Molecular epidemiology of HTLV-I-associated non-Hodgkin's lymphomas in Jamaica.

Abstract:

:As part of epidemiologic studies of human T-lymphotropic virus (HTLV)-I-associated malignancies in Jamaica, the authors evaluated 26 patients with non-Hodgkin's lymphoma for the presence of integrated HTLV-I provirus in their malignant cells. Fifteen of 26 patients had integrated provirus. All 15 also were HTLV-I antibody positive. Eleven patients did not have integrated provirus, and all 11 were antibody negative. All of the antibody-positive cases had onset of their disease in adulthood (age range, 21-57 years) as opposed to the broad age range of negative cases (4-66 years). Clinical features which were more common in provirus positive than negative patients included leukemic phase, skin involvement, and hypercalcemia, which are all features frequently seen in HTLV-I-associated adult T-cell leukemia/lymphoma (ATLL). The presence of skin involvement, circulating malignant cells, abnormal liver function tests, or the presence of two or more of these four features were statistically significantly different between virus-positive and virus-negative cases. Although the survival of positive cases (6 months) was shorter than that of negative cases (9 months), this was not statistically significant. The only significant determinant of survival was hypercalcemia, with those who developed hypercalcemia at some point in their disease course, independent of their HTLV-I status, surviving a mean of 5 months as compared to a mean of 17.5 months in those who never became hypercalcemic. The six HTLV-I-positive lymphomas that underwent cell typing were all primarily OKT4 positive, whereas two HTLV-I antibody-negative cases that were typed were B-cell lymphomas.

journal_name

Cancer

journal_title

Cancer

authors

Clark JW,Gurgo C,Franchini G,Gibbs WN,Lofters W,Neuland C,Mann D,Saxinger C,Gallo RC,Blattner WA

doi

10.1002/1097-0142(19880401)61:7<1477::aid-cncr2820

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

1477-82

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

61

pub_type

杂志文章

相关文献

CANCER文献大全
  • Presentation and outcome of frequent and rare sarcoma histologic subtypes: A study of 10,262 patients with localized visceral/soft tissue sarcoma managed in reference centers.

    abstract:BACKGROUND:The objective of this study was to describe characteristics at diagnosis and outcomes of adults with soft tissue sarcoma. METHODS:The authors conducted a retrospective multicenter study of 12,262 patients who were treated between January 1980 and 31 December 2013 in French Sarcoma Group centers and enrolled...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.31176

    authors: Penel N,Coindre JM,Giraud A,Terrier P,Ranchere-Vince D,Collin F,Guellec SLE,Bazille C,Lae M,de Pinieux G,Ray-Coquard IL,Bonvalot S,Cesne ALE,Robin YM,Stoeckle E,Toulmonde M,Blay JY

    更新日期:2018-03-15 00:00:00

  • The prognostic significance of p34cdc2 and cyclin D1 protein expression in prostate adenocarcinoma.

    abstract:BACKGROUND:Cyclin-dependent kinases (CDK) and cyclins constitute the subunits of the maturation-promoting factor that controls the process of cell division. High levels of these proteins have been reported in human malignancies of the stomach, colon, breast, and lung, and have been implicated in aberrant cell division ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970815)80:4<753::aid-cnc

    authors: Kallakury BV,Sheehan CE,Ambros RA,Fisher HA,Kaufman RP Jr,Ross JS

    更新日期:1997-08-15 00:00:00

  • Radiation tolerance of the spinal cord.

    abstract::A series of nine cases of radiation myelopathy seen at the University of California, San Francisco (UCSF) is reviewed, and their treatment data converted into nominal single doses (NSD) and equivalent single doses (ED). The 1% incidence level of myelopathy in the thoracic cord is 1015 rets (ED), and the 50% incidence...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197506)35:6<1558::aid-cncr282035

    authors: Wara WM,Phillips TL,Sheline GE,Schwade JG

    更新日期:1975-06-01 00:00:00

  • Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma.

    abstract:BACKGROUND:Stepwise progression of peripheral-type lung adenocarcinoma was characterized morphologically and was related to prognosis. Expression of the tumor suppressor gene p16 in pulmonary adenocarcinoma decreased, mainly as a result of aberrant methylation of the CpG islands of the promoter region. METHODS:Aberran...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20827

    authors: Tanaka R,Wang D,Morishita Y,Inadome Y,Minami Y,Iijima T,Fukai S,Goya T,Noguchi M

    更新日期:2005-02-01 00:00:00

  • Findings from NSABP Protocol No. B-04: comparison of radical mastectomy with alternative treatments. II. The clinical and biologic significance of medial-central breast cancers.

