Toxicity of high-dose cytosine arabinoside in the treatment of advanced childhood tumors resistant to conventional therapy. A Pediatric Oncology Group study.

abstract：BACKGROUND:Pediatric rhabdomyosarcomas (RMS) have a more advantageous prognosis after multimodality treatment compared with adult RMS, which might be related to a decreased sensitivity to chemotherapy in adults. Resistance to chemotherapy might be conveyed by the multidrug resistance (MDR)-associated proteins P-glycopr...

journal_title：Cancer

authors： Komdeur R,Klunder J,van der Graaf WT,van den Berg E,de Bont ES,Hoekstra HJ,Molenaar WM

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:The National Lung Screening Trial (NLST), which was conducted between 2002 and 2009, demonstrated that screening with low-dose computed tomography (LDCT) reduced lung cancer mortality by 20% among screening-eligible populations compared with chest x-ray. In this article, the authors provide an estimate of th...

journal_title：Cancer

authors： Ma J,Ward EM,Smith R,Jemal A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Low-grade gliomas (LGGs) and low-grade glioneuronal tumors (LGGNTs) diagnosed during the first year of life carry unique clinical characteristics and challenges in management. However, data on the treatment burden, outcomes, and morbidities are lacking. METHODS:A retrospective study of LGGs and LGGNTs diagn...

journal_title：Cancer

authors： Liu APY,Hastings C,Wu S,Bass JK,Heitzer AM,Ashford J,Vestal R,Hoehn ME,Ghazwani Y,Acharya S,Conklin HM,Boop F,Merchant TE,Gajjar A,Qaddoumi I

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the efficacy and toxicity of a high-dose 5-fluorouracil and actinomycin D regimen (the FA regimen) as salvage chemotherapy for patients with high-risk gestational trophoblastic tumors (GTTs). METHODS:From 1985 to 1997, 10 patients with refractory, high-risk GTTs w...

journal_title：Cancer

authors： Matsui H,Suzuka K,Iitsuka Y,Yamazawa K,Tanaka N,Mitsuhashi A,Seki K,Sekiya S

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Aberrant expression of the facilitative glucose transporter, GLUT1, is found in a wide spectrum of epithelial malignancies. The current study describes an immunohistochemical study of GLUT1 expression in benign, hyperplastic, and malignant endometrial epithelia. METHODS:One hundred sixteen formalin fixed, p...

journal_title：Cancer

authors： Wang BY,Kalir T,Sabo E,Sherman DE,Cohen C,Burstein DE

更新日期：2000-06-15 00:00:00

abstract：BACKGROUND:The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in situ carcinoma provides an op...

journal_title：Cancer

authors： Zauber NP,Sabbath-Solitare M,Marotta SP,Bishop DT

更新日期：1999-07-01 00:00:00

abstract：:A 28-year-old man with evidence of feminization was demonstrated after 4 years of investigation to have a estrogen-secreting interstitial cell tumor. Such feminizing neoplasms are uncommon, only 37 having been described. They are usually benign and are characterized by gynecomastia, a testicular mass and, with lesser ...

journal_title：Cancer

authors： Gabrilove JL,Nicolis GL,Mitty HA,Sohval AR

更新日期：1975-04-01 00:00:00

abstract：:Modes of cancer growth and DNA ploidy were studied in 66 patients with mucosal carcinoma of the stomach. The modes of growth were classified into five histologic patterns; elongated tubular (three patients), expansive (18 patients), tubular and solid (14 patients), carcinoma in situ (10 patients) and infiltrative (21 ...

journal_title：Cancer

authors： Okamura T,Korenaga D,Haraguchi M,Tsujitani S,Sugimachi K,Mori M,Enjoji M

更新日期：1987-03-15 00:00:00

abstract：:Since 1972 plasma CEA levels of 25 cancer patients have been assayed to evaluate the reliability of CEA as an early indicator of recurrent gastrointestinal cancer. Identification of significant elevations in CEA levels required definition of exactly what a given value meant. Intraassay and interassay accuracy was dete...

journal_title：Cancer

authors： Martin EW Jr,James KK,Hurtubise PE,Catalano P,Minton JP

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to ...

journal_title：Cancer

authors： Ali SM,Carney WP,Esteva FJ,Fornier M,Harris L,Köstler WJ,Lotz JP,Luftner D,Pichon MF,Lipton A,Serum HER-2\/neu Study Group.

