Abstract:
:Two female patients with desmoid tumors (aggressive fibromatosis) showed tumor regression after endocrine therapy. In one patient, tumor response to tamoxifen has been maintained over several years of treatment. In the second patient, who had inoperable mesenteric fibromatosis, the tumor progressed on tamoxifen but regressed after treatment with Zoladex (goserelin acetate, ICI, Melbourne, Australia) and medroxyprogesterone acetate (MPA). To the authors' knowledge this is the first report of the use of Zoladex in the treatment of desmoid tumors. This review of the literature reveals that the biology of this disease is related to the endogenous hormonal environment and that estrogen receptors have been documented in desmoid tumors. Thirty-five cases are identified where endocrine agents have been employed, with a response rate of 51%. Furthermore, tumors may respond to second-line hormonal therapy after failing to respond to initial endocrine treatment. Endocrine treatments have also been used in other disorders of fibroblastic origin. The authors recommend that endocrine treatment be employed in inoperable desmoid tumors or where there has been postsurgical recurrence. In addition, the role for endocrine therapy in other soft tissue neoplasms should be determined.
journal_name
Cancerjournal_title
Cancerauthors
Wilcken N,Tattersall MHdoi
10.1002/1097-0142(19910915)68:6<1384::aid-cncr2820subject
Has Abstractpub_date
1991-09-15 00:00:00pages
1384-8issue
6eissn
0008-543Xissn
1097-0142journal_volume
68pub_type
杂志文章,评审相关文献
CANCER文献大全abstract::A patient with a 17-year course of metastatic lobular carcinoma of the breast is described who developed large numbers of circulating carcinoma cells which were easily detectable in several routine peripheral blood smears shortly before death. This rare complication of carcinoma has been called "carcinocythemia." Carc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197712)40:6<3107::aid-cncr282040
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Thymic malignancies are rare tumors. The insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) system is involved in the development of the thymus. IGF-1R expression in thymic epithelial malignancies is unknown. METHODS:The authors investigated the expression of IGF-1R and phosphorylated AKT serine 4...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25367
更新日期:2010-10-15 00:00:00
abstract::The authors report on five patients with secondary leukemia (SL) and one of the "specific" chromosomal rearrangements usually encountered in de novo acute nonlymphoblastic leukemia: inv(16), t(15;17), t(8;21), and t(9;11). They were characterized by solid tumor as the primary malignancy in four of five cases, absence ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890615)63:12<2505::aid-cncr282
更新日期:1989-06-15 00:00:00
abstract::Cutaneous squamous cell carcinomas (SCC) arising in actinically damaged skin, unassociated with chronic inflammation or injury, are generally regarded as nonaggressive lesions. These tumors occasionally recur or metastasize, however, as do de novo SCC. The authors reviewed 63 patients with cutaneous SCC of the trunk o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850901)56:5<1099::aid-cncr2820
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Cisplatin is one of the single drugs that has shown the best documented effect in treating patients with locally recurrent or metastatic urothelial cancer. To the authors' knowledge, the effect of the combination of different platinum analogues in treating transitional cell carcinoma has not been evaluated p...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19951115)76:10<1797::aid-cncr282
更新日期:1995-11-15 00:00:00
abstract:BACKGROUND:English and Chinese are two of the most widely used primary languages in the world. Patients in many cancer centers have a variety of ethnic backgrounds and primary languages. The comparability of version 4 of the English and Chinese versions of the Functional Assessment of Cancer Therapy-General (FACT-G) an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20681
更新日期:2004-12-15 00:00:00
abstract:BACKGROUND:Obesity has been associated with inferior outcomes in operable breast cancer, but the relation between body mass index (BMI) and outcomes by breast cancer subtype has not been previously evaluated. METHODS:The authors evaluated the relation between BMI and outcomes in 3 adjuvant trials coordinated by the Ea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27527
