Abstract:
:The effects of cigarette smoking and other factors on the accuracy of clinical diagnosis of bronchogenic carcinoma were studied retrospectively in 14,074 autopsies performed over 26 years (1948-1973) at University Hospitals of Cleveland. Within a selected study group of 415 cases diagnosed as bronchogenic carcinoma either clinically, at atuopsy, or both, the disease was diagnosed accurately in 260 cases (63%), overdiagnosed in 38 cases (9%), and underdiagnosed in 117 cases (28%). Misdiagnoses occurred in female patients nearly twice as frequently as in male patients. Elderly men were over- and underdiagnosed more frequently than were young men. An accurate diagnosis of this neoplasm was strongly associated with a histroy of smoking and was also related to the number of hospital admissions, the diagnostic procedures used, and surveillance bias associated with a history of smoking or coughing. In 88% of the misdiagnosed cases, the tumor was either simulated or masked by other diseases. It is estimated from these data that the rate of unavoidable clinical misdiagnosis of the disease is 32% and the true error (overt misjudgment) in clinical diagnosis, 5%. Previous estimates of causal association between smoking and lung cancer would not be affected by the findings of this study.
journal_name
Cancerjournal_title
Cancerauthors
Cechner RL,Chamberlain W,Carter JR,Milojkovic-Mirceta L,Nash NPdoi
10.1002/1097-0142(19800701)46:1<190::aid-cncr28204subject
Has Abstractpub_date
1980-07-01 00:00:00pages
190-9issue
1eissn
0008-543Xissn
1097-0142journal_volume
46pub_type
杂志文章相关文献
CANCER文献大全abstract::Fifty-four patients with advanced squamous, large-cell or adeno-carcinoma of the lung were treated with a three drug regimen of high-dose cisplatin, vindesine and a four-day bleomycin infusion (CVB). All patients had measurable disease; none had previously received chemotherapy. Of 52 patients evaluable for response, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830315)51:6<1050::aid-cncr2820
更新日期:1983-03-15 00:00:00
abstract:BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25255
更新日期:2010-09-01 00:00:00
abstract::Thyroglobulin messenger RNA (mRNA) was located and quantified in tissue sections of differentiated human thyroid cancers by in situ hybridization using cloned complementary DNA probes. The cells of the well-differentiated follicular and papillary forms contained similar levels of thyroglobulin mRNA, corresponding to a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850715)56:2<345::aid-cncr28205
更新日期:1985-07-15 00:00:00
abstract:BACKGROUND:Myeloma survival varies markedly with International Staging System classification, presence of cytogenetic abnormalities, and, especially, gene expression profiling-based risk and delTP53 status, whose collective impact has not been examined in the context of specific therapies. METHODS:The authors examined...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25535
更新日期:2011-03-01 00:00:00
abstract::Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920901)70:5<1194::aid-cncr2820
更新日期:1992-09-01 00:00:00
abstract::An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportun...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<4072::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract::Twenty-two children with acute lymphocytic leukemia (ALL) who had relapsed while on therapy and for whom remissions were successfully reinduced were maintained with a combination of methotrexate, daunomycin, 6-mercaptopurine, prednisone, and vincristine (Djerassi-methotrexate with BOMB). The median duration of remissi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800901)46:5<1093::aid-cncr2820
更新日期:1980-09-01 00:00:00
abstract::This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (> 3 fmol/mg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to hypophysectomy. E...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801215)46:12+<2838::aid-cncr28
更新日期:1980-12-15 00:00:00
abstract::Disagreement persists about the superiority of Reagan and Ng's method over that of Broders' for the histologic grading of squamous carcinoma of the cervix. Uncertainty about the predictive value and reproducibility of any of the grading methods prompted a comparison of factors previously suggested as indicating the bi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920401)69:7<1750::aid-cncr2820
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Controlled-release (CR) morphine tablets have become routine therapy in the management of cancer pain. Compared with immediate-release (IR) morphine, this formulation provides the benefit of dosing every 12 hours. METHODS:This study reviewed the 10 published, well controlled, repeated-dose, comparative stud...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19980615)82:12<2299::aid-c
更新日期:1998-06-15 00:00:00
abstract:BACKGROUND:The objective of this study was to assess the impact of a prostate-specific antigen (PSA) complete response (PSA-CR), measured at the end of external-beam radiotherapy and short-term hormone therapy, on treatment outcomes. METHODS:The phase 3 Radiation Therapy Oncology Group 9413 trial, as part of its origi...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.28019
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:In various neoplasms expression of the proliferation-related Ki-67 antigen has successfully been linked with parameters of progression of disease. While a definite grading scheme for oligodendrogliomas has still not been agreed upon, any parameter of tumor proliferation that might be helpful in predicting cl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960901)78:5<1107::AID-CN
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25099
更新日期:2010-06-15 00:00:00
abstract::Image cytometry for the classification of fine needle aspirate (FNA) biopsies was evaluated in samples from 39 women. Eighteen of them had benign lesions, seven had premalignant lesions, nine had carcinoma in situ, and five had carcinoma. The term, premalignant, here refers to lesions with an increased risk of develop...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880701)62:1<114::aid-cncr28206
