Misdiagnosis of bronchogenic carcinoma: the role of cigarette smoking, surveillance bias, and other factors.

Abstract:

:The effects of cigarette smoking and other factors on the accuracy of clinical diagnosis of bronchogenic carcinoma were studied retrospectively in 14,074 autopsies performed over 26 years (1948-1973) at University Hospitals of Cleveland. Within a selected study group of 415 cases diagnosed as bronchogenic carcinoma either clinically, at atuopsy, or both, the disease was diagnosed accurately in 260 cases (63%), overdiagnosed in 38 cases (9%), and underdiagnosed in 117 cases (28%). Misdiagnoses occurred in female patients nearly twice as frequently as in male patients. Elderly men were over- and underdiagnosed more frequently than were young men. An accurate diagnosis of this neoplasm was strongly associated with a histroy of smoking and was also related to the number of hospital admissions, the diagnostic procedures used, and surveillance bias associated with a history of smoking or coughing. In 88% of the misdiagnosed cases, the tumor was either simulated or masked by other diseases. It is estimated from these data that the rate of unavoidable clinical misdiagnosis of the disease is 32% and the true error (overt misjudgment) in clinical diagnosis, 5%. Previous estimates of causal association between smoking and lung cancer would not be affected by the findings of this study.

journal_name

Cancer

journal_title

Cancer

authors

Cechner RL,Chamberlain W,Carter JR,Milojkovic-Mirceta L,Nash NP

doi

10.1002/1097-0142(19800701)46:1<190::aid-cncr28204

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

190-9

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

46

pub_type

杂志文章

相关文献

CANCER文献大全
  • Cisplatin, vindesine and bleomycin (CVB) combination chemotherapy of advanced non-small cell lung cancer.

    abstract::Fifty-four patients with advanced squamous, large-cell or adeno-carcinoma of the lung were treated with a three drug regimen of high-dose cisplatin, vindesine and a four-day bleomycin infusion (CVB). All patients had measurable disease; none had previously received chemotherapy. Of 52 patients evaluable for response, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830315)51:6<1050::aid-cncr2820

    authors: Itri LM,Gralla RJ,Kelsen DP,Chapman RA,Casper ES,Braun DW Jr,Howard JE,Golbey R,Heelan RT

    更新日期:1983-03-15 00:00:00

  • Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors.

    abstract:BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25255

    authors: Rausch SM,Clark MM,Patten C,Liu H,Felten S,Li Y,Sloan J,Yang P

    更新日期:2010-09-01 00:00:00

  • Quantification of thyroglobulin messenger RNA by in situ hybridization in differentiated thyroid cancers. Difference between well-differentiated and moderately differentiated histologic types.

    abstract::Thyroglobulin messenger RNA (mRNA) was located and quantified in tissue sections of differentiated human thyroid cancers by in situ hybridization using cloned complementary DNA probes. The cells of the well-differentiated follicular and papillary forms contained similar levels of thyroglobulin mRNA, corresponding to a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850715)56:2<345::aid-cncr28205

    authors: Bergé-Lefranc JL,Cartouzou G,De Micco C,Fragu P,Lissitzky S

    更新日期:1985-07-15 00:00:00

  • International staging system and metaphase cytogenetic abnormalities in the era of gene expression profiling data in multiple myeloma treated with total therapy 2 and 3 protocols.

    abstract:BACKGROUND:Myeloma survival varies markedly with International Staging System classification, presence of cytogenetic abnormalities, and, especially, gene expression profiling-based risk and delTP53 status, whose collective impact has not been examined in the context of specific therapies. METHODS:The authors examined...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25535

    authors: Waheed S,Shaughnessy JD,van Rhee F,Alsayed Y,Nair B,Anaissie E,Szymonifka J,Hoering A,Crowley J,Barlogie B

    更新日期:2011-03-01 00:00:00

  • Immunohistochemical identification of tissue factor in solid tumors.

    abstract::Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920901)70:5<1194::aid-cncr2820

    authors: Callander NS,Varki N,Rao LV

    更新日期:1992-09-01 00:00:00

  • Atypical human T-cell lymphotropic virus type-I-associated T-cell lymphoma in a low-prevalence Alaska Native population. Implications for disease surveillance.

