Presentation and outcome of frequent and rare sarcoma histologic subtypes: A study of 10,262 patients with localized visceral/soft tissue sarcoma managed in reference centers.

Abstract:

BACKGROUND:The objective of this study was to describe characteristics at diagnosis and outcomes of adults with soft tissue sarcoma. METHODS:The authors conducted a retrospective multicenter study of 12,262 patients who were treated between January 1980 and 31 December 2013 in French Sarcoma Group centers and enrolled in the "Conticabase." Diagnoses were systematically reviewed by expert pathologists, and entities were classified according to the 2013 World Health Organization classification. Diagnostic characteristics, treatments, and outcomes are described for the entire cohort, for the subgroup of patients with translocation-related sarcomas, and for 9 different histologic subtypes. RESULTS:The results stressed the magnitude of heterogeneity among adult sarcomas. For example, compared with other sarcomas, translocation-related sarcomas (2143 tumors; 20.8%) were associated with a younger age at presentation (40.6 vs 60.0 years; P < .0001), a low rate of predisposing conditions (0.01% vs 22.3%; P < .0001), a higher rate of lymph node involvement (4.7% vs 1.3%; P < .0001), and a higher rate of synchronous metastasis (11.9% vs 6.7%; P < .001); and complete (R0) resection (41.6% vs 31.9%; P < .0001), receipt of (neo)adjuvant radiation therapy (62.6% vs 42.2%; P < .0001), and receipt of (neo)adjuvant chemotherapy (36.6% vs 22.3%; P < .0001) were significantly more frequent. Overall, translocation-related sarcomas were associated with a lower rate of local relapse (18.1% vs 26.0%; P < .0001) but a higher rate of metastatic relapse (42.0% vs 30.7%; P < .0001). CONCLUSIONS:Collaborative efforts are urgently needed to better assess the natural history and management options for every histologic subtype of sarcoma. Cancer 2018;124:1179-87. © 2017 American Cancer Society.

journal_name

Cancer

journal_title

Cancer

authors

Penel N,Coindre JM,Giraud A,Terrier P,Ranchere-Vince D,Collin F,Guellec SLE,Bazille C,Lae M,de Pinieux G,Ray-Coquard IL,Bonvalot S,Cesne ALE,Robin YM,Stoeckle E,Toulmonde M,Blay JY

doi

10.1002/cncr.31176

subject

Has Abstract

pub_date

2018-03-15 00:00:00

pages

1179-1187

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

124

pub_type

杂志文章,多中心研究

相关文献

CANCER文献大全
  • Adjuvant radiotherapy versus combined sequential chemotherapy followed by radiotherapy in the treatment of resected nonsmall cell lung carcinoma. A randomized trial of 267 patients. GETCB (Groupe d'Etude et de Traitement des Cancers Bronchiques).

    abstract:BACKGROUND:The effect of adjuvant chemotherapy after resection of nonsmall cell lung cancer (NSCLC) remains an unresolved question. METHODS:From October, 1982, to November, 1986, 267 patients with resected NSCLC were included in a randomized trial. The adjuvant allocated treatments were either postoperative radiothera...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19950901)76:5<779::aid-cncr28207

    authors: Dautzenberg B,Chastang C,Arriagada R,Le Chevalier T,Belpomme D,Hurdebourcq M,Lebeau B,Fabre C,Charvolin P,Guérin RA

    更新日期:1995-09-01 00:00:00

  • Angiosarcoma in Japan. A review of 99 cases.

    abstract:BACKGROUND:Angiosarcoma is rare, and information about its clinical features are limited. Therefore, a large scale study of angiosarcoma was performed in Japan. METHODS:Through a nationwide Japanese study, 99 cases of angiosarcoma were collected and their clinicopathologic findings were summarized relative to predispo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950215)75:4<989::aid-cncr28207

    authors: Naka N,Ohsawa M,Tomita Y,Kanno H,Uchida A,Aozasa K

    更新日期:1995-02-15 00:00:00

  • Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns: a clinicopathologic study of 183 patients.