    abstract::Findings from 1665 women with primary breast cancer, treated at 34 NSABP institutions in Canada and the United States, have failed to demonstrate that patients with medial-central tumors had a greater probability of developing distant metastases or dying than did those with lateral tumors despite the greater incidence...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19811015)48:8<1863::aid-cncr2820

    authors: Fisher B,Wolmark N,Redmond C,Deutsch M,Fisher ER

    更新日期:1981-10-15 00:00:00

  • Endocrine therapy for desmoid tumors.

    abstract::Two female patients with desmoid tumors (aggressive fibromatosis) showed tumor regression after endocrine therapy. In one patient, tumor response to tamoxifen has been maintained over several years of treatment. In the second patient, who had inoperable mesenteric fibromatosis, the tumor progressed on tamoxifen but re...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19910915)68:6<1384::aid-cncr2820

    authors: Wilcken N,Tattersall MH

    更新日期:1991-09-15 00:00:00

  • Role of endoscopic retrograde cholangiopancreatography in differentiating pancreatic cancer coexisting with chronic pancreatitis.

    abstract::The pancreatographic appearance and the clinical presentation of ten patients presenting with adenocarcinoma of the head of the pancreas coexisting with chronic pancreatitis were compared with those of 45 patients with chronic pancreatitis (CP), without malignancy, investigated at the same time period. All ten patient...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900215)65:4<893::aid-cncr28206

    authors: Shemesh E,Czerniak A,Nass S,Klein E

    更新日期:1990-02-15 00:00:00

  • The relationship between shaved margin and inked margin status in breast excision specimens.

    abstract:BACKGROUND:The presence of tumor at the inked margins (IMs) of breast specimens is associated with an increased risk of local recurrence after breast-conserving therapy for invasive breast carcinoma and ductal carcinoma in situ (DCIS). Given the importance of margin status, some have advocated the use of shaved margins...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Guidi AJ,Connolly JL,Harris JR,Schnitt SJ

    更新日期:1997-04-15 00:00:00

  • Thermoradiation therapy for superficial malignant tumors.

    abstract:BACKGROUND:Between 1980-1990, 126 patients were treated with radiation therapy (RT) and hyperthermia using 915-MHz external microwave applicators. All but 11 patients had failed to respond to previous therapy. METHODS:The mean tumor volume was 73 +/- 13 cm3, and the mean radiation dose delivered was 45 +/- 1 Gy. Hyper...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930701)72:1<287::aid-cncr28207

    authors: Engin K,Leeper DB,Tupchong L,Waterman FM,Mansfield CM

    更新日期:1993-07-01 00:00:00

  • Chemotherapy of advanced salivary gland neoplasms.

    abstract::Fourteen patients with advanced salivary gland malignancies were treated with combination chemotherapy. Five of 13 patients responded to cyclophosphamide and adriamycin and two patients in the responding groups underwent further potentially curable treatment, rendering them disease-free. Three patients with mucoepider...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19821201)50:11<2261::aid-cncr282

    authors: Posner MR,Ervin TJ,Weichselbaum RR,Fabian RL,Miller D

    更新日期:1982-12-01 00:00:00

  • A Phase II trial of pegylated liposomal doxorubicin, vincristine, and reduced-dose dexamethasone combination therapy in newly diagnosed multiple myeloma patients.

    abstract:BACKGROUND:Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop resistance and cardiac and steroid t...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.10946

    authors: Hussein MA,Wood L,Hsi E,Srkalovic G,Karam M,Elson P,Bukowski RM

    更新日期:2002-11-15 00:00:00

  • Nuclear DNA profiles in primary melanomas and their metastases.

    abstract::DNA-aneuploid primary melanomas are said to show a greater propensity to metastasize than those without an aneuploid profile. A higher aneuploid rate has also been reported in metastatic melanomas than in primary lesions. The ploidy profile was determined of 26 primary melanomas and their first subsequent secondaries ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910501)67:9<2333::aid-cncr2820

    authors: Rode J,Williams RA,Charlton IG,Dhillon AP,Moss E

    更新日期:1991-05-01 00:00:00

  • Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications.

    abstract:BACKGROUND:Recent preclinical explorations strongly support the tumorigenic potential of bile on laryngopharyngeal mucosa. Herein, the authors describe, in bile-related human hypopharyngeal squamous cell carcinoma (HSCC), NF-κB-related messenger RNA (mRNA) and microRNA (miRNA) oncogenic phenotypes similar to those prev...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32369

    authors: Sasaki CT,Doukas SG,Costa J,Vageli DP

    更新日期:2019-10-15 00:00:00

  • Primary malignant fibrous histiocytoma of the aorta.