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The objective of this Phase II study was to evaluate the concept of sequential chemotherapy in the treatment of patients with advanced nonsmall cell lung carcinoma (NSCLC) by the administration of carboplatin plus gemcitabine followed by of paclitaxel. METHODS:Patients with Stage IIIB (pleural effusion) or ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010701)92:1<146::aid-cncr1302>
更新日期:2001-07-01 00:00:00
abstract::Four cases of non-Hodgkin's lymphoma (NHL) limited to the larynx are described. All were diffuse, high-grade, B-cell lymphomas of large lymphoid cell type (three centroblastic and one immunoblastic). Immunocytochemistry was performed on three cases; two showed monoclonal cytoplasmic immunoglobulin and one showed monoc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890901)64:5<1123::aid-cncr2820
更新日期:1989-09-01 00:00:00
abstract::The incidence of long thoracic nerve palsy after radical mastectomy has been documented to be approximately 10%. No cases have been reported after the more recent treatment for breast cancer, lumpectomy with axillary dissection. This more recent surgical procedure is customarily followed by aggressive radiation therap...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870915)60:6<1247::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract:BACKGROUND:The mode of tumor growth of intrahepatic cholangiocarcinoma (CC) varies considerably from patient to patient. This study describes the clinicopathologic variety of the extraductal mass-forming type of CC. METHODS:Patients with CC characterized by an extraductal mass (n = 26) who underwent hepatectomy from 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951215)76:12<2449::aid-cncr282
更新日期:1995-12-15 00:00:00
abstract::Over the last decade, new cytotoxic treatments and targeted therapies have altered treatment paradigms for patients with metastatic non-small cell lung cancer (NSCLC). We sought to analyze the impact of histology and biomarker selection criteria on outcomes of clinical trials in metastatic NSCLC reported over the last...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28956
更新日期:2014-12-15 00:00:00
abstract:BACKGROUND:The use of neoadjuvant and adjuvant chemotherapy in soft tissue sarcomas is controversial. This is a report of long-term (≥5 years) follow-up in patients with high-grade, high-risk soft tissue sarcomas treated with neoadjuvant chemotherapy, preoperative radiotherapy (RT), and adjuvant chemotherapy. METHODS:...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25350
更新日期:2010-10-01 00:00:00
abstract::Three separate histologic types of gastric pseudolymphoma (GPL) are described: (1) the common "inflammatory" type usually accompanied by ulceration and extensive fibrosis; (2) the entity known as "nodular lymphoid hyperplasia," which was associated with multiple intestinal lesions; and (3) the third reported case of a...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19830201)51:3<476::aid-cncr28205
更新日期:1983-02-01 00:00:00
abstract::One hundred fifteen patients underwent surgical treatment of renal cell carcinoma. Survival time was analyzed by statistical regression methods in order to determine the joint significance of stage, using both the Robson and TNM classifications, histologic grade, cell type, and demographic features of the patient samp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830901)52:5<899::aid-cncr28205
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960915)78:6<1267::AID-CN
更新日期:1996-09-15 00:00:00
abstract::The records of 12 patients with a diagnosis of pinealoma or ectopic pinealoma irradiated at Montefiore Hospital and Medical Center between 1961 and 1971 were reviewed. Diagnosis was made clinically and radiographically. Histology is available in three cases. Eight cases were treated with small fields (4 X 4 to 6 X 8 c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197606)37:6<2713::aid-cncr282037
更新日期:1976-06-01 00:00:00
abstract::The following case report describes a 22-year-old healthy man, non-smoker, non-drinker, who developed a squamous cell carcinoma of the buccal mucosa. The appearance of this unusual tumor in an unexpected clinical setting was unexplained until it was discovered that the patient had a lifetime habit of chewing plastic m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197704)39:4<1686::aid-cncr282039
更新日期:1977-04-01 00:00:00
abstract::Although cancer often is referred to as "a disease of the genes," it is indisputable that the (epi)genetic properties of individual cancer cells are highly variable, even within the same tumor. Hence, preexisting resistant clones will emerge and proliferate after therapeutic selection that targets sensitive clones. He...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.31630