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Estrogen receptor-alpha (ERalpha) is variably expressed in hepatocellular carcinoma (HCC) and is believed to be correlated with prognosis and survival. Recently, another estrogen receptor (ERbeta) has been identified, but its relevance in liver diseases is unknown. METHODS:The expression of ERbeta in the li...

journal_title：Cancer

authors： Iavarone M,Lampertico P,Seletti C,Francesca Donato M,Ronchi G,del Ninno E,Colombo M

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Failure to detect metastasis to para-aortic nodes in patients with locally advanced cervical cancer leads to suboptimal treatment. No previous studies have prospectively compared positron emission tomography (PET)/computed tomography (CT) with laparoscopic extraperitoneal staging in the evaluation of para-ao...

journal_title：Cancer

authors： Ramirez PT,Jhingran A,Macapinlac HA,Euscher ED,Munsell MF,Coleman RL,Soliman PT,Schmeler KM,Frumovitz M,Ramondetta LM

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The prognostic significance and optimal care of children with differentiated thyroid cancer and pulmonary metastases are not well established. METHODS:Of 209 patients younger than 25 years of age who were treated at University of Texas M. D. Anderson Cancer Center between 1960 and 1990 and for whom there wa...

journal_title：Cancer

authors： Vassilopoulou-Sellin R,Klein MJ,Smith TH,Samaan NA,Frankenthaler RA,Goepfert H,Cangir A,Haynie TP

更新日期：1993-02-15 00:00:00

abstract：:Improvement in the management of acute leukemia in adults has not progressed nearly so rapidly as has the treatment of childhood leukemia. One important difference is that most adults have myeloblastic or related forms of the disease (AML), whereas the majority of children have lymphoblastic leukemia (ALL). However, e...

journal_title：Cancer

authors： Clarkson BD,Dowling MD,Gee TS,Cunningham IB,Burchenal JH

更新日期：1975-08-01 00:00:00

abstract：:The American Joint Committee on Cancer proposes the following criteria for evaluating putative prognostic factors: they must be (1) significant, (2) independent, and (3) clinically important. Furthermore, we suggest the criteria for selecting a prognostic system that includes TNM and new prognostic factors. These crit...

journal_title：Cancer

authors： Burke HB,Henson DE

更新日期：1993-11-15 00:00:00

abstract：:Flow cytometry studies of the DNA distribution of tumor cells from 92 human breast cancers showed measurable aneuploidy (hyperploidy) in 83 cases (92%). The DNA ploidy values were unimodal in each case, but there was a bimodal distribution for the entire series. One group of tumors had a diploid or near diploid DNA di...

journal_title：Cancer

authors： Olszewski W,Darzynkiewicz Z,Rosen PP,Schwartz MK,Melamed MR

更新日期：1981-08-15 00:00:00

abstract：:Combined teletherapy and interstitial iridium 192 implantation can control locally advanced breast cancer in a consistent fashion without causing significant morbidity. Moreover, in the absence of clinically evident distant metastases, patients who undergo this treatment can survive comfortably for long periods of tim...

journal_title：Cancer

authors： Alderman SJ

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Although the anticancer effects of progesterone therapy for patients with endometrial carcinoma are widely acknowledged, a detailed assessment of the resultant morphologic alterations in tumor tissue kinetics has hitherto been lacking. METHODS:Biopsy and hysterectomy specimens of 14 endometrial carcinomas (...

journal_title：Cancer

authors： Saegusa M,Okayasu I

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Malignant fibrous histiocytoma (MFH) is a neoplasm of late adult life and often is reported in the pediatric population. It is thought to behave more benignly in children than in adults. METHOD:Clinical and pathologic features, treatment, and outcome of nine pediatric patients seen at British Columbia's Chi...

journal_title：Cancer

authors： Cole CH,Magee JF,Gianoulis M,Rogers PC

更新日期：1993-06-15 00:00:00

abstract：:One hundred fifteen patients underwent surgical treatment of renal cell carcinoma. Survival time was analyzed by statistical regression methods in order to determine the joint significance of stage, using both the Robson and TNM classifications, histologic grade, cell type, and demographic features of the patient samp...