    abstract:BACKGROUND:The term poorly differentiated (PD) carcinoma was proposed 20 years ago to define aggressive, follicular-derived thyroid carcinomas with behavior intermediate between follicular/papillary and anaplastic carcinomas. Among the variable histologic patterns recognized in such tumors, trabecular-insular-solid (TI...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20087

    authors: Volante M,Landolfi S,Chiusa L,Palestini N,Motta M,Codegone A,Torchio B,Papotti MG

    更新日期:2004-03-01 00:00:00

  • Mass screening for control of breast cancer.

    abstract::The serious import of breast cancer lies in its potential for metastatic spread, which probably starts early in the course of the disease. Detection of the lesion when immunocompetence can control the metastases leads to long-term survival. This usually involves detection of unsuspected, preclinical disease. This is t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840201)53:3+<665::aid-cncr2820

    authors: Strax P

    更新日期:1984-02-01 00:00:00

  • Deferred therapy in patients with advanced disease.

    abstract::Disease that is known to have extended beyond the prostatic capsule is unlikely to be cured by radical surgical excision, although the primary tumor may be controlled by external irradiation. The development of progressive (metastatic) disease is common and may be retarded by hormonal therapy. The timing of such treat...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930201)71:3+<1074::aid-cncr282

    authors: Smith PH

    更新日期:1993-02-01 00:00:00

  • Radiation therapy of malignant melanomas: an evaluation of clinically used fractionation schemes.

    abstract::To assess the importance of radiation dose fraction size in the treatment of malignant melanomas, the records of 48 patients (83 sites) treated at Tufts-New England Medical Center from 1971 to 1979 have been retrospectively reviewed. During this period, the dose fractionation schemes evolved from standard fraction siz...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810315)47:6<1262::aid-cncr2820

    authors: Strauss A,Dritschilo A,Nathanson L,Piro AJ

    更新日期:1981-03-15 00:00:00

  • A framework for cancer health economics research.

    abstract:LAY SUMMARY:Cancer has substantial economic impacts for patients, their families and/or caregivers, employers, and the health care system. However, there is only limited understanding of how economic issues can affect access to cancer care services and the receipt of high-quality cancer care. Health economics research ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33343

    authors: Halpern MT,Shih YT,Yabroff KR,Ekwueme DU,Bradley CJ,Davidoff AJ,Sabik LM,Lipscomb J

    更新日期:2020-11-25 00:00:00

  • Anti-HTLV-1 antibody positive cutaneous T-cell lymphoma.

    abstract:BACKGROUND:Adult T-cell leukemia/lymphoma (ATLL) is a neoplasm of the mature helper T-lymphocyte. Human T-lymphotropic virus type 1 (HTLV-1) has been shown to be the cause of this neoplasm. Recently, however, the HTLV-1 genome has been found in some patients with cutaneous T-cell lymphoma (CTCL), which suggests a causa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Kikuchi A,Ohata Y,Matsumoto H,Sugiura M,Nishikawa T

    更新日期:1997-01-15 00:00:00

  • Immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen-positive childhood T-cell leukemia. A Pediatric Oncology Group Study.

    abstract::The immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen (CALLA)-positive and CALLA-negative T-acute lymphoblastic leukemia (ALL) and of CALLA-positive non-T, non-B ALL (common ALL) of childhood were compared. Twenty-seven percent of children with T-ALL had blasts that expressed CA...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2020::aid-cncr282

    authors: Dowell BL,Borowitz MJ,Boyett JM,Pullen DJ,Crist WM,Quddus FF,Russell EC,Falletta JM,Metzgar RS

    更新日期:1987-06-15 00:00:00

  • Obesity at diagnosis is associated with inferior outcomes in hormone receptor-positive operable breast cancer.

