn G,Schumacher HR

doi

10.1002/1097-0142(19850101)55:1<77::aid-cncr282055

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

77-83

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

55

pub_type

杂志文章

相关文献

CANCER文献大全
  • Role of the gallium scan in Hodgkin's disease.

    abstract::The reports of 240 gallium scans on 165 patients with Hodgkin's disease were reviewed to compare results with higher doses with those in earlier studies that employed lower doses. Tracer concentrations in specific sites were correlated with radiologic and pathologic reports and with the clinical courses of the patient...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900301)65:5<1090::aid-cncr2820

    authors: Hagemeister FB,Fesus SM,Lamki LM,Haynie TP

    更新日期:1990-03-01 00:00:00

  • The risk for cancer among children of women who underwent in vitro fertilization.

    abstract:BACKGROUND:The possible association between ovarian carcinoma and ovulation-inducing drugs has led to renewed interest in the potential carcinogenic risks of these drugs. In vitro fertilization (IVF) has been linked to multiple pregnancies and possibly congenital malformations. However, to the authors' knowledge the as...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20000615)88:12<2845::aid-cncr26>

    authors: Lerner-Geva L,Toren A,Chetrit A,Modan B,Mandel M,Rechavi G,Dor J

    更新日期:2000-06-15 00:00:00

  • Decreased risk of radiation-associated second malignant neoplasms in actinomycin-D-treated patients.

    abstract::One hundred two long-term survivors of childhood cancers with second malignant neoplasms (SMNs) were collected from 10 institutions. Forty-seven cases fulfilling study criteria were studied to determine the risk of developing a SMN in irradiated fields after exposure to various chemotherapeutic agents. The case contro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197602)37:2+<1177::aid-cncr28203

    authors: D'Angio GJ,Meadows A,Miké V,Harris C,Evans A,Jaffe N,Newton W,Schweisguth O,Sutow W,Morris-Jones P

    更新日期:1976-02-01 00:00:00

  • Does socioeconomic status account for racial and ethnic disparities in childhood cancer survival?

    abstract:BACKGROUND:For many childhood cancers, survival is lower among non-Hispanic blacks and Hispanics in comparison with non-Hispanic whites, and this may be attributed to underlying socioeconomic factors. However, prior childhood cancer survival studies have not formally tested for mediation by socioeconomic status (SES). ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31560

    authors: Kehm RD,Spector LG,Poynter JN,Vock DM,Altekruse SF,Osypuk TL

    更新日期:2018-10-15 00:00:00

  • Bone-marrow examination in the staging of small-cell anaplastic carcinoma of the lung with special reference to subtyping. An evaluation of 203 consecutive patients.

    abstract::Histologic examination of bone-marrow from the posterior iliac crest was routinely done as a pretreatment staging procedure in 203 consecutive patients with small-cell anaplastic carcinoma of the lung. Subtyping of the patients according to the WHO classification included 27.8% with "fusiform" cell type (WHO II,1), 28...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197706)39:6<2563::aid-cncr282039

    authors: Hirsch F,Hansen HH,Dombernowsky P,Hainau B

    更新日期:1977-06-01 00:00:00

  • Transfusion-induced graft-versus-host disease in patients with malignant lymphoma. A case report and review of the literature.

    abstract::A case of transfusion-induced graft-versus-host disease (GVHD) occurring in a 31-year-old female with Hodgkin's disease in complete remission is reported. Clinical features are similar to 19 other reported cases of transfusion-induced GVHD associated with malignant lymphoma. The lack of relationship with underlying hi...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19901201)66:11<2346::aid-cncr282

    authors: Spitzer TR,Cahill R,Cottler-Fox M,Treat J,Sacher R,Deeg HJ

    更新日期:1990-12-01 00:00:00

  • The value of splenectomy in chronic lymphocytic leukemia.

    abstract::Between January 1, 1980, and July 31, 1985, 168 patients were treated at our institution for chronic lymphocytic leukemia (CLL). Splenectomy was performed on 32 (23 men and 9 women). The mean age of these surgical patients was 59.4 years (range, 43-75). Twenty-four patients had received chemotherapy and/or corticother...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870115)59:2<340::aid-cncr28205

    authors: Delpero JR,Gastaut JA,Letreut YP,Caamano A,Mathieu-Tubiana N,Maraninchi D,Simon-Lejeune C,Mascret B,Blanc AP,Sebahoun G