    abstract::A rare case of malignant fibrous histiocytoma of the aorta is reported. Review of the literature revealed that primary tumors of the aorta are exclusively mesenchymal tumors that almost invariably pursue a fatal course. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810801)48:3<840::aid-cncr28204

    authors: Chen KT

    更新日期:1981-08-01 00:00:00

  • Carboplatin-based versus cisplatin-based chemotherapy in the treatment of surgically incurable advanced bladder carcinoma.

    abstract:BACKGROUND:The carboplatin-based chemotherapeutic regimen M-CAVI (methotrexate, carboplatin, and vinblastine) is active against bladder carcinoma and can be administered to patients who are ineligible to receive cisplatin or doxorubicin. The authors designed a randomized study to evaluate whether M-CAVI offers a therap...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1097-0142(19971115)80:10<1966::aid-c

    authors: Bellmunt J,Ribas A,Eres N,Albanell J,Almanza C,Bermejo B,Solé LA,Baselga J

    更新日期:1997-11-15 00:00:00

  • Surviving cancer.

    abstract::Research trends on quality of life outcomes for cancer survivors are discussed. Epidemiologic data indicate that female cancer survivors, coming primarily from patient groups with gynecologic, breast, and colorectal cancers, will outnumber male survivors 3 to 1. Male survivors will come from the ranks of patient group...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19940815)74:4+<1484::aid-cncr282

    authors: Andersen BL

    更新日期:1994-08-15 00:00:00

  • A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus.

    abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) have activity in solid tumors. The authors evaluated an oral EGFR TKI, erlotinib, in patients with previously treated esophageal cancer. METHODS:Thirty patients with measurable, metastatic cancer of the esophageal and gastroeso...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25602

    authors: Ilson DH,Kelsen D,Shah M,Schwartz G,Levine DA,Boyd J,Capanu M,Miron B,Klimstra D

    更新日期:2011-04-01 00:00:00

  • Prevalence and clinical implications of cyclin D1 expression in diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program.

    abstract:BACKGROUND:Cyclin D1 expression has been reported in a subset of patients with diffuse large B-cell leukemia (DLBCL), but studies have been few and generally small, and they have demonstrated no obvious clinical implications attributable to cyclin D1 expression. METHODS:The authors reviewed 1435 patients who were diag...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28664

    authors: Ok CY,Xu-Monette ZY,Tzankov A,O'Malley DP,Montes-Moreno S,Visco C,Møller MB,Dybkaer K,Orazi A,Zu Y,Bhagat G,Richards KL,Hsi ED,Han van Krieken J,Ponzoni M,Farnen JP,Piris MA,Winter JN,Medeiros LJ,Young KH

    更新日期:2014-06-15 00:00:00

  • Resection alone in 58 children with limited stage, lymphocyte-predominant Hodgkin lymphoma-experience from the European network group on pediatric Hodgkin lymphoma.

    abstract:BACKGROUND:Lymphocyte-predominant Hodgkin lymphoma (LPHL) is a rare, CD20-positive, good prognostic lymphoma in children. Patients with early-stage LPHL who underwent successful surgical lymph node resection alone have been reported. To clarify the optimum treatment strategy in children, European study groups were aske...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22762

    authors: Mauz-Körholz C,Gorde-Grosjean S,Hasenclever D,Shankar A,Dörffel W,Wallace WH,Schellong G,Robert A,Körholz D,Oberlin O,Hall GW,Landman-Parker J

    更新日期:2007-07-01 00:00:00

  • Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis.

    abstract:BACKGROUND:Pigmented villonodular synovitis (PVNS) (also known as diffuse-type giant cell tumor) and tenosynovial giant cell tumors (TGCT) are rare, usually benign neoplasms that affect the synovium and tendon sheaths in young adults. These tumors are driven by the overexpression of colony stimulating factor-1 (CSF1). ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26409

    authors: Cassier PA,Gelderblom H,Stacchiotti S,Thomas D,Maki RG,Kroep JR,van der Graaf WT,Italiano A,Seddon B,Dômont J,Bompas E,Wagner AJ,Blay JY

    更新日期:2012-03-15 00:00:00

  • Plasma thyroid-stimulating hormone and thyroxine concentrations in breast cancer.

    abstract::Plasma TSH and thyroxine levels were measured in 74 early breast cancer patients and 53 with advanced disease, 77 patients with cancer arising in other organs and 67 healthy women of similar age. The mean plasma TSH levels were higher in the breast cancer cases than the other two groups; the difference was statistical...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197802)41:2<666::aid-cncr2820410

    authors: Rose DP,Davis TE

    更新日期:1978-02-01 00:00:00

  • Superficial cerebral astrocytoma attached to dura. Report of six cases in infants.