    abstract:BACKGROUND:Obesity has been associated with inferior outcomes in operable breast cancer, but the relation between body mass index (BMI) and outcomes by breast cancer subtype has not been previously evaluated. METHODS:The authors evaluated the relation between BMI and outcomes in 3 adjuvant trials coordinated by the Ea...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27527

    authors: Sparano JA,Wang M,Zhao F,Stearns V,Martino S,Ligibel JA,Perez EA,Saphner T,Wolff AC,Sledge GW Jr,Wood WC,Fetting J,Davidson NE

    更新日期:2012-12-01 00:00:00

  • Histopathologic grading and DNA ploidy in relation to survival among 206 adult astrocytic tumor patients.

    abstract:BACKGROUND:The authors studied the benefit of performing histopathologic grading and DNA ploidy characterization with respect to patient survival in a series of 206 astrocytomas (AST) for which they obtained 134 complete clinical follow-ups. METHODS:The material analyzed came from archival material, i.e., formalin-fix...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920715)70:2<538::aid-cncr28207

    authors: Salmon I,Kiss R,Dewitte O,Gras T,Pasteels JL,Brotchi J,Flament-Durand J

    更新日期:1992-07-15 00:00:00

  • A comparison of screening mammography results from programs for women of different socioeconomic status.

    abstract:BACKGROUND:The ability of screening mammography programs serving women of different socioeconomic status (SES) to diagnose early stage breast carcinoma in a comparably effective fashion has been questioned. METHODS:Results of screening 50,653 women of lower SES were compared with those of screening 45,923 more socioec...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980501)82:9<1692::aid-cn

    authors: Dershaw DD,Loring L,True SJ,Momrow DC,Liberman L,Morris EA

    更新日期:1998-05-01 00:00:00

  • High-dose etoposide and marrow transplantation.

    abstract::Etoposide underwent conventional Phase I testing in the 1970s. The dose-limiting toxicity in these studies was mild myelosuppression; other toxicities were infrequent. If a greater degree of myelosuppression is accepted, higher than standard doses could be given. This approach takes advantage of the steep dose-respons...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19910101)67:1+<292::aid-cncr2820

    authors: Herzig RH

    更新日期:1991-01-01 00:00:00

  • Time for reappraisal of extracranial treatment options? Synchronous brain metastases from nonsmall cell lung cancer.

    abstract:BACKGROUND:The optimal treatment of the primary tumor in patients with brain metastases (BM) from newly diagnosed nonsmall cell lung cancer (NSCLC) remains unclear. The authors aimed to identify patient groups with synchronous BM for whom radical treatment of the primary site may be appropriate. METHODS:The medical re...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25416

    authors: Lind JS,Lagerwaard FJ,Smit EF,Postmus PE,Slotman BJ,Senan S

    更新日期:2011-02-01 00:00:00

  • Combination external beam radiation and brachytherapy boost with androgen deprivation for treatment of intermediate-risk prostate cancer: long-term results of CALGB 99809.

    abstract:BACKGROUND:Combined transperineal prostate brachytherapy and external beam radiation therapy (EBRT) is widely used for treatment of prostate cancer. Long-term efficacy and toxicity results of a multicenter phase 2 trial assessing combination of EBRT and transperineal prostate brachytherapy boost with androgen deprivati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26203

    authors: Hurwitz MD,Halabi S,Archer L,McGinnis LS,Kuettel MR,DiBiase SJ,Small EJ

    更新日期:2011-12-15 00:00:00

  • Small cell carcinoma of the major salivary glands.

    abstract::Small cell carcinoma is primarily a pulmonary neoplasm that rarely arises in extrapulmonic sites including salivary glands of the head and neck. Twelve cases of small cell carcinoma of salivary gland origin were retrieved from the Armed Forces Institute of Pathology files. Six tumors occurred in the parotid gland and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860801)58:3<705::aid-cncr28205

    authors: Gnepp DR,Corio RL,Brannon RB

    更新日期:1986-08-01 00:00:00

  • Extraskeletal telangiectatic osteosarcoma.