    更新日期:1987-01-15 00:00:00

  • Parosteal osteoma of bones other than of the skull and face.

    abstract:BACKGROUND:Osteoma of the skull and facial bones is not uncommon, is usually asymptomatic, and may be associated with Gardner's syndrome. Osteomas involving other bones are unusual. METHODS:The authors describe 14 cases (eight men and six women from age 21-66 years) of parosteal osteoma of bones other than of the skul...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950515)75:10<2466::aid-cncr282

    authors: Bertoni F,Unni KK,Beabout JW,Sim FH

    更新日期:1995-05-15 00:00:00

  • Methyl CCNU and adriamycin for patients with metastatic sarcomas: a Southwest Oncology Group study.

    abstract::This protocol study (SWOG-7431) combining adriamycin and methyl CCNU (MAD) for metastatic sarcomas was initially used on patients who were refractory to cytoxan, vincristine, and/or actinomycin-D. After the initial good results, the study was expanded to include any untreated patients with metastatic sarcoma. The init...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800801)46:3<446::aid-cncr28204

    authors: Rivkin SE,Gottlieb JA,Thigpen T,El Mawla NG,Saiki J,Dixon DO

    更新日期:1980-08-01 00:00:00

  • A randomized phase 3 trial comparing nimotuzumab plus cisplatin chemoradiotherapy versus cisplatin chemoradiotherapy alone in locally advanced head and neck cancer.

    abstract:BACKGROUND:Because the addition of nimotuzumab to chemoradiation in patients with locally advanced head and neck cancer improved outcomes in a phase 2 study, the authors conducted a phase 3 study to confirm these findings. METHODS:This open-label, investigator-initiated, phase 3, randomized trial was conducted from 20...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.32179

    authors: Patil VM,Noronha V,Joshi A,Agarwal J,Ghosh-Laskar S,Budrukkar A,Murthy V,Gupta T,Mahimkar M,Juvekar S,Arya S,Mahajan A,Agarwal A,Purandare N,Rangarajan V,Balaji A,Chaudhari SV,Banavali S,Kannan S,Bhattacharjee A,D

    更新日期:2019-09-15 00:00:00

  • Mammography screening in African American women: evaluating the research.

    abstract:BACKGROUND:Notwithstanding some controversy regarding the benefits of screening mammography, it is generally assumed that the effects are the same for women of all race/ethnic groups. Yet evidence for its efficacy from clinical trial studies comes primarily from the study of white women. It is likely that mammography i...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11022

    authors: Jones BA,Patterson EA,Calvocoressi L

    更新日期:2003-01-01 00:00:00

  • Aberrant, highly hyperdiploid cells in human papillomavirus-positive, abnormal cytologic samples are associated with progressive lesions of the uterine cervix.

    abstract:BACKGROUND:Infection with oncogenic-type human papillomavirus (HPV) and consecutive cytologic abnormalities of the uterine cervix precede the evolution of carcinoma. However, the specificity of both changes is too low to predict the true malignant potential of the change in a given time point, because the majority of t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20848

    authors: Bollmann R,Méhes G,Speich N,Schmitt C,Bollmann M

    更新日期:2005-04-25 00:00:00

  • Reticulum cell sarcomas (large cell lymphomas) presenting in the skin. High frequency of true histiocytic lymphoma.

    abstract::The clinical and histologic data from 12 patients with "reticulum cell sarcoma" (large cell lymphoma) presenting in the skin were reviewed. Moreover, when appropriate material was available additional immunological, cytochemical and ultrastructural techniques were used to define the nature of the neoplastic cells. Eig...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821001)50:7<1367::aid-cncr2820

    authors: Willemze R,Ruiter DJ,Van Vloten WA,Meijer CJ

    更新日期:1982-10-01 00:00:00

  • The impact of pulmonary infections on the survival of lung cancer patients.

    abstract::To determine the impact of pulmonary infections on survival in patients with lung cancer, a retrospective review of the records of 121 such patients treated at Howard University Hospital in Washington, DC, was done. There were 77 men and 44 women; 118 were black. The mean age was 63.5 years. Forty-three patients had s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900801)66:3<593::aid-cncr28206

    authors: Perlin E,Bang KM,Shah A,Hursey PD,Whittingham WL,Hashmi K,Campbell L,Kassim OO

