Abstract:
BACKGROUND:Pediatric rhabdomyosarcomas (RMS) have a more advantageous prognosis after multimodality treatment compared with adult RMS, which might be related to a decreased sensitivity to chemotherapy in adults. Resistance to chemotherapy might be conveyed by the multidrug resistance (MDR)-associated proteins P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and lung resistance-related protein (LRP). It was therefore suggested that these proteins were expressed differently in pediatric and adult patients. METHODS:The expression of P-gp, MRP1, and LRP was assessed immunohistochemically in 45 specimens of untreated RMS: 29 were obtained from children younger than 16 years old and 16 were obtained from adults. All children had an embryonal or botryoid RMS. Among the adults, there were 10 embryonal, 3 alveolar, and 3 pleomorphic RMS. Samples were scored as negative or positive according to the percentage of immunoreactive tumor cells: 0.5 (1-5%), 1 (5-25%), 2 (26-50%), 3 (51-75%), or 4 (> 75%). RESULTS:Expression of LRP was more pronounced in embryonal and pleomorphic RMS in adults compared with RMS in children. In addition, LRP expression correlated with age at diagnosis. Alveolar RMS had remarkably low LRP expression. Expression of P-gp and MRP1 did not differ significantly between children and adults. CONCLUSIONS:In this series of embryonal and pleomorphic RMS, an increased LRP expression was observed in adults, which may explain their worse response to chemotherapy reported in other studies. In alveolar RMS, a low LRP expression was observed, suggesting that other mechanisms are responsible for the resistant phenotype in most of these tumors.
journal_name
Cancerjournal_title
Cancerauthors
Komdeur R,Klunder J,van der Graaf WT,van den Berg E,de Bont ES,Hoekstra HJ,Molenaar WMdoi
10.1002/cncr.11259subject
Has Abstractpub_date
2003-04-15 00:00:00pages
1999-2005issue
8eissn
0008-543Xissn
1097-0142journal_volume
97pub_type
杂志文章相关文献
CANCER文献大全abstract::To investigate the possible implications of heterogeneity among the non-Hodgkin's lymphomas for bone marrow purging using complement-fixing monoclonal antibodies to lymphoma-associated antigens, a panel of large cell lymphoma cell lines of diverse phenotypes was treated with monoclonal antibodies DLC-48 and LN-1. An a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880315)61:6<1082::aid-cncr2820
更新日期:1988-03-15 00:00:00
abstract::In a clinical trial, 42 patients with abdominal Burkitt's lymphoma (BL) were treated with a combination regimen, code-named CVA, consisting of cyclophosphamide (CTX), vincristine, and cystosine arabinoside. In addition, intrathecal methotrexate (i.t. MTX) was administered as prophylaxis against subsequent central nerv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4<1410::aid-cncr282040
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:Angiotropic large cell lymphoma (ALCL) is characterized by the intravascular proliferation of malignant lymphoid cells in small and medium-sized blood vessels. In the current study, the authors report an unusual case in which the initial presentation of the ALCL was that of superior vena cava (SVC) syndrome....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001215)89:12<2515::aid-cncr1>3
更新日期:2000-12-15 00:00:00
abstract::The 4F2 antigen is a cell-membrane glycoprotein which arises early in the G0-G1 phases of the cell cycle. This molecule is present in all established human cell lines and most malignant human cells. The authors used an indirect immunophosphatase method to study 50 squamous cell carcinomas of the larynx and ten lymph-n...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901001)66:7<1493::aid-cncr2820
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Circulating prostate cells can be detected in the venous blood of patients with clinically localized prostate carcinoma by applying reverse transcriptase-polymerase chain reaction (RT-PCR) techniques using primers specific for the prostate specific antigen (PSA) gene. This study evaluates whether the detecti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970615)79:12<2402::aid-c
更新日期:1997-06-15 00:00:00
abstract::The authors performed immunohistochemical and cytogenetic studies in a 73-year old man with malignant angioendotheliomatosis. The patient was referred for evaluation of fever of unknown origin, hepatic failure, and neurologic deterioration. Examination of a muscle biopsy revealed numerous, noncohesive atypical mononuc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900801)66:3<474::aid-cncr28206