    abstract::An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportun...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930615)71:12<4072::aid-cncr282

    authors: Davidson M,Braziel RM,Lairmore MD,Jacobson S,Sprott JM,Tucker SB,Levine PH,Kaplan JE

    更新日期:1993-06-15 00:00:00

  • Favorable response to maintenance therapy of second or subsequent remissions in childhood acute lymphocytic leukemia.

    abstract::Twenty-two children with acute lymphocytic leukemia (ALL) who had relapsed while on therapy and for whom remissions were successfully reinduced were maintained with a combination of methotrexate, daunomycin, 6-mercaptopurine, prednisone, and vincristine (Djerassi-methotrexate with BOMB). The median duration of remissi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800901)46:5<1093::aid-cncr2820

    authors: Kimball JC,Herson J,Sullivan MP

    更新日期:1980-09-01 00:00:00

  • Estrogen and progesterone receptors in the prediction of response of breast cancer to endocrine therapy.

    abstract::This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (> 3 fmol/mg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to hypophysectomy. E...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801215)46:12+<2838::aid-cncr28

    authors: Manni A,Arafah B,Pearson OH

    更新日期:1980-12-15 00:00:00

  • Histopathologic predictors of the behavior of surgically treated stage IB squamous cell carcinoma of the cervix. A Gynecologic Oncology Group study.

    abstract::Disagreement persists about the superiority of Reagan and Ng's method over that of Broders' for the histologic grading of squamous carcinoma of the cervix. Uncertainty about the predictive value and reproducibility of any of the grading methods prompted a comparison of factors previously suggested as indicating the bi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920401)69:7<1750::aid-cncr2820

    authors: Zaino RJ,Ward S,Delgado G,Bundy B,Gore H,Fetter G,Ganjei P,Frauenhoffer E

    更新日期:1992-04-01 00:00:00

  • Controlled-release morphine tablets in patients with chronic cancer pain: a narrative review of controlled clinical trials.

    abstract:BACKGROUND:Controlled-release (CR) morphine tablets have become routine therapy in the management of cancer pain. Compared with immediate-release (IR) morphine, this formulation provides the benefit of dosing every 12 hours. METHODS:This study reviewed the 10 published, well controlled, repeated-dose, comparative stud...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19980615)82:12<2299::aid-c

    authors: Warfield CA

    更新日期:1998-06-15 00:00:00

  • Prostate-specific antigen response after short-term hormone therapy plus external-beam radiotherapy and outcome in patients treated on Radiation Therapy Oncology Group study 9413.

    abstract:BACKGROUND:The objective of this study was to assess the impact of a prostate-specific antigen (PSA) complete response (PSA-CR), measured at the end of external-beam radiotherapy and short-term hormone therapy, on treatment outcomes. METHODS:The phase 3 Radiation Therapy Oncology Group 9413 trial, as part of its origi...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.28019

    authors: Cury FL,Hunt D,Roach M 3rd,Shipley W,Gore E,Hsu IC,Krisch RE,Seider MJ,Sandler H,Lawton C

    更新日期:2013-06-01 00:00:00

  • Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas.

    abstract:BACKGROUND:In various neoplasms expression of the proliferation-related Ki-67 antigen has successfully been linked with parameters of progression of disease. While a definite grading scheme for oligodendrogliomas has still not been agreed upon, any parameter of tumor proliferation that might be helpful in predicting cl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960901)78:5<1107::AID-CN

    authors: Kros JM,Hop WC,Godschalk JJ,Krishnadath KK

    更新日期:1996-09-01 00:00:00

  • Childhood cancer in relation to parental race and ethnicity: a 5-state pooled analysis.

    abstract:BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25099

    authors: Chow EJ,Puumala SE,Mueller BA,Carozza SE,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Spector LG

    更新日期:2010-06-15 00:00:00

  • Image cytometric classification of premalignant breast disease in fine needle aspirates.

    abstract::Image cytometry for the classification of fine needle aspirate (FNA) biopsies was evaluated in samples from 39 women. Eighteen of them had benign lesions, seven had premalignant lesions, nine had carcinoma in situ, and five had carcinoma. The term, premalignant, here refers to lesions with an increased risk of develop...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880701)62:1<114::aid-cncr28206

    authors: King EB,Chew KL,Duarte L,Hom JD,Mayall BH,Miller TR,Petrakis NL

    更新日期:1988-07-01 00:00:00

  • Racial/ethnic differences in survival rates in a population-based series of men with breast carcinoma.