    更新日期:1990-08-01 00:00:00

  • Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program.

    abstract:BACKGROUND:Traditional single-marker and multimarker molecular profiling approaches in bladder cancer do not account for major risk factors and their influence on clinical outcome. This study examined the prognostic value of molecular alterations across all disease stages after accounting for clinicopathological factor...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27763

    authors: Mitra AP,Castelao JE,Hawes D,Tsao-Wei DD,Jiang X,Shi SR,Datar RH,Skinner EC,Stein JP,Groshen S,Yu MC,Ross RK,Skinner DG,Cortessis VK,Cote RJ

    更新日期:2013-02-15 00:00:00

  • Outreach by the Hanford Tribal Service Program to Indian communities around the Hanford Nuclear Reservation.

    abstract:BACKGROUND:The Hanford Tribal Service Program offers technical assistance and health education to American Indian tribes in an area reported to be affected by radiation from the Hanford Nuclear Reservation, which was developed and operated by the United States federal government. This article describes strategies used ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Jensen RA

    更新日期:1996-10-01 00:00:00

  • Radiotherapy or surgery for head and neck squamous cell cancer: establishing the baseline for hypopharyngeal carcinoma?

    abstract:BACKGROUND:The authors compared the survival outcomes of radiotherapy+/-salvage surgery to surgery+/-postoperative radiotherapy for patients with squamous cell cancer of the hypopharynx. There was no evidence beyond observational studies and no consensus on the which treatment is most effective for this patient group. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24635

    authors: Hall SF,Groome PA,Irish J,O'Sullivan B

    更新日期:2009-12-15 00:00:00

  • Marrow neutrophil reserve after adjuvant chemotherapy for carcinoma of the breast.

    abstract::The hematologic factors of 16 female patients with breast carcinoma who had received adjuvant chemotherapy with L-phenylalanine-based programs for two years were compared with those for 13 normal female volunteers of similar age. The findings include significant suppression of the mean hemoglobin level, of leukocyte c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820615)49:12<2455::aid-cncr282

    authors: Corder MP,Jochimsen PR

    更新日期:1982-06-15 00:00:00

  • Acute nonlymphocytic leukemia in patients with nodular lymphoma.

    abstract::Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL-N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197710)40:4<1748::aid-cncr282040

    authors: Collins AJ,Bloomfield CD,Peterson BA,McKenna RW

    更新日期:1977-10-01 00:00:00

  • Tumor acquisition, propagation, and preservation. The culture of human colorectal cancer.

    abstract::Fourteen new colorectal cancer cell lines were developed as part of a tumor acquisition, propagation, and preservation program for biotherapy. Fifty-six specimens were received. Nine cell lines were generated from biopsies; seven of these cell lines were from metastatic lesions. Five additional cell lines were develop...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891015)64:8<1600::aid-cncr2820

    authors: Lewko WM,Ladd P,Hubbard D,He YJ,Vaghmar R,Husseini S,Chang L,Moore M,Thurman GB,Oldham RK

    更新日期:1989-10-15 00:00:00

  • The use of interstitial radiation therapy in the treatment of persistent, localized, and unresectable cancer in children.

    abstract::Two children with cancer that persisted after multiple exploratory laparotomies, external beam radiation therapy, and multidrug chemotherapy had gold 198 (198Au) seeds implanted into their localized but unresectable tumor. Both children are alive, are receiving no therapy, and are disease-free more than 2 years later....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860301)57:5<951::aid-cncr28205

    authors: Knight PJ,Doornbos JF,Rosen D,Lin JJ,Farha GJ

    更新日期:1986-03-01 00:00:00

  • Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapy.

    abstract:BACKGROUND:The goal of the current study was to define the clinical features and outcome of recurrent osteosarcoma (OS) in children and young adults initially treated with contemporary chemotherapy. METHODS:The authors reviewed the clinical features, therapy, and outcome for 59 patients from the Mayo Clinic (Rochester...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11799

    authors: Hawkins DS,Arndt CA

    更新日期:2003-12-01 00:00:00

  • Lack of correlation of a histochemical method for estrogen receptors analysis with the biochemical assay results.