journal_title：Cancer

authors： Selli C,Hinshaw WM,Woodard BH,Paulson DF

更新日期：1983-09-01 00:00:00

abstract：:The changes in skeletal muscle mass of 14 children with newly diagnosed acute leukemia were studied during the first 24 weeks of antileukemia therapy. A muscle index was calculated from the femoral quadriceps muscle thickness, measured by using an ultrasound method, and from the body surface area. Serum albumin concen...

journal_title：Cancer

authors： Koskelo EK,Saarinen UM,Siimes MA

更新日期：1990-07-15 00:00:00

abstract：BACKGROUND:It has been established that comparative genomic hybridization (CGH) on Papanicolaou-stained cervical smears can be used to identify chromosomal imbalances. METHODS:In this study, the authors identified normal and dysplastic squamous epithelial cells cytologically, eliminated surrounding bacteria or leukocy...

journal_title：Cancer

authors： Aubele M,Zitzelsberger H,Schenck U,Walch A,Höfler H,Werner M

更新日期：1998-12-25 00:00:00

abstract：BACKGROUND:In the United States, only approximately 0.4% of all melanomas are diagnosed in patients aged <20 years. To the authors' knowledge, melanoma in pediatric members of melanoma-prone families has not been fully investigated to date. The objective of the current study was to evaluate pediatric patients with mela...

journal_title：Cancer

authors： Goldstein AM,Stidd KC,Yang XR,Fraser MC,Tucker MA

更新日期：2018-09-15 00:00:00

abstract：:Four courses of ifosfamide with mesna given by intravenous infusions were combined with bolus doxorubicin in a phase II trial to treat patients with breast cancer. Ifosfamide can deplete intracellular glutathione levels and because doxorubicin resistance may be associated with elevated levels of intracellular glutathi...

journal_title：Cancer

authors： Millward MJ,Harris AL,Cantwell BM

更新日期：1990-06-01 00:00:00

abstract：:Epidermoid cancer accounts for 81% of the malignancies of the vulva. Although the etiology has not been delineated, chronic vulvitis is associated with cancer in almost one-third of the patients. The staging system should utilize the most precise and accurate parameters delineated for improved treatment. A new staging...

journal_title：Cancer

authors： Krupp P,Bohm JW,Lee FY,Collins JH

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a bro...

journal_title：Cancer

authors： Seidinger AL,Mastellaro MJ,Paschoal Fortes F,Godoy Assumpção J,Aparecida Cardinalli I,Aparecida Ganazza M,Correa Ribeiro R,Brandalise SR,Dos Santos Aguiar S,Yunes JA

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:An association between fats and colorectal carcinoma has been suggested, but the epidemiologic evidence by type of dietary fat is far less clear. Colorectal carcinoma rates have been relatively low in Mediterranean countries compared with most other Western countries, but the components of the Mediterranean ...

journal_title：Cancer

authors： Braga C,La Vecchia C,Franceschi S,Negri E,Parpinel M,Decarli A,Giacosa A,Trichopoulos D

更新日期：1998-02-01 00:00:00

abstract：:The diagnosis of breast cancer brings with it significant psychosocial concerns and questions. Part of providing comprehensive care for a woman with breast cancer requires the physician to be aware of the Reach To Recovery Program, which is a peer modeling program provided by the American Cancer Society. The women who...

journal_title：Cancer

authors： Rinehart ME

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Adenoid cystic carcinoma (ACC) of the head and neck (ACCHN) is a rare tumor of minor salivary, parotid, and submandibular glands. The biologic behavior of the disease is poorly understood, and nonsurgical treatment strategies have yet to be standardized. The long-term prognosis continues to be guarded, with ...

journal_title：Cancer

authors： Ellington CL,Goodman M,Kono SA,Grist W,Wadsworth T,Chen AY,Owonikoko T,Ramalingam S,Shin DM,Khuri FR,Beitler JJ,Saba NF

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:Patients with locoregional carcinoma of the esophagus or gastroesophageal junction have a poor survival rate after surgery. Preoperative chemotherapy or chemoradiotherapy has not improved the outcome for these patients. Our study was designed to assess the feasibility of preoperative induction combination ch...

journal_title：Cancer

authors： Ajani JA,Komaki R,Putnam JB,Walsh G,Nesbitt J,Pisters PW,Lynch PM,Vaporciyan A,Smythe R,Lahoti S,Raijman I,Swisher S,Martin FD,Roth JA

更新日期：2001-07-15 00:00:00