The changing landscape of phase II/III metastatic NSCLC clinical trials and the importance of biomarker selection criteria.

abstract：BACKGROUND:There is increasing evidence that radiation therapy (RT) can be omitted for select older patients who are compliant with hormonal blockade, but there is no recent claim-based analysis for determining patterns of care and guiding possible treatment recommendations. METHODS:Medicare beneficiaries who were 65 ...

journal_title：Cancer

authors： Wallace AS,Keene KS,Williams CP,Jackson BE,Pisu M,Partridge EE,Rocque GB

更新日期：2018-02-01 00:00:00

abstract：:A study of the effects of local tumor radiation alone (1500R) and cyclophosphamide alone (150 mg/kg) on the experimental solid tumor rat hepatoma 3924A has been completed. Cyclophosphamide was more effective in controlling tumor growth than either radiation or 5-fluorouracil (5-FU) (150 mg/kg) previously reported. Par...

journal_title：Cancer

authors： Looney WB,Hopkins HA,Grover WH,Macleod MS,Ritenour ER,Hobson AS

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND:Testing for oral high-risk human papillomavirus (HPV) DNA may be useful for identifying individuals at increased risk for HPV-driven oropharyngeal cancer (OPC). However, positivity for HPV DNA provides no information on the transforming potential of the infection. In contrast, the detection of high-risk HPV ...

journal_title：Cancer

authors： Rollo F,Pichi B,Benevolo M,Giuliani M,Latini A,Lorenzon L,Colafigli M,Frasca M,Pellini R,Cristaudo A,Donà MG

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:During the last decade, an inverse stage migration has been observed in radical prostatectomy series at tertiary centers. However, it remains unclear whether similar trends can also be observed in solely robotic practices, including nonreferral centers. The aim of this study was to investigate the clinical a...

journal_title：Cancer

authors： Albisinni S,Joniau S,Quackels T,De Coster G,Dekuyper P,Van Cleynenbreugel B,Van Damme N,Van Eycken E,Ameye F,Roumeguère T,Be-RALP Registry (Belgian Robotic-Assisted Laparoscopic Prostatectomy Registry).

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Supratentorial gangliogliomas (GGs) are rare tumors of the central nervous system and are commonly associated with chronic seizures. To date, only case reports and small series of patients with short-term follow-up have been available for the assessment of the potential of GGs to recur and progress. METHODS...

journal_title：Cancer

authors： Luyken C,Blümcke I,Fimmers R,Urbach H,Wiestler OD,Schramm J

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Proton therapy has been a hotly contested issue in both scientific publications and lay media. Proponents cite the modality's ability to spare healthy tissue, but critics claim the benefit gained from its use does not validate its cost compared with photon therapy. The objective of this study was to evaluate...

journal_title：Cancer

authors： Mailhot Vega RB,Kim J,Bussière M,Hattangadi J,Hollander A,Michalski J,Tarbell NJ,Yock T,MacDonald SM

更新日期：2013-12-15 00:00:00

abstract：BACKGROUND:An association between fats and colorectal carcinoma has been suggested, but the epidemiologic evidence by type of dietary fat is far less clear. Colorectal carcinoma rates have been relatively low in Mediterranean countries compared with most other Western countries, but the components of the Mediterranean ...

journal_title：Cancer

authors： Braga C,La Vecchia C,Franceschi S,Negri E,Parpinel M,Decarli A,Giacosa A,Trichopoulos D

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the results of thyroid fine-needle aspiration (FNA) and to determine the reasons for the discrepancies between the cytologic and histologic diagnoses. METHODS:The authors evaluated the cytologic and histologic results of 133 FNAs obtained from 92 patients who underw...

journal_title：Cancer

authors： Sidawy MK,Del Vecchio DM,Knoll SM

更新日期：1997-08-25 00:00:00

abstract：BACKGROUND:An association between laryngopharyngeal reflux (LPR) and laryngeal carcinoma has been suggested, but remains unproven. The current pilot study was performed to determine the incidence of LPR among patients with early laryngeal carcinomas or dysplasia and to examine the associations between levels of LPR and...

journal_title：Cancer

authors： Lewin JS,Gillenwater AM,Garrett JD,Bishop-Leone JK,Nguyen DD,Callender DL,Ayers GD,Myers JN

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Examination was performed on pathologic material from patients enrolled in the National Surgical Adjuvant Breast Project (NSABP) protocol B-18, in which the clinical effects of preoperative (preop) and postoperative (postop) doxorubicin and cyclophosphamide (AC) were compared. METHODS:Of the total number of...