    abstract::Forty-nine specimens of carcinoma of the breast were analyzed for estrogen receptor content using the sucrose gradient method and a histochemical method using a conjugate of estradiol (6-BSA-Fluor-CMO-17 beta-estradiol). The specimens analyzed by the histochemical method were graded for fluorescent intensity, percenta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820515)49:10<2148::aid-cncr282

    authors: Panko WB,Mattioli CA,Wheeler TM

    更新日期:1982-05-15 00:00:00

  • Ratios of pleural fluid to serum immunoglobulins in malignant pleural effusions.

    abstract::Pleural fluid and serum protein electrophoresis and quantitative immunoglobulin measurements were carried out in patients with pleural effusions. The mean pleural fluid/serum ratios of IgA, IgG, and IgM were elevated in patients with malignant pleural effusions compared with patients with nonmalignant pleural effusion...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831201)52:11<2151::aid-cncr282

    authors: Desai SD,Sackett DL

    更新日期:1983-12-01 00:00:00

  • Survivin expression is associated with bladder cancer presence, stage, progression, and mortality.

    abstract:BACKGROUND:The purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes. METHODS:Immunohistochemical staining for Survivin was carried ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22521

    authors: Shariat SF,Ashfaq R,Karakiewicz PI,Saeedi O,Sagalowsky AI,Lotan Y

    更新日期:2007-03-15 00:00:00

  • Increased incidence of symptomatic venous thrombosis in patients with cervical carcinoma treated with concurrent chemotherapy, radiation, and erythropoietin.

    abstract:BACKGROUND:Because studies have suggested that anemia has an adverse effect on outcome for patients with cervical carcinoma who are treated with radiation, recombinant human erythropoietin (rHuEpo) has been used increasingly to maintain hemoglobin levels in these patients. Erythropoietin may increase the risk of thromb...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11700

    authors: Wun T,Law L,Harvey D,Sieracki B,Scudder SA,Ryu JK

    更新日期:2003-10-01 00:00:00

  • A Web-based communication aid for patients with cancer: the CONNECT Study.

    abstract:BACKGROUND:Cancer patients and their oncologists often report differing perceptions of consultation discussions and discordant expectations regarding treatment outcomes. CONNECT, a computer-based communication aid, was developed to improve communication between patients and oncologists. METHODS:CONNECT includes assess...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.27874

    authors: Meropol NJ,Egleston BL,Buzaglo JS,Balshem A,Benson AB 3rd,Cegala DJ,Cohen RB,Collins M,Diefenbach MA,Miller SM,Fleisher L,Millard JL,Ross EA,Schulman KA,Silver A,Slater E,Solarino N,Sulmasy DP,Trinastic J,Weinfurt K

    更新日期:2013-04-01 00:00:00

  • Time to the initiation of adjuvant chemotherapy does not impact survival in patients with resected pancreatic cancer.

    abstract:BACKGROUND:Surgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuva...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30163

    authors: Mirkin KA,Greenleaf EK,Hollenbeak CS,Wong J

    更新日期:2016-10-01 00:00:00

  • Circulating CD44 and intercellular adhesion molecule-1 levels in low grade non-hodgkin lymphoma and B-cell chronic lymphocytic leukemia patients during interferon-alpha-2a treatment.

    abstract:BACKGROUND:Despite published reports regarding the association of elevated circulating CD44 and CD54 levels with unfavorable outcome in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL), little is known about therapy-related changes in either adhesion molecule. In an attempt to evaluate the effect of in...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Beksaç M,Arat M,Akan H,Koç H,Ilhan O,Ozcan M

    更新日期:2000-10-01 00:00:00

  • Symptomatic mucocutaneous toxicity of hydroxyurea in Philadelphia chromosome-negative myeloproliferative neoplasms: the Mister Hyde face of a safe drug.

    abstract:BACKGROUND:The current study was conducted to evaluate severe mucocutaneous toxicity during treatment with hydroxyurea (HU) in a large cohort of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). METHODS:Among 993 consecutive patients newly diagnosed with MPN at 4 centers in Rome betwee...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26194

    authors: Latagliata R,Spadea A,Cedrone M,Di Giandomenico J,De Muro M,Villivà N,Breccia M,Anaclerico B,Porrini R,Spirito F,Rago A,Avvisati G,Alimena G,Montanaro M,Andriani A,Gruppo Laziale SMPC Ph1 neg.

    更新日期:2012-01-15 00:00:00