    abstract:BACKGROUND:A rare occurrence, about 1500 men in the United States develop breast carcinoma each year. Little is known about survival patterns at the population level, particularly about racial/ethnic variation. METHODS:Using data from the Surveillance, Epidemiology, and End Results Program, we examined survival rates ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10521

    authors: O'Malley CD,Prehn AW,Shema SJ,Glaser SL

    更新日期:2002-06-01 00:00:00

  • Birth weight and risk of cancer.

    abstract:BACKGROUND:It is well established that prenatal biologic processes are important for the development of some childhood cancers, whereas less is known regarding their influence on adult cancer risk. High birth weight has been associated with risk of breast cancer, whereas studies of other specific cancers and all cancer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22773

    authors: Ahlgren M,Wohlfahrt J,Olsen LW,Sørensen TI,Melbye M

    更新日期:2007-07-15 00:00:00

  • Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma.

    abstract:BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10899

    authors: Ozaki Y,Kontani K,Hanaoka J,Chano T,Teramoto K,Tezuka N,Sawai S,Fujino S,Yoshiki T,Okabe H,Ohkubo I

    更新日期:2002-11-01 00:00:00

  • Gianturco expandable wire stents in the treatment of superior vena cava syndrome recurring after maximum-tolerance radiation.

    abstract::Two patients with superior vena cava syndrome (SVCS) recurring after maximum-tolerance radiation were treated by placing a Gianturco expandable wire stent (GEWS) into the obstructed superior vena cava. The SVCS symptoms rapidly disappeared and good short-term (6 months) palliation was achieved. GEWS placement is a pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870915)60:6<1243::aid-cncr2820

    authors: Rösch J,Bedell JE,Putnam J,Antonovic R,Uchida B

    更新日期:1987-09-15 00:00:00

  • The influence of histologic type on survival in non-Hodgkin's lymphoma.

    abstract::Histologic groups in 231 cases of malignant lymphoma were correlated with survival data at 100 months from the time of initiation of the study. Patients in the first two decades of life fared comparably with adults, but those over 60 years of age showed a poorer survival trend. Seven favorable and four unfavorable his...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810615)47:12<2894::aid-cncr282

    authors: Barcos M,Herrmann R,Pickren JW,Naeher C,Han T,Stutzman L,Henderson ES

    更新日期:1981-06-15 00:00:00

  • Current status of the treatment of epidermoid cancer of the vulva.

    abstract::Epidermoid cancer accounts for 81% of the malignancies of the vulva. Although the etiology has not been delineated, chronic vulvitis is associated with cancer in almost one-third of the patients. The staging system should utilize the most precise and accurate parameters delineated for improved treatment. A new staging...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197607)38:1<587::aid-cncr2820380

    authors: Krupp P,Bohm JW,Lee FY,Collins JH

    更新日期:1976-07-01 00:00:00

  • A population-based study of the impact of specific symptoms on quality of life in women with breast cancer 1 year after diagnosis.

    abstract:BACKGROUND:Whereas the role of specific symptoms, such as pain and fatigue, for quality of life (QOL) is unquestioned, their relative importance for long-lasting impairments in QOL in cancer patients has rarely been assessed quantitatively. The authors, therefore, aimed to identify symptoms most predictive of limitatio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22274

    authors: Arndt V,Stegmaier C,Ziegler H,Brenner H

    更新日期:2006-11-15 00:00:00

  • Ultrastructural studies of xenografted human germ cell tumors.

    abstract::Xenografts have been established in immune-suppressed mice from three embryonal cell carcinomas, two yolk sac carcinomas, and a 'seminoma-like' tumor that produces alphafetoprotein. The ultrastructural features of these xenografts have been studied in detail and compared with human germ cell tumors removed from patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820215)49:4<683::aid-cncr28204

    authors: Monaghan P,Raghavan D,Neville AM

    更新日期:1982-02-15 00:00:00

  • Pathologic stage III endometrial carcinoma. Prognostic factors and patterns of recurrence.

