Abstract:
BACKGROUND:Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to validate that the serum HER-2/neu profile predicts patient resistance to trastuzumab and to establish a clinically relevant cutoff. METHODS:This was an international, multicenter, retrospective analysis of individual pooled data from 307 patients with MBC who were treated with first-line trastuzumab-based therapy. Serum was collected at baseline and 30 to 120 days after the initiation of trastuzumab therapy. A serum HER-2/neu decrease >or=20% (receiver operating curve analysis) was defined as a significant HER-2/neu change. RESULTS:Of the 307 patients with MBC, 191 patients (62%) had a significant decline (>20%) in serum HER-2/neu and 116 patients (38%) did not. The objective response rate was 57% for patients who achieved this decline in serum HER-2/neu (>20%) compared with 28% for patients who did not. Patients who achieved this decline in serum HER-2/neu also had a significantly longer time to disease progression (320 days vs 180 days; P < .0001), longer duration of response (369 days vs 230 days; P = .008), and longer overall survival (898 days vs 593 days; P < .018). CONCLUSIONS:In this pooled analysis of 307 patients with MBC, individuals who did not achieve a significant decline (>or=20%) in serum HER-2/neu levels had decreased benefit from trastuzumab-based therapy, and these patients should be considered for clinical trials evaluating additional HER-2/neu-targeted interventions.
journal_name
Cancerjournal_title
Cancerauthors
Ali SM,Carney WP,Esteva FJ,Fornier M,Harris L,Köstler WJ,Lotz JP,Luftner D,Pichon MF,Lipton A,Serum HER-2\/neu Study Group.doi
10.1002/cncr.23689subject
Has Abstractpub_date
2008-09-15 00:00:00pages
1294-301issue
6eissn
0008-543Xissn
1097-0142journal_volume
113pub_type
杂志文章,多中心研究相关文献
CANCER文献大全abstract::Low-dose continuous infusion 5-fluorouracil (LDCI-FU) was administered to 28 women with advanced breast carcinoma. Daily doses ranged from 175 to 250 mg/m2. The LDCI-FU was delivered continuously until the appearance of toxicity and was reinstituted at a 20% dose reduction after toxicity completely resolved. Patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890201)63:3<419::aid-cncr28206
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Despite the recognition of ionizing radiation as a causal risk factor for a variety of solid tumors (including brain tumors), to date, such an association with pituitary adenoma (PA) has not been demonstrated. METHODS:To evaluate a possible association between past exposure to radiation and the occurrence o...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.10667
更新日期:2002-07-15 00:00:00
abstract::A marked increase in specific immunogenicity of tumor cells is induced upon incorporation of cholesteryl hemisuccinate (CHS) into the cell membrane, which presumably promotes the expression of latent tumor-associated antigens. Immunotherapy with CHS-treated and irradiated tumor cells as vaccine was found to be very ef...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19860801)58:3<650::aid-cncr28205
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:The prognostic significance of molecular phenotype in breast cancer is well established in the literature. Recent studies have demonstrated that subgross lesion distribution (unifocal, multifocal, and diffuse) and disease extent also carry prognostic significance in this disease. However, the correlation of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27877
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:The human papillomavirus (HPV) E2 protein is a transcriptional repressor of the oncogenes E6/E7 and loss of E2 function is considered a key step in carcinogenesis. Integration of HPV into the host genome may disrupt the E2 gene. Furthermore, methylation of CpG dinucleotides in E2-binding sites (E2BSs) in the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29315
更新日期:2015-06-15 00:00:00
abstract:BACKGROUND:Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, the authors examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with the risk of total, low-grade, and high-grade prostate cancer. METHODS:Dat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24423
更新日期:2009-08-15 00:00:00
abstract::The effect of cis-diamminedichloroplatinum II (DDP) and ionizing radiation on human bladder transitional cell carcinoma (TCC) was evaluated in nude mouse-grown human tumors following administration of single-agent and combination treatment. Combination of DDP and radiation resulted in accelerated tumor regression and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830801)52:3<452::aid-cncr28205
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND:For certain types of cancer, resection alone rarely achieves a cure, but patients nevertheless tend to have a prolonged survival before they die of the tumor. For other types of cancer, the opposite scenario prevails, suggesting that those biologic mechanisms that allow a curative resection are not identical...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930401)71:7<2299::aid-cncr2820
更新日期:1993-04-01 00:00:00
abstract::The discovery that the human papilloma virus (HPV) is associated with a high and increasing percentage of oropharyngeal squamous cell carcinomas (SCCs) is among the most significant advances in the field of head and neck oncology. HPV-positive oropharyngeal cancer (HPVOPC) has clinical, etiologic, pathologic, and mole...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28595
更新日期:2014-05-15 00:00:00
abstract::Data from a hospital-based case-control study between 1985-1990 were used to examine the effects of tobacco, alcohol, asbestos, and other occupational exposures on laryngeal cancer risk in 194 white men with primary cancer of the larynx and 184 age-matched control subjects. A dose-dependent effect for current cigarett...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920501)69:9<2244::aid-cncr2820
更新日期:1992-05-01 00:00:00
abstract::A primitive neuroectodermal tumor of peripheral nerve origin was examined by light and electron microscopy. The lesion arose in association with the S1 nerve root of the lumbosacral plexus in a 22-year-old female. Following a surgical biopsy, the patient received systemic chemotherapy; however, approximately one-and-a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801201)46:11<2456::aid-cncr282
更新日期:1980-12-01 00:00:00
abstract::The descriptive epidemiologic features of bladder cancer and lung cancer in Los Angeles County were studied for the period 1972-1976, using data from the Los Angeles County/University of Southern California Cancer Surveillance Program. The incidence pattern for bladder cancer was found to differ markedly from the patt...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830215)51:4<675::aid-cncr28205
更新日期:1983-02-15 00:00:00