    abstract::The first three well-documented cases of pure, extraskeletal telangiectatic osteosarcoma of the soft tissues are presented in this article. The distinctive gross features were a predominance of large, blood-filled spaces, which, on histologic examination, were large blood-filled cavities in association with cyst-like ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930515)71:10<3014::aid-cncr282

    authors: Mirra JM,Fain JS,Ward WG,Eckardt JJ,Eilber F,Rosen G

    更新日期:1993-05-15 00:00:00

  • Prevention of radiation enteritis by an absorbable polyglycolic acid mesh sling. A 60-case multicentric study.

    abstract::Radiation-induced small bowel injury is a limiting factor to postoperative tumoricidal pelvic doses exceeding 4500 to 5000 cGy. Data from a review of the literature showed the inadequacy of medical measures and the bad reproducibility of radiation therapeutic attempts to decrease small intestine damage. Recent studies...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/1097-0142(19911215)68:12<2545::aid-cncr282

    authors: Rodier JF,Janser JC,Rodier D,Dauplat J,Kauffmann P,Le Bouedec G,Giraud B,Lorimier G

    更新日期:1991-12-15 00:00:00

  • High-dose methotrexate in small cell lung cancer. Lack of efficacy in preventing CNS relapse.

    abstract::Few studies have incorporated high-dose methotrexate (MTX) with leucovorin rescue in the treatment of small cell lung cancer (SCLC). Potentially therapeutic levels of MTX can be achieved in the central nervous system (CNS) by systemic administration of high doses of this drug. Utilizing a combination chemotherapy prog...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830315)51:6<1056::aid-cncr2820

    authors: Neijstrom ES,Capizzi RL,Rudnick SA,Kirsch M,Delaney D,Kahn L,Lipper S,Carney C

    更新日期:1983-03-15 00:00:00

  • Evolution of colorectal cancer in schistsosomiasis: transitional mucosal changes adjacent to large intestinal carcinoma in colectomy specimens.

    abstract::In this study of 454 colorectal carcinoma colectomy specimens, (289 were associated with and 165 were unassociated with schistosomiasis. Schistosome infestation was found to play an etiologic role in bowel malignancy in patients having diffuse involvement of the large intestine and a history of ten years or more of co...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801001)46:7<1661::aid-cncr2820

    authors: Ming-Chai C,Chi-Yuan C,Pei-Yu C,Jen-Chun H

    更新日期:1980-10-01 00:00:00

  • Combination chemotherapy in abdominal Burkitt's lymphoma.

    abstract::In a clinical trial, 42 patients with abdominal Burkitt's lymphoma (BL) were treated with a combination regimen, code-named CVA, consisting of cyclophosphamide (CTX), vincristine, and cystosine arabinoside. In addition, intrathecal methotrexate (i.t. MTX) was administered as prophylaxis against subsequent central nerv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197710)40:4<1410::aid-cncr282040

    authors: Nkrumah FK,Perkins IV,Biggar RJ

    更新日期:1977-10-01 00:00:00

  • Genetic predisposition to breast cancer.

    abstract::Breast cancer is the most common cancer among American women. Because metastatic breast cancer is an incurable disease, efforts to decrease breast cancer mortality have focused on early detection and improved treatment. Identification and analysis of a specific genetic susceptibility could permit detection of suscepti...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19920915)70:4+<1747::aid-cncr282

    authors: Skolnick MH,Cannon-Albright LA

    更新日期:1992-09-15 00:00:00

  • Cancer of the urinary bladder in blacks and whites. A case-control study.

    abstract::Racial differences in the risk of cancer of the urinary bladder associated with cigarette smoking and alcohol consumption were examined in a study of 1663 cases (1534 whites and 129 blacks) and 4930 controls matched 3:1 by sex, race, and age to the cases. Significant increases in cancer risk associated with cigarette ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901215)66:12<2673::aid-cncr282

    authors: Harris RE,Chen-Backlund JY,Wynder EL

    更新日期:1990-12-15 00:00:00

  • Intravascular bronchioloalveolar tumor.

