The glucose distribution in 9L rat brain multicell tumor spheroids and its effect on cell necrosis.

abstract：:Three-hundred whole thyroid glands were collected at autopsy from patients who had no known clinical history of thyroid disease, and who varied from 13 to 82 years of age; 200 were male and 100 female. Thyroid glands were weighed, measured, and examined after previous formalin fixation. Histologic examination was done...

journal_title：Cancer

authors： Bisi H,Fernandes VS,de Camargo RY,Koch L,Abdo AH,de Brito T

更新日期：1989-11-01 00:00:00

abstract：:Forty-five immunocompetent patients with solid tumors were immunized with BCG, PPD, and tumor cells. The methods were practical, but the morbidity was significant, including painful draining ulcerations at vaccine sites, possible enhancement of tumor growth in three patients, and the discovery at autopsy of systemic t...

journal_title：Cancer

authors： Gerner RE,Moore GE

更新日期：1976-07-01 00:00:00

abstract：:Thirteen patients with a variety of advanced gynecologic malignancies were administered BCG via the dorsal lymphatics of the lower extremity in addition to standard accepted forms of therapy. Prolonged febrile courses, lymphangitis and suppurative adenitis were observed along the lymphatic pathway of the injected lowe...

journal_title：Cancer

authors： Mangan C,Jeglum KA,Sedlacek TV,Giuntoli RL,Wheeler JE,Rubin E,Mikuta JJ

更新日期：1977-12-01 00:00:00

abstract：:The purpose of this study was to determine whether the presence of more than 5% blasts in a differential count of cytocentrifuged cerebrospinal fluid (CSF) with less than 6 leukocytes/microliter was predictive of central nervous system (CNS) relapse in children with acute lymphoblastic leukemia (ALL). A double concent...

journal_title：Cancer

authors： Odom LF,Wilson H,Cullen J,Bank J,Blake M,Jamieson B

更新日期：1990-10-15 00:00:00

abstract：:The case of a 71-year-old woman who developed generalized weakness, lymphadenopathy, and a skin rash during methyldopa therapy is described. The prompt disappearance of symptoms following the discontinuation of the drug implicates it in the initial triggering of the abnormal lymphoid proliferation. Shortly thereafter,...

journal_title：Cancer

authors： Weisenburger DD

更新日期：1978-11-01 00:00:00

abstract：BACKGROUND:Human papillomaviruses (HPVs) commonly cause proliferative lesions of squamous epithelia, and infection with certain HPV types carries a high risk of malignant transformation, especially in the uterine cervix but also at other sites, including the esophagus. We used molecular techniques to detect and type HP...

journal_title：Cancer

authors： West AB,Soloway GN,Lizarraga G,Tyrrell L,Longley JB

更新日期：1996-06-15 00:00:00

abstract：:Scanning electron microscopy was used to examine the appearances of the colonic mucus layer of rats during chemical carcinogenesis with dimethylhydrazine. The normal colonic mucus layer had a dense homogeneous appearance and provided a complete cover for the mucosal epithelium. At high magnifications tiny fenestration...

journal_title：Cancer

authors： Traynor OJ,Costa NL,Wood CB

更新日期：1983-05-15 00:00:00

abstract：:The frequency and significance of hyperprolactinemia was studied in 21 consecutive, untreated male patients with bronchogenic carcinoma. Seven patients (33%) were found to have elevated serum prolactin (hPRL) levels. No correlation was demonstrated between increased hPRL levels, tissue histology, or tumor burden. L-do...

journal_title：Cancer

authors： Davis S,Proper S,May PB,Ertel NH

更新日期：1979-08-01 00:00:00

abstract：:The radionuclide, gallium-67, accumulates in a wide variety of neoplastic and inflammatory lesions. Diffuse bilateral lung localization of 67Ga occurred in two cases of interstitial pneumonitis associated with bleomycin therapy. Clinical symptoms and laboratory evaluation of pulmonary status correlated with scintigrap...

journal_title：Cancer

authors： Richman SD,Levenson SM,Bunn PA,Flinn GS,Johnston GS,DeVita VT

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:This study analyzed whether proliferative activity and expression of P-glycoprotein 170 (P-170) or glutathione S-transferase-pi (GST-pi) in human non-small cell lung carcinomas (NSCLC) represent independent factors in resistance to doxorubicin or whether an association exists between these factors. METHODS:...