    abstract::Reported are six cases of meningocerebral astrocytomas attached to dura, involving the superficial cortex, in infants under 1 year of age. They represent 1.25% of 483 intracranial tumors in infancy studied at the Children's Hospital in the last 12 years. Five were located in the frontal lobes, with variable extension ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841201)54:11<2505::aid-cncr282

    authors: Taratuto AL,Monges J,Lylyk P,Leiguarda R

    更新日期:1984-12-01 00:00:00

  • Squamous cell carcinoma antigen in the diagnosis and treatment follow-up of oral and facial squamous cell carcinoma.

    abstract::The squamous cell carcinoma (SCC) antigen was determined by radioimmunoassay in the serum of 40 untreated patients with SCC of the oromaxillofacial region. The mean (+/- SEM) serum concentration for these patients (3.8 +/- 0.8 ng/ml) was significantly higher than that of 52 disease-free patients coming to routine post...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900315)65:6<1321::aid-cncr2820

    authors: Fischbach W,Meyer T,Barthel K

    更新日期:1990-03-15 00:00:00

  • Consecutive lymphoma with monoclonal gammopathy in a married couple.

    abstract::Mixed cellularity Hodgkin's disease and diffuse non-Hodgkin's lymphoma, mixed cell type, occurred consecutively in a husband and wife. Both patients demonstrated monoclonal IgM gammopathies. The unusual nature and possible significance of these findings are discussed. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860115)57:2<277::aid-cncr28205

    authors: Offit K,Macris NT,Hellman G,Rotterdam HZ

    更新日期:1986-01-15 00:00:00

  • Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.

    abstract:BACKGROUND:Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26222

    authors: Zhang Y,Sturgis EM,Huang Z,Zafereo ME,Wei Q,Li G

    更新日期:2012-01-15 00:00:00

  • Gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists.

    abstract:BACKGROUND:The current study was conducted to examine gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists. METHODS:The participants included a convenience sample of 178 oncologists from Israel (52 of whom were women) and Canada (48 of whom were women). Oncol...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30236

    authors: Granek L,Krzyzanowska MK,Nakash O,Cohen M,Ariad S,Barbera L,Levy R,Ben-David M

    更新日期:2016-12-01 00:00:00

  • Comparative analysis of the sensitivity of endometrial cancer cells to epidermal growth factor and steroid hormones.

    abstract:BACKGROUND:Epidermal growth factor (EGF) and EGF-regulated processes play an important role in steroid signal transduction. Comparative analysis of EGF and steroid receptor expression and the sensitivity of early stages of proliferation induction, such as activation of phospholipid turnover to EGF and steroids, may pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951215)76:12<2524::aid-cncr282

    authors: Gershtein ES,Shatskaya VA,Kostyleva OI,Ermilova VD,Kushlinsky NE,Krasil'nikov MA

    更新日期:1995-12-15 00:00:00

  • Observations on growth rate of breast carcinomas and its possible implications for lead time.

    abstract::Doubling times were estimated for 15 breast carcinomas in 13 patients, and were found to be between 42 and 397 days with the average at 211 days. The mean lead time at mean growth rate from the average size of 44 preclinical to the average size of 118 clinical tumors was estimated to be 3 years. This period may be con...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197710)40:4<1722::aid-cncr282040

    authors: Lundgren B

    更新日期:1977-10-01 00:00:00

  • Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelial cancer.

    abstract:BACKGROUND:Recent studies have shown that multiple cytokines are secreted by ovarian epithelial cancer cells. Previous studies have shown that the cancer cell lines secrete macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-1 (IL-1), interleukin-6 (IL-6)...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931015)72:8<2433::aid-cncr2820

    authors: Moradi MM,Carson LF,Weinberg B,Haney AF,Twiggs LB,Ramakrishnan S

    更新日期:1993-10-15 00:00:00

  • Prolonged survival after cerebral metastasis of testicular carcinoma.

    abstract::A 30-year-old man underwent orchiectomy in 1962 for a testicular carcinoma composed of choriocarcinomatous and teratocarcinomatous elements. Bilateral pulmonary metastases regressed completely on combination chemotherapy. However, a cerebral metastasis developed in 1963 and caused severe neurologic signs. At craniotom...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810301)47:5<978::aid-cncr28204

    authors: Stolinsky DC

    更新日期:1981-03-01 00:00:00