更新日期:1990-08-01 00:00:00
abstract::The occurrence and staining patterns of Concanavalin A (Con A) binding histiocytes were studied in diagnostic lymph node specimens of 133 patients with Hodgkin's disease. Varying numbers of Con A binding histiocytes were present in all tumors. Two distinct cytoplasmic staining patterns of the Con A binding histiocytes...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830715)52:2<252::aid-cncr28205
更新日期:1983-07-15 00:00:00
abstract:BACKGROUND:Postgastrectomy patients undergoing chemoradiation risk chemoradiation-induced liver disease (CRILD). The objectives of this study were to investigate dosimetric implications and assess biologic susceptibility to CRILD in these patients. METHODS:Sixty-two patients with Stage IB-IV gastric/gastroesophageal a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20591
更新日期:2004-11-01 00:00:00
abstract::Between March 1973, and December 1976, 22 patients who developed disease progression during or after MOPP therapy were treated with a new combination, B-CAVe (Bleomycin 5 mg/m2 iv days 1, 28, 35; CCNU 100 mg/m2 po day 1; adriamycin 60 mg/m2 iv day 1; and vinblastine 5 mg/m2 iv day 1). Objective responses were achieved...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<1670::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:Hormone replacement therapy (HRT) has proven and presumable benefits for women desiring postmenopausal health preservation. Among HRT-associated risks, the fear of breast carcinoma intimidates women and physicians contemplating hormonal treatment and limits long-term compliance. Identifying effective alterna...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.11049
更新日期:2003-01-01 00:00:00
abstract::Radiotherapy was applied to 14 esophageal carcinomas with respiratory tract fistulas using various treatment regimens. Closure of the fistulas was observed in four cases after irradiation at a daily dose of 1.5 Gy. The period of closure was transient in two cases but long-term in the other two. One long-term closure c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890901)64:5<1026::aid-cncr2820
更新日期:1989-09-01 00:00:00
abstract::A parotid tumor having sebaceous differentiation and a particular histologic picture previously undescribed is reported. The tumor showed features of an adenolymphoma but almost completely lacked a lymphoid component. Sebaceous differentiation was seen in the epithelium of many cysts. Additionally, groups of oxyphilic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197904)43:4<1429::aid-cncr282043
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:The goal of the current study was to assess the toxicity, safety, and efficacy of pentostatin in patients with T-cell lymphoid malignancies. METHODS:Patients were eligible if they had biopsy-proven T-cell lymphoma or leukemia and failure to respond to previous therapy or an expected complete response rate t...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11899
更新日期:2004-01-15 00:00:00
abstract::A case of thymoma in a 12-year-old boy is presented. The patient had a history of thymic irradiation in infancy, and a family history of leukemia. The mass was readily resected and the patient is well 10 years later. The tumor contained an unusual admixture of normal thymic tissue with the neoplastic epithelial elemen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<953::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract::This study examines the interrelationships of depth of penetration, tumor size, and the number of positive nodes in Dukes C colorectal cancer. The results indicated that depth of tumor penetration was related to both tumor size and the number of positive regional lymph nodes. Tumors with positive nodes which failed to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840615)53:12<2707::aid-cncr282
更新日期:1984-06-15 00:00:00
abstract::Survival of patients with chronic myeloid leukemia seen in the University of Colorado Leukemia Clinic were reviewed with respect to therapy. A total of 55 patients seen consecutively through mid 1980 were included in this study. Of these patients 30 were treated with busulfan, 14 were treated with hydroxyurea and 11 r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821101)50:9<1683::aid-cncr2820
更新日期:1982-11-01 00:00:00