    abstract:BACKGROUND:This review was done to assess the outcomes and patterns of recurrence in a group of patients with Stage III endometrial carcinoma that might help guide adjuvant therapy. METHODS:A retrospective review was performed of 105 patients treated from 1970-1990 at three institutions. All patients underwent abdomin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930601)71:11<3697::aid-cncr282

    authors: Greven KM,Lanciano RM,Corn B,Case D,Randall ME

    更新日期:1993-06-01 00:00:00

  • Application of immunofluorescence for intraoperative evaluation of sentinel lymph nodes in patients with breast carcinoma.

    abstract:BACKGROUND:Sentinel lymph node (SLN) sampling is used to predict axillary lymph node (AxLN) metastasis in patients with breast carcinoma; AxLN sampling can be avoided in SLN-negative patients. Multistep sectioning and immunohistochemistry are reported to increase the sensitivity of micrometastasis detection. The author...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11689

    authors: Munakata S,Aihara T,Morino H,Takatsuka Y

    更新日期:2003-10-15 00:00:00

  • Virilizing adrenocortical tumors in adult women. Report of 10 patients, 2 of whom each had a tumor secreting only testosterone.

    abstract:BACKGROUND:Virilizing adrenocortical tumors are uncommon in adult women. These lesions generally secrete dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), but not testosterone, which usually is produced by ovarian tumors. Exceptionally, adrenal growths may give off testosterone and no other asse...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930915)72:6<1997::aid-cncr2820

    authors: Del Gaudio AD,Del Gaudio GA

    更新日期:1993-09-15 00:00:00

  • Sequential methotrexate and 5-fluorouracil with bleomycin and cisplatin in the chemotherapy of advanced squamous cancer of the head and neck.

    abstract::A bolus intravenous dose of 5-fluorouracil of 600 mg/M2 was added exactly 1 hour after methotrexate administration in an established combination program including bleomycin and cisplatin for advanced squamous cell cancer of the head and neck. Results were no better than those observed previously with the three drugs, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860215)57:4<706::aid-cncr28205

    authors: Vogl SE,Komisar A,Kaplan BH,Engstrom PF,Kasule OH,Stolbach L,Lerner H,Muggia F

    更新日期:1986-02-15 00:00:00

  • Nonperioperative strokes in children with central nervous system tumors.

    abstract:BACKGROUND:Nonperioperative strokes are rare yet potentially devastating events for children with central nervous system (CNS) tumors. The incidence of and risk factors for nonperioperative strokes in children with CNS tumors is unknown. METHODS:The authors performed a retrospective review of children from their insti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Bowers DC,Mulne AF,Reisch JS,Elterman RD,Munoz L,Booth T,Shapiro K,Doxey DL

    更新日期:2002-02-15 00:00:00

  • Clear cell carcinoma of the uterine endocervix with an in situ component.

    abstract::In the past all clear cell carcinomas of the female genital tract were thought to arise from mesonephric remnants. Recently increasing evidence has related their origin to müllerian rather than mesonephric epithelium. One of the main reasons that has been advanced to support their mesonephric origin has been their occ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197811)42:5<2435::aid-cncr282042

    authors: Hasumi K,Ehrmann RL

    更新日期:1978-11-01 00:00:00

  • Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma.

    abstract::In a randomized series of 70 patients with with colo rectal adenocarcinoma, a comparison of systemic 5-fluorouracil chemotherapy administered as a continuous 120-hours infusion vs. intravenous bolus injection daily for 5 days demonstrated superiority of prolonged intravenous infusion. The most striking advantage of pr...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197507)36:1<123::aid-cncr2820360

    authors: Seifert P,Baker LH,Reed ML,Vaitkevicius VK

    更新日期:1975-07-01 00:00:00

  • Pathology of small hepatocellular carcinoma. A proposal for a new gross classification.

    abstract::Review of 61 surgically resected small hepatocellular carcinomas (HCC) less than or equal to 3 cm in diameter yielded a simple gross classification system of five types based on tumor shape, which is highly correlated with microscopic and clinical features, including prognosis. Type 1 (single nodular type) tumors (n =...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870815)60:4<810::aid-cncr28206

    authors: Kanai T,Hirohashi S,Upton MP,Noguchi M,Kishi K,Makuuchi M,Yamasaki S,Hasegawa H,Takayasu K,Moriyama N

    更新日期:1987-08-15 00:00:00