journal_title：Cancer

authors： Fisher ER,Wang J,Bryant J,Fisher B,Mamounas E,Wolmark N

更新日期：2002-08-15 00:00:00

abstract：BACKGROUND:Patients age > or = 75 years with acute myeloid leukemia (AML) generally are offered palliative treatments instead of induction chemotherapy. The authors conducted a retrospective study comparing the outcomes among these elderly patients with the outcomes among younger patients to assess the impact of intens...

journal_title：Cancer

authors： Vey N,Coso D,Bardou VJ,Stoppa AM,Braud AC,Bouabdallah R,Sainty D,Mozziconacci MJ,Lafage M,Damaj G,Blaise D,Gastaut JA,Maraninchi D

更新日期：2004-07-15 00:00:00

abstract：:To determine whether the referral of lung cancer patients to university cancer centers was related to nonclinical factors, the medical charts were reviewed for almost all lung cancer patients diagnosed during the period of 1973-1976 in New Hampshire and Vermont. Greater distance from a cancer center, lower functional ...

journal_title：Cancer

authors： Greenberg ER,Dain B,Freeman D,Yates J,Korson R

更新日期：1988-10-15 00:00:00

abstract：BACKGROUND:Because of the small number of cases (five) reported between 1929 and 1969 and a significant increase reported in the decade of the 1970s, the Familial Ovarian Cancer Registry was established in 1981 to study the occurrence of familial ovarian cancer in the United States. METHODS:Any woman (with or without ...

journal_title：Cancer

authors： Piver MS,Baker TR,Jishi MF,Sandecki AM,Tsukada Y,Natarajan N,Mettlin CJ,Blake CA

更新日期：1993-01-15 00:00:00

abstract：BACKGROUND:Clear cell sarcoma (CCS) of tendons and aponeuroses is extremely rare in childhood and little information is available on its clinical management. Originally believed to be a type of melanoma of soft tissue origin, CCS is now considered a distinct clinicopathologic entity that behaves like a high-grade soft ...

journal_title：Cancer

authors： Ferrari A,Casanova M,Bisogno G,Mattke A,Meazza C,Gandola L,Sotti G,Cecchetto G,Harms D,Koscielniak E,Treuner J,Carli M

更新日期：2002-06-15 00:00:00

abstract：:Twenty-nine patients treated with adjuvant chemotherapy for carcinoma of the breast were evaluated for frequency and amount of weight gained during treatment. No difference with respect to age, menopausal status, estrogen receptor status, nodal status, biochemical parameters, or treatment regimen (CMF versus CMFVP) we...

journal_title：Cancer

authors： Huntington MO

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Heavy alcohol consumption, viral hepatitis, and diabetes are risk factors for hepatocellular carcinoma (HCC). However, to the authors' knowledge, the information concerning their interaction effect in patients with risk of HCC is sparse. METHODS:A population-based, case-control study of HCC was conducted du...

journal_title：Cancer

authors： Yuan JM,Govindarajan S,Arakawa K,Yu MC

更新日期：2004-09-01 00:00:00

abstract：:Detailed cytogenetic studies were performed in 41 patients with cutaneous T-cell lymphoma (CTCL): four patients had limited plaques, 13 patients had generalized plaques, eight patients had cutaneous tumors, 16 patients had generalized erythroderma, and four additional patients, who had relatively benign chronic dermat...

journal_title：Cancer

authors： Whang-Peng J,Bunn PA Jr,Knutsen T,Matthews MJ,Schechter G,Minna JD

更新日期：1982-10-15 00:00:00

abstract：BACKGROUND:Cell kinetics studies performed with immunohistochemical techniques to estimate the S-phase fraction have elucidated the proliferative potential of individual brain tumors. METHODS:The authors developed a new double-labeling method that enables other cell kinetics variables, including the duration of the S-...

journal_title：Cancer

authors： Shibuya M,Ito S,Davis RL,Wilson CB,Hoshino T

更新日期：1993-05-15 00:00:00

abstract：BACKGROUND:Telomerase is a ribonucleoprotein that maintains telomeric base pair repeats at the ends of mammalian chromosomes during DNA replication. Telomerase is expressed in various human tumors, some normal tissues, and immortalized cell lines. The assay of telomerase activity has potential as an adjunct for cancer ...

journal_title：Cancer

authors： Mu XC,Brien TP,Ross JS,Lowry CV,McKenna BJ

更新日期：1999-04-25 00:00:00

abstract：:A case of basosquamous or so-called transitional cloacogenic carcinoma of the sigmoid colon, which arose above the pelvic brim at the peritoneal reflection, is reported. We were not able to find a report of this histologic type of tumor arising this far from the pectinate line of the anus, which is the most common pri...