abstract::The authors retrospectively searched for human papillomavirus (HPV) types 16 and 18 in 60 cases of carcinoma arising from the nasal cavities (NC) and paranasal sinuses (PS) by using the polymerase chain reaction (PCR) on DNA extracted from formalin-fixed, paraffin-embedded tissues. In cases of SCC (n = 49), the author...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<353::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract:BACKGROUND:Malnutrition is a common complication of cancer treatment; it can affect energy levels and, as a consequence, quality of life. The goal of the current study was to evaluate the effect of dietetic intervention in a cohort of children treated for medulloblastoma and supratentorial primitive neuroectodermal tum...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11598
更新日期:2003-09-01 00:00:00
abstract::Thirty-six patients were evaluated between 1965 and 1983 for glioma of the optic nerves and/or chiasm. Median follow-up was 10.2 years. Pathologic verification was obtained in 32 patients. Tumor initially confined to the optic nerve recurred in one of five patients after complete resection. The actuarial survival for ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880215)61:4<635::aid-cncr28206
更新日期:1988-02-15 00:00:00
abstract:BACKGROUND:As increasing numbers of young patients with cancer survive, interest in the late effects of therapy is rising. METHODS:The sequelae of treatment were reviewed after a minimum of 5 years of observation in 109 surviving patients with sarcoma of the bladder or prostate who were enrolled in the Intergroup Rhab...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930401)71:7<2387::aid-cncr2820
更新日期:1993-04-01 00:00:00
abstract::A case of primary hemangiosarcoma of the spleen in a 48-year-old woman is presented. Twenty-eight months after splenectomy the patient developed a severe anemia of the microangiopathic type, thrombocytopenia, and a leukoerythroblastic peripheral blood picture. In contrast to x-ray and conventional 99mTc-methylene-diph...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840415)53:8<1682::aid-cncr2820
更新日期:1984-04-15 00:00:00
abstract:BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32392
更新日期:2019-11-15 00:00:00
abstract:BACKGROUND:Uterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in ina...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28844
更新日期:2014-10-15 00:00:00
abstract::The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2249::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract::Peripheral blood lymphocytes of patients with multiple myeloma, macroglobulinemia, and monoclonal gammopathy of uncertain significance were analyzed for B cells, and cells bearing kappa light chains and lambda light chains on their surfaces. Compared with controls, the number of B cells were decreased in all three gro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811115)48:10<2211::aid-cncr282
更新日期:1981-11-15 00:00:00
abstract::Data from the Cancer Registry in the Netherlands Antilles made clear that the incidence rate of cancer of the upper digestive tract in this country was among the highest in the world. To study the long-term trends in the incidence rate a retrospective population-based case-finding survey was performed. The author pres...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840401)53:7<1618::aid-cncr2820
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:It remains controversial whether modified radical neck dissection (MRND) for patients with papillary thyroid carcinoma improves prognosis. However, it is highly probable that the incidence of local recurrence is reduced by lymph node dissection. Sentinel lymph node (SLN) biopsy (SLNB) for patients with melan...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011201)92:11<2868::aid-cncr101
更新日期:2001-12-01 00:00:00
abstract::A clinical trial was conducted at the Institut Gustave Roussy between October 1972 and December 1980 to compare mastectomy with local excision plus Cobalt-irradiation, in patients with breast cancer tumors of 20 mm in diameter or less at macroscopic examination. Low-axillary dissection and extemporaneous histologic ex...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19840301)53:5<1209::aid-cncr2820
更新日期:1984-03-01 00:00:00
abstract::The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197808)42:2<447::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Partial nephrectomy (PN) is recommended for localized T1a (≤4 cm) renal masses and is preferred over radical nephrectomy (RN) for amenable T1b/T2 (>4 cm) tumors. The objective of the current study was to assess overall survival (OS) differences between PN and RN in patients with T1 and T2 renal cell carcinom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31582
更新日期:2018-10-01 00:00:00