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:A rare occurrence, about 1500 men in the United States develop breast carcinoma each year. Little is known about survival patterns at the population level, particularly about racial/ethnic variation. METHODS:Using data from the Surveillance, Epidemiology, and End Results Program, we examined survival rates ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10521
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:It is well established that prenatal biologic processes are important for the development of some childhood cancers, whereas less is known regarding their influence on adult cancer risk. High birth weight has been associated with risk of breast cancer, whereas studies of other specific cancers and all cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22773
更新日期:2007-07-15 00:00:00
abstract:BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10899
更新日期:2002-11-01 00:00:00
abstract::Two patients with superior vena cava syndrome (SVCS) recurring after maximum-tolerance radiation were treated by placing a Gianturco expandable wire stent (GEWS) into the obstructed superior vena cava. The SVCS symptoms rapidly disappeared and good short-term (6 months) palliation was achieved. GEWS placement is a pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870915)60:6<1243::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract::Histologic groups in 231 cases of malignant lymphoma were correlated with survival data at 100 months from the time of initiation of the study. Patients in the first two decades of life fared comparably with adults, but those over 60 years of age showed a poorer survival trend. Seven favorable and four unfavorable his...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810615)47:12<2894::aid-cncr282
更新日期:1981-06-15 00:00:00
abstract::Epidermoid cancer accounts for 81% of the malignancies of the vulva. Although the etiology has not been delineated, chronic vulvitis is associated with cancer in almost one-third of the patients. The staging system should utilize the most precise and accurate parameters delineated for improved treatment. A new staging...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<587::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Whereas the role of specific symptoms, such as pain and fatigue, for quality of life (QOL) is unquestioned, their relative importance for long-lasting impairments in QOL in cancer patients has rarely been assessed quantitatively. The authors, therefore, aimed to identify symptoms most predictive of limitatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22274
更新日期:2006-11-15 00:00:00
abstract::Xenografts have been established in immune-suppressed mice from three embryonal cell carcinomas, two yolk sac carcinomas, and a 'seminoma-like' tumor that produces alphafetoprotein. The ultrastructural features of these xenografts have been studied in detail and compared with human germ cell tumors removed from patien...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820215)49:4<683::aid-cncr28204
更新日期:1982-02-15 00:00:00
abstract:BACKGROUND:This review was done to assess the outcomes and patterns of recurrence in a group of patients with Stage III endometrial carcinoma that might help guide adjuvant therapy. METHODS:A retrospective review was performed of 105 patients treated from 1970-1990 at three institutions. All patients underwent abdomin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930601)71:11<3697::aid-cncr282
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Sentinel lymph node (SLN) sampling is used to predict axillary lymph node (AxLN) metastasis in patients with breast carcinoma; AxLN sampling can be avoided in SLN-negative patients. Multistep sectioning and immunohistochemistry are reported to increase the sensitivity of micrometastasis detection. The author...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11689
更新日期:2003-10-15 00:00:00
abstract:BACKGROUND:Virilizing adrenocortical tumors are uncommon in adult women. These lesions generally secrete dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), but not testosterone, which usually is produced by ovarian tumors. Exceptionally, adrenal growths may give off testosterone and no other asse...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930915)72:6<1997::aid-cncr2820
更新日期:1993-09-15 00:00:00
abstract::A bolus intravenous dose of 5-fluorouracil of 600 mg/M2 was added exactly 1 hour after methotrexate administration in an established combination program including bleomycin and cisplatin for advanced squamous cell cancer of the head and neck. Results were no better than those observed previously with the three drugs, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860215)57:4<706::aid-cncr28205
更新日期:1986-02-15 00:00:00
abstract:BACKGROUND:Nonperioperative strokes are rare yet potentially devastating events for children with central nervous system (CNS) tumors. The incidence of and risk factors for nonperioperative strokes in children with CNS tumors is unknown. METHODS:The authors performed a retrospective review of children from their insti...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-15 00:00:00
abstract::In the past all clear cell carcinomas of the female genital tract were thought to arise from mesonephric remnants. Recently increasing evidence has related their origin to müllerian rather than mesonephric epithelium. One of the main reasons that has been advanced to support their mesonephric origin has been their occ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197811)42:5<2435::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract::In a randomized series of 70 patients with with colo rectal adenocarcinoma, a comparison of systemic 5-fluorouracil chemotherapy administered as a continuous 120-hours infusion vs. intravenous bolus injection daily for 5 days demonstrated superiority of prolonged intravenous infusion. The most striking advantage of pr...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197507)36:1<123::aid-cncr2820360
更新日期:1975-07-01 00:00:00
abstract::Review of 61 surgically resected small hepatocellular carcinomas (HCC) less than or equal to 3 cm in diameter yielded a simple gross classification system of five types based on tumor shape, which is highly correlated with microscopic and clinical features, including prognosis. Type 1 (single nodular type) tumors (n =...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870815)60:4<810::aid-cncr28206
更新日期:1987-08-15 00:00:00