Stratification of risk factors in renal cell carcinoma.

abstract：BACKGROUND:Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to ...

journal_title：Cancer

authors： Ali SM,Carney WP,Esteva FJ,Fornier M,Harris L,Köstler WJ,Lotz JP,Luftner D,Pichon MF,Lipton A,Serum HER-2\/neu Study Group.

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Disruption of the lymphatic circulation through breast carcinoma-associated axillary lymph node dissection, with or without radiation therapy, reportedly is the most common cause of lymphedema in developed countries. There is no cure for breast carcinoma-associated lymphedema. Although intermittent pneumatic...

journal_title：Cancer

authors： Szuba A,Achalu R,Rockson SG

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Cyclin-dependent kinases (CDK) and cyclins constitute the subunits of the maturation-promoting factor that controls the process of cell division. High levels of these proteins have been reported in human malignancies of the stomach, colon, breast, and lung, and have been implicated in aberrant cell division ...

journal_title：Cancer

authors： Kallakury BV,Sheehan CE,Ambros RA,Fisher HA,Kaufman RP Jr,Ross JS

更新日期：1997-08-15 00:00:00

abstract：BACKGROUND:Activation of telomerase, a ribonucleoprotein enzyme complex that synthesizes telomere repeats, is associated with acquisition of unlimited cellular proliferation and is commonly detected in human cancer. Measurement of telomerase activity (TA) may provide important information as a diagnostic marker or a pr...

journal_title：Cancer

authors： Shoji Y,Yoshinaga K,Inoue A,Iwasaki A,Sugihara K

更新日期：2000-03-15 00:00:00

abstract：BACKGROUND:Children diagnosed with medulloblastoma whose tumor involves the brain stem or has spread through the cerebrospinal fluid pathways to other areas of the brain or spinal cord have a poor prognosis despite therapy with surgery, craniospinal irradiation (CSI), and chemotherapy. Preradiation chemotherapy may imp...

journal_title：Cancer

authors： Mosijczuk AD,Nigro MA,Thomas PR,Burger PC,Krischer JP,Morantz RA,Kurdunowicz B,Mulne AF,Towbin RB,Freeman AI

更新日期：1993-11-01 00:00:00

abstract：:This study examined public attitudes toward pain associated with cancer and its treatment. A variety of issues were assessed, including the extent to which pain is associated with cancer, fear of pain as a factor in the decision to delay seeking treatment, and concerns about the use of narcotic analgesics for pain con...

journal_title：Cancer

authors： Levin DN,Cleeland CS,Dar R

更新日期：1985-11-01 00:00:00

abstract：:The physician must suspect pancreatic cancer in patients older than age 40 years who present with minimal vague symptoms. The presence of common disorders such as gallstones, hiatal hernia and diverticulosis coli, does not exclude pancreatic cancer. Ultrasonography, computed tomography, ERCP and cytology are the essen...

journal_title：Cancer

authors： Moossa AR

更新日期：1982-12-01 00:00:00

abstract：:Eight hundred sixty-five patients with a microscopically curative resection for carcinoma of the lung were accepted for study, none of whom were excluded from analysis. Adjuvant therapy was randomly assigned about the tenth to 14th postoperative day; 432 patients (treated) were to receive CCNU and hydroxyurea for one ...

journal_title：Cancer

authors： Shields TW,Higgins GA Jr,Humphrey EW,Matthews MJ,Keehn RJ

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:This case-referent study was conducted to elucidate the role of selected exogenous agents in the etiology of head and neck cancer. The factors studied were tobacco smoking, alcohol intake, the use of moist oral snuff, dietary factors, occupational exposures, and oral hygiene. In this first report, the author...

journal_title：Cancer

authors： Lewin F,Norell SE,Johansson H,Gustavsson P,Wennerberg J,Biörklund A,Rutqvist LE

更新日期：1998-04-01 00:00:00

abstract：:The survival of cervical carcinoma patients with paraaortic/high common iliac nodal metastases was evaluated by retrospective chart review during a 13-year interval. Thirty-three patients with cervical carcinoma and surgically documented nodal metastases received primary, extended-field radiation therapy. Overall 2-ye...

journal_title：Cancer

authors： Podczaski E,Stryker JA,Kaminski P,Ndubisi B,Larson J,DeGeest K,Sorosky J,Mortel R