journal_title：Cancer

authors： Volm M,Mattern J,Samsel B

更新日期：1992-08-15 00:00:00

abstract：BACKGROUND:To define the clinicopathologic and prognostic features of patients with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) in North America, standard criteria were used to identify patients with ATLL. METHODS:Statistical analyses used included descriptive stati...

journal_title：Cancer

authors： Phillips AA,Shapira I,Willim RD,Sanmugarajah J,Solomon WB,Horwitz SM,Savage DG,Bhagat G,Soff G,Zain JM,Alobeid B,Seshan VE,O'Connor OA

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:Research suggests that patients' end-of-life (EOL) care is determined primarily by the medical resources available, and not by patient preferences. The authors examined whether patients' desire for life-extending therapy was associated with their EOL care. METHODS:Coping with Cancer is a multisite, prospect...

journal_title：Cancer

authors： Wright AA,Mack JW,Kritek PA,Balboni TA,Massaro AF,Matulonis UA,Block SD,Prigerson HG

更新日期：2010-10-01 00:00:00

abstract：:Two studies were performed to evaluate the safety, tolerability, and efficacy of irinotecan (CPT-11) in the treatment of adults with malignant glioma. Patients with progressive or recurrent malignant gliomas were enrolled. In the first study, CPT-11 was administered once every 3 weeks as a 90-minute intravenous infusi...

journal_title：Cancer

authors： Cloughesy TF,Filka E,Kuhn J,Nelson G,Kabbinavar F,Friedman H,Miller LL,Elfring GL

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:This study was designed to assess the toxicity of pelvic radiation therapy, 5-fluorouracil (5-FU) administered by protracted venous infusion, and leucovorin. METHODS:Pelvic radiation therapy consisted of 50.4-54 gray (Gy) administered in 28-30 fractions. Systemic treatment consisted of leucovorin (10 mg dai...

journal_title：Cancer

authors： Martenson JA,Shanahan TG,O'Connell MJ,Cobau CD,Schroeder G,Burch PA,Levitt R,Rowland KM Jr

更新日期：1999-08-15 00:00:00

abstract：:The authors describe the results of multimodality therapy in 27 patients with biopsy-proven primary central nervous system (CNS) lymphoma treated between 1976 and 1986. Treatment included surgical resection (15 patients), radiotherapy (27 patients), and chemotherapy (nine patients). Actuarial survival rates for the 27...

journal_title：Cancer

authors： Pollack IF,Lunsford LD,Flickinger JC,Dameshek HL

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:While the question of whether the trials of breast cancer screening have resulted in a reduction in breast cancer death has been the subject of much scrutiny, there has been less attention to the reduction in tumor size achieved by screening. METHODS:Size data for invasive breast tumors were assembled from ...

journal_title：Cancer

authors： Michaelson JS,Satija S,Kopans D,Moore R,Silverstein M,Comegno A,Hughes K,Taghian A,Powell S,Smith B

更新日期：2003-11-15 00:00:00

abstract：BACKGROUND:The results of an international, multicenter, randomized, double-blind, controlled study assessing the efficacy and safety of lenalidomide treatment in patients with refractory stage IV metastatic malignant melanoma are reported. METHODS:The study compared treatment with lenalidomide (25 mg/d on Days 1-21 o...

journal_title：Cancer

authors： Eisen T,Trefzer U,Hamilton A,Hersey P,Millward M,Knight RD,Jungnelius JU,Glaspy J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Recent advances in the early detection of prostatic adenocarcinoma have stimulated interest in the development of techniques for determining metastatic potential. METHODS:One hundred cases of adenocarcinoma, including 66 biopsy and radical prostatectomy specimens; 20 biopsies alone; and 14 transurethral res...

journal_title：Cancer

authors： Ross JS,Nazeer T,Church K,Amato C,Figge H,Rifkin MD,Fisher HA

更新日期：1993-11-15 00:00:00

abstract：BACKGROUND:The Akt/mammalian target of the rapamycin (mTOR) signaling pathway represents a promising target for cancer therapy. The phosphorylation status of Akt and of mTOR's phosphorylation target eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) is often used to assess the activity of Akt and mTOR signaling...

journal_title：Cancer

authors： Akcakanat A,Sahin A,Shaye AN,Velasco MA,Meric-Bernstam F

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...

journal_title：Cancer

authors： Chow EJ,Puumala SE,Mueller BA,Carozza SE,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Spector LG