abstract:BACKGROUND:Screening is effective in reducing the incidence and mortality of colorectal cancer. Rates of colorectal cancer test use continue to be low. METHODS:The authors analyzed data from the National Health Interview Survey concerning the use of the home-administered fecal occult blood test (FOBT) and sigmoidoscop...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20276
更新日期:2004-05-15 00:00:00
abstract::Major advances have been made in melanoma treatment with the use of molecularly targeted therapies and immunotherapies, and numerous regimens are now approved by the US Food and Drug Administration for patients with stage IV disease. However, therapeutic resistance remains an issue to both classes of agents, and relia...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.30681
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Bortezomib has preclinical and clinical in B-cell lymphomas, both alone and in combination with other agents. A phase 1 evaluation was conducted of bortezomib with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with untreated diffuse large B-cell lymphoma (DLBC...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25509
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:To define the clinicopathologic and prognostic features of patients with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia/lymphoma (ATLL) in North America, standard criteria were used to identify patients with ATLL. METHODS:Statistical analyses used included descriptive stati...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25147
更新日期:2010-07-15 00:00:00
abstract::A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197501)35:1<121::aid-cncr2820350
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:The objective of this study was to discover molecular biomarkers associated with the recurrence of esophageal squamous cell carcinoma (ESCC). METHODS:The authors retrospectively analyzed the hypermethylation status of 11 genes using methylation-specific polymerase chain reaction (PCR) and the expression of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27948
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Patients' estimates of their chances of therapeutic benefit from participation in early phase trials greatly exceed historical data. Ethicists worry that this therapeutic misestimation undermines the validity of informed consent. METHODS:The authors interviewed 45 patients enrolled in phase 1 or 2 oncology ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25201
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Patients scheduled to receive chemotherapy frequently undergo pretherapy dental treatment to eliminate potential sources of odontogenic infection. A prospective study was conducted to assess a new protocol emphasizing minimal pretherapy dental treatment. METHODS:Forty-eight consecutive patients diagnosed wi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-04-15 00:00:00
abstract:BACKGROUND:Hispanic Americans have been shown to receive fewer cancer screening procedures than nonminority populations. Although lack of insurance or a regular source of care appear to be important determinants, cultural factors also have been suggested. This study examines whether Hispanic patients receive cancer scr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010101)91:1+<257::aid-cncr15>3
更新日期:2001-01-01 00:00:00
abstract::Reported is the case of a 24-year-old white man with inoperable giant cell carcinoma of the thyroid who achieved tumor regression following therapy with bleomycin, Adriamycin and cisplatinum. After 2 courses of chemotherapy, the tumor was deemed operable, and the patient underwent total thyroidectomy followed by radia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821201)50:11<2252::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract::A Phase I/II accelerated fractionation study for high-grade cerebral astrocytomas began in October 1987. Forty-two patients, 25 men and 17 women, were entered in the study. Median age was 58.5 years of age (range, 32 to 78 years). Performance status was 0, 1, 2, and 3 on Eastern Cooperative Oncology Group (ECOG) scale...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910501)67:9<2247::aid-cncr2820
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:The authors have previously reported a tumor cell vaccine modified with superantigen staphylococcal enterotoxin A (SEA) and its antitumor effect. The tumor cell vaccines modified with multiple immune activators frequently elicited stronger immune responses against established tumors than single-modified vacc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20943
更新日期:2005-04-01 00:00:00
abstract::The DNA content of human plasma cells from myeloma patients relative to that of leukocytes was determined by flow and microscopic cytofluorometry after propidium iodide and fluorescent Feulgen staining, respectively. Mononucleated myeloma plasma cells from all of the 17 patients studied contained more DNA (17 to 58%) ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810515)47:10<2433::aid-cncr282
更新日期:1981-05-15 00:00:00
abstract::Seven adults had a distinct clinicopathologic type of lymphoproliferative disorder of the bone marrow. All patients presented with weakness and pancytopenia; no evidence of gross extramedullary involvement was found. In 5 cases severe and prolonged bone marrow hypoplasia was associated with combination chemotherapy; 1...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801015)46:8<1767::aid-cncr2820
更新日期:1980-10-15 00:00:00
abstract::Responding to growing concerns regarding the safety, quality, and efficacy of cancer care in the United States, the Institute of Medicine (IOM) of the National Academy of Sciences commissioned a comprehensive review of cancer care delivery in the US health care system in the late 1990s. The National Cancer Policy Boar...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26536
更新日期:2012-05-15 00:00:00
abstract:BACKGROUND:The diagnosis of malignant mesothelioma (MM) in serous effusions is difficult but may be achieved by the application of adjuvant methods. METHODS:The authors cytologically diagnosed 33 effusions as suspicious or positive for MM cells by using DNA-image cytometry (DNA-ICM), immunocytochemistry and AgNOR anal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23413
更新日期:2008-06-25 00:00:00
abstract::It is rare for small lymphocytic B-cell malignancies to be associated with osteolytic bone lesions and/or hypercalcemia. The authors present an unusual case of well-differentiated lymphocytic lymphoma (DWDL) in a 70-year-old man who had osteolytic bone lesions and subsequently developed severe refractory hypercalcemia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851115)56:10<2508::aid-cncr282
更新日期:1985-11-15 00:00:00
abstract:BACKGROUND:Clinical trials of monoclonal antibodies in combination with chemotherapy have reported previously unattained response rates in patients with B-cell chronic lymphocytic leukemia (B-CLL); however, the analysis of ZAP-70 protein and/or CD38 may explain better the discordant outcomes independent of treatment. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21535
更新日期:2005-12-15 00:00:00