更新日期：1990-07-15 00:00:00

abstract：BACKGROUND:Cetuximab in combination with docetaxel was examined in chemotherapy-refractory/resistant patients with advanced nonsmall-cell lung cancer (NSCLC) to determine response rate, survival, safety, and pharmacokinetics (PK). METHODS:Patients had evidence of epidermal growth factor receptor (EGFR) expression (> o...

journal_title：Cancer

authors： Kim ES,Mauer AM,William WN Jr,Tran HT,Liu D,Lee JJ,Windt P,Hong WK,Vokes EE,Herbst RS

更新日期：2009-04-15 00:00:00

abstract：:The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...

journal_title：Cancer

authors： Kosmidis PA,Axelrod AR,Palacas C,Stahl M

更新日期：1978-08-01 00:00:00

abstract：:Rational treatment of pediatric malignancies requires a detailed knowledge of the clinical pharmacology of those antineoplastic agents used therapeutically. A number of different agents are administered by the oral route. Recently, the clinical pharmacology of 6-mercaptopurine (6-MP) and methotrexate (MTX), the two ag...

journal_title：Cancer

authors： Poplack DG,Balis FM,Zimm S

更新日期：1986-07-15 00:00:00

abstract：:We synthesized doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH)-loaded human albumin microspheres (containing approximately 1% doxorubicin w/w) between 15 and 20 micron in diameter. Intrarenal arterial administration of 99mTC-labeled microspheres demonstrated a high renal entrapment ratio (97% of recovered r...

journal_title：Cancer

authors： Kerr DJ,Willmott N,McKillop JH,Cummings J,Lewi HJ,McArdle CS

更新日期：1988-09-01 00:00:00

abstract：:The hemoptysis which occurs following lymphography typically consists of one or more episodes of blood-tinged sputum, and generally requires no treatment. In contradistinction to this "mild" form of hemoptysis, the current report describes a case of hemoptysis following lymphography--hemoptysis so severe as to require...

journal_title：Cancer

authors： Marglin SI,Castellino RA

更新日期：1979-02-01 00:00:00

abstract：:Giant sections from cystectomy specimens in 45 cases of bladder cancer were examined microscopically after en bloc fixation and processing. There were 35 transitional cell, seven squamous cell, and three mixed transitional cell and squamous carcinomas. Broad front invasion was associated with papillary and superficial...

journal_title：Cancer

authors： Soto EA,Friedell GH,Tiltman AJ

更新日期：1977-02-01 00:00:00

abstract：:Previous studies have shown that magnetic resonance imaging (MRI) is sensitive to white matter changes in children receiving cranial radiation of 3000 cGy or greater. The current study used MRI to investigate the integrity of white matter in children receiving 1800 to 2400 cGy of cranial radiation. Ten survivors of ac...

journal_title：Cancer

authors： Kramer JH,Norman D,Brant-Zawadzki M,Ablin A,Moore IM

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate prevalence and risk factors for emotional and behavioral problems in dependent children of cancer patients using a multinational research design. METHODS:The sample comprised 350 ill parents, 250 healthy partners, and 352 children. Parents assessed the child's psychological func...

journal_title：Cancer

authors： Thastum M,Watson M,Kienbacher C,Piha J,Steck B,Zachariae R,Baldus C,Romer G

更新日期：2009-09-01 00:00:00

abstract：:Eleven patients with advanced soft tissue sarcoma were treated with whole body hyperthermia (41.8 degrees C-43.0 degrees C) for 2 hours, doxorubicin (45 mg/m2) at the beginning of peak temperature and cyclophosphamide (1000 mg/m2) 6 hours after doxorubicin. Warming was accomplished with a nylon and vinyl mesh water pe...

journal_title：Cancer

authors： Gerad H,van Echo DA,Whitacre M,Ashman M,Helrich M,Foy J,Ostrow S,Wiernik PH,Aisner J

更新日期：1984-06-15 00:00:00

abstract：BACKGROUND:Infection with oncogenic-type human papillomavirus (HPV) and consecutive cytologic abnormalities of the uterine cervix precede the evolution of carcinoma. However, the specificity of both changes is too low to predict the true malignant potential of the change in a given time point, because the majority of t...