更新日期：2010-06-15 00:00:00

abstract：:Multiple endocrine neoplasia, type 2b (MEN 2b) is a disorder characterized by C-cell disease of the thyroid gland (medullary carcinoma or C-cell hyperplasia, or both), pheochromocytoma, ganglioneuromatosis, and skeletal and connective tissue abnormalities. The medullary thyroid carcinoma (MTC) is bilateral and multice...

journal_title：Cancer

authors： Carney JA,Sizemore GW,Hayles AV

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:The ThinPrep Pap Test (TP), a liquid-based cervical cytology preparation, was approved for use in the U.S. in 1996. The purpose of this study was to compare TP performance and biopsy follow-up studies with a similar population of high risk patients sampled by conventional Papanicolaou (Pap) smear (CS). METH...

journal_title：Cancer

authors： Carpenter AB,Davey DD

更新日期：1999-06-25 00:00:00

abstract：BACKGROUND:Cancer patients with single tumors live longer today due to earlier detection and improved treatment methods. For this reason, the authors see more patients who develop a second primary tumor. The etiology of the second tumor can be the same as the first, whether treatment-induced or unknown. The prognoses o...

journal_title：Cancer

authors： Robinson E,Segal R,Struminger L,Faraggi D,El'ad-Yarum R,Mekori T

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Two evidence-based therapies exist for the treatment of high-risk prostate cancer (PCA): external-beam radiotherapy (RT) with hormone therapy (H) (RT + H) and radical prostatectomy (S) with adjuvant radiotherapy (S + RT). Each of these strategies is associated with different rates of local control, distant m...

journal_title：Cancer

authors： Parikh R,Sher DJ

更新日期：2012-01-01 00:00:00

abstract：:The aims of this study were as follows: to confirm that the presence of estrogen (ER) and progesterone (PgR) receptors is an indicator of clinical behavior of human breast cancer independent of other known prognostic factors; to seek clinical correlates of those receptor values that best predict the overall disease ev...

journal_title：Cancer

authors： Vollenweider-Zerargui L,Barrelet L,Wong Y,Lemarchand-Béraud T,Gómez F

更新日期：1986-03-15 00:00:00

abstract：BACKGROUND:Fulvestrant (ICI 182,780) is a new type of estrogen receptor (ER) antagonist that down-regulates the ER and has no known agonist effects. The authors report the prospectively planned combined analysis of data from 2 Phase III trials comparing fulvestrant 250 mg monthly (n=428) and anastrozole 1 mg daily (n=4...

journal_title：Cancer

authors： Robertson JF,Osborne CK,Howell A,Jones SE,Mauriac L,Ellis M,Kleeberg UR,Come SE,Vergote I,Gertler S,Buzdar A,Webster A,Morris C

更新日期：2003-07-15 00:00:00

abstract：:Blood vessel invasion and axillary lymph node involvement were examined in 175 breast cancer patients. The incidence of blood vessel invasion was 35%. The presence of blood vessel invasion was highly associated with early disease recurrence. The association of poor prognosis with blood vessel invasion was independent ...

journal_title：Cancer

authors： Weigand RA,Isenberg WM,Russo J,Brennan MJ,Rich MA

更新日期：1982-09-01 00:00:00

abstract：:Experience with high-dose cytosine arabinoside (HDAC) in pediatric solid tumors is limited. Sixteen children with solid tumors resistant to conventional therapies were registered in a pilot Pediatric Oncology Group (POG) study that required the administration of HDAC at 3 g/m2 every 12 hours for four doses. There were...

journal_title：Cancer

authors： Tebbi CK,Krischer J,Fernbach DJ,Mahoney DH,Alvarado C,Camitta B

更新日期：1990-11-15 00:00:00

abstract：:The possibility that urinary pepsinogen I is a tumor marker of stomach cancer after total gastrectomy was examined. To decide the cutoff level of urinary pepsinogen I after total gastrectomy, urine samples from 15 patients who had undergone total gastrectomy for stomach cancer in the early or advanced stages and had b...

journal_title：Cancer

authors： Yamaguchi T,Takahashi T,Yokota T,Kitamura K,Noguchi A,Kamiguchi M,Doi M,Ahn T,Sawai K,Yamane T

更新日期：1991-08-15 00:00:00

abstract：:In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use before 20 years of age was significantly associated with higher tumor cell proliferative activity, as indicated by a higher S-phase fraction (SPF), and a higher fraction of DNA aneuploid tumors, compared with later or never users (P ...

journal_title：Cancer

authors： Olsson H,Ranstam J,Baldetorp B,Ewers SB,Fernö M,Killander D,Sigurdsson H

更新日期：1991-03-01 00:00:00