journal_title：Cancer

authors： Strate RW,Richardson JD,Bannayan GA

更新日期：1977-09-01 00:00:00

abstract：:Associations were sought between specific histocompatibility antigens (HLA) of the human major histocompatibility complex and the incidence of head and neck squamous cell carcinoma (SqCC). Seventy sequential patients with SqCC and 217 control subjects from the same geographic region were typed for HLA-A, HLA-B, and HL...

journal_title：Cancer

authors： Houck JR,Romano PJ,Bartholomew M,Smith PJ,Kloszewski F,Vesell ES

更新日期：1992-05-01 00:00:00

abstract：:The oral cavity, oropharynx and nasopharynx are readily accessible to fine needle aspiration (FNA). This study reviews the author's experience with 93 FNA from these sites: 76 from the oral cavity, eight from the oropharynx, and eight from the nasopharynx. Thirty-nine (42%) of the FNA were positive for malignancy with...

journal_title：Cancer

authors： Scher RL,Oostingh PE,Levine PA,Cantrell RW,Feldman PS

更新日期：1988-12-15 00:00:00

abstract：:During the past eight years, 137 patients with mycosis fungoides were given total skin electron beam therapy (TSEB) using 2.5 to 4 MeV electrons. A single treatment delivers 400 rads to the entire skin surface, and patients are treated once a week for six to eight consecutive weeks. All have been followed for a median...

journal_title：Cancer

authors： Nisce LZ,Safai B,Kim JH

更新日期：1981-03-01 00:00:00

abstract：:The nuclear DNA content of 98 operable breast cancers was determined by flow cytometric analysis using paraffin-embedded tissue. All patients were on follow-up and failure of treatment or recurrences were identified. DNA ploidy data in the form of ploidy status and DNA index (DI) has been correlated with various clini...

journal_title：Cancer

authors： Sharma S,Mishra MC,Kapur BM,Verma K,Nath I

更新日期：1991-12-15 00:00:00

abstract：BACKGROUND:: Survival rates for gastrointestinal (GI) and bronchopulmonary (BP) neuroendocrine tumors (NETs) have not altered significantly (5-year survival rate: GI NETs, 64.1%; BP NETs, 87%-89%) in 30 years (from 1973 to 2004). No effective or specific antineoplastic agents are available to date, although somatostati...

journal_title：Cancer

authors： Drozdov I,Kidd M,Gustafsson BI,Svejda B,Joseph R,Pfragner R,Modlin IM

更新日期：2009-11-01 00:00:00

abstract：:The possibility that urinary pepsinogen I is a tumor marker of stomach cancer after total gastrectomy was examined. To decide the cutoff level of urinary pepsinogen I after total gastrectomy, urine samples from 15 patients who had undergone total gastrectomy for stomach cancer in the early or advanced stages and had b...

journal_title：Cancer

authors： Yamaguchi T,Takahashi T,Yokota T,Kitamura K,Noguchi A,Kamiguchi M,Doi M,Ahn T,Sawai K,Yamane T

更新日期：1991-08-15 00:00:00

abstract：:Urinary polyamine concentrations in 91 samples were assayed in 79 patients with malignant melanoma who were classified as to clinical stage, as well as to activity of disease. Patients with active disease had higher mean polyamine values, increased frequency of polyamine elevations, and increased frequency of two or m...

journal_title：Cancer

authors： Townsend RM,Banda PW,Marton LJ

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:The first analysis of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial (median follow-up, 33 months) demonstrated that in adjuvant endocrine therapy for postmenopausal patients with early-stage breast cancer, anastrozole was superior to tamoxifen in terms of disease-free survival (DFS), time to r...

journal_title：Cancer

authors： Baum M,Buzdar A,Cuzick J,Forbes J,Houghton J,Howell A,Sahmoud T,ATAC (Arimidex, Tamoxifen Alone or in Combination) Trialists' Group.

更新日期：2003-11-01 00:00:00

abstract：:Nineteen patients with locally advanced bladder cancer were treated with irradiation and concomitant 5-fluorouracil intravenous infusion with or without bolus mitomycin. Eighteen of the 19 patients were evaluated for local response. Eleven of the 18 patients (61%) obtained a complete local response within 3 to 6 month...

journal_title：Cancer

authors： Rotman M,Macchia R,Silverstein M,Aziz H,Choi K,Rosenthal J,Braverman A,Laungani GB

更新日期：1987-02-15 00:00:00

abstract：:The authors estimated cancer risk among 589 patients hospitalized with Crohn's disease between 1960-1976 by calculating the ratios of observed number of cancers (O) in our hospital sample to the expected number of cancers (E) based on the age- and sex-specific cancer rates of a standard population. The authors then co...

journal_title：Cancer

authors： Greenstein AJ,Sachar DB,Smith H,Janowitz HD,Aufses AH Jr

更新日期：1981-12-15 00:00:00