journal_title：Cancer

authors： Bollmann R,Méhes G,Speich N,Schmitt C,Bollmann M

更新日期：2005-04-25 00:00:00

abstract：BACKGROUND:Although cutaneous desmoplastic malignant melanoma (DMM) has been well characterized, those arising from the oral mucosa have been less well defined. METHODS:We evaluated the clinical and pathologic features of three patients with biopsy-proven DMM examined at the North Carolina Baptist Hospital. Routine he...

journal_title：Cancer

authors： Kilpatrick SE,White WL,Browne JD

更新日期：1996-08-01 00:00:00

abstract：:In the past all clear cell carcinomas of the female genital tract were thought to arise from mesonephric remnants. Recently increasing evidence has related their origin to müllerian rather than mesonephric epithelium. One of the main reasons that has been advanced to support their mesonephric origin has been their occ...

journal_title：Cancer

authors： Hasumi K,Ehrmann RL

更新日期：1978-11-01 00:00:00

abstract：:Among the patients showing evidence of cerebral metastases without previously known cancer history, lung cancer has been found 37 times as the primary tumor in our institution. There were 34 men and three women and all but two were heavy smokers. Only one presented at diagnosis with thoracic symptoms but the chest rad...

journal_title：Cancer

authors： Trillet V,Catajar JF,Croisile B,Turjman F,Aimard G,Bourrat C,Bret P,Carrie C,Chassard JL,Chauvin F

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:A -160 C --> A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC)...

journal_title：Cancer

authors： Wu MS,Huang SP,Chang YT,Lin MT,Shun CT,Chang MC,Wang HP,Chen CJ,Lin JT

更新日期：2002-03-01 00:00:00

abstract：:Treatment choices for localized prostate cancer appear to vary widely, although it is unclear whether this variation is a result of patient values or other factors. The authors conducted a systematic review of the literature, identifying 70 articles that focused on prostate cancer decision making. Studies suggest that...

journal_title：Cancer

authors： Zeliadt SB,Ramsey SD,Penson DF,Hall IJ,Ekwueme DU,Stroud L,Lee JW

更新日期：2006-05-01 00:00:00

abstract：:C57B1/6 mice were given intravenous tumor cells on day O. Mice were then given either a brief exposure to halothane anesthesia or given halothane and then underwent a hind limb amputation. Immune testing was done at varying time intervals and correlated with the development of artificial pulmonary metastases. The effe...

journal_title：Cancer

authors： Lundy J,Lovett EJ 3rd,Hamilton S,Conran P

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:Ideally, screening detects cancer at a more curable stage and, as a result, decreases the rate of subsequent diagnosis at a late stage. Although it is suggested that some cancer screening tests have led to substantial increases in early-stage incidence with only marginal reductions in late-stage incidence (e...

journal_title：Cancer

authors： Yang DX,Gross CP,Soulos PR,Yu JB

更新日期：2014-09-15 00:00:00

abstract：:The glucose consumption rate of 9L rat brain tumor cells was determined as a function of concentration. Glucose uptake followed Michaelis-Menten kinetics with a Km of 0.58 mM and a Vmax of 1.6 pg/cell-min. The glucose diffusion coefficient in spheroids of 9L tumor cells was determined to be 1.5 x 10(-6) cm2/s at 37 de...

journal_title：Cancer

authors： Li CK

更新日期：1982-11-15 00:00:00

abstract：BACKGROUND:Resistance to apoptosis is 1 of the key events that confer chemoresistance and is mediated by the overexpression of antiapoptotic proteins, which inhibit caspase activation. The objective of this study was to evaluate whether the activation of an alternative, caspase-independent cell death pathway could prom...

journal_title：Cancer

authors： Alvero AB,Montagna MK,Chen R,Kim KH,Kyungjin K,Visintin I,Fu HH,Brown D,Mor G

更新日期：2009-07-15 00:00:00

abstract：BACKGROUND:Flow cytometric analysis of trophoblastic tissue has shown that most partial hydatidiform moles (PMs) are triploid, whereas most complete moles (CMs) are diploid or tetraploid. Ploidy analysis can support a diagnosis of CM or PM. However, in some cases, a precise diagnosis cannot be rendered. METHODS:This s...

journal_title：Cancer

authors： Bocklage TJ,Smith HO,Bartow SA

更新日期：1994-06-01 00:00:00