更新日期:2018-12-15 00:00:00
abstract::For men diagnosed with clinically localized prostate cancer, definitive therapy with radical prostatectomy, external beam radiation therapy, or brachytherapy offers a high chance of cure. Currently, there are insufficient data to recommend 1 treatment approach over another, leaving physicians and patients to decide ba...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24344
更新日期:2009-07-01 00:00:00
abstract::Five hundred and sixty-six patients with either Stage III or IV Hodgkin's disease were prospectively randomized to test whether CCNU and/or vinblastine are more effective than mechlorethamine and/or vincristine with procarbazine and prednisone. The combination of CCNU, vinblastine, procarbazine, and prednisone (CVPP) ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19800815)46:4<654::aid-cncr28204
更新日期:1980-08-15 00:00:00
abstract:BACKGROUND:Proton therapy has been a hotly contested issue in both scientific publications and lay media. Proponents cite the modality's ability to spare healthy tissue, but critics claim the benefit gained from its use does not validate its cost compared with photon therapy. The objective of this study was to evaluate...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28322
更新日期:2013-12-15 00:00:00
abstract::Human prostate specimens from 25 patients provided 15 normal, four benign prostatic hypertrophy (BPH), and seven adenocarcinoma samples which were studied using a polyclonal antibody against prostatic specific antigen (PSA) and protein A-gold complex. Our study showed the presence of gold particles in cytoplasmic vesi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870915)60:6<1288::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract::Seven patients with advanced locoregional or metastatic squamous cell carcinoma of the skin were treated with cis-daimminedichloroplatin (cisplatin) and 5-fluorouracil (5-FU). Responses were seen in six of seven patients (three partial responses [PR] and three complete responses [CR]). One patient is alive and disease...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910415)67:8<2030::aid-cncr2820
更新日期:1991-04-15 00:00:00
abstract:BACKGROUND:We previously reported that a single prostate-specific antigen (PSA) measured at ages 44-50 was highly predictive of subsequent prostate cancer diagnosis in an unscreened population. Here we report an additional 7 years of follow-up. This provides replication using an independent data set and allows estimate...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25568
更新日期:2011-03-15 00:00:00
abstract:BACKGROUND:Salivary gland carcinomas (SGCs) are a rare malignancy with unknown etiology. The objective of the current study was to identify genetic variants modifying the risk of SGC and its major subtypes: adenoid cystic carcinoma and mucoepidermoid carcinoma. METHODS:The authors conducted a genome-wide association s...
journal_title:Cancer
pub_type: 杂志文章,收录出版
doi:10.1002/cncr.29381
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop resistance and cardiac and steroid t...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.10946
更新日期:2002-11-15 00:00:00
abstract::The American Joint Committee on Cancer proposes the following criteria for evaluating putative prognostic factors: they must be (1) significant, (2) independent, and (3) clinically important. Furthermore, we suggest the criteria for selecting a prognostic system that includes TNM and new prognostic factors. These crit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931115)72:10<3131::aid-cncr282
更新日期:1993-11-15 00:00:00
abstract:BACKGROUND:Despite the characteristic histopathologic appearance of alveolar soft-part sarcoma (ASPS), its histogenesis remains unclear, and cytogenetic analysis of ASPS is limited to eight cases so far because of the extreme rarity of this disease. METHODS:The authors document a cytogenetic study of a primary case of...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::A 55-year-old man is reported who initially developed chronic lymphocytic leukemia. Seven years later, after chemotherapy with chlorambucil, chronic myelogenous leukemia was diagnosed in addition to the chronic lymphocytic leukemia. Four previously reported cases with the same sequence of events are reviewed as well a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(1984)54:4<697::aid-cncr282054041
更新日期:1984-08-15 00:00:00