    abstract::A 17-year-old girl was operated for a solitary well-circumscribed pulmonary parenchymal tumor and reoperated ten times for multiple recurrent similar pulmonary tumors during 24 years. Histologic examination revealed the so-called intravascular bronchioloalveolar tumor (IVBAT) in all instances. The patient died from pn...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19871115)60:10<2471::aid-cncr282

    authors: Miettinen M,Collan Y,Halttunen P,Maamies T,Vilkko P

    更新日期:1987-11-15 00:00:00

  • Biomarker-based phase I dose-escalation, pharmacokinetic, and pharmacodynamic study of oral apricoxib in combination with erlotinib in advanced nonsmall cell lung cancer.

    abstract:BACKGROUND:Apricoxib, a novel once-daily selective cyclooxygenase-2 inhibitor, was investigated in combination with erlotinib for recurrent stage IIIB/IV nonsmall cell lung cancer to determine the maximum tolerated dose, dose-limiting toxicity, and recommended phase II dose (RP2D) based on changes in urinary prostaglan...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.25473

    authors: Reckamp K,Gitlitz B,Chen LC,Patel R,Milne G,Syto M,Jezior D,Zaknoen S

    更新日期:2011-02-15 00:00:00

  • The use and effectiveness of rituximab maintenance in patients with follicular lymphoma diagnosed between 2004 and 2007 in the United States.

    abstract:BACKGROUND:The authors examined the "real-world" effectiveness of rituximab (R) maintenance therapy (R-maintenance) compared with observation after R-based induction therapy in patients with previously untreated follicular lymphoma (FL) in the United States. METHODS:The National LymphoCare Study is a prospective, mult...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.28659

    authors: Nastoupil LJ,Sinha R,Byrtek M,Zhou X,Taylor MD,Friedberg JW,Link BK,Cerhan JR,Dawson K,Flowers CR

    更新日期:2014-06-15 00:00:00

  • Unusual clinical presentation of upper urothelial carcinoma in Taiwan.

    abstract:BACKGROUND:The unusual clinical picture of transitional cell carcinoma (TCC) in Taiwan appears to be different from that reported elsewhere. METHODS:The authors reviewed their experience of 135 cases of pathologically proven TCC of the upper urinary tract. Data regarding the gender ratio and clinical presentation were...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Chou YH,Huang CH

    更新日期:1999-03-15 00:00:00

  • Acute lymphoblastic leukemia. An unusual case of primary relapse in the uterine cervix.

    abstract::Female genital tract involvement by hematologic neoplasms is uncommon and is usually associated with disseminated disease. Lymphoid neoplasms, which involve the cervix and uterus primarily, are usually of either diffuse large cell or small cleaved cell type, and rarely Burkitt's (small non-cleaved) lymphoma or granulo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900901)66:5<1002::aid-cncr2820

    authors: Zutter MM,Gersell DJ

    更新日期:1990-09-01 00:00:00

  • Antigenic markers of hepatocellular carcinoma.

    abstract::One hundred thirty-five hepatocellular carcinomas were examined for the presence of antigenic tumor markers by the avidin-biotin-peroxidase complex method. Ninety-seven were from the US and 38 came from Argentina. The following markers were tested: alpha-fetoprotein (AFP), alpha-1-antitrypsin (AAT), hepatitis B surfac...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900101)65:1<84::aid-cncr282065

    authors: Chedid A,Chejfec G,Eichorst M,Villamil F,Terg R,Telenta M,Hojman R

    更新日期:1990-01-01 00:00:00

  • After treatment. Psychosocial issues in gynecologic cancer survivorship.

    abstract::The woman treated for gynecologic cancer must contend with a challenging group of issues in her efforts to recover psychologically in the months and years after treatment: chance of dying, changed self-perception, treatment-related menopause, impaired or lost fertility, sexual dysfunction, and relationship problems mu...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19951115)76:10+<2117::aid-cncr28

    authors: Auchincloss SS

    更新日期:1995-11-15 00:00:00